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1. Neuronal alpha-Synuclein Disease integrated staging system performance in PPMI, PASADENA, and SPARK baseline cohorts

Author

Dam, Tien, Pagano, Gennaro, Brumm, Michael C., Gochanour, Caroline, Poston, Kathleen L., Weintraub, Daniel, Chahine, Lana M., Coffey, Christopher, Tanner, Caroline M., Kopil, Catherine M., Xiao, Yuge, Chowdhury, Sohini, Concha-Marambio, Luis, DiBiaso, Peter, Foroud, Tatiana, Frasier, Mark, Jennings, Danna, Kieburtz, Karl, Merchant, Kalpana, Mollenhauer, Brit, Montine, Thomas J., Nudelman, Kelly, Seibyl, John, Sherer, Todd, Singleton, Andrew, Stephenson, Diane, Stern, Matthew, Soto, Claudio, Tolosa, Eduardo, Siderowf, Andrew, Dunn, Billy, Simuni, Tanya, and Marek, Kenneth

Published
2024
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4. A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research

Author

Simuni, Tanya, Chahine, Lana M, Poston, Kathleen, Brumm, Michael, Buracchio, Teresa, Campbell, Michelle, Chowdhury, Sohini, Coffey, Christopher, Concha-Marambio, Luis, Dam, Tien, DiBiaso, Peter, Foroud, Tatiana, Frasier, Mark, Gochanour, Caroline, Jennings, Danna, Kieburtz, Karl, Kopil, Catherine M, Merchant, Kalpana, Mollenhauer, Brit, Montine, Thomas, Nudelman, Kelly, Pagano, Gennaro, Seibyl, John, Sherer, Todd, Singleton, Andrew, Stephenson, Diane, Stern, Matthew, Soto, Claudio, Tanner, Caroline M, Tolosa, Eduardo, Weintraub, Daniel, Xiao, Yuge, Siderowf, Andrew, Dunn, Billy, and Marek, Kenneth

Published
2024
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5. Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study

Author

Siderowf, Andrew, Concha-Marambio, Luis, Lafontant, David-Erick, Farris, Carly M, Ma, Yihua, Urenia, Paula A, Nguyen, Hieu, Alcalay, Roy N, Chahine, Lana M, Foroud, Tatiana, Galasko, Douglas, Kieburtz, Karl, Merchant, Kalpana, Mollenhauer, Brit, Poston, Kathleen L, Seibyl, John, Simuni, Tanya, Tanner, Caroline M, Weintraub, Daniel, Videnovic, Aleksandar, Choi, Seung Ho, Kurth, Ryan, Caspell-Garcia, Chelsea, Coffey, Christopher S, Frasier, Mark, Oliveira, Luis M A, Hutten, Samantha J, Sherer, Todd, Marek, Kenneth, and Soto, Claudio

Published
2023
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6. Remote smartphone monitoring of Parkinson’s disease and individual response to therapy

Author

Omberg, Larsson, Chaibub Neto, Elias, Perumal, Thanneer M., Pratap, Abhishek, Tediarjo, Aryton, Adams, Jamie, Bloem, Bastiaan R., Bot, Brian M., Elson, Molly, Goldman, Samuel M., Kellen, Michael R., Kieburtz, Karl, Klein, Arno, Little, Max A., Schneider, Ruth, Suver, Christine, Tarolli, Christopher, Tanner, Caroline M., Trister, Andrew D., Wilbanks, John, Dorsey, E. Ray, and Mangravite, Lara M.

Published
2022
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7. Study in Parkinson’s disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial

Author

Patterson, Charity G., Joslin, Elizabeth, Gil, Alexandra B., Spigle, Wendy, Nemet, Todd, Chahine, Lana, Christiansen, Cory L., Melanson, Ed, Kohrt, Wendy M., Mancini, Martina, Josbeno, Deborah, Balfany, Katherine, Griffith, Garett, Dunlap, Mac Kenzie, Lamotte, Guillaume, Suttman, Erin, Larson, Danielle, Branson, Chantale, McKee, Kathleen E., Goelz, Li, Poon, Cynthia, Tilley, Barbara, Kang, Un Jung, Tansey, Malú Gámez, Luthra, Nijee, Tanner, Caroline M., Haus, Jacob M., Fantuzzi, Giamila, McFarland, Nikolaus R., Gonzalez-Latapi, Paulina, Foroud, Tatiana, Motl, Robert, Schwarzschild, Michael A., Simuni, Tanya, Marek, Kenneth, Naito, Anna, Lungu, Codrin, and Corcos, Daniel M.

