182 results on '"Xu, Yechun"'
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2. Genome-wide identification of SSR markers for Curcuma alismatifolia Gagnep., and their potential for wider application in this genus
3. Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
4. Role of anthocyanin metabolic diversity in bract coloration of Curcuma alismatifolia varieties
5. Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
6. Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
7. Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2
8. Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3
9. Structure-based development of potent and selective type-II kinase inhibitors of RIPK1
10. Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors
11. 6-Benzylaminopurine as a potential fresh-keeping agent for Curcuma alismatifolia cut flowers: Physiological and transcriptome analysis
12. Discovery of novel cGAS inhibitors based on natural flavonoids
13. Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2
14. Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo-controlled, phase 1b trial
15. Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors
16. Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety
17. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2
18. The genomic and bulked segregant analysis of Curcuma alismatifolia revealed its diverse bract pigmentation
19. Flavonoids from the roots and rhizomes of Sophoratonkinensis and their in vitro anti-SARS-CoV-2 activity
20. In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2
21. Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease
22. In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease
23. Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method
24. Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CLpro Inhibitors as anti-SARS-CoV‑2 Drug Candidate.
25. Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection
26. Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
27. Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation
28. Drug discovery and development targeting the life cycle of SARS-CoV-2
29. Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
30. Characterization of EST-SSR markers in Curcuma kwangsiensis S. K. Lee & C. F. Liang based on RNA sequencing and its application for phylogenetic relationship analysis and core collection construction
31. Allosteric Regulation of Hsp90α’s Activity by Small Molecules Targeting the Middle Domain of the Chaperone
32. Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
33. Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
34. Structure of M.sup.pro from SARS-CoV-2 and discovery of its inhibitors
35. Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase
36. Chemical Space Profiling of SARS-CoV‑2 PLpro Using DNA-Encoded Focused Libraries.
37. Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model.
38. Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
39. Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors
40. Structural basis for ligand recognition of the human thromboxane A2 receptor
41. Conformational Transition of Amyloid β-Peptide
42. Structural basis of ligand binding modes at the human formyl peptide receptor 2
43. Pigment Diversity in Leaves of Caladium × hortulanum Birdsey and Transcriptomic and Metabolic Comparisons between Red and White Leaves.
44. Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor
45. Discovery and Mechanism Study of SARS-CoV‑2 3C-like Protease Inhibitors with a New Reactive Group.
46. Multi-omics for COVID-19: driving development of therapeutics and vaccines.
47. Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors
48. Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination
49. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors
50. Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors
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