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8. Prevalence of uveitis in syphilis patients in Taiwan

Author

Chen, Chia-Yun, primary, Kuo, Hou-Ting, additional, Hsu, Alan Y., additional, Lin, Chun-Ju, additional, Hsia, Ning-Yi, additional, Tien, Peng-Tai, additional, Lai, Chun-Ting, additional, Chen, Huan-Sheng, additional, and Tsai, Yi-Yu, additional

Published
2023
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11. Acupuncture modulates development of myopia by reducing NLRP3 inflammasome activation via the dopamine-D1R signaling pathway.

Author

Chen, Chih-Sheng, Lin, Chi-Fong, Chou, Yung-Lan, Lee, Der-Yen, Tien, Peng-Tai, Wang, Yao-Chien, Chang, Ching-Yao, Lin, En-Shyh, Chen, Jamie Jiin, Wu, Ming-Yen, Ku, Hsiangyu, Gan, Dekang, Chang, Yung-Ming, Lin, Hui-Ju, and Wan, Lei

Subjects
HAMSTERS, DISEASE progression, PROTEINS, MYOPIA, ACUPUNCTURE, INFLAMMATION, ANIMAL experimentation, SIGNAL peptides, DOPAMINE, CELLULAR signal transduction, NUCLEOTIDES, LEUCINE, RESEARCH funding, VISUAL pigments, EPITHELIAL cells
Abstract

Background: Dopamine has been suggested to be a stop signal for eye growth and affects the development of myopia. Acupuncture is known to increase dopamine secretion and is widely used to treat myopia clinically. Objective: The aim of this study was to determine if acupuncture inhibits myopia progression in form deprived Syrian hamsters by inducing rises in dopamine content that in turn suppress inflammasome activation. Methods: Acupuncture was applied at LI4 and Taiyang every other day for 21 days. The levels of molecules associated with the dopamine signaling pathway, inflammatory signaling pathway and inflammasome activation were determined. A dopamine agonist (apomorphine) was used to evaluate if activation of the dopaminergic signaling pathway suppresses myopia progression by inhibiting inflammasome activation in primary retinal pigment epithelial (RPE) cells. A dopamine receptor 1 (D1R) inhibitor (SCH39166) was also administered to the hamsters. Results: Acupuncture inhibited myopia development by increasing dopamine levels and activating the D1R signaling pathway. Furthermore, we also demonstrated that nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome activation was inhibited by activation of the D1R signaling pathway. Conclusion: Our findings suggest that acupuncture inhibits myopia development by suppressing inflammation, which is initiated by activation of the dopamine—D1R signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema after Ranibizumab Injections

Author

Chang, Yen-Chieh, primary, Huang, Yu-Te, additional, Hsu, Alan Y., additional, Meng, Ping-Ping, additional, Lin, Chun-Ju, additional, Lai, Chun-Ting, additional, Hsia, Ning-Yi, additional, Chen, Huan-Sheng, additional, Tien, Peng-Tai, additional, Lin, Jane-Ming, additional, Chen, Wen-Lu, additional, and Tsai, Yi-Yu, additional

Published
2023
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16. Tinnitus as a Potential Risk Factor for Uveitis: A 14-Year Nationwide Population-Based Cohort Study in Taiwan

Author

Chen, Yi-Jye, Hsu, Alan Y., Lin, Chun-Ju, Hsia, Ning-Yi, Meng, Ping-Ping, Liao, Pei-Lun, Hsu, Min-Yen, Tien, Peng-Tai, Lai, Chun-Ting, Chen, Huan-Sheng, Chiang, Chun-Chi, and Tsai, Yi-Yu

Abstract

Tinnitus and uveitis have shared commonality in pathophysiology in terms of autoimmunity. However, no studies that have linked any association between the conditions of tinnitus and uveitis. This is a retrospective study conducted from the Taiwan National Health Insurance database in order to investigate whether tinnitus patients are at increased risk of uveitis. Patients newly diagnosed with tinnitus between 2001 and 2014 were recruited and followed up until 2018. The endpoint of interest was a diagnosis of uveitis. A total of 31,034 tinnitus patients and 124,136 matched comparisons were analyzed. Tinnitus patients were found to have a significantly higher cumulative incidence for uveitis than those without the diagnosis of tinnitus with incidence rate of 1.68 (95% CI 1.55–1.82) per 10 000 person-months for tinnitus group and 1.48 (95% CI 1.42–1.54) per 10 000 person-months for non-tinnitus group. Tinnitus patients were found to have increased risk of developing uveitis.

