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AIM:To establish a model of meibomian gland dysfunction in rats induced by eyeliner tattoo and investigate its potential mechanisms.METHODS:A total of 40 SD rats were selected, with 30 randomly chosen to have eyeliner tattoo applied their right eyes and designated as the eyeliner group. The remaining 10 rats were not given any treatment and served as the normal group. The corneal morphology of both groups was observed using a slit lamp at 1, 2, and 4 wk after establishment, and the tear film break-up time(BUT), Schirmer I test(SIt), corneal fluorescein staining score, and corneal irregularity score were calculated. The corneal Placido rings were examined using an ocular surface analyzer, and the corneal tissue structures of both groups were observed under a confocal microscope. After 4 wk and completion of clinical indicator recording, the eyeballs and upper and lower eyelid tissues were taken for pathological examination. The meibomian gland structures were observed through HE staining, the conjunctival goblet cells were observed using PAS staining, and the lipid droplets were observed with ORO staining.RESULTS:The slit lamp examination results showed that the eyeliner group rats exhibited in situ black pigmentation in the eyelids, with no eyelid deformation or scarring. The corneal epithelium was rough, with positive fluorescein staining, presenting as spotty staining that worsened over time. Compared with the normal group, the BUT was significantly shortened, tear secretion volume was significantly decreased, and the corneal fluorescein staining score and corneal irregularity score were significantly increased at 1, 2, and 4 wk after modeling in the eyeliner group(all P

The application of hydraulic oscillator can solve the problems of large friction and serious pressure support in the drilling process of extended reach well and long horizontal well, but the conventional hydraulic oscillator parameter setting is not reasonable, high pressure consumption, easy to make the ground machine pump overload operation and failure. Therefore, based on the LuGre dynamic friction model theory, a calculation model for the friction between drill string and rock wall under the condition of longitudinal oscillation is established, and the influence law of hydraulic oscillator oscillation parameters on drag reduction efficiency is studied. The results show that the change of oscillation intensity, oscillation frequency and oscillation amplitude can improve the drag reduction efficiency, and the increase trend of drag reduction efficiency is first increased and then decreased. The selection of each parameter has the optimal value. According to the analysis of orthogonal test results, it is found that the reduction degree of friction between drill string and borehole wall rock by each parameter is in the order of oscillation intensity, oscillation frequency and oscillation amplitude from the largest to the smallest.

Different malt samples with various total acid content were used to brew beer. The organic acid content in both the malt and the brewed beer was measured by using high-Performance liquid chromatography (HPLC) to establish the correlation between the total acid content in malt and the organic acid content in the beer. Additionally, gas chromatography-mass spectrometry (GC-MS) was used to detect the components of volatile compounds in the beer, and sensory evaluation was employed to assess the brewed beer's qualities. The results indicated that as the total acid content in malt increased, the pH value gradually decreased, and the content of succinic acid, malic acid, lactic acid, and acetic acid increased. There was a significant positive correlation between the total acid content in malt and the total acid content, malic acid content, and lactic acid content in the beer, with correlation coefficients of 0.94, 0.94, and 0.92, respectively. Different malt samples with varying total acid content demonstrated different characteristic aroma compounds in the brewed beer, contributing to differences in sensory attributes. As the total acid content in malt increased, the perceived acidity score of the brewed beer increased, while the scores for hop/fruit aroma, phenolic aroma, and alcohol perception decreased.

In order to explore the adsorption performance and mechanism of tricalcium phosphate for removing the U（Ⅵ）, the tricalcium phosphate powder was synthesized by the solid phase method using calcium carbonate and diammonium hydrogen phosphate as the raw materials. And then, the physical and chemical properties of tricalcium phosphate powder were characterized by X-ray diffraction（XRD）, Fourier transform infrared spectroscopy（FTIR）, scanning electron microscopy（SEM） and specific surface area analyzer（Brunauer-Emmett-Teller, BET). The effects of pH, solid-liquid ratio, adsorption time, initial U（Ⅵ） concentration, adsorption temperature on the U（Ⅵ） adsorption performance of tricalcium phosphate were also investigated. The kinetic adsorption, isothermal adsorption, thermodynamic adsorption models, as well as XRD, FTIR, X-ray photoelectron spectroscopy（XPS）, SEM, energy dispersive spectroscopy（EDS）, inductively coupled plasma optical emission spectrometer（ICP-OES） were used to reveal the U（Ⅵ） adsorption mechanism of tricalcium phosphate. The results show that the adsorption capacity of U（Ⅵ） by tricalcium phosphate is up to 999.25 mg/g, when the adsorption conditions are as follows: pH of 3.0, solid-liquid ratio of 0.1 g/L, adsorption time of 60 min, initial U（Ⅵ） mass concentration of 120 mg/L and adsorption temperature of 308 K. The adsorption process conforms to the pseudo-second-order kinetic model(chemical adsorption) and Langmuir model(monolayer adsorption), which is a spontaneous endothermic process. The U（Ⅵ） adsorption mechanism of tricalcium phosphate is the dissolution and precipitation process. In acidic aqueous solution, Ca2+ and PO3-4 dissolved from tricalcium phosphate can combine with UO2+2 to form meta-autunite (Ca(UO2)2-(PO4)2·6H2O) on the surface of tricalcium phosphate. The aforementioned results suggest that tricalcium phosphate can be utilized as a kind of promising adsorption materials for U（Ⅵ） containing wastewater treatment.

