16 results on '"Yoshiko Maeda"'
Search Results
2. Hard bilateral syphilitic testes with vasculitis: a case report and literature review
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Sat Prasad Nepal, Takehiko Nakasato, Takashi Fukagai, Takeshi Shichijo, Jun Morita, Yoshiko Maeda, Kazuhiko Oshinomi, Yoshihiro Nakagami, Tsutomu Unoki, Tetsuo Noguchi, Tatsuki Inoue, Ryosuke Kato, Satoshi Amano, Moyuru Mizunuma, Masahiro Kurokawa, Yoshiki Tsunokawa, Sou Yasuda, and Yoshio Ogawa
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Gumma ,Testis ,Syphilis ,Vasculitis ,Aortitis ,Hard ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background We report the case of a patient with syphilitic testicular gumma and vasculitis with adrenal failure due to chronic steroid use. Case presentation A 63-year-old male presented with hard right eye swelling and very firm bilateral testes on palpation, which he had for 2 years. Testicular tumor markers were negative; syphilis test was positive. Radiological examination suggested aortitis and bilateral testicular malignancy. The patient received ampicillin for the infection and prednisolone for vasculitis. Left orchidectomy was performed to confirm the presence of testicular tumor; histological examinations revealed granulomatous orchitis. The prednisolone doses were adjusted because of relapses and adverse effects of steroid use. Unfortunately, the patient died in the intensive care unit because of uncontrolled blood pressure and pneumonia. Conclusions This is a rare case of syphilis with testicular involvement and vasculitis. This report shows the importance of broadening the differential diagnoses of testicular firmness.
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- 2021
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3. A case of complete response following the administration of pembrolizumab and metastasectomy for lung and bone metastases of bladder cancer
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Takehiko Nakasato, Tatsuki Inoue, Ryosuke Kato, Yoshihiro Nakagami, Kazuhiko Oshinomi, Yoshiko Maeda, Jun Morita, Takeshi Shichijo, Toshiko Yamochi, and Takashi Fukagai
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bladder cancer ,complete response ,metastasectomy ,pembrolizumab ,urothelial cancer ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction Patients with metastatic urothelial carcinoma have poor prognosis and limited treatment options. Case presentation The patient was a 60‐year‐old male with bladder cancer and multiple lung metastases. He underwent three courses of gemcitabine and cisplatin chemotherapy, despite left femoral bone metastases. Tumor resection and bone replacement surgery was performed. Following the administration of four courses of pembrolizumab, lung metastasis completely resolved. However, after nine courses, right femoral neck bone metastasis was observed; therefore, tumor resection and bone replacement surgery were repeated. Pathologically, PD‐L1 expression was low in lung biopsy tissue and bone metastases. Pembrolizumab treatment continued for up to 20 courses; cancer recurrence and adverse events were not observed upon follow‐up examination after 1 year. Conclusion Patients responding well to systemic therapy may have resectable metastatic sites, and long‐term survival might be achieved with adjunctive metastasectomy. The effect of pembrolizumab was not associated with positive PD‐L1 expression.
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- 2022
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4. MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model
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William E. Tidyman, Alice F. Goodwin, Yoshiko Maeda, Ophir D. Klein, and Katherine A. Rauen
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costello syndrome ,hypotonia ,mek inhibitor ,myogenesis ,rasopathies ,ras/mapk ,Medicine ,Pathology ,RB1-214 - Abstract
Costello syndrome (CS) is a congenital disorder caused by heterozygous activating germline HRAS mutations in the canonical Ras/mitogen-activated protein kinase (Ras/MAPK) pathway. CS is one of the RASopathies, a large group of syndromes caused by mutations within various components of the Ras/MAPK pathway. An important part of the phenotype that greatly impacts quality of life is hypotonia. To gain a better understanding of the mechanisms underlying hypotonia in CS, a mouse model with an activating HrasG12V allele was utilized. We identified a skeletal myopathy that was due, in part, to inhibition of embryonic myogenesis and myofiber formation, resulting in a reduction in myofiber size and number that led to reduced muscle mass and strength. In addition to hyperactivation of the Ras/MAPK and PI3K/AKT pathways, there was a significant reduction in p38 signaling, as well as global transcriptional alterations consistent with the myopathic phenotype. Inhibition of Ras/MAPK pathway signaling using a MEK inhibitor rescued the HrasG12V myopathy phenotype both in vitro and in vivo, demonstrating that increased MAPK signaling is the main cause of the muscle phenotype in CS.
