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398 results on '"Tanaka, Nobumichi"'

3. Difference of oncological efficacy between two immune checkpoint inhibitors following first-line platinum-based chemotherapy in patients with unresectable, metastatic, advanced urothelial carcinoma: a multicenter real-world Japanese cohort

Author

Miyake, Makito, Nishimura, Nobutaka, Oda, Yuki, Miyamoto, Tatsuki, Iida, Kota, Inoue, Kuniaki, Tachibana, Akira, Yoshikawa, Takanosuke, Sakamoto, Keichi, Ohnishi, Mikiko, Maesaka, Fumisato, Takamatsu, Norimi, Mieda, Kosuke, Ohmori, Chihiro, Matsubara, Toshihiko, Tomizawa, Mitsuru, Shimizu, Takuto, Ohnishi, Kenta, Hori, Shunta, Morizawa, Yosuke, Gotoh, Daisuke, Nakai, Yasushi, Torimoto, Kazumasa, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Published
2024
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11. Ten-Year Outcomes of a Phase 3, Multicenter, Randomized Controlled Trial (SHIP0804) With 3-Month Neoadjuvant Androgen Deprivation Prior to 125I-Seed Transperineal Prostate Brachytherapy Followed by Nil Versus 9-Month Adjuvant Hormonal Therapy in Patients With Intermediate-Risk Prostate Cancer

Author

Momma, Tetsuo, Tsumura, Hideyasu, Fukagai, Takashi, Karasawa, Kumiko, Masui, Koji, Hashine, Katsuyoshi, Tanaka, Nobumichi, Katayama, Satoshi, Kusuhara, Yoshito, Eto, Masatoshi, Iinuma, Koji, Hayashi, Narihiko, Sugimoto, Mikio, Suzuki, Kazuhiro, Imamura, Ryoichi, Yonese, Junji, Fukuokaya, Wataru, Miki, Kenta, Aoki, Manabu, Takahashi, Hiroyuki, Saito, Shiro, Yorozu, Atsunori, Kikuchi, Takashi, Dokiya, Takushi, and Egawa, Shin

Published
2024
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20. Association between urine 6-sulfatoxy-melatonin level and intravesical Bacillus Calmette-Guerin treatment–induced sleep quality deterioration in patients with non-muscle invasive bladder cancer

Author

Miyake, Makito, Nishimura, Nobutaka, Ohnishi, Sayuri, Oda, Yuki, Miyamoto, Tatsuki, Shimizu, Takuto, Hori, Shunta, Morizawa, Yosuke, Gotoh, Daisuke, Nakai, Yasushi, Anai, Satoshi, Torimoto, Kazumasa, Aoki, Katsuya, Fujii, Tomomi, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Published
2022
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22. Enzalutamide Versus Abiraterone plus Prednisolone Before Chemotherapy for Castration-resistant Prostate Cancer: A Multicenter Randomized Controlled Trial

Author

Izumi, Kouji, Shima, Takashi, Mita, Koji, Kato, Yuki, Kamiyama, Manabu, Inoue, Shogo, Tanaka, Nobumichi, Hoshi, Seiji, Okamura, Takehiko, Yoshio, Yuko, Enokida, Hideki, Chikazawa, Ippei, Kawai, Noriyasu, Hashimoto, Kohei, Fukagai, Takashi, Shigehara, Kazuyoshi, Takahara, Shizuko, Kadono, Yoshifumi, and Mizokami, Atsushi

Published
2022
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25. The Circadian Rhythm of Intracellular Protoporphyrin IX Accumulation Through Heme Synthesis Pathway in Bladder Urothelial Cancer Cells Exposed to 5-Aminolevulinic Acid.