Abstract Introduction Unplanned hospital readmissions after surgery contribute significantly to healthcare costs and potential complications. Identifying predictors of readmission is inherently complex and involves an intricate interplay between medical factors, healthcare system factors and sociocultural factors. Therefore, the aim of this study was to elucidate the predictors of readmissions in an Asian surgical patient population. Methods A two-year single-institution retrospective cohort study of 2744 patients was performed in a university-affiliated tertiary hospital in Singapore, including patients aged 45 and above undergoing intermediate or high-risk non-cardiac surgery. Unadjusted analysis was first performed, followed by multivariable logistic regression. Results Two hundred forty-nine patients (9.1%) had unplanned 30-day readmissions. Significant predictors identified from multivariable analysis include: American Society of Anaesthesiologists (ASA) Classification grades 3 to 5 (adjusted OR 1.51, 95% CI 1.10–2.08, p = 0.01), obesity (adjusted OR 1.66, 95% CI 1.18–2.34, p = 0.04), asthma (OR 1.70, 95% CI 1.03–2.81, p = 0.04), renal disease (OR 2.03, 95% CI 1.41–2.92, p

During the driving of the fully mechanized driving face of the hydrogen sulfide coal roadway, due to the ventilation effect of the roadway, it is very easy to cause hydrogen sulfide gas accumulation and overrun in the front area of the driving face. In order to control the casualties and equipment damage caused by the accumulation and overrun of hydrogen sulfide gas in the fully mechanized mining face of coal mine, the research method of measuring the volume fraction of hydrogen sulfide gas with CD4 portable hydrogen sulfide instrument is used to test and analyze the distribution law of hydrogen sulfide gas emission and the change law of the volume fraction of hydrogen sulfide gas with time after the road-header stops cutting coal; It is revealed that the disturbance of coal cutting by the fully mechanized mining machine is the main cause of inducing the emission of hydrogen sulfide gas in the fully mechanized mining face, and the distribution law of the emission gradually decreases in the direction of the return air flow and the height of the roof and floor. By means of theoretical analysis, laboratory and field test, a new technical scheme for the integrated treatment of hydrogen sulfide extraction and purification in coal mine comprehensive mining face is proposed, the mechanism of the integrated treatment of hydrogen sulfide extraction and purification is studied, and the process technology and supporting device for the integrated treatment of hydrogen sulfide extraction and purification in coal mine comprehensive mining face are developed. The field application study shows that the volume fraction of hydrogen sulfide gas gushing at the position 1m after the suction tuyair and 1m after the outlet of the integrated treatment device of hydrogen sulfide extraction-purification on the excavation face decreases from 169.2×10−6 and 155.9×10−6 before extraction-purification to 13.9×10−6 and 10.2×10−6 after extraction-purification, respectively. The hydrogen sulfide extraction efficiency reached 91.8% and the hydrogen sulfide purification efficiency reached 93.5%, and the hydrogen sulfide hazard treatment effect is good, providing a new technical way for the treatment of the hydrogen sulfide hazard in the fully mechanized mining face.

