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369 results on '"Takeuchi, Jun"'

10. Effects of pemafibrate on lipid metabolism in patients with type 2 diabetes and hypertriglyceridemia: A multi-center prospective observational study, the PARM-T2D study

Author

Kito, Kenichi, Nomoto, Hiroshi, Sakuma, Ichiro, Nakamura, Akinobu, Cho, Kyu Yong, Kameda, Hiraku, Miya, Aika, Omori, Kazuno, Yanagiya, Shingo, Handa, Takahisa, Taneda, Shinji, Takeuchi, Jun, Nagai, So, Yamashita, Kumiko, Kurihara, Yoshio, Atsumi, Tatsuya, and Miyoshi, Hideaki

Published
2022
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15. Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model

Author

Arai, Takahito, Suzuki-Narita, Miyako, Takeuchi, Jun, Tajiri, Ikuko, Inage, Kazuhide, Kawarai, Yuya, Eguchi, Yawara, Shiga, Yasuhiro, Hozumi, Takashi, Kim, Geundong, Tsuchiya, Ryuto, Otagiri, Takuma, Mukaihata, Tomohito, Hishiya, Takahisa, Toshi, Noriyasu, Okuyama, Kohei, Tokeshi, Soichiro, Furuya, Takeo, Maki, Satoshi, Matsuura, Yusuke, Suzuki, Takane, Nakamura, Junichi, Hagiwara, Shigeo, Ohtori, Seiji, and Orita, Sumihisa

Published
2022
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19. Lowering of blood pressure and pulse rate by switching from DPP-4 inhibitor to luseogliflozin in patients with type 2 diabetes complicated with hypertension: A multicenter, prospective, randomized, open-label, parallel-group comparison trial (LUNA study)

Author

Hashimoto-Kameda, Reina, Cho, Kyu Yong, Nomoto, Hiroshi, Nakamura, Akinobu, Omori, Kazuno, Nagai, So, Edagawa, Sachiko, Kawata, Shinichiro, Takeuchi, Jun, Kameda, Hiraku, Kurihara, Yoshio, Aoki, Shin, Atsumi, Tatsuya, and Miyoshi, Hideaki

Published
2021
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20. Association Between Arch-Shaped Hypo-Autofluorescent Lesions Detected Using Fundus Autofluorescence and Postoperative Hypotony.

Author

Yoshikawa, Yuji, Takeuchi, Jun, Takahashi, Aya, Mizuno, Masaharu, Ishida, Tomoka, Koto, Takashi, and Inoue, Makoto

Subjects
*OCULAR hypotony, *OPTICAL coherence tomography, *INTRAOCULAR pressure, *RHODOPSIN, *VITRECTOMY
Abstract

Background: Chorioretinal folds are observed after vitrectomy due to ocular collapse caused by low intraocular pressure. The purpose of this study is to investigate the relationship between the postoperative hypotony, chorioretinal folds, and the fundus autofluorescence (FAF) findings. Methods: Two-hundred-and-seventy consecutive eyes that had undergone 25- or 27-gauge vitrectomy were examined. The associations between the arch-shaped hypo-autofluorescent lesions in the FAF images and the postoperative hypotony with intraocular pressure (IOP) ≤ 4 mmHg were determined on the day after the surgery. Results: Arch-shaped hypo-autofluorescent lesions were seen in 4 of the 270 eyes (1.5%), and hypo-autofluorescence was observed in 3 of 14 hypotonic eyes (18.5%). This was significantly more frequent than in the non-hypotony group (0.4%, p = 0.0004). Optical coherence tomography showed a loss of the ellipsoid zone and retinal pigment epithelial layer in the region of the arch-shaped lesions. None of the arch-shaped hypo-autofluorescent lesions involved the fovea, and the vision recovered in all cases. The hypo-autofluorescent lesions did not disappear during the 4 to 16 month observation period. Conclusions: The postoperative arch-shaped hypo-autofluorescent lesions were associated with postoperative hypotony and RPE damage due to chorioretinal folds. These findings remained even when the IOP was normalized and chorioretinal folds disappeared. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Effects of Switching from Liraglutide or Dulaglutide to Subcutaneous Semaglutide on Glucose Metabolism and Treatment Satisfaction in Patients with Type 2 Diabetes: Protocol for a Multicenter, Prospective, Randomized, Open-Label, Blinded-Endpoint, Parallel-Group Comparison Study (The SWITCH-SEMA 1 Study)

