25 results on '"Wigley, W Christian"'
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2. Dynamic Association of Proteasomal Machinery with the Centrosome
3. A Screen to Identify Cellular Modulators of Soluble Levels of an Amyotrophic Lateral Sclerosis (ALS)–Causing Mutant SOD1
4. Transmembrane domain of cystic fibrosis transmembrane conductance regulator: design, characterization, and secondary structure of synthetic peptides m1-m6
5. Restriction fragment length polymorphism (RFLP) analysis provides evidence for a high degree of homology of mitochondrial DNAs from rat hepatomasVersus normal rat livers
6. Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme
7. Hook2 contributes to aggresome formation
8. Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD.
9. Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function.
10. Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.
11. RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity.
12. Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.
13. Synthesis, Chemical Reactivityas Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones,Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents(1).
14. Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.
15. Hsp90 Inhibition: A Promising Therapeutic Approach for ARSACS.
16. A protein sequence that can encode native structure by disfavoring alternate conformations.
17. Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein.
18. Natural mutagenesis study of the human steroid 5alpha-reductase 2 isozyme.
19. Detection of a progression-linked DNA restriction fragment in rat hepatoma cells probed with a hexokinase CDNA.
20. NRF2 as an Emerging Therapeutic Target.
21. ChemInform Abstract: Synthesis and Biological Evaluation of 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A Novel and Highly Potent Antiinflammatory and Cytoprotective Agent.
22. Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
23. The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II-induced contraction of glomerular mesangial cells.
24. A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex.
25. A novel series of cysteine-dependent, allosteric inverse agonists of the nuclear receptor RORγt.
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