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19. Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17

Author

Chew, Emily Y., Ferris, Frederick L., III, SanGiovanni, John Paul, Agrón, Elvira, Clemons, Traci, Lindblad, Anne, Lindblad, Robert, Shah, Nilay, Sperduto, Robert, McBee, Wendy, Gensler, Gary, Harrington, Molly, Henning, Alice, Jones, Katrina, Thotapally, Kumar, Tull, Diana, Watson, Valerie, Williams, Kayla, Gentry, Christina, Kaufman, Francine, Morrison, Chris, Saverino, Elizabeth, Schenning, Sherrie, Blodi, Barbara, Danis, Ronald P., Davis, Matthew, Domalpally, Amitha, Glander, Kathy, Guilfoil, Gregory, Hubbard, Larry D., Johnson, Kristine, Klein, Ronald, Nardi, Barbara, Neider, Michael, Robinson, Nancy, Rosensteel, Eileen, Wabers, Hugh, Zhang, Grace, Ruby, Alan J., Capone, Antonio, Jr., Dass, Bawa, Drenser, Kimberly, Garretson, Bruce R., Hassan, Tarek S., Trese, Michael, Williams, George A., Wolfe, Jeremy, Bell, Tina, Zajechowski, Mary, Bezaire, Dennis, McIver, Fran, Medina, Anthony, Pagett, Jackie, Smith, Stephanie Hatch, Swartz, Lynn, Treuter, Tom, Antoszyk, Andrew, Brown, Justin, Browning, David J., Holland, Walter, Karow, Angella, Stalford, Kelly, Price, Angela, Ennis, Sarah, Fredenberg, Sherry, Herby, Jenna, Balasubramaniam, Uma, Clark, Loraine, McClain, Donna, McOwen, Michael, Watson, Lynn, Klein, Michael, Bailey, Steven T., Hwang, Thomas J., Lauer, Andreas, Stout, J. Timothy, McCollum, Patty, Johnson, Milt, Rice, Patrick B., Kim, Ivana, Loewenstein, John, Miller, Joan, Sobrin, Lucia, Young, Lucy, Sullivan, Jacqueline, Houlihan, Patricia, Merry, Linda, Lane, Ann Marie, Bator, Ursula Lord, Evans, Claudia, Brett, Sarah, Callahan, Charleen, Grillo, Marcia, Walsh, David, Zimmerman, Kamella Lau, Fish, Gary Edd, Anand, Rajiv, Coors, Lori E., Fuller, Dwain G., Spencer, Rand, Wang, Robert C., Duignan, Karen, Arceneaux, Sally, Aguado, Hank, Hesse, Nicholas, Mackens, Michael, Swan, Brian, Wong, Wai T., Cukras, Catherine, Dalal, Monica, Jacobs-El, Naima, Meyerle, Catherine, Nicholson, Benjamin, Wiley, Henry, Shimel, Katherine Hall, Garced, Angel, Oparah, Janice, Short, Greg, Temple, Alana, Ayukawa, Babilonia, Foster, Guy, Hayes, Darryl, Koutsandreas, Dessie, Nashwinter, Roula, Rowan, John, Bono, Michael, Cunningham, Denise, Palmer, Marilois, Zetina, Alicia, Orth, David H., Rezaei, Kourous, Civantos, Joseph, Hasan, Sohail, Packo, Kirk, Figliulo, Celeste, Stanberry, Pam, Farmer, Tara, Nelson, Kiersten, Townsend-Patrick, Shannya, Rosenfeld, Philip, Chen, Royce, Doshi, Rishi, Dubovy, Sander, Kim, Brian T., Lowrance, Matthew, Moshfeghi, Andrew, Nahas, Zayna, Schienbaum, Gary, Vishak, John, Weng, Christina, Yehoshua, Zohar, Rodriguez, Belen, Rebimbas, Jose, Gleichauf, Jane, Kicak, Mike, Mena, Jason, Odem, Tim, Sferza-Camp, Elizabeth, Disgdiertt, Alicia, Oramas, Jim, Rams, Isabel, Thatcher, Stephanie, Bressler, Susan B., Bressler, Neil M., Finkelstein, Daniel, Sherman, Steven H., Solomon, Sharon, Ying, Howard S., Denbow, Rita, Phillips, Deborah, Radcliffe, Elizabeth, Belt, Judy, Cain, Dennis, Emmert, David, Herring, Mark, McDonald, Jacquelyn, Hubbard, G. Baker, Bergstrom, Chris S., Cribbs, Blaine, Hendrick, Andrew, Johnson, Brandon, Laird, Philip, Mehta, Sonia, Olsen, Timothy, Townsend, Justin, Yan, Jion, Yeh, Steven, Curtis, Linda, Brower, Judy, Yi, Hannah, Dobbs, Jannah Rutter, Jordan, Debbie, Elman, Michael J., Liss, Robert A., Starr, JoAnn, Belz, Jennifer, Putzulo, Charlene, Coffey, Teresa, Davis, Ashley, Singletary, Pamela, Andreani, Giorya Shabi, Cain, Theresa, Ketner, Daniel, Sotirakos, Peter, Chandra, Suresh, Blodi, Barbara A., Altaweel, Michael M., Gottlieb, Justin L., Ip, Michael, Nork, T. Michael, Stevens, Thomas S., Burke, Kathryn, Olson, Shelly, Dietzman, Kristine, Soderling, Barbara, Somers, Guy, Wealti, Angie, Krolnik, Denise, Peterson, John, Reed, Sandra, Friberg, Thomas, Eller, Andrew, Gallagher, Denise, Labriola, Leanne, Pokrifka, Melissa, Gedansky, Aron, Anthony, Natalie, Grzybowski, Cassandra, Matthews, Dawn, Murajda-Jumba, Sharon, Toro, Jessica, Callanan, David G., Solley, Wayne A., Williams, Patrick, Lash, Sandy, Boleman, Bob, Dock, Chris, Shami, Michel, Arrington, Brenda, Meeks, Ashaki, Margherio, Alan R., Raphaelian, Paul, Markus, Debra, Langdon, Justin, Truax, Elizabeth, Lewis, Sandy, Terry, Brad, Noffke, Amy, Oh, Kean, Sarrafizadeh, Ramin, Sneed, Scott, Hammersley, Julie, Neal, Serena, Doran, Mary, Jones, Nan, Preston, Lisa, Jessick, Heather, Marsh, Tanya Tracy, Tolentino, Michael, Berger, Adam, Hamilton, Richard, Misch, David, Moon, Suk Jin, Sutherland, Dawn, Dilts, Vera, Henderson, Sara, Medina, Esmeralda, Trueman, Donald, Holm, Laura, Strickland, Jason, Ie, Darmakusuma, Lipkowitz, Jeffrey L., Shah, Kekul B., Geraghty, Susan, Sannazzaro, Beverly, Harper, Morgan, Bayer, Krista, Lansing, Mary B., Fox, Lauren B., Lee, Rebecca, Stallman, Jay B., Jacobson, Michael, Koh, Sean, Lampert, Scott, Miller, John, Rivellese, Mark, Sharma, Atul, Stoltz, Robert A., Vanderveldt, Stephanie, Marcus, Leslie, Hendricks, Starr, Hollman, Ryan, Betanzos, Grethel, Ellorin, Leslie, Fulbright, Shelly, McCormick, Debbie, Edwards, Paul A., Hall, Julianne, Monk, Mary, Gutkowski, Melanie, Mazurek, Melina, Murphy, Janet, Gusas, Katherine, Moffett, Crystal, Burley, David, Chesney, Nicole, Kilgo, Katie, Rusinek, Brian, Stern, Bradley, Troszak, Tracy, Baker-Levingston, Rhonda, Baker, Carl W., Caldwell, Tracey, Walker, Tammy, Lambert, Lynnette F., Martin, Tracey, Palmer, Mary Jill, Williams, Tana, Novak, Michael A., Coney, Joseph, Miller, David G., Pendergast, Scott, Singerman, Lawrence, Zakov, Nicholas, Zegarra, Hernando, DuBois, Kim, Rath, Susan, Revella, Lori, Brink, Tammy, Drury, Kim, Hogue, Lisa, Ilc, Mary, Keller, Connie, McNamara, Elizabeth, Tanner, Vivian, Cunningham, Tamara, DuBois, John, Greanoff, Gregg, Nitzsche, Trina, Smith-Brewer, Sheila, Isernhagen, Ricky D., Kitchens, John W., Stone, Thomas W., Wood, William J., Holcomb, Diana, Therrien, Virginia, Buck, Michelle, Van Arsdall, Jeanne, Slade, Edward, Schneiderman, Todd E., Spinak, David J., Gaedke, Jackie, Brown, Heather Davis, Helgren, Dan, Pangelinan, Jenifer Garrison, Halperin, Lawrence, Anagnoste, Scott, Dhalla, Mandeep, Rosenberg, Krista, Taney, Barry, Thompson, W. Scott, Lopez, Jaclyn, Hamlin, Monica, Lopez, Monica, Mariano, Jamie, Quinchia, Evelyn, Aramayo, Patricia, Veksler, Rita, Lee, Michael, Dreyer, Richard, Handelman, Irvin, Ma, Colin, Peters, Mark, Hobbs, Stephen, III, Milliron, Amanda, Kopfer, Marcia, Connaughton, Michele, Hoerner, A. Christine, Logan, R. Joseph, Wohlsein, Harry J., Boyer, David, Chu, Thomas G., Dayani, Pouya, Liao, David, Novack, Roger L., Rahhal, Firas M., Roe, Richard, Tabandeh, Homayoun, Bayramyan, Janet, Gasparyan, Tammy, Hoang, Connie, Kurokouchi, Janet, Lo, Tammy Eileen, Ngo, Richard, Nguyen, Mary Ann, Peyton, Michael, Yoon, Charles, Sierra, Julio, Zamboni, Adam, Kessinger, Jeff, Protacio, Eric, Smucker, Adam, Rath, Pamela, Bergren, Robert, Doft, Bernard, Liu, Judy, Olsen, Karl, Merlotti, Lori, Ingram, Willia, Marfisi, Kellianne, Yeckel, Kimberly, Carmelo, Heather Schultz, Fec, Amanda, McBroom, Keith, Steinberg, David, Levy, Marc, Abrams, Jody, Chen, Melvin, Torres, Waldemar, Jelemensky, Peggy, Prybylski, Mark, Raphael, Tara, Appleby, Diana, Rodman, Charlotte, Sneath, Mark, Rosa, Robert H., Jr., Hoelscher, Vanessa, Castano, Adelia, Parker, Jocelyn, Hoskins, John, Anderson, Nicholas, Googe, Joseph, Jr., McMillan, Tod A., Miller, James, Jr., Perkins, Stephen, Oliver, Kristina, Beerbower, Jennifer, Gilliland, Bruce, Hunt, Cecile, Jacobus, Mike, Lince, Raul, Morris, Christopher, Oelrich, Sarah, Whetstone, Jerry, Chan, Clement K., Lin, Steven, Walther, Kim, Gonzales, Tiana, Myers, Lenise, Huff, Kenneth, Brown, David M., Chen, Eric, Benz, Matthew S., Fish, Richard H., Kim, Rosa Y., Major, James, Jr., Wong, Tien Pei, Wycoff, Charles, Cone, Cassandra, Gilaspia, Debbie Goates, Landaverde, Nubia, Smith, Robert, Zamora, Deneva, Sneed, Veronica, Vela, Melina, Kegley, Eric, Greven, Craig, Kurup, Shree, Richards, Charles, Slusher, Madison, Everhart, Cara, Fish, Joan, Clark, Mark, Miller, David, Tyler, Marshall, Jumper, J. Michael, Fu, Arthur D., Johnson, Robert N., Lujan, Brandon, McDonald, H. Richard, Rodriguez, Rosa, Ansari, Nina, Joaquin, Jeanifer, Linares, Silvia, Lopez, Lizette, Sabio, Jessica, Grout, Sean, Indermill, Chad, Urias, Yesmin, Zimmerman, Roberto, Margulies, Linda, Schmidt, Sara J., Meier, Joy L., Hadley, Sherry