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- 2022
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5. MRI-guided conservative management of a left segmental testicular infarction
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Sat Prasad Nepal, MBBS, Takeshi Shichijo, MD, PhD, Yoshio Ogawa, MD, PhD, Takehiko Nakasato, MD, PhD, Yoshihiro Nakagami, MD, PhD, Jun Morita, MD, PhD, Kazuhiko Oshinomi, MD, Ph.D, Yoshiko Maeda, MD, PhD, Tsutomu Unoki, MD, PhD, Tatsuki Inoue, MD, Ryosuke Kato, MD, Satoshi Amano, MD, and Moyuru Mizunuma, MD
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Segmental testicular infarction ,MRI ,Conservative treatment ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Segmental testicular infarction is a rare condition. Patients present with clinical features similar to torsion and testicular tumors, with most undergoing surgery. A 55-year-old male patient presented with left scrotal pain. We did a Doppler ultrasonogram and magnetic resonance imaging to diagnose his condition and rule out testicular torsion and tumor. We decided not to operate and asked the patient for follow-up. There was no pain in the left testis, and magnetic resonance imaging showed a reduction in the left testicular lesion after 4 months.
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- 2021
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6. The Japanese Herbal Medicine Yokukansan Exerted Antioxidant and Analgesic Effects in an Experimental Rat Model of Hunner-Type Interstitial Cystitis
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Tatsuki Inoue, Mana Tsukada, Yoshiki Tsunokawa, Yoshiko Maeda, Seiya Fukuoka, Takashi Fukagai, Yoshio Ogawa, and Masataka Sunagawa
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Hunner-type interstitial cystitis ,Yokukansan ,antioxidant effect ,hydroxyl radical ,Kampo formula ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: The Japanese herbal medicine Yokukansan (YKS) has analgesic properties and is used for various pain disorders. The purpose of the present study was to investigate the effects of YKS in Hunner-type interstitial cystitis (HIC) using an experimental rat model of HIC and to explore its antioxidant activity and role as the underlying mechanism of action. Materials and Methods: The antioxidant capacity of YKS was evaluated by determining its hydroxyl radical (·OH) scavenging capacity using electron spin resonance (ESR). Next, the effects of YKS administration were explored using a toll-like receptor-7 agonist-induced rat model of HIC. The von Frey test was performed to assess bladder pain. Three days after HIC induction, the bladder was removed, and the expression of oxidative stress parameters in the bladder wall was investigated (reactive oxygen metabolites (ROMs), ·OH, and 8-hydroxy-2’-deoxyguanosine (8-OhdG)). Results: YKS had a ·OH scavenging capacity according to the ESR study. In the von Frey test, a significant decrease in the withdrawal threshold was observed in the HIC group compared with the control group; however, the decrease was ameliorated by the administration of YKS. Oxidative stress parameters showed increasing tendencies (ROMs test and 8-OHdG) or a significant increase (·OH) in the HIC group compared with the control group; however, the increase was significantly suppressed by the administration of YKS. Conclusions: These findings suggest that YKS is effective against HIC and that its antioxidant activity is involved in the mechanism of action.