BACKGROUND With the comprehensive development of the agricultural ecological geological survey and the improvement of people's attention to the ecological environment in our country, the demand for biogeochemical reference materials in biological analysis food analysis and agricultural products analysis is increasing. The existing biogeochemical reference materials are in short supply, and there is an urgent need to develop new reference materials. With the full deployment and development of agro-ecological geological surveys, the demand for biogeochemical reference materials is increasing. OBJECTIVES To reproduce tea composition reference materials (GBW10016a & GBW10052a) to take the place of old tea composition reference materials (GBW10016 & GBW10052). METHODS According to the development needs of geological surveys, the focus of this paper is on the preparation of two tea reference materials, GBW10016a and GBW10052a. The progress includes sampling, processing and preparation, particle size test, uniformity test, stability test, content test, and calculation of identification value and uncertainty.In the sampling process, the sample collection locations are Wuyishan City, Fujian Province and Wuyuan County, Shangrao City, Jiangxi Province. The candidates are oolong tea and green tea. The tea samples both weigh 400kg.In the processing and preparation, the samples were cleaned, freeze-dried, heated and dried, ball milled, screened, sub-packed and inactivated. In the particle size test, the BT-9000s laser particle size distributor was used to test the particle size of the samples. The particle size of GBW10016a & GBW10052a centrally distributed in the range of 75μm to 200μm, and the cumulative distribution content reached 98% in the range of 175μm to 200μm.In the uniformity testing process, 15 bottles of samples were randomly selected for analysis of more than 30 elements. The analysis results show that the relative standard deviation of the elements is less than 7%, the measured values F in the variance test are less than the critical value F. It shows that the uniformity of the samples is acceptable.In the stability testing process, the short-term and long- term stability of the samples are good according to the analysis and testing in different time periods.In the content testing process, a total of 61 indicators were analyzed by accurate and reliable methods such as inductively coupled plasma-mass spectrometry/optical emission spectrometry (ICP-MS/OES) and atomic fluorescence spectrometry (AFS) in multiple laboratories.In the process of calculation of identification value and uncertainty, the Grubbs algorithm and the Dixon algorithm were carried out to check and exclude individual out-group data in the group at the first step. The Cochrane algorithm was used to carry out precision testing at the second step. The Shapiro-Wilk algorithm was used to complete the data normality test.The whole preparation process of the tea reference materials follow three specifications: Technical Norm of Primary Reference Materials (JJG 1006—1994), General and Statistical Principles for Characterization of Reference Materials (JJF 1343—2012) and The Production of Reference Materials for Geoanalysis(JJF 1646—2017). RESULTS GBW10016a (GSB-7a) and GBW10052a (GSB-30a) tea reference materials are successfully reproduced, and have been approved as national first-class reference materials. The GBW10016a (GSB-7a) and GBW10052a (GSB-30a) are characterized by strong representativeness, multi-component planting, and accurate and reliable customization results. A total of 61 indicators are involved in this reproduction: Ag, Al, As, B, Ba, Be, Bi, Br, Ca, Cd, Ce, Cl, Co, Cr, Cs, Cu, Dy, Er, Eu, F, Fe, Gd, Ge, Hf, Hg, Ho, I, K, La, Li, Lu, Mg, Mn, Mo, N, Na, Nb, Nd, Ni, P, Pb, Pr, Rb, S, Sb, Sc, Se, Si, Sm, Sn, Sr, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn. GBW10016a (GSB-7a) contains 54 elements with certified values and uncertainties, and 3 elements with reference values. GBW10052a (GSB-30a) contains 57 elements with certified values and uncertainties, and 3 elements with reference values. For GBW10016a (GSB-7a), Ag and Sn are added, and Ge and Tl are upgraded from the reference values of the original batch (GBW10016) to the certified values. For GBW10052a, Al, Ag, Cl, I, N, S, Sb, Sc, Si and Sn are upgraded from the reference values of the original batch (GBW10052) to the certified values. Due to the current level of analysis technology and objective conditions, the elements of Hf and Nb cannot be given reference values. CONCLUSIONS The reference materials effectively support the needs of geochemical investigation and evaluation of the agricultural ecological environment, analysis of biological samples and food and agricultural products. With the development of ecological environmental research and food safety and hygiene inspection, people pay more and more attention to the characteristic elements, and the requirements are increasing. Problems still exists in the analysis of biological samples, such as discrete analysis results of the same method between laboratories and systematic errors among the main analysis methods of individual elements. There are technical difficulties in the analysis of some elements. Analysis and testing technology needs to be continuously improved to cope with the characteristics of a special biological sample matrix, low composition content and difficult testing.

Yeast plays an important role in fermented cereal products, especially fermented flour products, affecting the texture, aroma, appearance and nutrition of the products. In order to select grain microbial starter and improve the quality of fermented flour products, yeasts were isolated from traditional old flour and natural flour collected from different provinces and cities in China. Yeast identification was carried out by combining morphology and 26S rDNA sequence alignment. High-sugar-resistant, heat-resistant and high-quality yeasts were screened out to verify their application characteristics in steamed bread, toast bread and frozen dough. The results showed that 65 strains of yeasts were isolated, all of which were Saccharomyces cerevisiae, and 9 strains with strong fermentation ability were screened out, among which 5 strains could improve the specific volume, texture and taste of steamed bread, and the other 4 strains were resistant to high sugar and heat, which could improve the texture and flavor of toast bread. Besides, one strain had strong frost resistance, which could prolong the vitality period of frozen dough. The discovered strain is expected to be developed into a high-quality starter for fermented grain products, improve the performance of different kinds of fermented flour products, provide differentiated products for consumers, and promote the innovative development of grain processing industry.