L., Rosenthal, William, Johnson, Barbara, Swafford, Lois, Shields, Richard, Varner, R. Scott, Rosen, Richard, Gentile, Ronald, Rivas, Melissa, Tai, Katy W., Carrasquillo-Boyd, Wanda, Masini, Robert, Stoller, Glenn, Carnevale, Ken, LaRosa, Diane M., Burger, Barbara, Conway, Tereza, Del Castillo, Carla, Diaz, Julissa, Jones, Susan, Mondoc, Nina, Balfour, Charlene, Vitha, C.H., Lutz, Jennifer, McGinley, Barbara, El Baba, Fadi, Lavorna, Ann Marie, Jones, Renee, Lewis, Jean, Tenzler, Ruth, Salvas-Mladek, Mary, Van Kesteren, Diane, McLean, W. Copley, Jr., Bridges, W. Zachery, Jr., Stone, Cameron, Ammons, Denise, Lamy, Mary, Menzel, Andrea, Raymer, Lea Doll, Campbell, Barbara, Hawkins, Lisa, Rickman, Leslie, Sherlin, Lorraine, Price, Paula, Sinyai, Albert, Kingsley, Ronald, Bradford, Reagan H., Jr., Leonard, Robert E., II, Icks, Sonny, Bergman, Vanessa, Ross, Brittany, Burris, Russ, Butt, Amanda, Richmond, Rob, Lyon, Alice, Gill, Manjot, Jampol, Lee, Mizra, Rukhsana, Rozenbajgier, Zuzanna, Chapman, Jeremy, Kaminski, Lori, Degillio, Andrea, Simjanoski, Evica, Heier, Jeffrey, Cho, Hyung, Cleary, Tina Scheufele, Goldman, Darin, Shah, Chirag, Topping, Trexler, Weber, Marissa, Wiegand, Torsten, Schindelheim, Jeremy, Bankert, Joy, Stone, Jennifer, Nowak, Alison, Chong, Sandy, Williams, Lindsay, Bennett, Steven, Donovan, Dennis, Graham, Margaret, Jones, Cullen, Fung, Anne, Bayabo, Jan-Kristine, Bosch, Razelda, Cruz, Esperanza, Emerson, Ashley, Fleming, Alycia, Barsness, Denice, Rodriguez, Jorge, Soboleva, Marina, Scott, Ingrid U., Bowie, Esther, Neely, Kimberly A., Quillen, David A., Walter, Laura, Bennett, Timothy, Strong, James, Wells, John, III, Clark, Lloyd, Johnson, David, Miller, Peggy, Taylor, Mallie, Swinford, Tiffany, Spivey, Robbin, Banach, Michael, Ho, Lawrence, Lanning, Richard, Pheasant, Thomas R., Prensky, Jay G., Truong, Steven, Teatsworth, Julia, Dietrich, Michelle, Wasilus, Ann, Miller, Ann, Rakes, Megan, Slagle, Teresa, Richards, Michelle, Schuessler, Patricia, Stover, Lacy, Beer, Paul, Falk, Naomi S., Shannon, Mary Beth, Olmeda, Jeannie, Berdeen, Don, Fisher, Joseph F., Jr., Folk, James, Russell, Stephen, Taylor, Barbara, Hinz, Connie, Walshire, Jean, Stockman, Heather, Critser, Bruce, Karakas, Stefani, Montague, Cindy, Verdick, Randy, Gupta, Omesh, Maguire, Joseph, Brady, Christopher, DeCroos, Francis Char, Dollin, Michael, Garg, Sunir, Gerstenblith, Adam, Haller, Julia, Ho, Allen C., Hsu, Jason, Kaiser, Richard, Pitcher, John, Regillo, Carl, Shah, Rajiv, Spirn, Marc, Tasman, William, Vander, James, Senderowitsch, Noga, Formoso, Michele, Markun, Michelle, George, Cedric, Centinaro, Christina, Grande, Lisa, Carey, Stefanie, Liebenbaum, Elaine, Sadda, SriniVas, Humayun, Mark, Sierra, Rachel, Corona, Elizabeth, Padilla, Margaret, Nu, Moonseok, Ramos, Sylvia, Barnett, Cullen, Currie, Glenn, Gottlieb, Cornelia, Garfinkel, Richard, Berinstein, Daniel, Colyer, Marcus, Deegan, William, III, Min-Shyue Lai, Michael, Murphy, Robert, Osman, Michael, Rivers, Michael, Sanders, Reginald, von Fricken, Manfred A., Oliver, Debbie, Kirshon, Jeanne, Snowden, Tanya Alexander, Blondo, Thomas, Cronise, Alysia, Denny, Vanessa, Mendez, Kylie, Newgen, Janine, Davis, Justin, Flory, Mike, Frantz, Robert, Murphy, Bryan, Rauch, Steve, Kim, Judy E., Bachman, Jane, Connor, Thomas B., Jr., Han, Dennis P., Stepian, Kimberly, Weinberg, David V., Wirostko, William J., Packard, Krissa, Kaczanowski, Tracy, Williams, Vesper, Barwick, Vicki, Flanders, Judy, Backes, Dennis, Beringer, Joe, Keller, Kristy, Selchert, Kathy, Bernstein, Paul, Teske, Michael, Vitale, Albert, Allman, Susan, Carlstrom, Bonnie, Wegner, Kimberley, Haroldsen, Anne, Harrison, Deborah, Fry, Cyrie, Gilman, James, Jenkins, Glen, Morris, Paula, Rauser, Michael, Fan, Joseph, Suthar, Mukesh, Santiago, Gisela, Halsey, Kara Rollins, Quesada, Christy, Kiernan, William, Knabb, Jesse, Lewis, Richard Alan, Dorenbach, Cindy, Spencer, Steven, Barnett, Dana, Morales, Joseph, Fishburne, Barron C., Gross, Jeffrey G., Magee, Michael A., Flowers, Amy, McDowell, Angie, Price, Randall, Huang, Suber, Tang, Johnny, Wilker, Shawn, Hornsby, Cherie, Ferguson, Lisa, Krogstad, Kirk, Adamovsky, Riva, Allchin, Peggy, Carlton, Kathleen, Clow, Claudia, Sholtis, Kelly, Burke, Stephanie, Harrod, Mark, Hrvatin, Stacie, Pankhurst, Geoffrey, Sabates, Nelson R., Cassell, Michael, Desai, Komal, Poulose, Abraham, Sabates, Felix, Chen, Yin, Gallimore, Gary, Konior, Yolanda, Kim, Nicola, Uwaydat, Sami, Troillett, Deborah, Aletter, Karen, Frank, Robert N., Abrams, Gary, Puklin, James, Tewari, Asheesh, Milanovic, Cheryl, Bailey, Melanie, Griffith, David, McDonald, Dena, Morehead, Kit, Sadikovic, Zlatan, Schillace, Lisa, Silvis, Elizabeth, Joondeph, Brian, Christmas, Nancy, Kimura, Alan, Liu, Mimi, Petty, Stephen, Zilis, John, Benitez, Jenny, Catlett, Cassandra Berryman, Fluegel, Eric, Mowry, Shane, Nguyen, Hoang, Reflow, David, Houghton, Odette M., Garg, Seema, Landers, Maurice B., Meredith, Travis, Barnhart, Sandy, Karmalkar, Megha, Cantrell, Debra, Esquejo-Leon, Rona Lyn, Manor, Linda, Pope, Sue, Stines, David, Stokely, Amelia, Hainsworth, Dean, Helming, Dyann, Eichelberger, Debbie, Leaton, Mary Paige, Hamm, Chuck, Chaum, Edward, Iannaccone, Alessandro, Jennings, Barbara, Murray, Tracy, Mastellone, Joe, Millay, Robert, Kim, Brian, Goddard, Theresa, Beaudette, Liza Jarrett, Changelian-Aitken, Nina, Corrada, Fernando, Dubuque, Jason, Iezzi, Raymond, Bakri, Sophie J., Pulido, Jose S., Vogen, Diane, Nielsen, Rebecca, Berg, Karin, Burrington, Jean, Howard, Shannon, Overend, Joan, Krason, Zbigniew, Lewison, Denise, Link, Thomas, Blinder, Kevin J., Engelbrecht, Nicholas E., Grand, M. Gilbert, Joseph, Daniel P., Shah, Gaurav K., Smith, Bradley, Thomas, Matthew, Weeks, Rhonda, Boyd, Lynda, Gabel, Dana, Adelman, Ron, Huang, John, Kempton, James, Parnes, Aaron, Dupont, Jennifer, Perotti, Elizabeth, Donaldson, Victoria, Fong, Kenneth, Ossorio, Pamela, Agarwal, Anita, Sternberg, Paul, Owings, Sandy, Adkins, Tony, Lok, Elaine, Munn, Garvin, Skellie, Buddy, Bhagat, Neelakshi, Roy, Monique S., Zarbin, Marco, Fay, Catherine, Lazar, Michael, Malpica, Beth, Mikheyav, Tatiana, Ulanski, Lawrence, II, Lim, Jennifer, Niec, Marcia, Johnson, Tametha, Ovando, Yesenia, Carroll, Catherine Nail, Janowicz, Mark, Schwartz, Steven, Cupp, David, Gorin, Michael, Heilweil, Gad, Hosseini, Hamid, Hubschman, Jean-Pierre, Kreiger, Allan, McCannel, Tara Young, Pan, Carolyn, Sarraf, David, Tsui, Irena, Udoetek, Joshua, Voleti, Vinad, Hitchcock, Logan, Ostrick, Rosaleen, Chun, Melissa, Kageyama, Jennie, Davila, Nilo, Lipka, Kristin, Shin, Christina, Owsley, Cynthia, Albert, Michael, Jr., Feist, Richard, Mason, John, Thomley, Martin, Johnson, Angelia, Emond, Tracy, Hamela, Joanna, Marsh, Angela, Searcey, Karen, Rookard, Kia, He, Yu-Guang, Ufret-Vincenty, Rafael L., Molai, Mike, Anderson, William, Horna, John, Letson, Alan, Cebulla, Colleen, Chang, Susie, Davidorf, Fred, Salerno, Jill, Sladoje, Laura, Stetson, Christina, Perry, Jeri, Savage, Scott, Toth, Cynthia, Jaffe, Glenn, Schuman, Stefanie, Sarin, Neeru, Crowell, Jim, Keaton, Tiffanie, Kelly, Michael, Lutman, Brian, Skelly, Marriner, Welch, Lauren, Morse, Lawrence, Hunter, Allan, Soon-Chun Park, Susanna, Wallace, Cynthia, Dhillon, Ember, Salvador, Marisa, Holderreed, Barbara, Chandra, Karishma, Kaur, Sashi, Redenbo, Ellen, Hom, Smiley, Cooney, Michael, Barbazetto, Irene, Klancnik, James M., Jr., Sorenson, John A., Yannuzzi, Lawrence, Scolaro, Maria, Agresta, Eugene, Gonzalez, Nancy, Grover, Sandeep, Chalam, K.V., Gupta, Shailesh, Lyons, Christopher, Li, Wenhua, Patel, Chirag, Carrion, Jose, Ferreyra, Henry, Rodriguez, Amberly, Molina, Iliana, Balea, Gabriel, Emory, Pam, Rico, Marlene, Siqueiros, Giorgio, Brucker, Alexander J., Dunaief, Joshua, Grunwald, Juan, Kim, Benjamin, Maguire, Albert M., VanderBeek, Brian, Drossner, Sheri, DuPont, Joan, Salvo, Rebecca, Berger, Jim, Devine, Cheryl, Nyberg, Bill, Weeney, Laurel, DiLoreto, David, Chung, Mina, Davis, Valerie, MacDowell, Peter, Gara, George O., Castillo, Daniel, Czubinski, Andrea, Keim, Melissa, Hardy, Brandi, Hollar, Rachel Grunhaus, Schueckler, Lynn, Lyon, Alice T., Weinberg, Aaron, Shiloach, Mira, Pelkofer, Nicole, Zhou, Qin, McPoland, Laura, Apte, Rajendra, Rao, P. Kumar, Pistorius, Sam, Kambarian, Jamie, Adcock, Eve, Gould, Sarah, Quinn, Melanie, Curtis, Rhonda, Frost, Amy, Meyer, Charla, Rathert, Greg, Yu, Jeannette J., Clemons, Traci E., van Asten, Freekje, and Keenan, Tiarnan D.

