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Road traffic crashes are becoming thorny issues being faced worldwide. Traffic crashes are spatiotemporal events and the research on the spatiotemporal patterns and variation trends of traffic crashes has been carried out. However, the impact of built environment on traffic crash spatiotemporal trends has not received much attention. Moreover, the spatial non-stationarity between the variation trends of traffic crashes and their influencing factors is usually neglected. To make up for the lack of analysis of built environment factors influencing spatiotemporal hotspot trends in traffic crashes, this paper proposed a method of "ST-GWLR" for analyzing the influence of built environment factors on spatiotemporal hotspot trends of traffic crashes by combining the spatiotemporal hotspot trend analysis and Geographically Weighted Logistic Regression (GWLR) modeling methods. Firstly, the traffic crash spatiotemporal hotspot trends were explored using the space-time cube model, hotspot analysis, and Mann-Kendall trend test. Then, the GWLR was introduced to capture the spatial non-stationarity neglected by the classic Global Logistic Regression (GLR) model, to improve the accuracy of the model estimation. GWLR model is used for the first time to analyze the significant local correlation between the traffic crash spatiotemporal hotspot trends and the built environment factors, to accurately and effectively identify the built environment factors that have significant influences on the hotspot trends of traffic crashes. The performance of the GWLR models and GLR models was examined and compared sufficiently. The results showed that the proposed ST-GWLR, which captured spatial non-stationarity, performed better than the classic GLR combined with spatiotemporal analysis, and improved the prediction accuracy of the models by 14.9%, 13.9%, and 15.1%, respectively. There were significant local correlations between intensifying hotspots and persistent hotspots of traffic crashes and the built environment factors. The findings of this paper have positive implications for traffic safety management and urban built environment planning. [ABSTRACT FROM AUTHOR]

Land cover and its changes over time are significant for better understanding the Earth's fundamental characteristics and processes, such as global climate change, hydrology, and the carbon cycle. A number of land cover-geoprocessing models have been proposed for land cover-data production with different spatial and temporal resolutions. With the massive growth in land cover data and the increasing demand for efficient model utilization, developing efficient and convenient land cover-geoprocessing models has become a formidable challenge. Although some model-migration methods have been proposed for handling the massive data, the intricacy of land cover-data and -heterogeneity models frequently prevent current strategies from directly meeting demand. In this paper, we propose the PAMC-LC-containerization approach to overcome the difficulties associated with moving existing land cover models in the open web environment. Based on the idea of model migration, we design a standardized model description and hierarchical encapsulation strategy for land cover models, and develop migration and deployment methods. Furthermore, we assess the viability and efficacy of the proposed approach by using coupled workflows for model migration and the introduction of visualization on the Mts-WH dataset and the Google dataset. The experimental results show that the PAMC-LC approach can simplify and streamline the model migration process, with important ramifications for increasing productivity, reusing models, and lowering additional data-transmission costs. [ABSTRACT FROM AUTHOR]

Keloids are benign fibroproliferative tumors that severely diminish the quality of life due to discomfort, dysfunction, and disfigurement. Recently, ultrasound technology as a noninvasive adjuvant therapy is developed to optimize treatment protocols. However, the biophysical mechanisms have not yet been fully elucidated. Here, it is proposed that piezo‐type mechanosensitive ion channel component 1 (Piezo1) plays an important role in low‐frequency sonophoresis (LFS) induced mechanical transduction pathways that trigger downstream cellular signaling processes. It is demonstrated that patient‐derived primary keloid fibroblasts (PKF), NIH 3T3, and HFF‐1 cell migration are inhibited, and PKF apoptosis is significantly increased by LFS stimulation. And the effects of LFS is diminished by the application of GsMTx‐4, the selective inhibitor of Piezo1, and the knockdown of Piezo1. More importantly, the effects of LFS can be imitated by Yoda1, an agonist of Piezo1 channels. Establishing a patient‐derived xenograft keloid implantation mouse model further verified these results, as LFS significantly decreased the volume and weight of the keloids. Moreover, blocking the Piezo1 channel impaired the effectiveness of LFS treatment. These results suggest that LFS inhibits the malignant characteristics of keloids by activating the Piezo1 channel, thus providing a theoretical basis for improving the clinical treatment of keloids. [ABSTRACT FROM AUTHOR]

