162 results on '"Yamazoe, Yasushi"'
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2. Construction of a fused grid-based CYP2C8-Template system and the application
3. Construction of a fused grid-based CYP2C18-Template system and its application to drug metabolism
4. Construction of a fused grid-based CYP2C19-Template system and the application
5. Construction of a fused grid-based template system of CYP2C9 and its application
6. Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system
7. Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 1. Focusing on polycyclic arenes and the related chemicals
8. Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether
9. A category approach to predicting the repeated-dose hepatotoxicity of allyl esters
10. Novel Cell-based Reporter Assay System Using Epitope-tagged Protein for the Identification of Agonistic Ligands of Constitutive Androstane Receptor (CAR)
11. Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling
12. Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes
13. Polycyclic Aromatic Hydrocarbons Activate CYP3A4 Gene Transcription through Human Pregnane X Receptor
14. Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase
15. Clioquinol is sulfated by human jejunum cytosol and SULT1A3, a human-specific dopamine sulfotransferase
16. Development of Two-dimensional Template System for the Prediction of CYP2B6-mediated Reaction Sites
17. Predicting Oxidation Sites with Order of Occurrence among Multiple Sites for CYP4A-mediated Reactions
18. Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians
19. Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in a Stable Human-derived Cell Line using a Dual Reporter Plasmid
20. Possible protective role of pregnenolone-16α-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis
21. Authorsʼ response to Letter to the Editor by Jeff Kelsey et al. “Response to ‘Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether.’” 2015
22. Simultaneous Expression of Plural Forms of Human Cytochrome P450 at Desired Ratios in HepG2 Cells: Adenovirus-mediated Tool for Cytochrome P450 Reconstitution
23. Cytochrome b 5 Potentiation of Cytochrome P-450 Catalytic Activity Demonstrated by a Vaccinia Virus-Mediated in situ Reconstitution System
24. Characterization and Expression of Hepatic Sulfotransferase Involved in the Metabolism of N-Substituted Aryl Compounds
25. Protein-Protein Interactions between Rat Hepatic Cytochromes P450 (P450s) and UDP-Glucuronosyltransferases (UGTs): Evidence for the Functionally Active UGT in P450-UGT Complex
26. Role of Human Hepatocyte Nuclear Factor 4α in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA
27. Broad but Distinct Role of Pregnane X Receptor on the Expression of Individual Cytochrome P450s in Human Hepatocytes
28. ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output
29. Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids
30. Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator
31. Inhibition of CYP3A4 by 6′,7′-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells
32. Chenodeoxycholic Acid-mediated Activation of the Farnesoid X Receptor Negatively Regulates Hydroxysteroid Sulfotransferase
33. Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction
34. Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region
35. Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements
36. Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin
37. Differences in Transactivation between Rat CYP3A1 and Human CYP3A4 Genes by Human Pregnane X Receptor
38. Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity
39. Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine
40. Metabolism of N,N-Dipropyl-2-[4-Methoxy-3-(2-Phenyl-Ethoxy)-Phenyl]-Ethyl-Amine-Monohydrochloride (NE-100), A Novel Sigma Ligand: Contribution of Cytochrome P450 Forms Involved in the Formation of Individual Metabolites in Human Liver and Small Intestine
41. Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice
42. Paradisin C: a new CYP3A4 inhibitor from grapefruit juice
43. Effects of Serum Albumin and Liver Cytosol on CYP2C9- and CYP3A4-mediated Drug Metabolism
44. Genetic Polymorphism of Human Cytochrome P450 Involved in Drug Metabolism
45. Selective Suppressions of Human CYP3A Forms CYP3A5 and CYP3A7 by Troglitazone in HepG2 Cells
46. Amounts and variation in grapefruit juice of the main components causing grapefruit–drug interaction
47. Intestinal Cytochrome P450 and Response to Rifampicin in Rabbits
48. Inhibitory Effect of Natural Furanocoumarins on Human Microsomal Cytochrome P450 3A Activity
49. UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression.
50. Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice.
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