Published
2019
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20. PM2.5, vegetation density, and childhood cancer: a case-control registry-based study from Texas 1995-2011.

Author

Williams, Lindsay A, Haynes, David, Sample, Jeannette M, Lu, Zhanni, Hossaini, Ali, McGuinn, Laura A, Hoang, Thanh T, Lupo, Philip J, and Scheurer, Michael E

Subjects
*CHILDHOOD cancer, *NORMALIZED difference vegetation index, *LIKELIHOOD ratio tests, *ETIOLOGY of cancer, *CANCER patients
Abstract

Background Air pollution is positively associated with some childhood cancers, whereas greenness is inversely associated with some adult cancers. The interplay between air pollution and greenness in childhood cancer etiology is unclear. We estimated the association between early-life air pollution and greenness exposure and childhood cancer in Texas (1995 to 2011). Methods We included 6101 cancer cases and 109 762 controls (aged 0 to 16 years). We linked residential birth address to census tract annual average fine particulate matter <2.5 µg/m³ (PM2.5) and Normalized Difference Vegetation Index (NDVI). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) between PM2.5/NDVI interquartile range increases and cancer. We assessed statistical interaction between PM2.5 and NDVI (likelihood ratio tests). Results Increasing residential early-life PM2.5 exposure was associated with all childhood cancers (OR = 1.10, 95% CI = 1.06 to 1.15), lymphoid leukemias (OR = 1.15, 95% CI = 1.07 to 1.23), Hodgkin lymphomas (OR = 1.27, 95% CI = 1.02 to 1.58), non-Hodgkin lymphomas (OR = 1.24, 95% CI = 1.02 to 1.51), ependymoma (OR = 1.27, 95% CI = 1.01 to 1.60), and others. Increasing NDVI exposure was inversely associated with ependymoma (0- to 4-year-old OR = 0.75, 95% CI = 0.58 to 0.97) and medulloblastoma (OR = 0.75, 95% CI = 0.62 to 0.91) but positively associated with malignant melanoma (OR = 1.75, 95% CI = 1.23 to 2.47) and Langerhans cell histiocytosis (OR = 1.56, 95% CI = 1.07 to 2.28). There was evidence of statistical interaction between NDVI and PM2.5 (P  < .04) for all cancers. Conclusion Increasing early-life exposure to PM2.5 increased the risk of childhood cancers. NDVI decreased the risk of 2 cancers yet increased the risk of others. These findings highlight the complexity between PM2.5 and NDVI in cancer etiology. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16