Author

Nomoto, Hiroshi, Oba-Yamamoto, Chiho, Takahashi, Yuka, Takeuchi, Jun, Nagai, So, Yokoyama, Hiroki, Taneda, Shinji, Kurihara, Yoshio, Aoki, Shin, Kameda, Hiraku, Cho, Kyu Yong, Nakamura, Akinobu, Atsumi, Tatsuya, and Miyoshi, Hideaki

Published
2021
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23. Dynamic control of plant water use using designed ABA receptor agonists

Author

Vaidya, Aditya S., Helander, Jonathan D. M., Peterson, Francis C., Elzinga, Dezi, Dejonghe, Wim, Kaundal, Amita, Park, Sang-Youl, Xing, Zenan, Mega, Ryousuke, Takeuchi, Jun, Khanderahoo, Bardia, Bishay, Steven, Volkman, Brian F., Todoroki, Yasushi, Okamoto, Masanori, and Cutler, Sean R.

Published
2019

29. Glycaemic control efficacy of switching from dipeptidyl peptidase‐4 inhibitors to oral semaglutide in subjects with type 2 diabetes: A multicentre, prospective, randomized, open‐label, parallel‐group comparison study (SWITCH‐SEMA 2 study)

Author

Furusawa, Sho, Nomoto, Hiroshi, Yokoyama, Hiroki, Suzuki, Yuka, Tsuzuki, Atsushi, Takahashi, Kiyohiko, Miya, Aika, Kameda, Hiraku, Cho, Kyu Yong, Takeuchi, Jun, Nagai, So, Taneda, Shinji, Kurihara, Yoshio, Nakamura, Akinobu, and Atsumi, Tatsuya

Subjects
GLYCEMIC control, CD26 antigen, TYPE 2 diabetes, SODIUM-glucose cotransporters, SEMAGLUTIDE, INSULIN aspart, MULTIPLE regression analysis
Abstract

Aim: To assess whether oral semaglutide provides better glycaemic control, compared with dipeptidyl peptidase‐4 inhibitor (DPP‐4i) continuation, in people with type 2 diabetes. Materials and Methods: In this multicentre, open‐label, prospective, randomized, parallel‐group comparison study, participants receiving DPP‐4is were either switched to oral semaglutide (3‐14 mg/day) or continued on DPP‐4is. The primary endpoint was the change in glycated haemoglobin (HbA1c) over 24 weeks. Secondary endpoints included changes in metabolic parameters and biomarkers, along with the occurrence of adverse events. Factors associated with HbA1c improvement were also explored. Results: In total, 174 eligible participants were enrolled; 17 dropped out of the study. Consequently, 82 participants in the DPP‐4i group and 75 participants in the semaglutide group completed the study and were included in the analysis. Improvement in HbA1c at week 24 was significantly greater when switching to semaglutide compared with DPP‐4i continuation [−0.65 (95% confidence interval: −0.79, −0.51) vs. +0.05 (95% confidence interval: −0.07, 0.16) (p <.001)]. Body weight, lipid profiles and liver enzymes were significantly improved in the semaglutide group than in the DPP‐4i continuation group. Multiple linear regression analysis revealed that baseline HbA1c and homeostasis model assessment 2‐R were independently associated with HbA1c improvement after switching to semaglutide. Seven participants in the semaglutide group discontinued medication because of gastrointestinal symptoms. Conclusions: Although the potential for gastrointestinal symptoms should be carefully considered, switching from DPP‐4is to oral semaglutide may be beneficial for glycaemic control and metabolic abnormalities in people with higher HbA1c and insulin resistance. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Tbx5 and the Retinotectum Projection

Author

Koshiba-Takeuchi, Kazuko, Takeuchi, Jun K., Matsumoto, Ken, Momose, Tsuyoshi, Uno, Kenichiro, Hoepker, Veit, Ogura, Keiko, Takahashi, Naoki, Nakamura, Harukazu, Yasuda, Kunio, and Ogura, Toshihiko

Published
2000

32. Prospective analysis of patient‐reported outcomes and physician‐reported outcomes with gynecologic cancer chemotherapy.