Author

Nishimura, Nobutaka, Miyake, Makito, Onishi, Sayuri, Tomizawa, Mitsuru, Shimizu, Takuto, Onishi, Kenta, Hori, Shunta, Morizawa, Yosuke, Gotoh, Daisuke, Nakai, Yasushi, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Abstract

Simple Summary: This study investigated the circadian rhythm of intracellular protoporphyrin IX (PPIX) accumulation in bladder cancer cells exposed to 5-aminolevulinic acid to understand the variability in red fluorescence intensity observed during photodynamic diagnosis-assisted transurethral resection among different tumors and patients. We identified the circadian rhythm of the clock genes PER2 and BMAL1 and their impact on PPIX accumulation in bladder cancer cell lines UM-UC-3 and J82, as well as in mouse xenograft models. Additionally, enzymes involved in heme synthesis, including coproporphyrinogen oxidase and ferrochelatase, were found to follow circadian rhythms. When red fluorescence intensity was quantified and compared among the four groups based on surgery start times, from 9 a.m. to 5 p.m., it peaked in surgeries performed between 3 and 5 p.m. These findings suggest that optimizing surgery timing based on circadian rhythms may improve the efficacy of photodynamic diagnosis in bladder cancer. Background/Objectives: The standard recommendation for patients with non-muscle invasive bladder cancer is 5-aminolevulinic acid-mediated photodynamic diagnosis. The intensity of the fluorescence caused by the intracellular accumulation of protoporphyrin IX (PPIX) varies among tumors and patients. This study investigated the circadian rhythm of intracellular PPIX accumulation in bladder urothelial cancer cells exposed to 5-aminolevulinic acid. Methods: The expression of two clock genes, PER2 and BMAL1, and their impact on intracellular PPIX accumulation were evaluated in two bladder cancer cell lines, UM-UC-3 and J82, and mouse xenograft models. We evaluated the enzymes involved in the heme synthesis pathway that potentially affect the circadian rhythm of intracellular PPIX accumulation. The red fluorescence intensity of the images captured during photodynamic diagnosis-assisted transurethral resection of bladder tumors was quantified and compared among the four groups according to surgery start time: 9 a.m.–11 a.m., 11 a.m.–1 p.m., 1–3 p.m., and 3–5 p.m. Results: We observed the circadian rhythm of intracellular PPIX accumulation, which was potentially regulated by the clock genes PER2 and BMAL1. Two enzymes involved in the heme synthesis pathway, coproporphyrinogen oxidase and ferrochelatase, exhibit a circadian rhythm. The fluorescence intensity started gradually increasing at 12 p.m., and the highest level was observed in patients who underwent surgery between 3 and 5 p.m. Conclusions: Our findings suggest that it may be possible to optimize the timing of the photodynamic diagnosis in photodynamic diagnosis-assisted transurethral resection of bladder cancer based on the circadian rhythm to improve tumor detection and treatment outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Intravesical Bacillus Calmette-Guerin treatment-induced sleep quality deterioration in patients with non-muscle invasive bladder cancer: functional outcome assessment based on a questionnaire survey and actigraphy

Author

Miyake, Makito, Nishimura, Nobutaka, Oda, Yuki, Owari, Takuya, Hori, Shunta, Morizawa, Yosuke, Gotoh, Daisuke, Nakai, Yasushi, Anai, Satoshi, Torimoto, Kazumasa, Aoki, Katsuya, Yoneda, Tatsuo, Fujii, Tomomi, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Published
2022
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34. Dose modification in enzalutamide and abiraterone plus prednisolone for castration‐resistant prostate cancer: A subanalysis from the ENABLE study for PCa.

Author

Tanaka, Nobumichi, Izumi, Kouji, Nakai, Yasushi, Shima, Takashi, Kato, Yuki, Mita, Koji, Kamiyama, Manabu, Inoue, Shogo, Hoshi, Seiji, Okamura, Takehiko, Yoshio, Yuko, Enokida, Hideki, Chikazawa, Ippei, Kawai, Noriyasu, Hashimoto, Kohei, Fukagai, Takashi, Shigehara, Kazuyoshi, Takahara, Shizuko, and Mizokami, Atsushi

Published
2025
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35. External validation of a genitourinary cancer-specific prognostic scoring system to predict survival for patients with bone metastasis (modified B-FOM scoring model): Comparison with other scoring models in terms of accuracy

Author

Owari, Takuya, Miyake, Makito, Nakai, Yasushi, Tanaka, Nobumichi, Itami, Yoshitaka, Hirao, Shuya, Momose, Hitoshi, Nakagawa, Yoshinori, Iida, Kouta, Maesaka, Fumisato, Shimizu, Takuto, Iemura, Yusuke, Matsumoto, Yoshihiro, Kuwada, Masaomi, Otani, Takeshi, Otsuka, Kenji, Okajima, Eijiro, Hosokawa, Yukinari, Okamura, Ryosuke, and Fujimoto, Kiyohide

Published
2021
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37. Photodynamic Therapeutic Effect during 5‐Aminolevulinic Acid‐Mediated Photodynamic Diagnosis‐Assisted Transurethral Resection of Bladder Tumors.