Author

Chew, Emily Y., Ferris, Frederick L., III, SanGiovanni, John Paul, Agrón, Elvira, Clemons, Traci, Lindblad, Anne, Lindblad, Robert, Shah, Nilay, Sperduto, Robert, McBee, Wendy, Gensler, Gary, Harrington, Molly, Henning, Alice, Jones, Katrina, Thotapally, Kumar, Tull, Diana, Watson, Valerie, Williams, Kayla, Gentry, Christina, Kaufman, Francine, Morrison, Chris, Saverino, Elizabeth, Schenning, Sherrie, Blodi, Barbara, Danis, Ronald P., Davis, Matthew, Domalpally, Amitha, Glander, Kathy, Guilfoil, Gregory, Hubbard, Larry D., Johnson, Kristine, Klein, Ronald, Nardi, Barbara, Neider, Michael, Robinson, Nancy, Rosensteel, Eileen, Wabers, Hugh, Zhang, Grace, Ruby, Alan J., Capone, Antonio, Jr., Dass, Bawa, Drenser, Kimberly, Garretson, Bruce R., Hassan, Tarek S., Trese, Michael, Williams, George A., Wolfe, Jeremy, Bell, Tina, Zajechowski, Mary, Bezaire, Dennis, McIver, Fran, Medina, Anthony, Pagett, Jackie, Smith, Stephanie Hatch, Swartz, Lynn, Treuter, Tom, Antoszyk, Andrew, Brown, Justin, Browning, David J., Holland, Walter, Karow, Angella, Stalford, Kelly, Price, Angela, Ennis, Sarah, Fredenberg, Sherry, Herby, Jenna, Balasubramaniam, Uma, Clark, Loraine, McClain, Donna, McOwen, Michael, Watson, Lynn, Klein, Michael, Bailey, Steven T., Hwang, Thomas J., Lauer, Andreas, Stout, J. Timothy, McCollum, Patty, Johnson, Milt, Rice, Patrick B., Kim, Ivana, Loewenstein, John, Miller, Joan, Sobrin, Lucia, Young, Lucy, Sullivan, Jacqueline, Houlihan, Patricia, Merry, Linda, Lane, Ann Marie, Bator, Ursula Lord, Evans, Claudia, Brett, Sarah, Callahan, Charleen, Grillo, Marcia, Walsh, David, Zimmerman, Kamella Lau, Fish, Gary Edd, Anand, Rajiv, Coors, Lori E., Fuller, Dwain G., Spencer, Rand, Wang, Robert C., Duignan, Karen, Arceneaux, Sally, Aguado, Hank, Hesse, Nicholas, Mackens, Michael, Swan, Brian, Wong, Wai T., Cukras, Catherine, Dalal, Monica, Jacobs-El, Naima, Meyerle, Catherine, Nicholson, Benjamin, Wiley, Henry, Shimel, Katherine Hall, Garced, Angel, Oparah, Janice, Short, Greg, Temple, Alana, Ayukawa, Babilonia, Foster, Guy, Hayes, Darryl, Koutsandreas, Dessie, Nashwinter, Roula, Rowan, John, Bono, Michael, Cunningham, Denise, Palmer, Marilois, Zetina, Alicia, Orth, David H., Rezaei, Kourous, Civantos, Joseph, Hasan, Sohail, Packo, Kirk, Figliulo, Celeste, Stanberry, Pam, Farmer, Tara, Nelson, Kiersten, Townsend-Patrick, Shannya, Rosenfeld, Philip, Chen, Royce, Doshi, Rishi, Dubovy, Sander, Kim, Brian T., Lowrance, Matthew, Moshfeghi, Andrew, Nahas, Zayna, Schienbaum, Gary, Vishak, John, Weng, Christina, Yehoshua, Zohar, Rodriguez, Belen, Rebimbas, Jose, Gleichauf, Jane, Kicak, Mike, Mena, Jason, Odem, Tim, Sferza-Camp, Elizabeth, Disgdiertt, Alicia, Oramas, Jim, Rams, Isabel, Thatcher, Stephanie, Bressler, Susan B., Bressler, Neil M., Finkelstein, Daniel, Sherman, Steven H., Solomon, Sharon, Ying, Howard S., Denbow, Rita, Phillips, Deborah, Radcliffe, Elizabeth, Belt, Judy, Cain, Dennis, Emmert, David, Herring, Mark, McDonald, Jacquelyn, Hubbard, G. Baker, Bergstrom, Chris S., Cribbs, Blaine, Hendrick, Andrew, Johnson, Brandon, Laird, Philip, Mehta, Sonia, Olsen, Timothy, Townsend, Justin, Yan, Jion, Yeh, Steven, Curtis, Linda, Brower, Judy, Yi, Hannah, Dobbs, Jannah Rutter, Jordan, Debbie, Elman, Michael J., Liss, Robert A., Starr, JoAnn, Belz, Jennifer, Putzulo, Charlene, Coffey, Teresa, Davis, Ashley, Singletary, Pamela, Andreani, Giorya Shabi, Cain, Theresa, Ketner, Daniel, Sotirakos, Peter, Chandra, Suresh, Blodi, Barbara A., Altaweel, Michael M., Gottlieb, Justin L., Ip, Michael, Nork, T. Michael, Stevens, Thomas S., Burke, Kathryn, Olson, Shelly, Dietzman, Kristine, Soderling, Barbara, Somers, Guy, Wealti, Angie, Krolnik, Denise, Peterson, John, Reed, Sandra, Friberg, Thomas, Eller, Andrew, Gallagher, Denise, Labriola, Leanne, Pokrifka, Melissa, Gedansky, Aron, Anthony, Natalie, Grzybowski, Cassandra, Matthews, Dawn, Murajda-Jumba, Sharon, Toro, Jessica, Callanan, David G., Solley, Wayne A., Williams, Patrick, Lash, Sandy, Boleman, Bob, Dock, Chris, Shami, Michel, Arrington, Brenda, Meeks, Ashaki, Margherio, Alan R., Raphaelian, Paul, Markus, Debra, Langdon, Justin, Truax, Elizabeth, Lewis, Sandy, Terry, Brad, Noffke, Amy, Oh, Kean, Sarrafizadeh, Ramin, Sneed, Scott, Hammersley, Julie, Neal, Serena, Doran, Mary, Jones, Nan, Preston, Lisa, Jessick, Heather, Marsh, Tanya Tracy, Tolentino, Michael, Berger, Adam, Hamilton, Richard, Misch, David, Moon, Suk Jin, Sutherland, Dawn, Dilts, Vera, Henderson, Sara, Medina, Esmeralda, Trueman, Donald, Holm, Laura, Strickland, Jason, Ie, Darmakusuma, Lipkowitz, Jeffrey L., Shah, Kekul B., Geraghty, Susan, Sannazzaro, Beverly, Harper, Morgan, Bayer, Krista, Lansing, Mary B., Fox, Lauren B., Lee, Rebecca, Stallman, Jay B., Jacobson, Michael, Koh, Sean, Lampert, Scott, Miller, John, Rivellese, Mark, Sharma, Atul, Stoltz, Robert A., Vanderveldt, Stephanie, Marcus, Leslie, Hendricks, Starr, Hollman, Ryan, Betanzos, Grethel, Ellorin, Leslie, Fulbright, Shelly, McCormick, Debbie, Edwards, Paul A., Hall, Julianne, Monk, Mary, Gutkowski, Melanie, Mazurek, Melina, Murphy, Janet, Gusas, Katherine, Moffett, Crystal, Burley, David, Chesney, Nicole, Kilgo, Katie, Rusinek, Brian, Stern, Bradley, Troszak, Tracy, Baker-Levingston, Rhonda, Baker, Carl W., Caldwell, Tracey, Walker, Tammy, Lambert, Lynnette F., Martin, Tracey, Palmer, Mary Jill, Williams, Tana, Novak, Michael A., Coney, Joseph, Miller, David G., Pendergast, Scott, Singerman, Lawrence, Zakov, Nicholas, Zegarra, Hernando, DuBois, Kim, Rath, Susan, Revella, Lori, Brink, Tammy, Drury, Kim, Hogue, Lisa, Ilc, Mary, Keller, Connie, McNamara, Elizabeth, Tanner, Vivian, Cunningham, Tamara, DuBois, John, Greanoff, Gregg, Nitzsche, Trina, Smith-Brewer, Sheila, Isernhagen, Ricky