Author

Takenaga, Tomo, Kuji, Shiho, Tanabe, Ken‐ichiro, Kanamori, Ryo, Imai, Haruka, Takeuchi, Jun, Kondo, Haruhiro, Ohara, Tatsuru, Iwatani, Tsuguo, and Suzuki, Nao

Subjects
TASTE disorders, NAUSEA, PERIPHERAL neuropathy, CANCER chemotherapy, CONSTIPATION, HEALTH outcome assessment, PHYSICIANS' attitudes, TREATMENT effectiveness, CANCER patients, ELECTRONIC health records, INSOMNIA, FATIGUE (Physiology), ADVERSE health care events, FEMALE reproductive organ tumors, LONGITUDINAL method, DISEASE exacerbation
Abstract

Objective: Gynecologic cancer chemotherapy impacts the quality of life (QOL) of patients, with lasting adverse events that may require treatment adjustments or discontinuation. Consequently, real‐time symptom monitoring before outpatient visits has resulted in improved QOL for patients and extended survival times. This study investigated whether there are differences between electronic patient‐reported outcomes (e‐PRO‐CTCAE) and physician‐assessed outcomes (NCI‐CTCAE) evaluated in an outpatient setting in gynecologic cancer chemotherapy. Methods: The study was conducted on 50 patients who received their first chemotherapy treatment at St. Marianna University Hospital Obstetrics and Gynecology from July 1, 2021 to December 31, 2022. PRO‐CTCAE and NCI‐CTCAE were evaluated at each instance of chemotherapy and 2 weeks after. The PRO‐CTCAE was additionally collected weekly using e‐PRO. Results: The values for "Joint Pain," "Nausea," "Taste Disturbance," "Constipation," "Insomnia," "Fatigue," "Limb Edema," and "Concentration Impairment" were consistently higher in PRO‐CTCAE than in NCI‐CTCAE, indicating that physicians underestimated the severity of adverse events. In contrast, there was no significant difference in "Peripheral Neuropathy," demonstrating that physicians had a good understanding of this condition in patients. The weekly responses obtained from e‐PRO revealed that symptom exacerbations peaked outside of clinic visits. Conclusions: This study demonstrated physicians tend to underestimate most adverse events. Moreover, the responses using e‐PRO revealed peak symptom deterioration occurred outside of outpatient visits. This suggested that e‐PRO and actions taken in response to them can improve patients' QOL. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Improvement of glycaemic control and treatment satisfaction by switching from liraglutide or dulaglutide to subcutaneous semaglutide in patients with type 2 diabetes: A multicentre, prospective, randomized, open‐label, parallel‐group comparison study (SWITCH‐SEMA 1 study)

Author

Takahashi, Yuka, Nomoto, Hiroshi, Yokoyama, Hiroki, Takano, Yoshinari, Nagai, So, Tsuzuki, Atsushi, Cho, Kyu Yong, Miya, Aika, Kameda, Hiraku, Takeuchi, Jun, Taneda, Shinji, Kurihara, Yoshio, Atsumi, Tatsuya, Nakamura, Akinobu, and Miyoshi, Hideaki

Subjects
PATIENT satisfaction, GLYCEMIC control, TYPE 2 diabetes, WEIGHT loss, SEMAGLUTIDE
Abstract