Published
2022
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9. Post-Traumatic Stress Disorder and Risk of Parkinson's Disease in a Veteran Cohort.

Author

Weaver, Frances M., Cao, Lishan, Stroupe, Kevin T., Gonzalez, Beverly, Brown, Ethan, Colletta, Kalea, Tanner, Caroline M., and Goldman, Samuel M.

Subjects
PARKINSON'S disease, MEDICAL care use, POST-traumatic stress disorder, VETERANS' health, LOGISTIC regression analysis
Abstract

Post-traumatic stress disorder (PTSD) may be a risk factor for Parkinson's disease (PD). We examined the relation between PTSD and PD in a cohort of 158,122 Veterans who had any Veterans Health Administration (VHA) or Medicare health care utilization between 10/1/1999– 2/17/2021. Using a nested case-control design we matched 10 controls to each Veteran with PD by sex, race, and rank. In conditional logistic regression models adjusted for camp and smoking, a PTSD diagnosis was significantly associated with PD (OR = 1.35; p = 0.0002); odds were higher if PTSD was coded before PD (OR = 1.53, p < 0.0001). PTSD may be a risk factor for PD. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Parkinson's Disease.

Author

Tanner, Caroline M. and Ostrem, Jill L.

Subjects
*MOVEMENT disorders, *PARKINSON'S disease, *ALZHEIMER'S disease, *PARKINSONIAN disorders
Abstract

The article reviews recent advances in Parkinson's disease research, emphasizing the growing global burden of the disorder as the aging population increases. Topics discussed include the clinical and biological definitions of Parkinson's disease, the impact of genetic and environmental factors on its onset, and current management strategies for motor and nonmotor symptoms.

Published
2024
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13. Occupational Pesticide Exposure in Parkinson's Disease Related to GBA and LRRK2 Variants.

Author

Brown, Ethan G., Goldman, Samuel M., Coffey, Christopher S., Siderowf, Andrew, Simuni, Tanya, Meng, Cheryl, Brumm, Michael C., Caspell-Garcia, Chelsea, Marek, Kenneth, and Tanner, Caroline M.

Subjects
PARKINSON'S disease, DARDARIN, PROPORTIONAL hazards models, ACTIVITIES of daily living
Abstract

Background: The penetrance of common genetic risk variants for Parkinson's disease (PD) is low. Pesticide exposure increases PD risk, but how exposure affects penetrance is not well understood. Objective: To determine the relationship between occupational pesticide exposure and PD in people with LRRK2 and GBA risk variants. Methods: Participants of the Parkinson's Progression Markers Initiative (PPMI) with a LRRK2-G2019 S or GBA risk variant provided information about occupational pesticide exposure. We compared exposure in carriers with and without PD. Among carriers with PD, we used Cox proportional hazard models to compare time-to impairment in balance, cognition, and activities of daily living (ADLs) between participants with and without prior occupational pesticide exposure. Results: 378 participants with a risk variant provided exposure information; 176 with LRRK2-G2019 S (54 with and 122 without PD) and 202 with GBA variants (47 with and 155 without PD). Twenty-six participants reported pesticide exposure. People with a GBA variant and occupational pesticide exposure had much higher odds of PD (aOR: 5.4, 95% CI 1.7–18.5, p < 0.01). People with a LRRK2 variant and a history of occupational pesticide exposure had non-significantly elevated odds of PD (aOR 1.3, 95% CI 0.4–4.6, p = 0.7). Among those with PD, pesticide exposure was associated with a higher risk of balance problems and cognitive impairment in LRRK2-PD and functional impairment in GBA-PD, although associations were not statistically significant. Conclusions: Occupational pesticide exposure may increase penetrance of GBA-PD and may be associated with faster symptom progression. Further studies in larger cohorts are necessary. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Epidemiology of Parkinson's Disease: An Update.