D., Kitchens, John W., Stone, Thomas W., Wood, William J., Holcomb, Diana, Therrien, Virginia, Buck, Michelle, Van Arsdall, Jeanne, Slade, Edward, Schneiderman, Todd E., Spinak, David J., Gaedke, Jackie, Brown, Heather Davis, Helgren, Dan, Pangelinan, Jenifer Garrison, Halperin, Lawrence, Anagnoste, Scott, Dhalla, Mandeep, Rosenberg, Krista, Taney, Barry, Thompson, W. Scott, Lopez, Jaclyn, Hamlin, Monica, Lopez, Monica, Mariano, Jamie, Quinchia, Evelyn, Aramayo, Patricia, Veksler, Rita, Lee, Michael, Dreyer, Richard, Handelman, Irvin, Ma, Colin, Peters, Mark, Hobbs, Stephen, III, Milliron, Amanda, Kopfer, Marcia, Connaughton, Michele, Hoerner, A. Christine, Logan, R. Joseph, Wohlsein, Harry J., Boyer, David, Chu, Thomas G., Dayani, Pouya, Liao, David, Novack, Roger L., Rahhal, Firas M., Roe, Richard, Tabandeh, Homayoun, Bayramyan, Janet, Gasparyan, Tammy, Hoang, Connie, Kurokouchi, Janet, Lo, Tammy Eileen, Ngo, Richard, Nguyen, Mary Ann, Peyton, Michael, Yoon, Charles, Sierra, Julio, Zamboni, Adam, Kessinger, Jeff, Protacio, Eric, Smucker, Adam, Rath, Pamela, Bergren, Robert, Doft, Bernard, Liu, Judy, Olsen, Karl, Merlotti, Lori, Ingram, Willia, Marfisi, Kellianne, Yeckel, Kimberly, Carmelo, Heather Schultz, Fec, Amanda, McBroom, Keith, Steinberg, David, Levy, Marc, Abrams, Jody, Chen, Melvin, Torres, Waldemar, Jelemensky, Peggy, Prybylski, Mark, Raphael, Tara, Appleby, Diana, Rodman, Charlotte, Sneath, Mark, Rosa, Robert H., Jr., Hoelscher, Vanessa, Castano, Adelia, Parker, Jocelyn, Hoskins, John, Anderson, Nicholas, Googe, Joseph, Jr., McMillan, Tod A., Miller, James, Jr., Perkins, Stephen, Oliver, Kristina, Beerbower, Jennifer, Gilliland, Bruce, Hunt, Cecile, Jacobus, Mike, Lince, Raul, Morris, Christopher, Oelrich, Sarah, Whetstone, Jerry, Chan, Clement K., Lin, Steven, Walther, Kim, Gonzales, Tiana, Myers, Lenise, Huff, Kenneth, Brown, David M., Chen, Eric, Benz, Matthew S., Fish, Richard H., Kim, Rosa Y., Major, James, Jr., Wong, Tien Pei, Wycoff, Charles, Cone, Cassandra, Gilaspia, Debbie Goates, Landaverde, Nubia, Smith, Robert, Zamora, Deneva, Sneed, Veronica, Vela, Melina, Kegley, Eric, Greven, Craig, Kurup, Shree, Richards, Charles, Slusher, Madison, Everhart, Cara, Fish, Joan, Clark, Mark, Miller, David, Tyler, Marshall, Jumper, J. Michael, Fu, Arthur D., Johnson, Robert N., Lujan, Brandon, McDonald, H. Richard, Rodriguez, Rosa, Ansari, Nina, Joaquin, Jeanifer, Linares, Silvia, Lopez, Lizette, Sabio, Jessica, Grout, Sean, Indermill, Chad, Urias, Yesmin, Zimmerman, Roberto, Margulies, Linda, Schmidt, Sara J., Meier, Joy L., Hadley, Sherry L., Rosenthal, William, Johnson, Barbara, Swafford, Lois, Shields, Richard, Varner, R. Scott, Rosen, Richard, Gentile, Ronald, Rivas, Melissa, Tai, Katy W., Carrasquillo-Boyd, Wanda, Masini, Robert, Stoller, Glenn, Carnevale, Ken, LaRosa, Diane M., Burger, Barbara, Conway, Tereza, Del Castillo, Carla, Diaz, Julissa, Jones, Susan, Mondoc, Nina, Balfour, Charlene, Vitha, C.H., Lutz, Jennifer, McGinley, Barbara, El Baba, Fadi, Lavorna, Ann Marie, Jones, Renee, Lewis, Jean, Tenzler, Ruth, Salvas-Mladek, Mary, Van Kesteren, Diane, McLean, W. Copley, Jr., Bridges, W. Zachery, Jr., Stone, Cameron, Ammons, Denise, Lamy, Mary, Menzel, Andrea, Raymer, Lea Doll, Campbell, Barbara, Hawkins, Lisa, Rickman, Leslie, Sherlin, Lorraine, Price, Paula, Sinyai, Albert, Kingsley, Ronald, Bradford, Reagan H., Jr., Leonard, Robert E., II, Icks, Sonny, Bergman, Vanessa, Ross, Brittany, Burris, Russ, Butt, Amanda, Richmond, Rob, Lyon, Alice, Gill, Manjot, Jampol, Lee, Mizra, Rukhsana, Rozenbajgier, Zuzanna, Chapman, Jeremy, Kaminski, Lori, Degillio, Andrea, Simjanoski, Evica, Heier, Jeffrey, Cho, Hyung, Cleary, Tina Scheufele, Goldman, Darin, Shah, Chirag, Topping, Trexler, Weber, Marissa, Wiegand, Torsten, Schindelheim, Jeremy, Bankert, Joy, Stone, Jennifer, Nowak, Alison, Chong, Sandy, Williams, Lindsay, Bennett, Steven, Donovan, Dennis, Graham, Margaret, Jones, Cullen, Fung, Anne, Bayabo, Jan-Kristine, Bosch, Razelda, Cruz, Esperanza, Emerson, Ashley, Fleming, Alycia, Barsness, Denice, Rodriguez, Jorge, Soboleva, Marina, Scott, Ingrid U., Bowie, Esther, Neely, Kimberly A., Quillen, David A., Walter, Laura, Bennett, Timothy, Strong, James, Wells, John, III, Clark, Lloyd, Johnson, David, Miller, Peggy, Taylor, Mallie, Swinford, Tiffany, Spivey, Robbin, Banach, Michael, Ho, Lawrence, Lanning, Richard, Pheasant, Thomas R., Prensky, Jay G., Truong, Steven, Teatsworth, Julia, Dietrich, Michelle, Wasilus, Ann, Miller, Ann, Rakes, Megan, Slagle, Teresa, Richards, Michelle, Schuessler, Patricia, Stover, Lacy, Beer, Paul, Falk, Naomi S., Shannon, Mary Beth, Olmeda, Jeannie, Berdeen, Don, Fisher, Joseph F., Jr., Folk, James, Russell, Stephen, Taylor, Barbara, Hinz, Connie, Walshire, Jean, Stockman, Heather, Critser, Bruce, Karakas, Stefani, Montague, Cindy, Verdick, Randy, Gupta, Omesh, Maguire, Joseph, Brady, Christopher, DeCroos, Francis Char, Dollin, Michael, Garg, Sunir, Gerstenblith, Adam, Haller, Julia, Ho, Allen C., Hsu, Jason, Kaiser, Richard, Pitcher, John, Regillo, Carl, Shah, Rajiv, Spirn, Marc, Tasman, William, Vander, James, Senderowitsch, Noga, Formoso, Michele, Markun, Michelle, George, Cedric, Centinaro, Christina, Grande, Lisa, Carey, Stefanie, Liebenbaum, Elaine, Sadda, SriniVas, Humayun, Mark, Sierra, Rachel, Corona, Elizabeth, Padilla, Margaret, Nu, Moonseok, Ramos, Sylvia, Barnett, Cullen, Currie, Glenn, Gottlieb, Cornelia, Garfinkel, Richard, Berinstein, Daniel, Colyer, Marcus, Deegan, William, III, Min-Shyue