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190 results on '"Tian, Tiantian"'

1. Explainable Deep Learning with Human Feedback for Perioperative Complications Prediction

Author

Wang, Junya, Wu, Guanxiong, Tian, Tiantian, Lin, Qihua, Xiao, Chu, Tao, Xiaoyu, Li, Jianqiang, Li, Yuantao, Chen, Jie, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Huang, De-Shuang, editor, Zhang, Xiankun, editor, and Pan, Yijie, editor

Published
2024
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18. PD-1/PD-L1 Inhibitor Plus Chemotherapy Versus PD-1/PD-L1 Inhibitor in Microsatellite Instability Gastrointestinal Cancers: A Multicenter Retrospective Study

Author

Chen, Mifen, primary, Wang, Zhenghang, additional, Liu, Zimin, additional, Deng, Ting, additional, Wang, Xiaodong, additional, Chang, Zhiwei, additional, Zhang, Qi, additional, Yang, Wenlei, additional, Liu, Ning, additional, Ji, Zhi, additional, Zhang, Xiaotian, additional, Wang, Xicheng, additional, Peng, Zhi, additional, Li, Yi, additional, Cao, Yujuan, additional, Jin, Xuan, additional, Lu, Hongxia, additional, Qu, Huajun, additional, Tang, Yong, additional, Xu, Chunlei, additional, Fang, Weijia, additional, Zhang, Hangyu, additional, Yan, Dong, additional, Wang, Li, additional, Li, Jiayi, additional, Zhang, Jingdong, additional, Wang, Qiwei, additional, Xue, Liying, additional, Yin, Fei, additional, Han, Guangjie, additional, Cheng, Zhiqiang, additional, Liu, Qing, additional, Jin, Yongdong, additional, Zhang, Yinjie, additional, Li, Lanxing, additional, Cao, Baoshan, additional, Yao, Yanhong, additional, Chen, Zhiyu, additional, Zou, Jianling, additional, Ying, Jieer, additional, Wei, Qing, additional, Tian, Tiantian, additional, Zhao, Weifeng, additional, Li, Longmei, additional, Zhang, Tong, additional, Song, Fanghua, additional, Ba, Ya-er, additional, Li, Na, additional, Gao, Hui, additional, Ji, Yinghua, additional, Bao, Liying, additional, Zhao, Xiaochen, additional, Cai, Jinping, additional, Yuan, Zheping, additional, Shen, Lin, additional, and Li, Jian, additional

Published
2023
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20. Current and potential trends in the bioactive properties and health benefits of Prunus mume Sieb. Et Zucc: a comprehensive review for value maximization.

Author

Tian, Tiantian, Cao, Hui, Farag, Mohamed A., Fan, Siting, Liu, Luxuan, Yang, Wenjing, Wang, Yuxuan, Zou, Liang, Cheng, Ka-Wing, Wang, Mingfu, Ze, Xiaolei, Simal-Gandara, Jesus, Yang, Chao, and Qin, Zhiwei

Subjects
*PRUNUS, *STRUCTURE-activity relationships, *MOLECULAR weights, *MANUFACTURING processes, *BIOACTIVE compounds
Abstract

Prunus mume Sieb. Et Zucc (P. mume) is an acidic fruit native to China (named Chinese Mei or greengage plum). It is currently cultivated in several Asian countries, including Japan ("Ume"), Korea (Maesil), and Vietnam (Mai or Mo). Due to its myriad nutritional and functional properties, it is accepted in different countries, and its characteristics account for its commercialization. In this review, we summarize the information on the bioactive compounds from the fruit of P. mume and their structure-activity relationships (SAR); the pulp has the highest enrichment of bioactive chemicals. The nutritional properties of P. mume and the numerous uses of its by-products make it a potential functional food. P. mume extracts exhibit antioxidant, anticancer, antimicrobial, and anti-hyperuricaemic properties, cardiovascular protective effects, and hormone regulatory properties in various in vitro and in vivo assays. SAR shows that the water solubility, molecular weight, and chemical conformation of P. mume extracts are closely related to their biological activity. However, further studies are needed to evaluate the fruit's potential nutritional and functional therapeutic mechanisms. The industrial process of large-scale production of P. mume and its extracts as functional foods or nutraceuticals needs to be further optimized. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Silica nanoparticles induce apoptosis via the unfolded protein response in NRK-52E cells and rat kidney