Author

Deliz, Juan R, Tanner, Caroline M., and Gonzalez-Latapi, Paulina

Abstract

Purpose of Review: In recent decades, epidemiological understanding of Parkinson disease (PD) has evolved significantly. Major discoveries in genetics and large epidemiological investigations have provided a better understanding of the genetic, behavioral, and environmental factors that play a role in the pathogenesis and progression of PD. In this review, we provide an epidemiological update of PD with a particular focus on advances in the last five years of published literature. Recent Findings: We include an overview of PD pathophysiology, followed by a detailed discussion of the known distribution of disease and varied determinants of disease. We describe investigations of risk factors for PD, and provide a critical summary of current knowledge, knowledge gaps, and both clinical and research implications. We emphasize the need to characterize the epidemiology of the disease in diverse populations. Summary: Despite increasing understanding of PD epidemiology, recent paradigm shifts in the conceptualization of PD as a biological entity will also impact epidemiological research moving forward and guide further work in this field. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study

Author

Arnedo, Vanessa, Clark, Adrienne, Fraiser, Mark, Kopil, Catherine, Chowdhury, Sohini, Sherer, Todd, Daegele, Nichole, Casaceli, Cynthia, Dorsey, Ray, Wilson, Renee, Mahes, Sugi, Salerno, Christina, Crawford, Karen, Casalin, Paola, Malferrari, Giulia, Weisz, Mali Gani, Orr-Urtreger, Avi, Montine, Thomas, Baglieri, Chris, Christini, Amanda, Russell, David, Dahodwala, Nabila, Giladi, Nir, Factor, Stewart, Hogarth, Penelope, Standaert, David, Hauser, Robert, Jankovic, Joseph, Saint-Hilaire, Marie, Richard, Irene, Shprecher, David, Fernandez, Hubert, Brockmann, Katrina, Rosenthal, Liana, Barone, Paolo, Espay, Alberto, Rowe, Dominic, Marder, Karen, Santiago, Anthony, Hu, Shu-Ching, Isaacson, Stuart, Corvol, Jean-Christophe, Ruiz Martinez, Javiar, Tolosa, Eduardo, Tai, Yen, Politis, Marios, Smejdir, Debra, Rees, Linda, Williams, Karen, Kausar, Farah, Richardson, Whitney, Willeke, Diana, Peacock, Shawnees, Sommerfeld, Barbara, Freed, Alison, Wakeman, Katrina, Blair, Courtney, Guthrie, Stephanie, Harrell, Leigh, Hunter, Christine, Thomas, Cathi-Ann, James, Raymond, Zimmerman, Grace, Brown, Victoria, Mule, Jennifer, Hilt, Ella, Ribb, Kori, Ainscough, Susan, Wethington, Misty, Ranola, Madelaine, Mejia Santana, Helen, Moreno, Juliana, Raymond, Deborah, Speketer, Krista, Carvajal, Lisbeth, Carvalo, Stephanie, Croitoru, Ioana, Garrido, Alicia, Payne, Laura Marie, Viswanth, Veena, Severt, Lawrence, Facheris, Maurizio, Soares, Holly, Mintun, Mark A., Cedarbaum, Jesse, Taylor, Peggy, Biglan, Kevin, Vandenbroucke, Emily, Haider Sheikh, Zulfiqar, Bingol, Baris, Fischer, Tanya, Sardi, Pablo, Forrat, Remi, Reith, Alastair, Egebjerg, Jan, Ahlberg Hillert, Gabrielle, Saba, Barbara, Min, Chris, Umek, Robert, Mather, Joe, De Santi, Susan, Post, Anke, Boess, Frank, Taylor, Kirsten, Grachev, Igor, Avbersek, Andreja, Muglia, Pierandrea, Merchant, Kaplana, Tauscher, Johannes, Simuni, Tanya, Uribe, Liz, Cho, Hyunkeun Ryan, Caspell-Garcia, Chelsea, Coffey, Christopher S, Siderowf, Andrew, Trojanowski, John Q, Shaw, Leslie M, Seibyl, John, Singleton, Andrew, Toga, Arthur W, Galasko, Doug, Foroud, Tatiana, Tosun, Duygu, Poston, Kathleen, Weintraub, Daniel, Mollenhauer, Brit, Tanner, Caroline M, Kieburtz, Karl, Chahine, Lana M, Reimer, Alyssa, Hutten, Samantha J, Bressman, Susan, and Marek, Kenneth

Published
2020
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17. A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson’s disease

Author

Hollenbach, Jill A., Norman, Paul J., Creary, Lisa E., Damotte, Vincent, Montero-Martin, Gonzalo, Caillier, Stacy, Anderson, Kirsten M., Misra, Maneesh K., Nemat-Gorgani, Neda, Osoegawa, Kazutoyo, Santaniello, Adam, Renschen, Adam, Marin, Wesley M., Dandekar, Ravi, Parham, Peter, Tanner, Caroline M., Hauser, Stephen L., Fernandez-Viña, Marcelo, and Oksenberg, Jorge R.