Lai, Michael, Murphy, Robert, Osman, Michael, Rivers, Michael, Sanders, Reginald, von Fricken, Manfred A., Oliver, Debbie, Kirshon, Jeanne, Snowden, Tanya Alexander, Blondo, Thomas, Cronise, Alysia, Denny, Vanessa, Mendez, Kylie, Newgen, Janine, Davis, Justin, Flory, Mike, Frantz, Robert, Murphy, Bryan, Rauch, Steve, Kim, Judy E., Bachman, Jane, Connor, Thomas B., Jr., Han, Dennis P., Stepian, Kimberly, Weinberg, David V., Wirostko, William J., Packard, Krissa, Kaczanowski, Tracy, Williams, Vesper, Barwick, Vicki, Flanders, Judy, Backes, Dennis, Beringer, Joe, Keller, Kristy, Selchert, Kathy, Bernstein, Paul, Teske, Michael, Vitale, Albert, Allman, Susan, Carlstrom, Bonnie, Wegner, Kimberley, Haroldsen, Anne, Harrison, Deborah, Fry, Cyrie, Gilman, James, Jenkins, Glen, Morris, Paula, Rauser, Michael, Fan, Joseph, Suthar, Mukesh, Santiago, Gisela, Halsey, Kara Rollins, Quesada, Christy, Kiernan, William, Knabb, Jesse, Lewis, Richard Alan, Dorenbach, Cindy, Spencer, Steven, Barnett, Dana, Morales, Joseph, Fishburne, Barron C., Gross, Jeffrey G., Magee, Michael A., Flowers, Amy, McDowell, Angie, Price, Randall, Huang, Suber, Tang, Johnny, Wilker, Shawn, Hornsby, Cherie, Ferguson, Lisa, Krogstad, Kirk, Adamovsky, Riva, Allchin, Peggy, Carlton, Kathleen, Clow, Claudia, Sholtis, Kelly, Burke, Stephanie, Harrod, Mark, Hrvatin, Stacie, Pankhurst, Geoffrey, Sabates, Nelson R., Cassell, Michael, Desai, Komal, Poulose, Abraham, Sabates, Felix, Chen, Yin, Gallimore, Gary, Konior, Yolanda, Kim, Nicola, Uwaydat, Sami, Troillett, Deborah, Aletter, Karen, Frank, Robert N., Abrams, Gary, Puklin, James, Tewari, Asheesh, Milanovic, Cheryl, Bailey, Melanie, Griffith, David, McDonald, Dena, Morehead, Kit, Sadikovic, Zlatan, Schillace, Lisa, Silvis, Elizabeth, Joondeph, Brian, Christmas, Nancy, Kimura, Alan, Liu, Mimi, Petty, Stephen, Zilis, John, Benitez, Jenny, Catlett, Cassandra Berryman, Fluegel, Eric, Mowry, Shane, Nguyen, Hoang, Reflow, David, Houghton, Odette M., Garg, Seema, Landers, Maurice B., Meredith, Travis, Barnhart, Sandy, Karmalkar, Megha, Cantrell, Debra, Esquejo-Leon, Rona Lyn, Manor, Linda, Pope, Sue, Stines, David, Stokely, Amelia, Hainsworth, Dean, Helming, Dyann, Eichelberger, Debbie, Leaton, Mary Paige, Hamm, Chuck, Chaum, Edward, Iannaccone, Alessandro, Jennings, Barbara, Murray, Tracy, Mastellone, Joe, Millay, Robert, Kim, Brian, Goddard, Theresa, Beaudette, Liza Jarrett, Changelian-Aitken, Nina, Corrada, Fernando, Dubuque, Jason, Iezzi, Raymond, Bakri, Sophie J., Pulido, Jose S., Vogen, Diane, Nielsen, Rebecca, Berg, Karin, Burrington, Jean, Howard, Shannon, Overend, Joan, Krason, Zbigniew, Lewison, Denise, Link, Thomas, Blinder, Kevin J., Engelbrecht, Nicholas E., Grand, M. Gilbert, Joseph, Daniel P., Shah, Gaurav K., Smith, Bradley, Thomas, Matthew, Weeks, Rhonda, Boyd, Lynda, Gabel, Dana, Adelman, Ron, Huang, John, Kempton, James, Parnes, Aaron, Dupont, Jennifer, Perotti, Elizabeth, Donaldson, Victoria, Fong, Kenneth, Ossorio, Pamela, Agarwal, Anita, Sternberg, Paul, Owings, Sandy, Adkins, Tony, Lok, Elaine, Munn, Garvin, Skellie, Buddy, Bhagat, Neelakshi, Roy, Monique S., Zarbin, Marco, Fay, Catherine, Lazar, Michael, Malpica, Beth, Mikheyav, Tatiana, Ulanski, Lawrence, II, Lim, Jennifer, Niec, Marcia, Johnson, Tametha, Ovando, Yesenia, Carroll, Catherine Nail, Janowicz, Mark, Schwartz, Steven, Cupp, David, Gorin, Michael, Heilweil, Gad, Hosseini, Hamid, Hubschman, Jean-Pierre, Kreiger, Allan, McCannel, Tara Young, Pan, Carolyn, Sarraf, David, Tsui, Irena, Udoetek, Joshua, Voleti, Vinad, Hitchcock, Logan, Ostrick, Rosaleen, Chun, Melissa, Kageyama, Jennie, Davila, Nilo, Lipka, Kristin, Shin, Christina, Owsley, Cynthia, Albert, Michael, Jr., Feist, Richard, Mason, John, Thomley, Martin, Johnson, Angelia, Emond, Tracy, Hamela, Joanna, Marsh, Angela, Searcey, Karen, Rookard, Kia, He, Yu-Guang, Ufret-Vincenty, Rafael L., Molai, Mike, Anderson, William, Horna, John, Letson, Alan, Cebulla, Colleen, Chang, Susie, Davidorf, Fred, Salerno, Jill, Sladoje, Laura, Stetson, Christina, Perry, Jeri, Savage, Scott, Toth, Cynthia, Jaffe, Glenn, Schuman, Stefanie, Sarin, Neeru, Crowell, Jim, Keaton, Tiffanie, Kelly, Michael, Lutman, Brian, Skelly, Marriner, Welch, Lauren, Morse, Lawrence, Hunter, Allan, Soon-Chun Park, Susanna, Wallace, Cynthia, Dhillon, Ember, Salvador, Marisa, Holderreed, Barbara, Chandra, Karishma, Kaur, Sashi, Redenbo, Ellen, Hom, Smiley, Cooney, Michael, Barbazetto, Irene, Klancnik, James M., Jr., Sorenson, John A., Yannuzzi, Lawrence, Scolaro, Maria, Agresta, Eugene, Gonzalez, Nancy, Grover, Sandeep, Chalam, K.V., Gupta, Shailesh, Lyons, Christopher, Li, Wenhua, Patel, Chirag, Carrion, Jose, Ferreyra, Henry, Rodriguez, Amberly, Molina, Iliana, Balea, Gabriel, Emory, Pam, Rico, Marlene, Siqueiros, Giorgio, Brucker, Alexander J., Dunaief, Joshua, Grunwald, Juan, Kim, Benjamin, Maguire, Albert M., VanderBeek, Brian, Drossner, Sheri, DuPont, Joan, Salvo, Rebecca, Berger, Jim, Devine, Cheryl, Nyberg, Bill, Weeney, Laurel, DiLoreto, David, Chung, Mina, Davis, Valerie, MacDowell, Peter, Gara, George O., Castillo, Daniel, Czubinski, Andrea, Keim, Melissa, Hardy, Brandi, Hollar, Rachel Grunhaus, Schueckler, Lynn, Lyon, Alice T., Weinberg, Aaron, Shiloach, Mira, Pelkofer, Nicole, Zhou, Qin, McPoland, Laura, Apte, Rajendra, Rao, P. Kumar, Pistorius, Sam, Kambarian, Jamie, Adcock, Eve, Gould, Sarah, Quinn, Melanie, Curtis, Rhonda, Frost, Amy, Meyer, Charla, Rathert, Greg, Keenan, Tiarnan D., Clemons, Traci E., van Asten, Freekje, Danis, Ronald G., Rosenfeld, Philip J., Klein, Michael L., Ratnapriya, Rinki, and Swaroop, Anand