Published
2023
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17. sj-pdf-1-aim-10.1177_09645284231170886 – Supplemental material for Acupuncture modulates development of myopia by reducing NLRP3 inflammasome activation via the dopamine-D1R signaling pathway

Author

Chen, Chih-Sheng, Lin, Chi-Fong, Chou, Yung-Lan, Lee, Der-Yen, Tien, Peng-Tai, Wang, Yao-Chien, Chang, Ching-Yao, Lin, En-Shyh, Chen, Jamie Jiin, Wu, Ming-Yen, Ku, Hsiangyu, Gan, Dekang, Chang, Yung-Ming, Lin, Hui-Ju, and Wan, Lei

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-1-aim-10.1177_09645284231170886 for Acupuncture modulates development of myopia by reducing NLRP3 inflammasome activation via the dopamine-D1R signaling pathway by Chih-Sheng Chen, Chi-Fong Lin, Yung-Lan Chou, Der-Yen Lee, Peng-Tai Tien, Yao-Chien Wang, Ching-Yao Chang, En-Shyh Lin, Jamie Jiin Chen, Ming-Yen Wu, Hsiangyu Ku, Dekang Gan, Yung-Ming Chang, Hui-Ju Lin and Lei Wan in Acupuncture in Medicine

Published
2023
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18. Short-Term Effects of Brolucizumab in the Treatment of Wet Age-Related Macular Degeneration or Polypoidal Choroidopathy Refractory to Previous Anti-Vascular Endothelial Growth Factor Therapy

Author

Hsu, Alan Y., primary, Lin, Chih-Ying, additional, Lin, Chun-Ju, additional, Lai, Chun-Ting, additional, Hsia, Ning-Yi, additional, Lin, Jane-Ming, additional, Tien, Peng-Tai, additional, Meng, Ping-Ping, additional, Ku, Wei-Ning, additional, Chen, Wen-Lu, additional, and Tsai, Yi-Yu, additional

Published
2022
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21. Changes of Estimated Glomerular Filtration Rate and Glycated Hemoglobin A1c in Diabetic Macular Edema Patients Treated by Ranibizumab and Aflibercept in the Tertiary Referral Hospital

Author

Ku, Wei-Ning, primary, Tien, Peng-Tai, additional, Lin, Chun-Ju, additional, Chiang, Chun-Chi, additional, Hsia, Ning-Yi, additional, Lai, Chun-Ting, additional, Muo, Chih-Hsin, additional, Bair, Henry, additional, Chen, Huan-Sheng, additional, Lin, Jane-Ming, additional, Chen, Wen-Lu, additional, and Tsai, Yi-Yu, additional

Published
2022
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22. Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema After Dexamethasone Implants

Author

Huang, Yu-Te, primary, Chang, Yen-Chieh, additional, Meng, Ping-Ping, additional, Lin, Chun-Ju, additional, Lai, Chun-Ting, additional, Hsia, Ning-Yi, additional, Chen, Huan-Sheng, additional, Tien, Peng-Tai, additional, Bair, Henry, additional, Lin, Jane-Ming, additional, Chen, Wen-Lu, additional, and Tsai, Yi-Yu, additional

Published
2022
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24. Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study

Author

Huang, Yu-Te, primary, Wang, I, additional, Lin, Chun-Ju, additional, Lai, Chun-Ting, additional, Hsia, Ning-Yi, additional, Chen, Huan-Sheng, additional, Tien, Peng-Tai, additional, Bair, Henry, additional, Lin, Jane-Ming, additional, Chen, Wen-Lu, additional, Chen, Chang-He, additional, Wu, Wen-Chuan, additional, and Tsai, Yi-Yu, additional

Published
2022
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27. The incidence of uveitis after systemic lymphoma in Taiwan

Author

Huang, Yu-Te, primary, Lin, Chun-Ju, additional, Liao, Pei-Lun, additional, Hsu, Min-Yen, additional, Chang, Cheng-Hsien, additional, Tien, Peng-Tai, additional, Lai, Chun-Ting, additional, Hsia, Ning-Yi, additional, Bair, Henry, additional, Chen, Huan-Sheng, additional, Chiang, Chun-Chi, additional, and Tsai, Yi-Yu, additional

Published
2022
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32. Chronic Kidney Disease as A Potential Risk Factor for Uveitis: A 13-Year Nationwide Population-Based Cohort Study in Taiwan.