Published
2019

18. The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism

Author

Tanner, Caroline M., Cummings, Steven R., Schwarzschild, Michael A., Brown, Ethan G., Dorsey, E. Ray, Espay, Alberto J., Galifianakis, Nicholas B., Goldman, Samuel M., Litvan, Irene, Luthra, Nijee, McFarland, Nikolaus R., Mitchell, Kyle T., Standaert, David G., Bauer, Douglas C., Greenspan, Susan L., Beck, James C., and Lyles, Kenneth W.

Published
2021
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19. Dry‐Cleaning Chemicals and a Cluster of Parkinson's Disease and Cancer: A Retrospective Investigation.

Author

Dorsey, E. Ray, Kinel, Dan, Pawlik, Meghan E., Zafar, Maryam, Lettenberger, Samantha E., Coffey, Madeleine, Auinger, Peggy, Hylton, Kevin L., Shaw, Carol W., Adams, Jamie L., Barbano, Richard, Braun, Melanie K., Schwarz, Heidi B., Lawrence, B. Paige, Kieburtz, Karl, Tanner, Caroline M., de Miranda, Briana R., and Goldman, Samuel M.

Abstract

Background: Environmental exposure to trichloroethylene (TCE), a carcinogenic dry‐cleaning chemical, may be linked to Parkinson's disease (PD). Objective: The objective of this study was to determine whether PD and cancer were elevated among attorneys who worked near a contaminated site. Methods: We surveyed and evaluated attorneys with possible exposure and assessed a comparison group. Results: Seventy‐nine of 82 attorneys (96.3%; mean [SD] age: 69.5 [11.4] years; 89.9% men) completed at least one phase of the study. For comparison, 75 lawyers (64.9 [10.2] years; 65.3% men) underwent clinical evaluations. Four (5.1%) of them who worked near the polluted site reported PD, more than expected based on age and sex (1.7%; P = 0.01) but not significantly higher than the comparison group (n = 1 [1.3%]; P = 0.37). Fifteen (19.0%), compared to four in the comparison group (5.3%; P = 0.049), had a TCE‐related cancer. Conclusions: In a retrospective study, diagnoses of PD and TCE‐related cancers appeared to be elevated among attorneys who worked next to a contaminated dry‐cleaning site. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Knowledge gaps and research recommendations for essential tremor

Author

Hopfner, Franziska, Haubenberger, Dietrich, Galpern, Wendy R., Gwinn, Katrina, Van't Veer, Ashlee, White, Samantha, Bhatia, Kailash, Adler, Charles H., Eidelberg, David, Ondo, William, Stebbins, Glenn T., Tanner, Caroline M., Helmich, Rick C., Lenz, Fred A., Sillitoe, Roy V., Vaillancourt, David, Vitek, Jerrold L., Louis, Elan D., Shill, Holly A., Frosch, Matthew P., Foroud, Tatiana, Kuhlenbäumer, Gregor, Singleton, Andrew, Testa, Claudia M., Hallett, Mark, Elble, Rodger, and Deuschl, Günther

Published
2016
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27. Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression.

Author

Brumm, Michael C., Siderowf, Andrew, Simuni, Tanya, Burghardt, Elliot, Choi, Seung Ho, Caspell-Garcia, Chelsea, Chahine, Lana M., Mollenhauer, Brit, Foroud, Tatiana, Galasko, Douglas, Merchant, Kalpana, Arnedo, Vanessa, Hutten, Samantha J., O'Grady, Alyssa N., Poston, Kathleen L., Tanner, Caroline M., Weintraub, Daniel, Kieburtz, Karl, Marek, Kenneth, and Coffey, Christopher S.

