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A prospective, analytical and cross-sectional study to find out the role of contact with tuberculous patients during the process of development of Tuberculous Cervical Lymphadenitis was currently carried out in the Department of ENT- Head & Neck Surgery of Tribhuvan University Teaching Hospital Kathmandu. Nepal. Altogether 103 cases of histopathologically confirmed cases of Tuberculous Cervical Lymphadenitis of more than six weeks of duration were included in the study during the period of one year from March, 2000 to February, 2001. History of contact with tuberculous patients in the past during the development of the disease process was found to he positive in 19(18.4%) of the 103 cases. In rest of the 84 cases history of contact with tuberculous patients was found to he negative (81.6%). The result of this study so far indicates that there is a minimal role of contact with tuberculous patients for the development of tuberculous cervical lymphadenitis. Mutual tuberculosis is known as a chronic communicable disease, in our study majority eases of Tuberculous Cervical Lymphadenitis did not give any history of contact with tuberculous patients in the past. [ABSTRACT FROM AUTHOR]

The diagnosis of Tuberculous Cervical lymphadenitis (TCL) is challenging. The present study aimed to assess the performance of GeneXpert ultra (GXu) in the diagnosis of TCL on Formalin Fixed, Paraffin Embedded Tissues (FFPET). This study included 35 TCL cases confirmed by positive microbiology and/or positive GXu on Fresh Tissues (FT). The diagnostic performance parameters of GXu on FFPET were determined with reference to microbiology (positive Ziehl Neelsen and/or positive culture) and with reference to positive microbiology and/or positive GXu on FT. The GXu on FFPET was positive in 26/35 (74%) cases. With reference to positive ZN and or culture, the sensitivity, specificity, positive predictive value, and negative predictive value of GXu on FFPET were 63%, 100%, 100% and 71% respectively. With reference to positive microbiology and/or positive GXu on FT, these rates were 74%, 100%, 100% and 40% respectively. GXu on FFPET is a reliable tool for the detection of Mycobacterium tuberculosis complex particularly for cases where microbiological investigations have not been performed. • GeneXpert ultra analyses are routinely performed on Fresh tissues. • Mycobacterium detection by GeneXpert ultra on FFPE lymph nodes is reliable. • GeneXpert ultra on FFPE lymph nodes is an alternative of GeneXpert ultra on Fresh tissue. [ABSTRACT FROM AUTHOR]