Author

Lin, Chun-Ju, Tien, Peng-Tai, Lai, Chun-Ting, Hsia, Ning-Yi, Chang, Cheng-Hsien, Bair, Henry, Chen, Huan-Sheng, Yang, Yu-Cih, Lin, Jan-Ming, Chen, Wen-Lu, and Tsai, Yi-Yu

Subjects
*DISEASE risk factors, *IRIDOCYCLITIS, *UVEITIS
Abstract

To investigate whether patients with chronic kidney disease (CKD) are at increased risk of uveitis. Data was collected from the Taiwan National Health Insurance system and included patients newly diagnosed with CKD between 2000 and 2012. The endpoint of interest was a diagnosis of uveitis. 30,256 CKD patients and 121,024 matched comparisons were analyzed. CKD patients were found to have a significantly higher cumulative uveitis incidence. Through multivariate Cox regression analysis, the CKD group was found to have higher risk of developing uveitis (adjusted hazard ratio 1.51). After stratified by gender, age, and comorbidities (hypertension, diabetes, and hyperlipidemia), the increased risk of uveitis in CKD patients remained significant. Patients with CKD were found to have higher risk of developing uveitis. For patients over 18 years old and with hypertension, diabetes, or hyperlipidemia, the presence of CKD was demonstrated as an additional crucial factor for uveitis development. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Astigmatism Management with Astigmatism-Correcting Intraocular Lens Using Two Toric Calculators – A Comparative Case Series

Author

Huang, Yu-Te, primary, Lin, Chun-Ju, additional, Lai, Chun-Ting, additional, Hsia, Ning-Yi, additional, Tien, Peng-Tai, additional, Bair, Henry, additional, Chen, Huan-Sheng, additional, Chiang, Chun-Chi, additional, Lin, Jane-Ming, additional, Chen, Wen-Lu, additional, Wu, Wen-Chuan, additional, and Tsai, Yi-Yu, additional

Published
2021
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36. Short-Term Outcomes of Refractory Diabetic Macular Edema Switch From Ranibizumab to Dexamethasone Implant and the Influential Factors: A Retrospective Real World Experience

Author

Hsia, Ning-Yi, primary, Lin, Chun-Ju, additional, Chen, Huan-Sheng, additional, Chang, Cheng-Hsien, additional, Bair, Henry, additional, Lai, Chun-Ting, additional, Lin, Jane-Ming, additional, Chen, Wen-Lu, additional, Tien, Peng-Tai, additional, Wu, Wen-Chuan, additional, and Tsai, Yi-Yu, additional

Published
2021
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38. Preoperative Vision, Gender, and Operation Time Predict Visual Improvement After Epiretinal Membrane Vitrectomy: A Retrospective Study

Author

Bair, Henry, primary, Kung, Wei-Hsun, additional, Lai, Chun-Ting, additional, Lin, Chun-Ju, additional, Chen, Huan-Sheng, additional, Chang, Cheng-Hsien, additional, Lin, Jane-Ming, additional, Hsia, Ning-Yi, additional, Chen, Wen-Lu, additional, Tien, Peng-Tai, additional, Wu, Wen-Chuan, additional, and Tsai, Yi-Yu, additional

Published
2021
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39. Short-term Outcomes of Refractory Diabetic Macular Edema Switch from Ranibizumab to Dexamethasone Implant and the Influential Factors: A Retrospective Real World Experience.

Author

Hsia, Ning-Yi, primary, Lin, Chun-Ju, additional, Chen, Huan-Sheng, additional, Chang, Cheng-Hsien, additional, Bair, Henry, additional, Lai, Chun-Ting, additional, Lin, Jane-Ming, additional, Chen, Wen-Lu, additional, Tien, Peng-Tai, additional, Wu, Wen-Chuan, additional, and Tsai, Yi-Yu, additional

Published
2020
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40. Relationship between Uveitis and Thyroid Disease: A 13-Year Nationwide Population-based Cohort Study in Taiwan.