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- 2022
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7. Indications for ureteropyeloscopy in the detection of upper urinary tract tumors
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Jun Morita, Michio Naoe, Kohzo Fuji, Aya Hiramatsu, Tsutomu Unoki, Yuki Matsui, Hideaki Shimoyama, Takehiko Nakasato, Kazuhiko Oshinomi, Katsuyuki Saito, Yoshiko Maeda, and Yoshio Ogawa
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Indications ,upper urinary tract tumors ,ureteropyeloscopy ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objectives: Ureteropyeloscopy has recently become an essential technique in the diagnosis of upper urinary tract tumors. However, no consensus has been reached regarding its indications. In addition, it is accompanied by several limitations and potential adverse events such as dissemination of malignant cells, adhesion of the ureter to the surrounding tissue, ureteral stricture, and ureteral perforation. In order to determine when and what circumstances dictate the need for ureteropyeloscopy to detect upper urinary tract tumors, we investigated the indications for ureteropyeloscopy based on voided urine cytology and preoperative radiographic findings. Patients and Methods: In this retrospective study, we evaluated 92 patients (62 men and 30 women) with a mean age of 66.4 years (range, 15–87 years) who had undergone diagnostic ureteropyeloscopy at our institution for the past 10 years. All patients were divided into six subgroups based on voided urine cytology and preoperative radiographic findings: subgroups A1 (n = 18) and A2 (n = 2), positive cytology (positive catheter urine cytology/negative catheter urine cytology) and positive images; Subgroup B (n = 19), positive cytology and negative images; Subgroups C1 (n = 30) and C2 (n = 10), negative cytology and positive images (upper urinary tract carcinomas/other abnormal findings); Subgroup D (n = 13), negative cytology and negative images. Ureteropyeloscopic findings including histology were compared with urine cytology and radiographic findings. Results: Voided urine cytology exhibited 60.4% sensitivity and 77.3% specificity, while preoperative radiographic findings exhibited 70.8% sensitivity and 63.6% specificity. Carcinomas were detected in all patients in Subgroups A1 and A2. Carcinomas were also detected in 9 patients (47.4%) in Subgroup B, of whom 5 showed a history of bladder tumors. The remaining 10 patients all had a history of bladder cancer. In Subgroups C1, C2, and D, carcinomas were detected in 14 patients (46.7%), 1 patient (10%), and 4 patients (30.8%), respectively. These results suggested that ureteropyeloscopy should be recommended for patients with negative cytology. Three complications (pyelonephritis, renal failure, and urinary retention) were noted, but none of these was severe and all were cured within a few days. No malignant findings were obtained in any of the patients during follow-up after negative findings in ureteropyeloscopy. Conclusions: Ureteropyeloscopy is essential for detecting upper urinary tract carcinoma in patients with negative voided urine cytology and positive radiographic findings. In addition, ureteropyeloscopy seems to be used commonly among patients with positive urine cytology and negative radiographic findings, or those with bleeding from the ureteral orifice. However, unless conservative nephron-sparing treatment is considered, ureteropyeloscopy may be unnecessary for patients with positive urine cytology and positive radiographic findings.
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- 2018
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8. Treatment strategy for prostatic abscess: Eighteen cases' report and review of literature
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Kazuhiko Oshinomi, Yuki Matsui, Tsutomu Unoki, Hideaki Shimoyama, Takehiko Nakasato, Jun Morita, Yoshiko Maeda, Michio Naoe, Kohzou Fuji, and Yoshio Ogawa
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Prostatic abscess ,transrectal ultrasound ,transurethral resection of the prostate ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objectives: Prostatic abscesses are rare. The incidence of prostatic abscess has declined markedly with the widespread use of antibiotics. Obtaining improvement is difficult in many cases of prostate abscess. Today, there are no guidelines or algorithms for the treatment of prostatic abscess. In this study, the shape and size of the abscess, in addition to patient background characteristics and the clinical course, were evaluated, and the treatment strategy for prostatic abscess was examined. Methods and Material: All patients with a diagnosis of prostatic abscess in Showa University Hospital between 2003 and 2017 were retrospectively reviewed. Regarding the treatment options, the patients were divided into two groups, the conservative therapy group and the drainage group. In each group, background characteristics, culture reports, shape/size of abscess, and the presence of recurrence were evaluated. Results: All 18 patients with a diagnosis of prostatic abscess between 2003 and 2017 were retrospectively reviewed; 13 patients improved with conservative treatment alone, but drainage was performed in five patients with poor response to antibiotic therapy. All five cases requiring transurethral drainage were multifocal abscesses. Conclusions: In making a decision about the approach for drainage, it is important to assess the size and shape of the abscess using transrectal ultrasonography (TRUS), computed tomography (CT) and magnetic resonance imaging (MRI). If the abscess is the multifocal type, drainage should be considered. Based on the present study, whether the abscess is focal type or multifocal type, transurethral drainage should be considered if the abscess size exceeds 30 mm.
