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Purpose: The present paper is aimed to investigate the relationship between intangible assets, macroeconomic environment and market value of German, English and Portuguese public companies from 1999 to 2016. Although the IAS 38, assigns value to intangible assets, there is a gap between accounting and the market need. This gap is given by accounting conservatism in the accounting of intangible assets and by their difficult measurement. The verification of the impact of the intangibles on the company’s market value is done through the methodology proposed by Gu and Lev (2011), using proxies such as CDS, Libor and Euribor and sensitivity tests. IDE is expected to reflect intangible capital and create shareholder value. This study seeks to interpret the contribution of intangibles and to forecast their impact on the market. Originality/value: The theme of evaluation of intangible assets has been approached in several ways. Its relevance lies in the need to establish methods for its measurement. Design/methodology/approach: The methodological approach is quantitative research with panel data using Stata-15. The database is the Capital IQ with public companies, listed in Germany, England, and Portugal from 1999 to 2016, with annual frequency. Findings: The results suggest that the comprehension value has a positive and significant relationship with the market value of the companies and that the intangible capital and the intangibles-driven-earnings are positively related to research and development expenses and general, administrative procedures. Objetivo: O presente artigo tem o propósito de investigar qual é a relação entre intangíveis, ambiente macroeconômico e valor de mercado das empresas abertas alemãs, inglesas e portuguesas no período de 1999 a 2016. Apesar de o IAS 38 atribuir valor aos ativos intangíveis, há uma grande lacuna entre a contabilização e a necessidade do mercado. Essa lacuna é dada pelo conservadorismo contábil na contabilização dos ativos intangíveis e por sua difícil mensuração. A verificação do impacto dos intangíveis no valor de mercado da empresa é feita por meio da metodologia proposta por Gu e Lev (2011), utilizando proxies como CDS, Libor e Euribor e testes de sensibilidade. Espera-se que o IDE reflita o capital intangível e crie valor ao acionista. Este estudo busca interpretar a contribuição dos intangíveis e a previsão de seu impacto no mercado. Originalidade/valor: O tema de avaliação dos ativos intangíveis tem sido abordado de diversas formas. Sua relevância está na necessidade de estabelecer métodos para sua mensuração. Design/metodologia/abordagem: A abordagem metodológica é uma pesquisa quantitativa com dados em painel com a utilização do Stata-15. A base de dados é o Capital IQ com empresas de capital aberto, listadas na Alemanha, na Inglaterra e em Portugal de 1999 a 2016, com frequência anual. Resultados: Os resultados sugerem que o comprehension value tem uma relação positiva e significante com o valor de mercado das empresas, e que o intangible capital e o intangibles-driven-earnings são positivamente relacionados com os gastos de pesquisa e desenvolvimento e gastos de vendas, gerais e administrativos.

Purpose: The present paper is aimed to investigate the relationship between intangible assets, macroeconomic environment and market value of German, English and Portuguese public companies from 1999 to 2016. Although the IAS 38, assigns value to intangible assets, there is a gap between accounting and the market need. This gap is given by accounting conservatism in the accounting of intangible assets and by their difficult measurement. The verification of the impact of the intangibles on the company's market value is done through the methodology proposed by Gu and Lev (2011), using proxies such as CDS, Libor and Euribor and sensitivity tests. IDE is expected to reflect intangible capital and create shareholder value. This study seeks to interpret the contribution of intangibles and to forecast their impact on the market. Originality/value: The theme of evaluation of intangible assets has been approached in several ways. Its relevance lies in the need to establish methods for its measurement. Design/methodology/approach: The methodological approach is quantitative research with panel data using Stata-15. The database is the Capital IQ with public companies, listed in Germany, England, and Portugal from 1999 to 2016, with annual frequency. Findings: The results suggest that the comprehension value has a positive and significant relationship with the market value of the companies and that the intangible capital and the intangibles-driven-earnings are positively related to research and development expenses and general, administrative procedures. [ABSTRACT FROM AUTHOR]

Subclinical mastitis in goats causes economic losses and risks to public health. Given the need for research that shows the most isolated staphylococci species and sensibility tests comparing the resistance between coagulase-negative (CNS) and positive Staphylococcus (CPS) goats with subclinical mastitis, the aim of this study was to identify the microorganisms isolated from milk samples of goats with subclinical mastitis, as well as define the staphylococci species and determine the sensitivity profile of Staphylococcus spp. to antimicrobials. To collect samples, tests were performed for mug of black background and California mastitis test (CMT), collecting milk from CMT positive animals. A total of 226 samples from seven herds of dairy goats was collected and forwarded to the laboratory, where they were seeded for the isolation of the microorganism and implementing the antibiotic sensibility test. Of these, 122 samples had bacterial growth and the most isolated staphylococci species were: S. epidermidis (24.55%), S. lugdunensis (15.40%) and S. intermedius (13.64%). Samples showed increased resistance to antimicrobials: penicillin (81.8%), oxacillin (60.0%) and ampicillin (55.5%). Greater sensitivity to: enrofloxacin (99.1%), erythromycin (98.2%), gentamicin (98.2%) and vancomycin (98.2%) were observed. The S. epidermidis showed higher antimicrobial resistance to amoxicillin and penicillin than S. lugdunensis and S. intermedius. Similar resistance in vitro between CNS and CPS was observed to most antimicrobials. It is important to control the overuse of antibiotics to prevent the emergence of resistant strains.