Aim: To investigate the effects of switching from liraglutide or dulaglutide to once‐weekly semaglutide on glycaemic control and treatment satisfaction in patients with type 2 diabetes. Materials and Methods: In this multicentre, open‐labelled, prospective, randomized, parallel‐group comparison study, patients treated with liraglutide 0.9‐1.8 mg/day (plan A) or dulaglutide 0.75 mg/week (plan B) were either switched to semaglutide or continued current therapy. The primary endpoint was the mean change in glycated haemoglobin over 24 weeks. The secondary endpoints included the changes of Diabetes Treatment Satisfaction Questionnaire scores, body weight and metabolic indices. Results: In total, 110 patients were enrolled, and 10 were excluded; therefore, 37 patients in plan A and 63 patients in plan B completed the study. Glycated haemoglobin levels were significantly reduced in the semaglutide group in both plans [plan A, 7.8% ± 1.0% to 7.8% ± 0.7% (liraglutide) vs. 7.9% ± 0.7% to 7.3% ± 0.7% (semaglutide), p <.01; plan B, 7.8% ± 1.0% to 7.9% ± 1.2% (dulaglutide) vs. 7.8% ± 0.8% to 7.1% ± 0.6% (semaglutide), p <.01]. Semaglutide also improved Diabetes Treatment Satisfaction Questionnaire scores in both groups (plan A, +0.1 vs. +8.3, p <.01; plan B, −1.2 vs. +3.5, p <.01). Switching from dulaglutide yielded greater reductions in body weight and improved metabolic parameters. Conclusions: Once‐weekly semaglutide administration improved glycaemic control and treatment satisfaction after switching from liraglutide or dulaglutide. These results highlighted a useful treatment option for patients with metabolic abnormalities despite glucagon‐like receptor‐1 receptor agonist treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Distinct Function of 2 Chromatin Remodeling Complexes That Share a Common Subunit, Williams Syndrome Transcription Factor (WSTF)

Author

Yoshimura, Kimihiro, Kitagawa, Hirochika, Fujiki, Ryoji, Tanabe, Masahiko, Takezawa, Shinichiro, Takada, Ichiro, Yamaoka, Ikuko, Yonezawa, Masayoshi, Kondo, Takeshi, Furutani, Yoshiyuki, Yagi, Hisato, Yoshinaga, Shin, Masuda, Takeyoshi, Fukuda, Toru, Yamamoto, Yoko, Ebihara, Kanae, Li, Dean Y., Matsuoka, Rumiko, Takeuchi, Jun K., Matsumoto, Takahiro, Kato, Shigeaki, and Groudine, Mark T.

Published
2009
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47. Comparison of the Relationship between Visual Acuity and Motor Function in Non-Elderly and Elderly Adults.

Author

Ito, Sadayuki, Nakashima, Hiroaki, Machino, Masaaki, Segi, Naoki, Ishizuka, Shinya, Takegami, Yasuhiko, Takeuchi, Jun, Ouchida, Jun, Hasegawa, Yukiharu, and Imagama, Shiro

Subjects
VISUAL acuity, OLDER people, WALKING speed, BACK muscles, ADULTS
Abstract

This study aimed to clarify the relationship between visual acuity and motor function in younger and elderly participants and to compare differences between non-elderly and elderly participants. In total, 295 participants who underwent visual and motor functional examinations were included; participants with visual acuity ≥0.7 were assigned to the normal group (N group) and those with visual acuity ≤0.7 were assigned to the low-visual-acuity group (L group). Motor function was compared between the N and L groups; the analysis was performed by grouping participants into those aged >65 years (elderly) and those aged <65 years (non-elderly). The non-elderly group (average age, 55.6 ± 6.7 years) had 105 and 35 participants in the N and L groups, respectively. Back muscle strength was significantly lower in the L group than in the N group. The elderly group (average age, 71.1 ± 5.1 years) had 102 and 53 participants in the N and L groups, respectively. Gait speed was significantly lower in the L group than in the N group. These results reveal differences in the relationship between vision and motor function in non-elderly and elderly adults and indicate that poor vision is associated with lower back-muscle strength and walking speed in younger and elderly participants, respectively. [ABSTRACT FROM AUTHOR]

Published
2023
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