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26 results on '"Yu, Yi‐Chuan"'

16. Neutrophil‐lymphocyte ratio in relation to risk of hepatocellular carcinoma in patients with non‐alcoholic fatty liver disease.

Author

Thomas, Claire E., Yu, Yi‐Chuan, Luu, Hung N., Wang, Renwei, Paragomi, Pedram, Behari, Jaideep, and Yuan, Jian‐Min

Subjects
*NON-alcoholic fatty liver disease, *NEUTROPHIL lymphocyte ratio, *HEPATOCELLULAR carcinoma, *DISEASE risk factors, *LYMPHOCYTE count
Abstract

Background: Blood neutrophil to lymphocyte ratio (NLR) or lymphocyte count may be important markers for immune function. Previous work has shown higher NLR was associated with higher risk of hepatitis B‐related hepatocellular carcinoma (HCC). However, studies in non‐alcoholic fatty liver disease (NAFLD) patients are lacking. Methods: Utilizing the University of Pittsburgh Medical Center (UPMC) electronic health records, we created a retrospective cohort of 27,834 patients diagnosed with NAFLD from 2004 to 2018 with complete NLR data. After an average 5.5 years of follow‐up, 203 patients developed HCC. Cox proportional hazard regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of HCC incidence associated with different levels of NLR and lymphocyte count. Results: Compared with the lowest tertile of NLR (<1.97), the highest tertile of NLR (≥3.09) was statistically significantly associated with a 43% higher risk of HCC incidence (HR = 1.43, 95% CI: 1.01–2.03, ptrend = 0.031) after adjustment for age, sex, race, body mass index, smoking status, history of type 2 diabetes, hyperlipidemia, hypertension, and fibrosis‐4 score category. Conversely the highest tertile of lymphocyte count (≥2.15 K/ul) was significantly associated with a 36% lower risk of HCC (HR = 0.64, 95% CI: 0.43–0.94, ptrend = 0.028) compared to the lowest tertile (<1.55 K/ul). There was no association between neutrophil count and HCC risk. Conclusions: Higher NLR and lower lymphocyte count are associated with significantly higher risk of HCC among NAFLD patients. These findings warrant further investigation of immune response and surveillance in association with HCC development in NAFLD patients. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Ambulatory blood pressure monitoring among emergency medical services night shift workers

Author

Patterson, P Daniel, primary, Mountz, Kristina A, additional, Agostinelli, Michael G, additional, Weaver, Matthew D, additional, Yu, Yi-Chuan, additional, Herbert, Brandon M, additional, Markosyan, Mark A, additional, Hopkins, David R, additional, Alameida, Alana C, additional, Maloney III, John A, additional, Martin, Sarah E, additional, Brassil, Bridget N, additional, Martin-Gill, Christian, additional, Guyette, Francis X, additional, Callaway, Clifton W, additional, and Buysse, Daniel J, additional

Published
2020
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24. Ambulatory blood pressure monitoring among emergency medical services night shift workers.

Author

Patterson, P. Daniel, Mountz, Kristina A., Agostinelli, Michael G., Weaver, Matthew D., Yi-Chuan Yu, Herbert, Brandon M., Markosyan, Mark A., Hopkins, David R., Alameida, Alana C., Maloney III, John A., Martin, Sarah E., Brassil, Bridget N., Martin-Gill, Christian, Guyette, Francis X., Callaway, Clifton W., Buysse, Daniel J., and Yu, Yi-Chuan

Abstract

Objectives: Higher 24-hour blood pressure (BP) and blunted BP dipping during sleep and night-time hours are associated with adverse health outcomes. Night shift work may affect 24-hour BP and dipping patterns, but empirical data in emergency medical services (EMS) clinician shift workers are sparse. We implemented ambulatory blood pressure monitoring (ABPM) in EMS workers to characterise BP during night shift work versus a non-workday, and sleep versus wake.Methods: Participants worked night shifts. Hourly ABPM and wrist actigraphy (to measure sleep) were collected during two 24-hour periods, one scheduled night shift and one non-workday. Blunted BP dipping was defined as a BP decrease of <10%.Results: Of 56 participants, 53 (53.6% female, mean age 26.5 (SD 7.5) years) completed the study. During daytime sleep on a workday, 49.1% of participants had blunted systolic BP (SBP) or diastolic BP (DBP) dipping. During night-time sleep on a non-workday, 25% had blunted SBP dipping and 3.9% blunted DBP dipping. Blunted SBP or DBP dipping occurred among all participants who did not nap during the night shift or who napped <60 min. Blunted SBP dipping occurred in only 14.3% of participants who napped 60-120 min.Conclusions: During night shift work, the BP dipping of EMS shift workers is blunted; however, most who nap for 60 min or longer experience a healthy dip in BP. The potential health consequences of these observations in EMS clinicians warrant further study. [ABSTRACT FROM AUTHOR]

Published
2021
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