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María del Rosario Sánchez-Valerio,1 Karim Mohamed-Noriega,2 Irma Zamora-Ginez,1 Blanca Guadalupe Baez Duarte,1 Verónica Vallejo-Ruiz3 1Faculty of Medicine, Autonomous University of Puebla, Puebla, Puebla, México; 2Autonomous University of Nuevo León (UANL), Faculty of Medicine, University Hospital “José E. Gonzalez, Ophthalmology Department, Monterrey, México; 3Eastern Biomedical Research Center, Mexican Social Security Institute (IMSS), Metepec, Puebla, MéxicoCorrespondence: María del Rosario Sánchez-Valerio Tel +52 22 26039032Email rosyoft_@hotmail.comPurpose: To assess the time of exposure to the computer and dry eye disease (DED) in subjects with computer vision syndrome (CVS).Methods: A cross-sectional study was conducted in office workers, computer users of both sexes, with an age range of 18– 45 years without comorbidities; we included 108 subjects divided into 3 groups according to the time of computer exposure in hours per day (H/D): < 4 (n = 23), 4 − 7.9 (n = 49), > 8 (n = 39). A specific questionnaire was applied to them on the exposure time and the type of visual display terminal (VDT) used, as well as the computer vision symptoms scale (CVSS17). DED was diagnosed with the Ocular Surface Disease Index (OSDI). Ocular surface damage and signs of DED were evaluated with the tear rupture time test (TBUT), the integrity of the ocular surface by ocular surface staining (OSS) and the production of the aqueous basal tear film using the Schirmer test.Results: Average computer exposure time, measured differently, was positively correlated with DED development. The computer exposure time measured in hours per year and TBUT showed a significant negative correlation (p < 0.001) (rho − 0.463). Years of computer exposure and staining of the ocular surface showed a significant positive correlation (p < 0 0.001; rho 0.404). The accumulated exposure time was negatively correlated with TBUT (p < 0.001; rho − 0.376) and positively with OSS (p < 0.001; rho 0.433). Schirmer test did not correlate with computer exposure time.Conclusion: The prolonged time of exposure to the computer in subjects with CVS was significantly correlated with the DED tests, in the different ways of measuring it; but not with the Schirmer test.Keywords: computer vision syndrome, dry eye disease.

Introduction: Despite the large number of drugs active in AGC, no combination can be considered as the gold standard treatment. Modest increase have been obtained in overall survival with the most widely employed regimens such as CF or ECF, often obtained at expense of increased toxicity. So there is a strong need to develop new active drugs to improve the clinical outcome. Taxotere showed to be effective in preclinical studies and some phase II trials confirmed its clinical efficacy. Recently, the addition of TXT to CDDP + FU (TCF regimen), obtained, in a large randomised phase III trial, better survival than CF alone. However the toxicity of this combination was relevant and mainly due to the association with CDDP. Considering these data the GOIM started a phase II study aiming to evaluate efficacy and safety of a three drugs combination, employing EPI instead of CDDP.Materials and methods: Forty-one histologically proven untreated gastric cancer patients, with advanced measurable disease, age between 18 and 75 years, performance status greater-or-equal, slanted 70 (Kfsky scale) and available to sign written informed consent, were enrolled. They received the following treatment: Epirubicin at 60 mg/m2 on day 1, Taxotere at 50 mg/m2 on day 1, Folinic Acid at 100 mg/m2 on days 1-2, Fluorouracil bolus at 400 mg/m2 on days 1-2 and Fluorouracil 22 h continuous infusion on days 1-2 every three weeks.Results: Amongst the 38 evaluable patients we observed 5 CR (13%), 9 PR (24%), 9 SD (24%) and 15 PD (39%) for an ORR of 37% (95% CI: 22-52) and a tumor growth control rate of 61%. The median time to progression was 4 months and the median survival was 9 months.The treatment was well tolerated. The main grade III-IV haematologic toxicities were leucopenia 7%, neutropenia 5% and anemia 5% while non-haematologics were diarrhoea 2%, alopecia 2% and cardiac 2%.Conclusion: The three drugs combination of Taxotere, Epirubicin and Fluorouracil is active and well tolerated first-line treatment in advanced gastric cancer patients. [ABSTRACT FROM AUTHOR]