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3 results on '"Vega Widya Karisma"'

1. UVA-Triggered Drug Release and Photo-Protection of Skin

Author

Vega Widya Karisma, Wei Wu, Mingxing Lei, Huawen Liu, Muhammad Farrukh Nisar, Matthew D. Lloyd, Charareh Pourzand, and Julia Li Zhong

Subjects
caged iron chelators, drug delivery systems (DDS), skin photo-protection, smart sunscreens, up-conversion nanoparticles, UVA-triggered drug release, Biology (General), QH301-705.5
Abstract

Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.

Published
2021
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2. PERUBAHAN KOMPOSISI KIMIA TEMPE KACANG MERAH (Phaseolus vulgaris L.) SELAMA PENGOLAHAN

Author

Feri Kusnandar, Vega Widya Karisma, Antung Sima Firlieyanti, and Eko Hari Purnomo

Subjects
Agriculture, Microbiology, QR1-502
Abstract

Kacang merah (Phaseolus vulgaris L.) mengandung zat gizi namun juga mengandung komponen antinutrisiyang menyebabkan penurunan nilai gizinya. Kacang merah berpotensi untuk diolah menjadi tempe.Perubahan komposisi kimia dan komponen antinutrisi dari kacang merah dapat terjadi selama pengolahantempe. Penelitian ini bertujuan untuk mengevaluasi perubahan komposisi kimia dan kandungan antinutrisi darikacang merah selama proses pengolahan tempe. Kacang merah diberi perlakuan perendaman, perebusan,perendaman asam dan fermentasi kapang (campuran Rizophus oryzae dan Rizophus oligosporus).Komposisi kimia, kandungan asam amino, aktivitas inhibisi antitripsin, kadar total isoflavon, dan oligosakaridadari kacang merah dievaluasi. Kacang merah mengandung protein dan karbohidrat yang tinggi (23,01% bkdan 71,51%bk). Komposisi protein kacang merah didominasi oleh asam aspartat (2.75 g/100g), asamglutamat (3,71 g/100g), leusin (1,80 g/100g) dan lisin (1,50 g/100g). Kacang merah menunjukkan aktivitasinhibisi antiripsin (0,58x106 TUI), mengandung isoflavon (152,76 mg/100g) dan oligosakarida dalam bentukstakiosa (13,97 mg/g) dan rafinosa (1,88 mg/g). Proses perendaman, perebusan, perendaman asam, danfermentasi kapang mempengaruhi secara signifikan (pKata kunci: kacang merah, asam amino, antitripsin, isoflavon, oligosakarida DOI : https://doi.org/10.33005/jtp.v14i1.2187

Published
2020
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3. Bach2 regulates autophagy to modulate UVA-induced photoaging in skin fibroblasts

Author

Chen Jingyi, Yingying Guo, Jiefu Luo, Jörg W. Bartsch, Li Chang, Charareh Pourzand, Yang Xing, Mei Wang, Julia Li Zhong, Muhammad Farrukh Nisar, Vega Widya Karisma, Xia Lei, and Mingxing Lei

Subjects
0301 basic medicine, Senescence, Ultraviolet Rays, Photoaging, ATG5, Cell, Skin Diseases, Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Autophagy, medicine, Animals, Cells, Cultured, Skin, Gene knockdown, Chemistry, Fibroblasts, medicine.disease, Embryonic stem cell, In vitro, Skin Aging, Cell biology, Basic-Leucine Zipper Transcription Factors, 030104 developmental biology, medicine.anatomical_structure, 030217 neurology & neurosurgery
Abstract

Senescence is a cellular process that can be initiated by certain stressors such as UVA irradiation. The mechanism by which skin cells protect themselves from the UVA-induced senescence has not been fully investigated. Here, we demonstrate that Bach2 modulates the extent of UVA-induced photoaging through regulation of autophagy in skin fibroblasts. In fact chronic exposure of skin fibroblasts to UVA resulted in a significant decrease in Bach2 expression, both in vitro and in vivo. In addition, knockdown of Bach2 in skin fibroblasts led to an increased expression of cell senescence-related genes, which further enhanced the UVA irradiation-induced photoaging. On the other hand, the overexpression of Bach2 resulted in a decrease in the expression of cell senescence-related genes. We also demonstrate that the knockdown of Bach2 in skin fibroblasts can lead to a decreased expression of autophagy-related genes and vice versa, suggesting that autophagy is involved in Bach2-mediated regulation of senescence in skin fibroblasts. Additionally, inhibition of autophagy with autophagy inhibitor 3-MA suppressed the expression of autophagy-related proteins and promoted cell senescence. Furthermore, knockout of Atg5 or Atg7 in embryonic mouse fibroblasts led to a significant increase in the expression of cell senescence-related genes. Immunoprecipitation assays further demonstrated that Bach2 directly interacts with Beclin-1, Atg3, Atg7, and LC3 in fibroblasts. Taken together, these findings revealed a critical role for Bach2 in suppressing the UVA irradiation-induced cell senescence via autophagy in skin fibroblasts. Bach2 can therefore be a potential target for the therapy of UV-induced photoaging because of its ability to regulate the process of autophagy in the skin.

Published
2021
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