Published
2018
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25. Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors

Author

Di Angelantonio, Emanuele, Thompson, Simon G, Kaptoge, Stephen, Moore, Carmel, Walker, Matthew, Armitage, Jane, Ouwehand, Willem H, Roberts, David J, Danesh, John, Donovan, Jenny, Ford, Ian, Henry, Rachel, Hunt, Beverley J, Le Huray, Bridget, Mehenny, Susan, Miflin, Gail, Green, Jane, Stredder, Mike, Watkins, Nicholas A, McDermott, Alan, Ronaldson, Clive, Thomson, Claire, Tolkien, Zoe, Williamson, Lorna, Allen, David, Sambrook, Jennifer, Hammerton, Tracey, Bruce, David, Choudry, Fizzah, Ghevaert, Cedric, Johnston, Kirstie, Kelly, Anne, King, Andrew, Mo, Alfred, Page, Lizanne, Richardson, Penny, Senior, Peter, Umrania, Yagnesh, Wong, Henna, Murphy, Gavin, Newland, Adrian C, Wheatley, Keith, Greaves, Michael, Turner, Marc, Aziz, Tahir, Brain, Richard, Davies, Christine, Turner, Ruth, Wakeman, Paula, Dent, Alison, Wakeman, Alan, Anthony, Ben, Bland, Desmond, Parrondo, Will, Vincent, Helen, Weatherill, Candy, Forsyth, Andrea, Butterfield, Carol, Wright, Tracey, Ellis, Karen, Poynton, Pat, Brooks, Carolyn, Martin, Emma, Littler, Lara, Williams, Lindsay, Blair, Donna, Ackerley, Karen, Woods, Lynn, Stanley, Sophie, Walsh, Gemma, Franklin, Gayle, Howath, Cheryl, Sharpe, Sarah, Smith, Deborah, Botham, Lauren, Williams, Caroline, Alexander, Claire, Sowerbutts, Gareth, Furnival, Diane, Thake, Michael, Patel, Shilpa, Roost, Carolyn, Sowerby, Sandra, Appleton, Mary Joy, Bays, Eileen, Bowyer, Geoff, Clarkson, Steven, Halson, Stuart, Holmes, Kate, Humphries, Gareth, Parvin-Cooper, Lee, Towler, Jason, Addy, Joanne, Barrass, Patricia, Stennett, Louise, Burton, Susan, Dingwall, Hannah, Clarke, Victoria, Potton, Maria, Bolton, Thomas, Daynes, Michael, Spackman, Sarah, Momodu, Abudu, Fenton, James, King, Adam, Muhammed, Omer, Oates, Nicholas, Peakman, Tim, Ryan, Christine, Spreckley, Kristian, Stubbins, Craig, Williams, Joanna, Brennan, James, Mochon, Cedric, Taylor, Samantha, Warren, Kimberley, and Mant, Jonathan

Published
2017
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26. Development and characterization of DIA 12.3, a fully human intact anti-CEACAM1 monoclonal antibody.

Author

Centonze, Michela, Fiori, Valentina, Kujawski, Maciej, Li, Lin, Wong, Patty, Williams, Lindsay, Di Mambro, Tomas, Dominici, Sabrina, Sparti, Angelo, Shively, John E., and Magnani, Mauro

Subjects
CELL adhesion molecules, KILLER cells, MONOCLONAL antibodies, CELL adhesion, EPITHELIAL cells, CARCINOEMBRYONIC antigen, POSITRON emission tomography
Abstract

Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1), a homotypic cell adhesion molecule glycoprotein with apical expression on normal epithelial cells and activated lymphocytes, is overexpressed on many tumors and acts as an inhibitory receptor on NK cells, preventing their killing of CEACAM1 positive tumors. Production of humanized anti-CEACAM1 antibodies to block the inhibitory activity of CEACAM1 for immunotherapy and immunoimaging. Starting from a scFv, a fully human intact anti-CEACAM1 (DIA 12.3) that recognizes the N-terminal domain of CEACAM1 was developed and shown to bind CEACAM1 positive tumor cells and enhanced NK cell killing of CEACAM1 positive targets. DIA 12.3 bound to human neutrophils without activation, indicating they would be safe for human use. DIA 12.3 exhibited some cross-reactivity to CEACAM5, a tumor marker with high sequence homology to the N-terminal domain of CEACAM1. CEACAM1 PET imaging with 64Cu-COTA-DIA 12.3 showed excellent imaging of CEACAM1 positive tumors with reduced binding to CEACAM5 tumors. Based on its immunoinhibitory an immunoimaging activities, DIA 12.3 shows promise for therapeutic studies in man. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Comparison of IL‐2‐antibody to IL‐2‐Fc with or without stereotactic radiation therapy in CEA immunocompetent mice with CEA positive tumors.

Author

Williams, Lindsay, Li, Lin, Yazaki, Paul J., Wong, Patty, Hong, Teresa, Poku, Erasmus K., Hui, Susanta, Ghimire, Hemendra, Shively, John E., and Kujawski, Maciej

Subjects
*RADIOTHERAPY, *IMMUNOLOGIC memory, *CHIMERIC proteins, *POSITRON emission tomography, *TRANSGENIC mice
Abstract

Background: The potent immune effects of interleukin‐2 (IL‐2) for cancer therapy can be increased by genetic fusion of IL‐2 to the Fc domain of an antibody (IL‐2‐Fc) or tumor targeted by genetic fusion to a whole antibody known as an immunocytokine (ICK). Methods: An anti‐CEA ICK (M5A‐IL‐2) was compared to an IL‐2‐Fc fusion protein using tumor therapy and PET imaging in CEA transgenic immunocompetent mice bearing CEA positive colon or breast tumors. Combination with stereotactic radiation therapy (SRT) was performed with either ICK or IL‐2‐Fc. Results: ICK and IL‐2‐Fc had comparable antitumor effects in both tumor models, although ICK had higher tumor uptake and slower blood clearance than an IL‐2‐Fc. Analysis of IFNγ+/CD8+ and FoxP3+/CD4+ T cells revealed higher levels of IFNγ‐producing CD8+ T cells in ICK treated mice versus more efficient Treg elimination in IL‐2‐Fc treated mice. No significant or lasting toxicity was detected for either agent. Combination therapies with SRT revealed comparable efficacy and induction of immune memory for both ICK and IL‐2‐Fc when mice were rechallenged post‐therapy. Conclusions: IL‐2‐Fc had comparable antitumor efficacy to CEA‐targeted M5A‐IL‐2 ICK, while both fusion proteins induced immune memory when combined with SRT. Differences in the therapeutic mechanisms of both agents were observed. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Factors associated with infant sex and preterm birth status for selected birth defects from the National Birth Defects Prevention Study, 1997–2011.

Author

Williford, Eva M., Yang, Wei, Howley, Meredith M., Ma, Chen, Collins, Ronnie T., Weber, Kari A., Heinke, Dominique, Petersen, Julie M., Agopian, A. J., Archer, Natalie P., Olshan, Andrew F., Williams, Lindsay A., Browne, Marilyn L., and Shaw, Gary M.

Abstract

Background: Birth defects and preterm birth co‐occur, with some overlapping risk factors. Many birth defects and preterm births tend to have a male preponderance. We explored potential risk factors impacting sex and preterm (<37 weeks of gestation) birth differences among infants with selected birth defects delivered from 1997 to 2011 using data from the National Birth Defects Prevention Study (NBDPS). Methods: The NBDPS was a large multisite, population‐based case–control study. Using random forests, we identified important predictors of male preterm, female preterm, and male term, each compared with female term births for each birth defect. Using logistic regression, we estimated odds ratios for associations between important predictors and sex‐preterm birth status by birth defect. Results: We examined 11,379 infants with nine specific birth defects. The top 10 most important predictors of sex‐preterm birth status from the random forests varied greatly across the birth defects and sex‐preterm comparisons within a given defect group, with several being novel factors. However, one consistency was that short interpregnancy interval was associated with sex‐preterm birth status for many of the studied birth defects. Although obesity has been identified as a risk factor for preterm birth and birth defects in other research, it was not associated with sex‐preterm birth status for any of the examined defects. Conclusions: We confirmed expected associations for sex‐preterm birth status differences and found new potential risk factors for further exploration among the studied birth defects. [ABSTRACT FROM AUTHOR]

Published
2024
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32. A scoping review of school‐based anthropometric measurement.

