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Your search keyword '"Tjon, Jennifer M.L."' showing total 4 results
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4 results on '"Tjon, Jennifer M.L."'

1. Hematopoietic stem cell transplantation for CTLA-4 insufficiency across Europe: A European Society for Blood and Marrow Transplantation Inborn Errors Working Party study

Author

Tsilifis, Christo, Speckmann, Carsten, Lum, Su Han, Fox, Thomas A., Soler, Adriana Margarit, Mozo, Yasmina, Corral, Dolores, Ewins, Anna-Maria, Hague, Rosie, Oikonomopoulou, Christina, Kałwak, Krzysztof, Drabko, Katarzyna, Wynn, Robert, Morris, Emma C., Elcombe, Suzanne, Bigley, Venetia, Lougaris, Vassilios, Malagola, Michele, Hauck, Fabian, Sedlacek, Petr, Laberko, Alexandra, Tjon, Jennifer M.L., Buddingh, Emilie P., Wehr, Claudia, Grimbacher, Bodo, Gennery, Andrew R., Lankester, Arjan C., Albert, Michael H., Neven, Bénédicte, and Slatter, Mary A.

Published
2024
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2. The degree of HLA matching determines the incidence of cytokine release syndrome and associated nonrelapse mortality in matched related and unrelated allogeneic stem cell transplantation with post-transplant cyclophosphamide.

Author

von dem Borne, Peter A., Kemps-Mols, Berit M., de Wreede, Liesbeth C., van Beek, Adriaan A., Snijders, Tjeerd J.F., van Lammeren, Daniëlle, Tijmensen, Janneke, Sijs-Szabó, Aniko, Oudshoorn, Mirjam A., Halkes, Constantijn J.M, van Balen, Peter, Marijt, W.A. Erik, Tjon, Jennifer M.L., Vermaat, Joost S.P, and Veelken, Hendrik

Subjects
CYTOKINE release syndrome, STEM cell transplantation, ORGANIZING pneumonia, MULTIPLE organ failure, INFLAMMATION
Abstract

Cytokine release syndrome (CRS) occurs frequently after haplo-identical allogeneic stem cell transplantation (alloSCT) with post-transplant cyclophosphamide (PTCy), increasing nonrelapse mortality (NRM) and decreasing survival. Data on CRS in HLA-matched alloSCT are limited and effects of specific HLA-mismatches on CRS development unknown. We hypothesized that in HLA-matched alloSCT increasing degrees of HLA-mismatching influence CRS incidence, NRM and survival. Retrospective analysis of 126 HLA-matched PTCy-alloSCT patients showed that higher degrees of HLA-mismatching significantly increased CRS incidence (26%, 75% and 90% CRS with 12/12, 10/10 and 9/10 matched donors, respectively). Maximum temperature during CRS increased with higher HLA-mismatch. Specific associations between HLA-mismatches and CRS could be determined. Grade 2 CRS and CRS-induced grade 3 fever were associated with significantly increased NRM (p < 0.001 and p = 0.003, respectively) and inferior survival (p < 0.001 and p = 0.005, respectively). NRM was mainly caused by disease conditions that may be considered CRS-induced inflammatory responses (encephalopathy, cryptogenic organizing pneumonia and multi-organ failure). [ABSTRACT FROM AUTHOR]

Published
2024
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