Author

Nishimura, Nobutaka, Miyake, Makito, Onishi, Sayuri, Fujii, Tomomi, Miyamoto, Tatsuki, Tomizawa, Mitsuru, Shimizu, Takuto, Morizawa, Yosuke, Hori, Shunta, Gotoh, Daisuke, Nakai, Yasushi, Torimoto, Kazumasa, Tanaka, Nobumichi, Fujimoto, Kiyohide, and Zhou, Xuelin

Subjects
TRANSURETHRAL resection of bladder, ENERGY levels (Quantum mechanics), IMMUNOHISTOCHEMISTRY, REACTIVE oxygen species, MEMBRANE potential, BLADDER cancer
Abstract

Background. Photodynamic diagnosis‐assisted transurethral resection of bladder tumors (PDD‐TURBT) enhances detection of elusive lesions compared to standard white light‐transurethral resection of bladder tumors (WL‐TURBT). If minimal light exposure during PDD‐TURBT induces the accumulation of reactive oxygen species (ROS), potentially resulting in phototoxicity in small lesions, apoptosis may be triggered in residual small tumors, allowing them to escape resection. We investigated the hypothesis of a potential photodynamic therapeutic effect during PDD‐TURBT. Methods and Materials. Our study, conducted between January 2016 and December 2020 at Nara Medical University Hospital, focused on a specific emphasis on ROS production. Immunohistochemical analysis for thymidine glycol and Nε‐hexanoyl‐lysine was performed on 69 patients who underwent 5‐aminolevulinic acid‐mediated PDD‐TURBT and 28 patients who underwent WL‐TURBT. Additionally, we incrementally applied the minimal irradiation energy to T24 and UM‐UC‐3 cells treated with 5‐aminolevulinic acid using instruments similar to those used in PDD‐TURBT and evaluated intracellular ROS production and phototoxicity. Results. Immunohistochemical analysis revealed a significant increase in production of thymidine glycol and Nε‐hexanoyl‐lysine within the PDD‐TURBT group. In T24 and UM‐UC‐3 cells treated with 5‐aminolevulinic acid and light exposure, immunofluorescent staining demonstrated a dose‐dependent increase in intracellular ROS production. In addition, higher irradiation energy levels were associated with a greater increase in ROS production and phototoxicity, as well as more significant decrease in mitochondrial membrane potential. Conclusion. Although the irradiation energy used in PDD‐TURBT did not reach the levels commonly used in photodynamic therapy, our findings support the presence of a potential cytotoxic effect on bladder lesions during PDD‐TURBT. [ABSTRACT FROM AUTHOR]

Published
2024
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38. A prospective study of oral 5-aminolevulinic acid to prevent adverse events in patients with localized prostate cancer undergoing low-dose-rate brachytherapy: Protocol of the AMBER study

Author

Miyake, Makito, Tanaka, Nobumichi, Asakawa, Isao, Yamaki, Kaori, Inoue, Takashi, Suzuki, Shota, Hori, Shunta, Nakai, Yasushi, Anai, Satoshi, Torimoto, Kazumasa, Toritsuka, Michihiro, Nakagawa, Hitoshi, Tsukamoto, Shinji, Fujii, Tomomi, Ohbayashi, Chiho, Hasegawa, Masatoshi, Kasahara, Masato, and Fujimoto, Kiyohide

Published
2020
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40. Fluorescent cystoscopy-assisted en bloc transurethral resection versus conventional transurethral resection in patients with non-muscle invasive bladder cancer: study protocol of a prospective, open-label, randomized control trial (the FLEBER study)

