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Background: Ambulatory (A) blood pressure (BP), central BP and pulse wave velocity (PWV) are parameters recommended by hypertension guidelines for estimating BP control and vascular impairment. Recent advances in technology made available devices allowing combined non-invasive estimation of these parameters over the 24-h during ABPM. However, at present, there is limited evidence on the usefulness of such an approach for routine hypertension management. Objective: We recently launched an investigator-initiated, international, multicenter, observational, prospective study aiming at: i) evaluating non-invasive 24-h ABP and arterial stiffness estimates (through 24-h pulse wave analysis, PWA) in hypertensive subjects; ii) assessing the changes in estimates following treatment; iii) weighing the impact of 24-h PWA on target organ damage and cardiovascular prognosis; iv) assessing the relationship between arterial stiffness, BP absolute level and variability, and prognosis. Methods: Approximately 2000 subjects, referred to 20 hypertension clinics for routine diagnostic evaluation and follow-up of hypertension, will be recruited. Data collection will include ABPM, performed with a device allowing simultaneous non-invasive assessment of BP and arterial stiffness (BPLab), and clinical data (including cardiovascular outcomes). A web-based telemedicine platform will be used for data collection. Subjects will visit the centers at 6-12 month intervals. First follow-up results are expected to be available in the next 2-years. Conclusions: The results of the VASOTENS Registry will help defining the normalcy thresholds for current and future indices derived from 24-h PWA, according to outcome data. They will also provide supporting evidence for the inclusion of such evaluation in recommendations on hypertension management.