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- 2018
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9. A Novel, Circulating Tumor Cell Enrichment Method Reduces ARv7 False Positivity in Patients with Castration-Resistant Prostate Cancer
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Takehiko Nakasato, Chiho Kusaka, Mika Ota, Yuki Hasebe, Kumiko Ueda, Tsutomu Unoki, Kazuhiko Oshinomi, Jun Morita, Yoshiko Maeda, Takeshi Shichijo, Michio Naoe, and Yoshio Ogawa
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ar-v7 ,androgen receptors ,docetaxel ,cabazitaxel ,abiraterone ,enzalutamide ,Medicine (General) ,R5-920 - Abstract
Background: The AR-V7 splice variant is a cause of castration-resistant prostate cancer (CRPC). However, testing for the presence of AR-V7 by real-time polymerase chain reaction (RT-PCR) shows AR-V7 positivity in healthy individuals. We hypothesized that the positivity reflects contamination by hematopoietic cells. We tried a novel circulating tumor cell (CTC) enrichment instrument, using Celsee, to clear hematopoietic cells. Methods: We tested whole blood or Celsee-enriched samples for AR-V7 by RT-PCR, and included samples from 41 CRPC patients undergoing sequential therapy. We evaluated the associations between AR-V7 status and clinical factors. We evaluated factors affecting AR-V7 positivity. Results: AR-V7 positivity was lower in Celsee-enriched than in whole blood specimens. AR-V7 and clinical factors did not predict the therapy effectiveness. We found no significant differences in the effectiveness of enzalutamide/abiraterone (Enz/Abi) upon AR-V7 evaluation. All AR-V7 positive patients had resistance to Enz/Abi. Docetaxel (DTX), cabazitaxel (CBZ), and Radium223 treatment showed no significant difference in the treatment effectiveness, regardless of AR-V7 presence. AR-V7 was more frequently positive than Extent of disease (EOD) 2 in cases with bone metastases. Conclusion: Celsee CTC enrichment suppresses AR-V7 false positivity. All AR-V7 positive patients presented resistance to Enz/Abi. DTX, CBZ, and Radium223 were effective and remain treatment options. AR-V7 positivity should progressively appear in patients with advanced bone metastases.
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- 2020
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10. Gender-specific impacts of apnea, age, and BMI on parasympathetic nerve dysfunction during sleep in patients with obstructive sleep apnea.