Author

Miyake, Makito, Nishimura, Nobutaka, Inoue, Takashi, Suzuki, Shota, Fujii, Tomomi, Owari, Takuya, Hori, Shunta, Nakai, Yasushi, Toritsuka, Michihiro, Nakagawa, Hitoshi, Tsukamoto, Shinji, Anai, Satoshi, Torimoto, Kazumasa, Yoneda, Tatsuo, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Published
2021
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45. The impact of the definition of biochemical recurrence following salvage radiotherapy on outcomes and prognostication in patients with recurrent prostate cancer after radical prostatectomy: a comparative study of three definitions

Author

Miyake, Makito, Tanaka, Nobumichi, Asakawa, Isao, Owari, Takuya, Hori, Shunta, Morizawa, Yosuke, Nakai, Yasushi, Inoue, Takeshi, Anai, Satoshi, Torimoto, Kazumasa, Hasegawa, Masatoshi, Fujii, Tomomi, Konishi, Noboru, and Fujimoto, Kiyohide

Published
2019
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47. Routine Surveillance of Upper Urinary Tract Imaging for Diagnosing Upper Urinary Tract Urothelial Cancer Recurrence in Patients with Nonmuscle Invasive Bladder Cancer.

Author

Nishimura, Nobutaka, Miyake, Makito, Miyamoto, Tatsuki, Shimizu, Takuto, Fujii, Tomomi, Morizawa, Yosuke, Hori, Shunta, Gotoh, Daisuke, Nakai, Yasushi, Torimoto, Kazumasa, Tanaka, Nobumichi, Fujimoto, Kiyohide, and Zhou, Xuelin

Subjects
NON-muscle invasive bladder cancer, TRANSURETHRAL resection of bladder, CANCER relapse, TRANSITIONAL cell carcinoma, URINARY organs, BLADDER cancer
Abstract

Background. Although routine surveillance imaging to examine upper urinary tract urothelial cancer recurrence during follow‐up of nonmuscle invasive bladder cancer is recommended, its necessity remains invalidated. A single‐institute long‐term follow‐up cohort study to evaluate the clinical impact of routine surveillance imaging and identify risk factors for upper urinary tract urothelial cancer recurrence after nonmuscle invasive bladder cancer treatment was conducted. Methods and Materials. A retrospective chart review of 864 patients with primary nonmuscle invasive bladder cancer who underwent initial transurethral resection of bladder tumor between 1980 and 2020 was conducted. The opportunities to diagnose its recurrence were examined. Moreover, oncological outcomes included upper urinary tract urothelial cancer recurrence‐free survival and overall survival. Results. Of 864 patients, 19 (2.2%) experienced upper urinary tract urothelial cancer recurrence. Among 19 patients, recurrence was detected through routine imaging in 12 (63.2%), cystoscopy in 2 (10.5%), urine cytology in 2 (10.5%), and presence of gross hematuria in 1 (5.3%). All patients had high‐ or highest‐risk NMIBC at diagnosis of primary nonmuscle invasive bladder cancer. On multivariate Fine‐Gray proportional regression analyses, a tumor size of ≥30 mm and carcinoma in situ were independently associated with short upper urinary tract urothelial cancer recurrence‐free survival (P = 0.040 and 0.0089, respectively). Conclusion. Most patients experiencing upper urinary tract urothelial cancer recurrence were diagnosed by routine surveillance imaging, suggesting its clinical importance, especially for patients with nonmuscle invasive bladder cancer accompanied by a tumor size of ≥30 mm and carcinoma in situ. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Response to Pembrolizumab After Dose-Reduced Cisplatin Plus Gemcitabine Chemotherapy Is Inferior to That After Carboplatin Plus Gemcitabine Chemotherapy in Cisplatin-Unfit Patients With Advanced Urothelial Carcinoma

Author

Miyake, Makito, Shimizu, Takuto, Nishimura, Nobutaka, Kiba, Keisuke, Maesaka, Fumisato, Oda, Yuki, Tachibana, Akira, Tomizawa, Mitsuru, Ohmori, Chihiro, Matsumura, Yoshiaki, Ichikawa, Kazuki, Mizobuchi, Shinichiro, Yoshikawa, Takanosuke, Hori, Shunta, Morizawa, Yosuke, Gotoh, Daisuke, Nakai, Yasushi, Anai, Satoshi, Torimoto, Kazumasa, Aoki, Katsuya, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Published
2022
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