Author

Wilson, Oliver W. A., Thai, Michella, Williams, Lindsay, Nutter, Sarah, Myre, Maxine, and Russell‐Mayhew, Shelly

Subjects
WELL-being, BEST practices, PRESCHOOL teachers, HIGH schools
Abstract

Summary: Though anthropometric measurement (AM) frequently occurs in school settings, it is not without risks to child wellbeing. The aim of this scoping review was to examine how AM in school settings takes place and is reported on to make recommendations on best practices. We identified and extracted data from 440 studies published since 2005 that conducted AM in school (pre‐school through secondary/high school) settings. Privacy and sensitivity of AM were unclear in over 90% of studies. Thirty‐one studies (7.0%) reported protecting student privacy, while nine (2.0%) reported public measurement. Only five studies reported sensitivity regarding AM (1.1%). Exactly who conducted AM was not specified in 201 studies (45.7%). Sixty‐nine studies did not provide a weight status criteria citation (19.2%), and 10 used an incorrect citation (2.7%). In summary, serious shortcomings in the reporting of how AM is conducted and by whom, along with details concerning weight status classification, are evident. There is considerable room for improvement regarding the reporting of key methodological details. We propose best practices for AM in school settings, which also double as conditions that should be met before AM takes place in school settings. [ABSTRACT FROM AUTHOR]

Published
2023
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41. From Copying to Learning: Using Exemplars to Engage Students with Assessment Criteria and Feedback

Author

Handley, Karen and Williams, Lindsay

Abstract

Feedback is central to pedagogic theory, and if feedback is to be effective, students need to engage with it and apply it at some point in the future. However, student dissatisfaction with feedback--as evidenced in the National Student Survey--suggests that there are problems which limit student engagement with feedback, such as their perception that much of their feedback is irrelevant to future assignments. This article reports on a study which sought to enhance engagement by giving students exemplar assignments annotated with feedback "before" submission of their final assignments. This was done by providing an online facility where students could view exemplars and post comments or questions to tutors and peers on a discussion board. The exemplar facility was highly valued by students, although there were no quantitative effects such as an increase in students' assignment marks when compared with the previous cohort. The article reflects on possible reasons for this result and discusses ways to improve the exemplar facility, for example by facilitating dialogue between tutors and students. The article concludes with lessons learned about how to construct exemplars, and considers how exemplars might also be used within marking teams to improve consistency of marking. (Contains 1 table and 1 note.)

Published
2011
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44. Sex differences in methylation profiles are apparent in medulloblastoma, particularly among SHH tumors.

Author

Moss, Rachel M., Sorajja, Natali, Mills, Lauren J., Moertel, Christopher L., Hoang, Thanh T., Spector, Logan G., Largaespada, David A., and Williams, Lindsay A.

Subjects
CEREBELLAR tumors, MEDULLOBLASTOMA, METHYLATION, DNA methylation, HIERARCHICAL clustering (Cluster analysis), TUMORS
Abstract

Background: Medulloblastoma, the most common malignant pediatric brain tumor, displays marked sex differences in prevalence of the four main molecular subgroups: SHH, WNT, Group 3 and Group 4. Males are more frequently diagnosed with SHH, Group 3 and 4 tumors, which have worse prognoses than WNT tumors. Little is known about sex differences in methylation profiles within subgroups. Methods: Using publicly available methylation data (Illumina HumanMethylation450K array), we compared beta values for males versus females. Differentially methylated positions (DMP) by sex within medulloblastoma subgroups were identified on the autosomes. DMPs were mapped to genes and Reactome pathway analysis was run by subgroup. Kaplan-Meier survival curves (Log-Rank p-values) were assessed for each sex within subgroup. MethylCIBERSORT was used to investigate the tumor microenvironment using deconvolution to estimate the abundances of immune cell types using DNA methylation data. Results: There were statistically significant differences in sex by medulloblastoma subgroups (chi-squared p-value=0.00004): Group 3 (n=144; 65% male), Group 4 (n=326; 67% male), SHH (n=223; 57% male) and WNT (n=70; 41% male). Females had worse survival than males for SHH (p-value=0.02). DMPs by sex were identified within subgroups: SHH (n=131), Group 4 (n=29), Group 3 (n=19), and WNT (n=16) and validated in an independent dataset. Unsupervised hierarchical clustering showed that sex-DMPs in SHH did not correlate with other tumor attributes. Ten genes with sex DMPs (RFTN1, C1orf103, FKBP1B, COL25A1, NPDC1, B3GNT1, FOXN3, RNASEH2C, TLE1, and PHF17) were shared across subgroups. Significant pathways (p<0.05) associated with DMPs were identified for SHH (n=22) and Group 4 (n=4) and included signaling pathways for RET proto-oncogene, advanced glycosylation end product receptor, regulation of KIT, neurotrophic receptors, NOTCH, and TGF-b. In SHH, we identified DMPs in four genes (CDK6, COL25A1, MMP16, PRIM2) that encode proteins which are the target of therapies in clinical trials for other cancers. There were few sex differences in immune cell composition within tumor subgroups. Conclusion: There are sexually dimorphic methylation profiles for SHH medulloblastoma where survival differences were observed. Sex-specific therapies in medulloblastoma may impact outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Genetic ancestry, differential gene expression, and survival in pediatric B‐cell acute lymphoblastic leukemia.

Author

Barragan, Freddy A., Mills, Lauren J., Raduski, Andrew R., Marcotte, Erin L., Grinde, Kelsey E., Spector, Logan G., and Williams, Lindsay A.

Subjects
LYMPHOBLASTIC leukemia, ACUTE leukemia, GENE expression, HISPANIC American children, GENEALOGY, CHILD death, CD19 antigen
Abstract

Background: Black children have lower incidence yet worse survival than White and Latinx children with B‐cell acute lymphoblastic leukemia (B‐ALL). It is unclear how reported race/ethnicity (RRE) is associated with death in B‐ALL after accounting for differentially expressed genes associated with genetic ancestry. Methods: Using Phase 1 and 2 NCI TARGET B‐ALL cases (N = 273; RRE‐Black = 21, RRE‐White = 162, RRE‐Latinx = 69, RRE‐Other = 9, RRE‐Unknown = 12), we estimated proportions of African (AFR), European (EUR), and Amerindian (AMR) genetic ancestry. We estimated hazard ratios (HR) and 95% confidence intervals (95% CI) between ancestry and death while adjusting for RRE and clinical measures. We identified genes associated with genetic ancestry and adjusted for them in RRE and death associations. Results: Genetic ancestry varied within RRE (RRE‐Black, AFR proportion: Mean: 78.5%, Range: 38.2%–93.6%; RRE‐White, EUR proportion: Mean: 94%, Range: 1.6%–99.9%; RRE‐Latinx, AMR proportion: Mean: 52.0%, Range: 1.2%–98.7%). We identified 10, 1, and 6 differentially expressed genes (padjusted <0.05) associated with AFR, AMR, and EUR ancestry proportion, respectively. We found AMR and AFR ancestry were statistically significantly associated with death (AMR each 10% HR: 1.05, 95% CI: 1.03–1.17, AFR each 10% increase HR: 1.03, 95% CI:1.01–1.19). RRE differences in the risk of death were larger in magnitude upon adjustment for genes associated with genetic ancestry for RRE‐Black, but not RRE‐Latinx children (RRE‐Black HR: 3.35, 95% CI: 1.31, 8.53; RRE‐Latinx HR: 1.47, 0.88–2.45). Conclusions: Our work highlights B‐ALL survival differences by RRE after adjusting for ancestry differentially expressed genes suggesting other factors impacting survival are important. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Watching, Waiting

Author

Williams, Lindsay M.

Subjects
Arts, visual and performing, Literature/writing
Abstract

She is There She is there, standing between the two beds with padded headboards, golden buttons they had and she is wearing her apron, the bottom winding around her hands. [...]

Published
2013

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