Public Map Service Platforms (PMSPs) provide embedded map services in domains such as forests and rivers. Users from different domains (Domain Users) prefer specific spatial features, and extracting the Browsing Interests of Domain Users (BIDUs) can help elucidate users' access intentions and provide suitable recommendations. Previous research has found that access frequency of spatial features is an indicator of users' browsing interests; however, high-frequency spatial features are sparsely distributed, resulting in inaccurate extraction of browsing interests. Our objective is to model the spatial co-occurrence of spatial features and employ BIDUs extraction to address this limitation. First, to extract spatial features in tiles, we proposed a k-nearest neighbor method for Point-of-Interest (POI) extraction and a template-based method for Land Uses/Land Covers extraction. Then, we developed the word2vec model to construct a POI semantic space to quantify spatial co-occurrence and employed multi-domain user classification to verify its effectiveness. Finally, a combined word2vec and singular value decomposition model is proposed to perform topic extraction as a representation of BIDUs. Compared with the baseline models, the proposed model integrates spatial co-occurrence from massive POIs to achieve high-accuracy BIDU extraction. Our findings can help construct domain user profiles and support the development of intelligent PMSPs. [ABSTRACT FROM AUTHOR]

An imbalance in urban development in China has become a contradiction. Points of Interest (POIs) serve as representations of the spatial distribution of urban functions. Analyzing POI spatial co-occurrence patterns can reveal the agglomeration patterns of urban functions across cities at different levels, providing insights into imbalances in urban development. Using POI data from 297 cities in China, the Word2vec model was employed to model the POI spatial co-occurrence patterns, allowing for the quantification of fine-granular urban functionality. Subsequently, the cities were clustered into five tiers representing different levels of development. An urban hierarchical disparity index and graph were introduced to examine variations in urban functions across different tiers. A significant correlation between POI spatial co-occurrence patterns and the GDP of cities at different levels was demonstrated. This study revealed a notable polarization trend characterized by the development of top-tier cities and lagging tail-end cities. Top-tier cities exhibit advantages in terms of their commercial environments, such as international banks, companies, and transportation facilities. Conversely, tail-end cities face deficiencies in urban infrastructure. It is crucial to coordinate resource allocation and establish sustainable development strategies that foster mutual support between the top-tier and tail-end cities. [ABSTRACT FROM AUTHOR]

OpenStreetMap (OSM) road networks provide public digital maps underlying many spatial applications such as routing engines and navigation services. However, turning relationships and time restrictions at OSM intersections are lacking in these maps, posing a threat to the accuracy and reliability of the services. In this paper, a new turn information detection method for OSM intersections using the dynamic connection information from crowdsourced trajectory data is proposed to address this problem. In this solution, the OSM intersection structure is extracted and simplified and crowdsourced trajectories are projected onto OSM road segments using an improved Hidden Markov Model (HMM) map matching method that explicitly traces the turning connections in road networks. Optimal path analysis increases the turning support related to short road segments. On this basis, this study transforms complex turning identification scenarios into the simple analyses of traffic connectivity. Furthermore, a voting strategy is used to identify and calculate turning time restrictions. The experimental results, using trajectory data from three cities in China, show that the turning relationships can be detected at a precision of 90.71% with a recall of 96.55% and an F1-value of 93.54% in Shanghai. For Wuhan, the precision is 95.33% and the recall is 95.00%, with an F1-value of 95.16%. The precision and recall when identifying turning time restrictions both reach 90% in Xiamen. These results demonstrate the effectiveness of the proposed turning detection method. [ABSTRACT FROM AUTHOR]

Taking location-based service (LBS) as the research scenario and aiming at the limitation of visualizing LBS points of interest (POI) in conventional web maps, this article proposes a visualization method of LBS-POI based on tag cloud, which is called "LBS tag cloud". In this method, the user location is taken as the layout center, and the name of the POI is converted into a text tag and then placed around the center. The tags' size, color, and placement location are calculated based on other attributes of the POI. The calculation of placement location is at the core of the LBS tag cloud. Firstly, the tag's initial placement position and layout priority are calculated based on polar coordinates, and the tags are placed in the initial placement position in the order of layout priority. Then, based on the force-directed model, a repulsive force is applied to the tag from the layout center to make it move to a position without overlapping with other tags. During the move, the quadtree partition of the text glyph is used to optimize the detection of overlaps between tags. Taking scenic spots as an example, the experimental results show that the LBS tag cloud can present the attributes and distribution of POIs completely and intuitively and can effectively represent the relationship between the POIs and user location, which is a new visualization form suitable for spatial cognition. [ABSTRACT FROM AUTHOR]