Author

Naimeng Liu, Meng Li, Huan Pang, Tian Tiantian, Xinyue Li, Minghua Jin, Hao Wu, Chuyue Qian, and Mindan Sun

Abstract

Silica nanoparticles (SiNPs) have multiple applications, particularly in the field of biomedical science. However, SiNPs can cause a multitude of diseases, including chronic kidney disease (CKD). The molecular mechanism of renal toxicity caused by SiNPs is complex and remains to be clarified. Therefore, we examined the role and mechanism of apoptosis via the unfolded protein response (UPR) induced by SiNPs. We utilized an in vitro model of NRK-52E cells and an in vivo rat model with SiNPs administered via tracheal drip. After the NRK-52E cells were exposed to SiNPs, cell viability decreased; the mitochondrial membrane potential, calcium content, reactive oxygen species, and apoptosis rate increased; and light microscopy revealed cell damage. Meanwhile, apoptosis, the UPR, and oxidative stress-related proteins were all increased in NRK-52E cells. Moreover, an increase in the concentration of SiNPs was positively correlated with renal damage, as detected by light microscopy and transmission electron microscopy. As the SiNP concentration increased, apoptosis, the UPR, and oxidative stress-related proteins increased and the activity of antioxidant enzymes decreased in rat kidney. We conclude that the UPR plays a key role in apoptosis induced by SiNPs in the kidney.

Published
2023

26. Industrial application of antimicrobial peptides based on their biological activity and structure-activity relationship.

Author

Tian, Tiantian, Xie, Wansheng, Liu, Luxuan, Fan, Siting, Zhang, Heqian, Qin, Zhiwei, and Yang, Chao

Subjects
*PEPTIDE antibiotics, *ANTIMICROBIAL peptides, *STRUCTURE-activity relationships, *AMINO acid residues, *SCIENTIFIC knowledge, *INDUSTRIAL applications
Abstract

Last several years, a rapid increase in drug resistance to traditional antibiotics has driven the emergence and development of antimicrobial peptides (AMPs). AMPs have also gained considerable attention from scientists due to their high potency in combatting infectious pathogens. A subset of analogues and their derivatives with specific targets have been successfully designed based on natural peptide patterns. In this review, scientific knowledge on the mechanisms of action related to biological activity and structure-activity relationship (SAR) of AMPs are summarized, and the biological applications in several important fields are critically discussed. SAR shows that the positive charge, secondary structure, special amino acid residues, hydrophobicity, and helicity of AMPs are closely related to their biological activities. The combination of nanotechnology, bioinformatics, and genetic engineering can accelerate to achieve the application of AMPs as effective, safe, economical, and nonresistant antimicrobial agents in medicine, the food and feed industries, and agriculture in coming years. Given the intense interest in AMPs, further investigations are needed in the future to evaluate the specific structure and function that make their use favorable in several industries. This review may provide a comprehensive reference for future studies on chemical modifications, mechanistic exploration, and applications of AMPs. [ABSTRACT FROM AUTHOR]

Published
2023
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27. The role and mechanism of unfolded protein response signaling pathway in methylmercury‐induced apoptosis of mouse spermatocytes germ cell‐2 cells

Author

Zhang, Xiayu, primary, Hao, Huifang, additional, Ma, Kai, additional, Pang, Huan, additional, Li, Xinyue, additional, Tian, Tiantian, additional, Hou, Shanshan, additional, Ning, Xiaofan, additional, Wu, Hao, additional, Hou, Qiaohong, additional, Li, Meng, additional, Sun, Yunxiang, additional, Song, Xiuling, additional, and Jin, Minghua, additional

Published
2022
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30. Pseudoprogression during immunotherapy for gastric adenocarcinoma: A case report and literature review.