Subjects
PARKINSON'S disease, DISEASE progression, DYSAUTONOMIA, BIOMARKERS, ALPHA-synuclein
Abstract

Background: Identifying a meaningful progression metric for Parkinson's disease (PD) that reflects heterogeneity remains a challenge. Objective: To assess the frequency and baseline predictors of progression to clinically relevant motor and non-motor PD milestones. Methods: Using data from the Parkinson's Progression Markers Initiative (PPMI) de novo PD cohort, we monitored 25 milestones across six domains ("walking and balance"; "motor complications"; "cognition"; "autonomic dysfunction"; "functional dependence"; "activities of daily living"). Milestones were intended to be severe enough to reflect meaningful disability. We assessed the proportion of participants reaching any milestone; evaluated which occurred most frequently; and conducted a time-to-first-event analysis exploring whether baseline characteristics were associated with progression. Results: Half of participants reached at least one milestone within five years. Milestones within the cognitive, functional dependence, and autonomic dysfunction domains were reached most often. Among participants who reached a milestone at an annual follow-up visit and remained active in the study, 82% continued to meet criteria for any milestone at one or more subsequent annual visits and 55% did so at the next annual visit. In multivariable analysis, baseline features predicting faster time to reaching a milestone included age (p < 0.0001), greater MDS-UPDRS total scores (p < 0.0001), higher GDS-15 depression scores (p = 0.0341), lower dopamine transporter binding (p = 0.0043), and lower CSF total α-synuclein levels (p = 0.0030). Symptomatic treatment was not significantly associated with reaching a milestone (p = 0.1639). Conclusion: Clinically relevant milestones occur frequently, even in early PD. Milestones were significantly associated with baseline clinical and biological markers, but not with symptomatic treatment. Further studies are necessary to validate these results, further assess the stability of milestones, and explore translating them into an outcome measure suitable for observational and therapeutic studies. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Caregiver-Reported Burden in RE-KINECT: Data From a Prospective Real-World Tardive Dyskinesia Screening Study.

Author

Cutler, Andrew J., Caroff, Stanley N., Tanner, Caroline M., Shalhoub, Huda, Lenderking, William R., Pagé, Véronique, Franey, Ericha, and Yonan, Chuck

Abstract

Background: RE-KINECT (NCT03062033), a real-world study of possible tardive dyskinesia (TD) in antipsychotic-treated patients, included a questionnaire to assess the effects of patients' abnormal involuntary movements on caregivers. Aims: To capture the experiences of caregivers who assisted individuals with abnormal involuntary movements that were confirmed by clinicians as being consistent with TD. Methods: Qualified (nonpaid) caregivers were invited to complete a questionnaire that included the following: caregivers' sociodemographic characteristics, their perceptions about the impact of abnormal involuntary movements on patients, and the impact of these movements on themselves (caregivers). Results: Of the 41 participating caregivers, 25 (61.0%) were women, 20 (48.8%) were employed full time or part time, and 35 (85.4%) were family members or friends. Based on responses from caregivers who noticed patients' abnormal involuntary movements and were caring for individuals who also noticed those movements, 48.0% of patients had "a lot" of severity in ≥1 body region and 76.0% had abnormal involuntary movements in ≥2 regions. Caregiver ratings were significantly correlated with patient ratings (but not with clinician ratings) for maximum severity of abnormal involuntary movements and the number of affected regions (both p <.05). Based on their own judgments and perceptions, caregivers reported that the patient's movements had "some" or "a lot" of impact on their (caregiver's) ability to continue usual activities (50.0%), be productive (58.3%), socialize (55.6%), or take care of self (50.0%). Conclusions: Caregivers as well as patients are negatively affected by TD, and the impact of TD on caregivers' lives should be considered when determining treatment options. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Dietary fat intake, pesticide use, and Parkinson's disease

Author

Kamel, Freya, Goldman, Samuel M., Umbach, David M., Chen, Honglei, Richardson, Gina, Barber, Marie Richards, Meng, Cheryl, Marras, Connie, Korell, Monica, Kasten, Meike, Hoppin, Jane A., Comyns, Kathleen, Chade, Anabel, Blair, Aaron, Bhudhikanok, Grace S., Webster Ross, G., William Langston, J., Sandler, Dale P., and Tanner, Caroline M.

Published
2014
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35. What Patients Say: Large-Scale Analyses of Replies to the Parkinson's Disease Patient Report of Problems (PD-PROP).