Author

Lin, Chun-Ju, Tien, Peng-Tai, Chang, Cheng-Hsien, Hsia, Ning-Yi, Yang, Yu-Cih, Lai, Chun-Ting, Bair, Henry, Chen, Huan-Sheng, Tsai, Yi-Yu, and Chang, Cheng-Hsien MD, PhD

Subjects
*THYROID diseases, *UVEITIS, *NATIONAL health insurance, *COHORT analysis, *AGE groups, *DATABASES, *RETROSPECTIVE studies, *DISEASE incidence, *NATIONAL health services, *LONGITUDINAL method
Abstract

Purpose: To investigate whether patients with thyroid disease are at increased risk of uveitis.Methods: Data was collected from the Taiwan National Health Insurance system and included patients newly diagnosed with thyroid disease from 2000 to 2012. The endpoint of interest was a diagnosis of uveitis.Results: In analyzing 21,396 patients with thyroid disease, yielding 85,584 matched comparisons, patients with thyroid disease to have a significantly higher cumulative incidence of uveitis when compared to the control cohort with the Kaplan-Meier analysis. This result was further confirmed by Cox regression analysis. The increased risk was persistent in both genders. The association between thyroid disease and uveitis was stronger in patients without diabetes or hypertension.Conclusion: Patients with thyroid disease were found to have a higher risk for uveitis. For certain age groups or patients without diabetes or hypertension, the role of thyroid disease might be more crucial for uveitis development. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Endoscopy-assisted extraction of orbital and nasal foreign body.

Author

Huang, Yu-Te, Kung, Wei-Hsun, Chang, Cheng-Hsien, Ku, Wei-Ning, Tien, Peng-Tai, Chiang, Chun-Chi, and Tsai, Yi-Yu

Abstract

Penetrating orbital injury with a foreign body is a complex problem that requires an interdisciplinary therapeutic approach. Conventionally, an external approach using either transconjuntival or transseptal entry is used by an ophthalmologist. However, there is a risk of damage to the optic nerve and orbital tissue using only the traditional approach. This study concerns a 36-year-old male who has an intra-orbital foreign body (OrbFB). Timely three-dimensional reconstruction computed tomography scan demonstrated an 8-cm-long intra-OrbFB adjacent to the optic nerve penetrating to the contralateral nasal cavity. Endoscopic inspection confirmed a chopstick fragment. Assisted by transnasal endoscopy, the chopstick penetrating from the orbit to the nasal cavity was smoothly removed. Nasal endoscopy is useful for an ophthalmologist in removing foreign body in the orbit. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Endogenous endophthalmitis caused by Cryptococcus neoformans Var. Gattii mimicking choroidal tumor: From positron-emission tomography/computed tomography to histopathology

Author

Lin, Chun-Ju, Chen, Wen-Lu, Lin, Jane-Ming, Tien, Peng-Tai, and Tsai, Yi-Yu

Subjects
Positron emission tomography -- Usage, Cryptococcus -- Research, Endophthalmitis -- Care and treatment, Vitrectomy -- Usage, Health
Abstract

Byline: Chun-Ju. Lin, Wen-Lu. Chen, Jane-Ming. Lin, Peng-Tai. Tien, Yi-Yu. Tsai A 60-year-old immunocompetent female with pneumonia history about 10 years ago suffered from blurred vision overall survival for 3 [...]

Published
2017

50. Significant improvement of ocular clinical pictures of iris metastasis from small-cell lung cancer after systemic chemotherapy.

Author

Huang, Li-Ying, Hsia, Ning-Yi, Lai, Chun-Ting, Tien, Peng-Tai, Lin, Chun-Ju, Lin, Jane-Ming, Tsai, Yi-Yu, and Chen, Wen-Lu

Abstract

The uveal tract is the most common ophthalmic site of ocular metastasis from systemic tumors due to the luxurious blood flow within the choroidal tissue. However, iris metastasis from systemic cancer is uncommon, accounting for only 8% of cases of uveal metastasis. There are several methods for the treatment of iris tumor. Here, we reported a case of iris metastasis from small-cell lung cancer. The tumor shrunk after systemic treatment for lung cancer and showed no recurrence after a 4-month follow-up. [ABSTRACT FROM AUTHOR]

Published
2021
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