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Kazuhiro Yamaguchi, Yuji Inoue, Noboru Ohki, Natsumi Satoya, Fukumi Inoue, Yoshiko Maeda, Haruki Sekiguchi, Mayumi Suzuki, Takao Tsuji, Kazutetsu Aoshiba, and Atsushi Nagai
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Medicine ,Science - Abstract
BACKGROUND: The gender-specific influences of various confounding factors, including apnea, age, BMI, and cigarette consumption, on the function of the parasympathetic nerve system (PNS) during sleep in OSA patients has never been investigated. METHODS: One hundred ninety-seven males and 63 females with OSA were subjected to full PSG examinations including assessment of R-R intervals (RRIs) during an overnight ECG. The PNS-derived modulatory effect on the RRIs and the variability of this effect were quantified during REM and NREM using instantaneous time-frequency analysis with complex demodulation. The spectral domain with the maximum instantaneous amplitude in the high-frequency band between 0.15 and 0.4 Hz was defined as the main HF peak and used as a surrogate marker of PNS discharge. Based on density-spectrum-array maps of the main HF peaks (HF-DSA map), shifts in the central frequency of the main HF peak over time were continuously observed. When the main HF peaks on the HF-DSA maps maintained the same central frequency for more than 20 sec or 5 min, the PNS functions were considered to be "stable" or "very stable", respectively. RESULTS: Apneas enhanced PNS-derived cardiac-modulation during REM in males, but more importantly, they made PNS-function unstable during both REM and NREM in males and during NREM in females. Aging blunted the PNS-derived cardiac-modulation during both REM and NREM regardless of gender, but aging had no impact on the stability of PNS-function. BMI blunted PNS-eliciting cardiac-modulation during REM in males and during NREM in both males and females. BMI made the PNS unstable during REM in females. Neither height nor cigarette consumption influenced any PNS-related parameter. CONCLUSIONS: The PNS-derived cardiac-modulation was generally inhibited by aging and obesity, in which the effect of obesity was gender-specific. The PNS instability at nighttime was mainly induced by apneas but by obesity particularly during REM in females.
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- 2014
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11. Prostate cancer detection rate and Gleason score in relation to prostate volume as assessed by magnetic resonance imaging cognitive biopsy and standard biopsy.
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Nepal, Sat Prasad, Takehiko Nakasato, Yoshio Ogawa, Michio Naoe, Takeshi Shichijo, Yoshiko Maeda, Jun Morita, Kazuhiko Oshinomi, Tsutomu Unoki, Tatsuki Inoue, Ryosuke Kato, and Madoka Omizu
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BIOPSY ,MAGNETIC resonance imaging ,MULTIVARIATE analysis ,PROSTATE tumors ,STATISTICS ,LOGISTIC regression analysis ,PROSTATE-specific antigen ,DESCRIPTIVE statistics ,DIGITAL rectal examination ,TUMOR grading - Abstract
Objective: This study aimed to assess the relationship of the prostate cancer and Gleason scores (GSs) or ISUP Grade system with prostate volume (PV) as assessed by magnetic resonance imaging (MRI) cognitive biopsy and standard biopsy. Material and methods: Data were collected from 659 patients who underwent MRI cognitive biopsy and standard biopsy from January 2014 to January 2018. The biopsies were performed because of increased prostate-specific antigen (PSA) levels (>4 ng/mL) and/or abnormal digital rectal examination findings. Transrectal ultrasound was used to measure PV. Results: Prostate cancer detection rates in patients with increased PVs of ≤40 cc and >40 cc were 68.8% and 51.6% (p<0.001), respectively. ISUP Grade group ≥2 (Gleason score ≥3+4) detection rates for increased PVs of ≤40 cc and >40 cc were 68% and 73%, and 22.3% and 37.8%, respectively, for those with ISUP Grade group ≥4 (Gleason score ≥8) (p=0.003). Among the patients with PV>40 cc, univariate logistic regression showed a significant relationship between ISUP Grade group ≥2 and PSA, free/total PSA, PSA density, and MRI (p<0.05). On multivariable logistic regression, MRI (p=0.014) and PSA (p=0.039) predicted ISUP Grade group ≥2 in patients with PV>40 cc. Conclusion: Although the detection rates of prostate cancer decreased as PV increased, the detection of prostate cancer aggressiveness increased as PV increased. This increase in high ISUP Grade lesions with the rise in PV is due to the use of MRI during prostate biopsy with standard biopsy. [ABSTRACT FROM AUTHOR]
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- 2020
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12. Management of Right-Sided Polyorchidism with Torsion: A Case Report with Literature Review.