Author

Marras, Connie, Arbatti, Lakshmi, Hosamath, Abhishek, Amara, Amy, Anderson, Karen E., Chahine, Lana M., Eberly, Shirley, Kinel, Dan, Mantri, Sneha, Mathur, Soania, Oakes, David, Purks, Jennifer L., Standaert, David G., Tanner, Caroline M., Weintraub, Daniel, and Shoulson, Ira

Subjects
PARKINSON'S disease, NATURAL language processing, REPORTING of diseases, MACHINE learning
Abstract

Background: Free-text, verbatim replies in the words of people with Parkinson's disease (PD) have the potential to provide unvarnished information about their feelings and experiences. Challenges of processing such data on a large scale are a barrier to analyzing verbatim data collection in large cohorts. Objective: To develop a method for curating responses from the Parkinson's Disease Patient Report of Problems (PD-PROP), open-ended questions that asks people with PD to report their most bothersome problems and associated functional consequences. Methods: Human curation, natural language processing, and machine learning were used to develop an algorithm to convert verbatim responses to classified symptoms. Nine curators including clinicians, people with PD, and a non-clinician PD expert classified a sample of responses as reporting each symptom or not. Responses to the PD-PROP were collected within the Fox Insight cohort study. Results: Approximately 3,500 PD-PROP responses were curated by a human team. Subsequently, approximately 1,500 responses were used in the validation phase; median age of respondents was 67 years, 55% were men and median years since PD diagnosis was 3 years. 168,260 verbatim responses were classified by machine. Accuracy of machine classification was 95% on a held-out test set. 65 symptoms were grouped into 14 domains. The most frequently reported symptoms at first report were tremor (by 46% of respondents), gait and balance problems (>39%), and pain/discomfort (33%). Conclusion: A human-in-the-loop method of curation provides both accuracy and efficiency, permitting a clinically useful analysis of large datasets of verbatim reports about the problems that bother PD patients. [ABSTRACT FROM AUTHOR]

Published
2023
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37. CSF biomarkers associated with disease heterogeneity in early Parkinson’s disease: the Parkinson’s Progression Markers Initiative study

Author

Kang, Ju-Hee, Mollenhauer, Brit, Coffey, Christopher S., Toledo, Jon B., Weintraub, Daniel, Galasko, Douglas R., Irwin, David J., Van Deerlin, Vivianna, Chen-Plotkin, Alice S., Caspell-Garcia, Chelsea, Waligórska, Teresa, Taylor, Peggy, Shah, Nirali, Pan, Sarah, Zero, Pawel, Frasier, Mark, Marek, Kenneth, Kieburtz, Karl, Jennings, Danna, Tanner, Caroline M., Simuni, Tanya, Singleton, Andrew, Toga, Arthur W., Chowdhury, Sohini, Trojanowski, John Q., Shaw, Leslie M., and The Parkinson’s Progression Marker Initiative

Published
2016
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39. Trichloroethylene: An Invisible Cause of Parkinson's Disease?

Author

Dorsey, E. Ray, Zafar, Maryam, Lettenberger, Samantha E., Pawlik, Meghan E., Kinel, Dan, Frissen, Myrthe, Schneider, Ruth B., Kieburtz, Karl, Tanner, Caroline M., De Miranda, Briana R., Goldman, Samuel M., and Bloem, Bastiaan R.

Subjects
PARKINSON'S disease, TRICHLOROETHYLENE, LITERATURE reviews, OCCUPATIONAL exposure, INDUSTRIAL contamination, MOVEMENT disorders
Abstract

The etiologies of Parkinson's disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common environmental contaminant little recognized for its likely role in PD: trichloroethylene (TCE). TCE is a simple, six-atom molecule that can decaffeinate coffee, degrease metal parts, and dry clean clothes. The colorless chemical was first linked to parkinsonism in 1969. Since then, four case studies involving eight individuals have linked occupational exposure to TCE to PD. In addition, a small epidemiological study found that occupational or hobby exposure to the solvent was associated with a 500% increased risk of developing PD. In multiple animal studies, the chemical reproduces the pathological features of PD. Exposure is not confined to those who work with the chemical. TCE pollutes outdoor air, taints groundwater, and contaminates indoor air. The molecule, like radon, evaporates from underlying soil and groundwater and enters homes, workplaces, or schools, often undetected. Despite widespread contamination and increasing industrial, commercial, and military use, clinical investigations of TCE and PD have been limited. Here, through a literature review and seven illustrative cases, we postulate that this ubiquitous chemical is contributing to the global rise of PD and that TCE is one of its invisible and highly preventable causes. Further research is now necessary to examine this hypothesis. [ABSTRACT FROM AUTHOR]

Published
2023
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40. The Impact of the COVID‐19 Pandemic on Care Partners of People with Parkinson's Disease.