Author

Zhang, Lanying, Tian, Tiantian, Zhang, Yingying, Yu, Shuliang, Chen, Fangjie, Qiao, Lili, Hu, Pingping, and Zhang, Jiandong

Subjects
*LITERATURE reviews, *IMMUNOTHERAPY, *TUMOR markers, *GASTRECTOMY, *STOMACH cancer, *MUCINOUS adenocarcinoma
Abstract

Immunotherapy is a novel treatment option for various types of cancers. However, the optimal timing for response evaluation has not been well defined. Here, we present a gastric cancer (GC) patient with microsatellite instability-high who experienced recurrence 5 years and 11 months after radical gastrectomy. Then, the patient was treated with radiotherapy, targeted drugs, and immunotherapy. Immunotherapy resulted in 5 months of continuous progression, accompanied by significantly increased tumor marker CA19-9. However, the patient exhibited a satisfactory response without altering the treatment. Based on this, we hypothesized that some persistent progression with elevated tumor markers, known as pseudoprogression (PsP), might be observed in patients with recurrent GC during immunotherapy. This process might be prolonged, but if the treatment is continued, it will eventually produce remarkable therapeutic effects. PsP might challenge the globally accepted immune response evaluation criteria for solid tumors. [ABSTRACT FROM AUTHOR]

Published
2023
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31. The role and mechanism of unfolded protein response signaling pathway in methylmercury‐induced apoptosis of mouse spermatocytes germ cell‐2 cells.

Author

Zhang, Xiayu, Hao, Huifang, Ma, Kai, Pang, Huan, Li, Xinyue, Tian, Tiantian, Hou, Shanshan, Ning, Xiaofan, Wu, Hao, Hou, Qiaohong, Li, Meng, Sun, Yunxiang, Song, Xiuling, and Jin, Minghua

Subjects
UNFOLDED protein response, GERM cells, CELLULAR signal transduction, REACTIVE oxygen species, CALCIUM ions
Abstract

The study aimed to explore the role and mechanism of unfolded protein response (UPR) in methylmercury (MeHg)‐induced Mouse Spermatocytes (GC‐2spd[ts]) apoptosis. Methods such as MTT, flow cytometry, and Western Blot were used to evaluate the cell viability, membrane potential (MMP), reactive oxygen species (ROS), calcium ion (Ca2+), rate of cell apoptosis, and the expression of apoptosis‐related and UPR‐related protein. The results showed that with the increase of MeHg concentration, cell viability and MMP decreased, ROS, Ca2+, rate of cell apoptosis, and the expression of apoptosis‐related protein and UPR‐related protein increased. To further explore the effect of ROS‐induced oxidative damage on it, the ROS inhibitor N‐acetyl‐L‐cysteine (NAC) was used. The effects of MeHg on germ cell (GC‐2) cells were partially inhibited after NAC pretreatment. Our present study proved that MeHg might induce cell apoptosis by activating the UPR signaling pathway in GC‐2 cells and affect normal reproductive function. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Current and potential trends in the bioactive properties and health benefits of Prunus mume Sieb. Et Zucc: a comprehensive review for value maximization

Author

Tian, Tiantian, primary, Cao, Hui, additional, Farag, Mohamed A., additional, Fan, Siting, additional, Liu, Luxuan, additional, Yang, Wenjing, additional, Wang, Yuxuan, additional, Zou, Liang, additional, Cheng, Ka-Wing, additional, Wang, Mingfu, additional, Ze, Xiaolei, additional, Simal-Gandara, Jesus, additional, Yang, Chao, additional, and Qin, Zhiwei, additional

Published
2022
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44. Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition

Author

Liu, Qiqi, primary, Hao, Yuying, additional, Du, Rui, additional, Hu, Dan, additional, Xie, Jian, additional, Zhang, Jingxin, additional, Deng, Guodong, additional, Liang, Ning, additional, Tian, Tiantian, additional, Käsmann, Lukas, additional, Rades, Dirk, additional, Rim, Chai Hong, additional, Hu, Pingping, additional, and Zhang, Jiandong, additional

Published
2021
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50. Pyrotinib combined with CDK4/6 inhibitor in HER2‐positive metastatic gastric cancer: A promising strategy from AVATAR mouse to patients

Author

Chen, Zuhua, primary, Xu, Yingying, additional, Gong, Jifang, additional, Kou, Furong, additional, Zhang, Mengqi, additional, Tian, Tiantian, additional, Zhang, Xiaotian, additional, Zhang, Cheng, additional, Li, Jian, additional, Li, Zhongwu, additional, Lai, Yumei, additional, Zou, Jianjun, additional, Zhu, Xiaoyu, additional, Gao, Jing, additional, and Shen, Lin, additional

Published
2020
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