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Nepal, Sat Prasad, Takehiko Nakasato, Michio Naoe, Hideaki Shimoyama, Yoshio Ogawa, Kohzo Fuji, Yoshiko Maeda, Jun Morita, Kazuhiko Oshinomi, Yuki Matsui, Tsutomu Unoki, and Aya Hiramatsu
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Polyorchidism is a rare congenital condition associated with various anomalies; triorchidism is the most common form of this condition. A 21-year-old patient visited our hospital with pain in the right testis. He was diagnosed with right-sided polyorchidism with torsion and underwent manual detorsion followed by orchidopexy. We preserved the extra testis but did not perform histology, as radiological examination revealed no malignant features. [ABSTRACT FROM AUTHOR]
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- 2019
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13. Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.
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Chun-Yi Wu, Don-Hong Wang, Xiaobing Wang, Dixon, Seth M., Liping Meng, Ahadi, Sara, Enter, Daniel H., Chao-Yu Chen, Jason Kato, Leon, Leonardo J., Ramirez, Laura M., Yoshiko Maeda, Reis, Carolina F., Ribeiro, Brianna, Weems, Brittany, Hsing-Jien Kung, and Lam, Kit S.
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- 2016
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14. Spectroscopic Ellipsometry Study on Refractive Index Spectra of Colloidal β-FeOOH Nanorods with Their Self-Assembled Thin Films.
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Hideatsu Maeda and Yoshiko Maeda
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SPECTRUM analysis , *ELLIPSOMETRY , *REFRACTIVE index , *MOLECULAR self-assembly , *THIN films , *COLLOIDAL crystals , *DISPERSION (Chemistry) - Abstract
We prepared monodisperse colloidal β-FeOOH (square prismatic crystalline) nanorods. Self-assembled dry thin films of the rods were formed on quartz substrates by evaporating drops of repulsive-rod suspensions. Using spectroscopic ellipsometry, the complex refractive index spectra of the β-FeOOH nanorod films were deduced, which are further corrected on the basis of absorption spectra measured for β-FeOOH nanorod suspensions, with aid of the KramersâKroÌnig relation and an optical two-phase mixing model. Simultaneously, in this correction process, the rod volume fraction in the films and the complex mean refractive index spectra of purely the rod were extracted together. The real part of the refractive index spectra of the β-FeOOH rod, nâ²c(λ), shows a maximal value of 2.365 (aver.) at 410 nm (λm) (hence a normal dispersion at λ > λmand an anomalous dispersion at λ < λm). At λ = 589.3 nm (λDfor âsodium lightâ), the nâ²c(λ) value is consistent with refractive indices predicted by GladstoneâDaleâs and Andersonâs refractivity formulas with the density of the β-FeOOH rod, 3.638 ± 0.104 g/cm3, measured in this work. [ABSTRACT FROM AUTHOR]
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- 2011
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15. Direct Observation of Brownian Dynamics of Hard Colloidal Nanorods.
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Hideatsu Maeda and Yoshiko Maeda
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SELENIUM , *WELDING rods , *BROWNIAN motion , *CLUSTER theory (Nuclear physics) - Abstract
We synthesize monodisperse selenium (Se) colloidal rods, and the suspensions exhibit the smectic phase at a particle volume fraction () of 0.28. Side-by-side rod clustering occurs at > 0.04. Cluster-size distributions and persistence times are determined for various . In dense suspensions ( > 0.1), individual rods reveal characteristic fundamental motions, e.g., reptation and synchronized rotation. Mean-square displacements of the rods suggest a cage trapping and escape. Estimated translational and rotational diffusion coefficients show a large difference from predictions by computer simulations. [ABSTRACT FROM AUTHOR]
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- 2007
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16. Effects of Peak Inspiratory Flow on Development of Ventilator-induced Lung Injury in Rabbits.
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Yoshiko Maeda
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- 2004
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