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1. Protective effect of Yerba mate (Ilex paraguariensis St. Hill.) against oxidative damage in vitro in rat brain synaptosomal/mitochondrial P2 fractions

Author

Hemerson Silva da Rosa, Ana Zilda Ceolin Colpo, María Eduarda de Lima, Vanderlei Folmer, Isaac Túnez, Abel Santamaría, Sonia Galván-Arzate, Marisol Maya-López, [Eduarda de Lima, Maria] Inst Nacl Neurol & Neurocirug, Lab Aminoticidos Excitadores, Mexico City, DF, Mexico, [Colpo, Ana C.] Inst Nacl Neurol & Neurocirug, Lab Aminoticidos Excitadores, Mexico City, DF, Mexico, [Maya-Lopez, Marisol] Inst Nacl Neurol & Neurocirug, Lab Aminoticidos Excitadores, Mexico City, DF, Mexico, [Santamaria, Abel] Inst Nacl Neurol & Neurocirug, Lab Aminoticidos Excitadores, Mexico City, DF, Mexico, [Eduarda de Lima, Maria] Univ Fed Pampa, Programa Pos Grad Bioquim, Uruguaiana, Brazil, [Colpo, Ana C.] Univ Fed Pampa, Programa Pos Grad Bioquim, Uruguaiana, Brazil, [Rosa, Hemerson] Univ Fed Pampa, Programa Pos Grad Bioquim, Uruguaiana, Brazil, [Folmer, Vanderlei] Univ Fed Pampa, Programa Pos Grad Bioquim, Uruguaiana, Brazil, [Tunez, Isaac] Univ Cordoba, Dept Bioquim & Biol Mol, Fac Med & Enfermeria, Inst Maimonides Invest Biomed Cordoba, Cordoba, Spain, [Galvan-Arzate, Sonia] Inst Nacl Neurol & Neurocirug, Dept Neuroquim, Mexico City, DF, Mexico, CONACyT (Mexico), and CAPES (Brazil)

Subjects
0301 basic medicine, Antioxidant, medicine.medical_treatment, Generation, Medicine (miscellaneous), Rat brain, Biology, Stress, Neuroprotection, Lipid peroxidation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, food, Antioxidant activity, Chlorogenic acid, Yerba mate extract, Yerba-mate, Antioxidant defense, medicine, TX341-641, Quinolinic acid, chemistry.chemical_classification, Reactive oxygen species, Nutrition and Dietetics, Nutrition. Foods and food supply, Proteins, Glutathione, food.food, In vitro, 030104 developmental biology, Impairment, chemistry, Biochemistry, Mitochondrial dysfunction, Phenolic-compounds, 030217 neurology & neurosurgery, Synaptosomes, Food Science
Abstract

Yerba mate extracts are naturally enriched with several antioxidant compounds. Therefore, this natural product constitutes a fertile field of research directed to test its antioxidant and therapeutic properties in the Central Nervous System. We tested the ability of yerba mate to prevent the chemically-induced reactive oxygen species (ROS) formation, lipid peroxidation, glutathione balance (GSH:GSSG) disruption and mitochondrial dysfunction in vitro in rat brain synaptosomal/mitochondrial fractions, and compared these effects with those of its most abundant compound chlorogenic acid (CGA). Yerba mate prevented glutathione depletion and mitochondrial dysfunction, and these effects were correlated with its ability to prevent ROS formation. CGA prevented oxidative damage and mitochondrial dysfunction, but its effects were less intense than those of the extract. Our results suggest that the protective properties exhibited by yerba mate cannot be merely attributable to its main component CGA. (C) 2017 Elsevier Ltd. All rights reserved.

Published
2017
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2. Peri-ovulatory endocrine regulation of the prostanoid pathways in the bovine uterus at early dioestrus

Author

Fabio Luiz D’Alexandri, Claudia Maria Bertan Membrive, Veerle Van Hoeck, João Alberto Negrão, Guilherme Pugliesi, Fernando Silveira Mesquita, M. L. Oliveira, Mario Binelli, Craig E. Wheelock, Universidade de São Paulo (USP), Univ Fed Pampa, Universidade Estadual Paulista (Unesp), and Karolinska Inst Stockholm

Subjects
0301 basic medicine, medicine.medical_specialty, media_common.quotation_subject, Uterus, Down-Regulation, Prostaglandin, Biology, Dinoprost, Endometrium, Dinoprostone, prostaglandins, 03 medical and health sciences, chemistry.chemical_compound, Endocrinology, MORTALIDADE EMBRIONÁRIA ANIMAL, Ovulation Induction, Internal medicine, Genetics, medicine, Animals, endometrium, Molecular Biology, Ovulation, media_common, Estrous cycle, Prostanoid, Diestrus, Up-Regulation, 030104 developmental biology, medicine.anatomical_structure, Reproductive Medicine, chemistry, physiology, Cattle, Female, Animal Science and Zoology, Folliculogenesis, oestrogen, Corpus luteum, Signal Transduction, Developmental Biology, Biotechnology
Abstract

Made available in DSpace on 2018-11-28T04:17:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01 LFEM Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) We hypothesised that different endocrine profiles associated with pre-ovulatory follicle (POF) size would impact on uterine prostanoid pathways and thereby modulate the histotroph composition. Beef cows (n=15 per group) were hormonally manipulated to have small (SF-SCL group) or large (LF-LCL group) pre-ovulatory follicles (POF) and corpora lutea (CL). Seven days after induction of ovulation, animals were slaughtered and uterine tissues and flushings were collected for quantification of prostanoids. The POF and CL size and the circulating progesterone concentrations at Day 7 were greater (P0.1) in prostanoid concentrations in the endometrium or in uterine flushings was detected between groups. However, prostaglandin F2 and E2 concentrations in the uterine flushings were positively correlated with the abundance of transcripts for prostaglandin endoperoxide synthase 2 (0.779 and 0.865, respectively; P

Published
2017
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