Author

Speelberg, Daniël H.B., Hulshoff, Max J., Book, Elaine, Dahodwala, Nabila, Korell, Monica, Tanner, Caroline M., and Marras, Connie

Subjects
PARKINSON'S disease, COVID-19 pandemic, CARE of people, INCOME, BURDEN of care, HOME health aides
Abstract

Background: Since the onset of the coronavirus disease 2019 pandemic, the caregiving routine for care partners of people with Parkinson's disease (PwPD) changed substantially. Objectives: To understand the nature and severity of burden in care partners of PwPD during the ongoing pandemic. We also sought to describe care partners' perceived change in burden and factors associated with increased burden. Methods: Cross‐sectional online questionnaire‐based study among care partners of PwPD, registered in the Fox Insight study. The questionnaire consisted of the Modified Caregiver Strain Index, whether an aspect of strain had changed over the course of the pandemic and additional pandemic‐specific infection and lifestyle‐related items. Results: Two hundred seventy‐three non‐paid primary care partners responded to the questionnaire, 73% female with a median age at enrollment of 64 years, 56% reporting a household income greater than 75,000 USD per year, and 61% retired. An increase in burden compared to before the pandemic was prevalent, ranging from 33% to 63% for individual items. Emotional strain increased most frequently (63%). Decreases in burden were uncommon; work adjustments (7%) and time demands (6%) decreased most frequently. PD‐related factors and care partner roles in personal care of the PwPD were the factors that were associated with strain in multivariable analysis, whereas social and pandemic‐related factors were not. Conclusion: In this affluent and mostly retired cohort, increases in emotional strain during the pandemic were prevalent. Despite this, caregiving roles in personal care and severity of symptoms in the PwPD were more strongly associated with strain than social and pandemic‐related factors. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Rotenone, Paraquat, and Parkinson's Disease

Author

Tanner, Caroline M., Kamel, Freya, Ross, G. Webster, Hoppin, Jane A., Goldman, Samuel M., Korell, Monica, Marras, Connie, Bhudhikanok, Grace S., Kasten, Meike, Chade, Anabel R., Comyns, Kathleen, Richards, Marie Barber, Meng, Cheryl, Priestley, Benjamin, Fernandez, Hubert H., Cambi, Franca, Umbach, David M., Blair, Aaron, Sandler, Dale P., and Langston, J. William

Published
2011

45. Meeting Report: Consensus Statement: Parkinson's Disease and the Environment: Collaborative on Health and the Environment and Parkinson's Action Network (CHE PAN) Conference 26-28 June 2007

Author

Bronstein, Jeff, Carvey, Paul, Chen, Honglei, Cory-Slechta, Deborah, DiMonte, Donato, Duda, John, English, Paul, Goldman, Samuel, Grate, Stephen, Hansen, Johnni, Hoppin, Jane, Jewell, Sarah, Kamel, Freya, Koroshetz, Walter, Langston, James W., Logroscino, Giancarlo, Nelson, Lorene, Ravina, Bernard, Rocca, Walter, Ross, George W., Schettler, Ted, Schwarzschild, Michael, Scott, Bill, Seegal, Richard, Singleton, Andrew, Steenland, Kyle, Tanner, Caroline M., Van Den Eeden, Stephen, and Weisskopf, Marc

Published
2009
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49. Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease: A Randomized Clinical Trial

Author

Kieburtz, Karl, Tilley, Barbara C., Elm, Jordan J., Babcock, Debra, Hauser, Robert, Ross, G. Webster, Augustine, Alicia H., Augustine, Erika U., Aminoff, Michael J., Bodis-Wollner, Ivan G., Boyd, James, Cambi, Franca, Chou, Kelvin, Christine, Chadwick W., Cines, Michelle, Dahodwala, Nabila, Derwent, Lorelei, Dewey, Richard B., Jr, Hawthorne, Katherine, Houghton, David J., Kamp, Cornelia, Leehey, Maureen, Lew, Mark F., Liang, Grace S. Lin, Luo, Sheng T., Mari, Zoltan, Morgan, John C., Parashos, Sotirios, Pérez, Adriana, Petrovitch, Helen, Rajan, Suja, Reichwein, Sue, Roth, Jessie Tatsuno, Schneider, Jay S., Shannon, Kathleen M., Simon, David K., Simuni, Tanya, Singer, Carlos, Sudarsky, Lewis, Tanner, Caroline M., Umeh, Chizoba C., Williams, Karen, and Wills, Anne-Marie

Published
2015
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