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Foram admitidos no Hospital das Clínicas da FMRPUSP, durante os anos de 1983 a 1988, 494 pacientes vítimas de acidentes ofídicos e escorpiônicos que receberam soro antiveneno (SAV) e nos quais foi avaliada a freqüência e tipo das manifestações imediatas, bem como o valor prognóstico do teste de sensibilidade. Do total de pacientes vítimas de ofidismo, 82 (25,6%) apresentaram reações imediatas, das quais as mais comuns foram as cutâneas, isoladas (40%) ou associadas com sintomas respiratórios (19%), seguidas de manifestações gastrintestinais (17%). Choque anafilático foi detectado em 10 pacientes (12%). Em relação aos acidentes escorpiônicos, reações imediatas foram observadas em 13 pacientes (7,5%), também com predomínio de lesões cutâneas. Sintomatologia cardiocirculatória foi detectada em apenas 1 paciente. Devido ao baixo valor preditivo positivo (31,8%) e à baixa sensibilidade (54,6%), propomos que o teste de sensibilidade intradérmico seja abolido da rotina de atendimento de urgência aos pacientes vítimas de acidentes por animais peçonhentos. Anti-histamínicos (bloqueadores dos receptores H1 e H2) e corticosteróides devem ser administrados por via parenteral anteriormente à soroterapia, no sentido de prevenir ou minimizar as reações de hipersensibilidade imediatas que podem ocorrer. O soro antiveneno deve ser sempre administrado por via intravenosa, de preferência sem diluição, gota a gota, durante 15 a 30 minutos, sob contínua supervisão da equipe médica.The frequency and class of immediate-type hypersensitivity manifestations were studied in 494 snakebitten and scorpion stung patients who were treated with intravenous injections of antivenom sera. These patients were admitted to HC-FMRPUSP from 1983 to 1988. The effectiveness of a hypersensitivity skin test was also investigated. Eighty two out of 320 patients admitted following snake bites (25.6%) had immediate-type reactions consisting of isolated skin lesions (40%), skin lesions plus respiratory manifestations (19%) and gastrointestinal involvement (17%). Anaphylactic shock ocurred in ten patients (12%). Thirteen out of 174 patients admitted following scorpion stings had immediate-type reactions (7.5%). There was also a preponderance of skin reactions. Anaphylactic shock was observed in one patient. The positive predictive value of hypersensitivity skin test was 31.8% and its sensibility was 54.8%. These data show that a hypersensitivity skin test is inefective in predicting immediate-type hypersensitivity manifestations in patients given snake and scorpion antivenom. Considering these results, this test should be eliminated as a routine procedure when treating victims of poisonous animals. These studies indicate that prior to the administration of antivenom anti-hystamine (H1 and H2-antagonists) as well corticosteroids should be given by i.v. route in order to prevent or reduce hypersensitivity reactions. Antivenom sera must always be given under continuous medical surveillance by an intravenous route, without dilution, drop by drop for 15-30 minutes.

Na intensa rotina da Secção de Elucidação Diagnóstica do antigo Departamento de Profilaxia da Lepra de Sio Paulo, o autor teve a idéia de utilizar o éter sulfúrico na pesquisa da sensibilidade térmica, pois este líquido entra em ebulição a 35° C, praticamente h temperatura da pele humana e, ao fazê-lo, evidentemente promove sensação nítida de frio ou gelado, subtraindo 90 calorias por grama de éter vaporizado. Os receptores térmicos para o frio se superpõem, para finalidades práticas, aos receptores para o quente. Uma bolinha de algodão embebido em éter, deslizando na pele, vai permitir o rápido mapeamento da sensibilidade térmica do corpo humano todo, mesmo em pequenas Areas de difícil acesso ao tubo de água quente e fria que 6 classicamente utilizado na pesquisa da sensibilidade térmica. O resfriamento promovido pelo éter praticamente constante em toda a prova e facilmente reproduzível. Os pacientes testados acusam a sensação de frio ou gelado nas Areas normoestésicas e sentem calor ou apenas resfriamento, respectivamente nas áreas anestésicas e hipoest6sicas. 0 contraste da sensação fria deixada pelo éter 6 facilmente conseguido pela polpa digital do dedo indicador do observador. A prova do éter, ern todos os testes realizados, revelou-se prática, sensível, rápida, precisa e de fácil consecução, podendo contribuir para o diagnóstico precoce da hansenlase.