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7 results on '"Tarish, Firas"'

1. High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

Author

Zhang, Ning, Harbers, Luuk, Simonetti, Michele, Diekmann, Constantin, Verron, Quentin, Berrino, Enrico, Bellomo, Sara E., Longo, Gabriel M. C., Ratz, Michael, Schultz, Niklas, Tarish, Firas, Su, Peng, Han, Bo, Wang, Wanzhong, Onorato, Sofia, Grassini, Dora, Ballarino, Roberto, Giordano, Silvia, Yang, Qifeng, Sapino, Anna, Frisén, Jonas, Alkass, Kanar, Druid, Henrik, Roukos, Vassilis, Helleday, Thomas, Marchiò, Caterina, Bienko, Magda, and Crosetto, Nicola

Published
2024
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3. High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.

Author

Ning Zhang, Harbers, Luuk, Simonetti, Michele, Diekmann, Constantin, Verron, Quentin, Berrino, Enrico, Bellomo, Sara E., Longo, Gabriel M. C., Ratz, Michael, Schultz, Niklas, Tarish, Firas, Peng Su, Bo Han, Wanzhong Wang, Onorato, Sofia, Grassini, Dora, Ballarino, Roberto, Giordano, Silvia, Qifeng Yang, and Sapino, Anna

Abstract

Somatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but their prevalence and spatial distribution in early-stage, localized tumors and their surrounding normal tissues are poorly characterized. Here, we perform multi-region, single-cell DNA sequencing to characterize the SCNA landscape across tumor-rich and normal tissue in two male patients with localized prostate cancer. We identify two distinct karyotypes: ‘pseudodiploid’ cells harboring few SCNAs and highly aneuploid cells. Pseudo-diploid cells form numerous small-sized subclones ranging from highly spatially localized to broadly spread subclones. In contrast, aneuploid cells do not form subclones and are detected throughout the prostate, including normal tissue regions. Highly localized pseudo-diploid subclones are confined within tumor-rich regions and carry deletions in multiple tumor-suppressor genes. Our study reveals that SCNAs are widespread in normal and tumor regions across the prostate in localized prostate cancer patients and suggests that a subset of pseudo-diploid cells drive tumorigenesis in the aging prostate. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

Author

Asim, Mohammad, Tarish, Firas, Zecchini, Heather I., Sanjiv, Kumar, Gelali, Eleni, Massie, Charles E., Baridi, Ajoeb, Warren, Anne Y., Zhao, Wanfeng, Ogris, Christoph, McDuffus, Leigh-Anne, Mascalchi, Patrice, Shaw, Greg, Dev, Harveer, Wadhwa, Karan, Wijnhoven, Paul, Forment, Josep V., Lyons, Scott R., Lynch, Andy G., O’Neill, Cormac, Zecchini, Vincent R., Rennie, Paul S., Baniahmad, Aria, Tavaré, Simon, Mills, Ian G., Galanty, Yaron, Crosetto, Nicola, Schultz, Niklas, Neal, David, and Helleday, Thomas

Published
2017
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7. Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair.

Author

Tarish, Firas L., Schultz, Niklas, Tanoglidi, Anna, Hamberg, Hans, Letocha, Henry, Karaszi, Katalin, Hamdy, Freddie C., Granfors, Torvald, and Helleday, Thomas

Subjects
PROSTATE cancer, CASTRATION, RADIOTHERAPY, DOUBLE-strand DNA breaks, ANDROGEN receptors
Abstract

The article discusses a study focusing on the radiosensitization of prostate cancer tissue through castration. Topics discussed include the impairment of DNA double-strand break repair, the radiotherapy that the patients received in the study, and the monitoring of the androgen receptor in the study.

Published
2015
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