In order to realize the on-line and accurate measurement of roadway air volume, taking the return air roadway and auxiliary transportation roadway in Shangsitou north wing of Wangpo Coal Mine as the research object, the wind speed structure field of rectangular roadway and semi-circular arch roadway section was simulated by CFD method, and the regional distribution of average wind speed in roadway section under different air volume conditions of the same roadway section was compared. The air volume basically had no effect on the regional range and location of the average wind speed distribution of the roadway section and the dimensionless wind velocity structure field of roadway section was further obtained, which was the theoretical foundation for arranging multiple wind speed collection points in the roadway section average wind speed distribution area to accurately calculate the roadway average wind speed. Based on the dimensionless wind speed structure field of roadway section, the position of data acquisition point of roadway average wind speed was determined according to the distribution area of roadway section average wind speed, and the nine point acquisition method of roadway section average wind speed was constructed, which could accurately obtain the roadway average wind speed and check whether there was data distortion in the wind speed sensor. Combined with the nine point acquisition method of roadway section average wind speed, the gantry and folding fully automatic on-line test device for roadway air volume suitable for rectangular roadway and arch roadway were designed respectively. The structural size of the test device and the motion track of wind speed sensor were customized according to the position of roadway average wind speed data acquisition point. The fully automatic on-line test device for roadway air volume was deployed at 10 wind measuring stations in Wangpo Coal Mine. The relative error between manual wind measurement and device wind measurement data was less than 8%. The research showed that the wind measurement accuracy of the fully automatic on-line test device for roadway air volume could meet the mine requirements, and could realize the synchronous on-line measurement of the air volume of multiple roadways in the mine.

Decomposing the output signal of fiber optical current transformer (FOCT) with time-frequency conversion is the key step to obtain the gradual fault characteristics. Aiming at the characteristics of FOCT gradual fault signal with large time domain span and random deterioration process,the output signal is sampled across intervals,and the wavelet packet decomposition algorithm is used to extract fault signal features according to the frequency band of the fault signal. The characteristic parameters are screened to obtain the optimal characteristic parameters that characterize the FOCT degradation trend.The principal component analysis method is proposed to reduce the dimensionality of high-dimensional features,the problem of high signal feature dimensionality is solved,and the need for fast fault feature identification is met. Experiment results show that the wavelet algorithm can decompose the signal into various frequency bands and obtain 64 sub-sequences containing signals of different frequency bands. The operating status of the transformer is determined by the energy ratio of each frequency band of the wavelet signal,and the gradual fault identification is realized.

For improving the anti - corrosion performance of the mechanical galvanized layer, the centrifugal dipping was used to prepare the Ruspert coating and the Luxiubao coating on its surface independently. The surface morphology of the coatings was observed and analyzed with a metallurgical microscope. The cross - sectional morphology and element distribution of coatings were characterized by scanning electron microscope (SEM, equipped with EDS energy spectrum). The salt spray corrosion products of the coatings were analyzed by XRD, and the adhesive strength of the coatings was tested and analyzed through the cross - cut method. Moreover, the porosity of the coatings was tested by the filter paper method, and the corrosion resistance of the coatings was evaluated by the salt spray test. Results showed that the mechanical galvanized composite coating was composed of a mechanical galvanized layer and a coating prepared on it subsequently. The bonding interface between the mechnical galvanized layer and the coating had no pores, spallings or cracks. In addition, the two types of coatings were both formed by alternately stacked scaly Al. The salt spray corrosion products mainly included Zn5(CO3)2(OH)6, Mg4Al2(OH)14·3H2O, Al2SiO5, Zn4CO3(OH)6·H2O and ZnCO3. The adhesive strengthes between the two post - treatment coatings and the galvanized layer were good, and the surface porosity of the two coatings was zero. The time for the appearance of red rust for the Ruspert coating was 1 000 h, which was 650 h longer than that for the mechanical galvanized layer, while the time for the appearance of red rust for the Luxiubao coating was 1 500 h, which was 1 150 h longer than that for the mechanical galvanized layer. To sum up, the application of Ruspert and Luxiubao coatings on the surface of the mechanical galvanized layer could significantly extend the service life of the galvanized layer, and the effect of Luxiubao coating was better. The Ruspert and Luxiubao coatings had broad application prospects as post - treatment processes for mechanical galvanizing.

Objective: This study aimed to investigate the hypoglycemic effect of chrysanthemum polysaccharide on type 2 diabetes (T2DM) rats. Methods: The chrysanthemum polysaccharides were extracted by water extraction and alcohol precipitation. After feeding rats with high-fat and high-sugar feed for 6 weeks, STZ (30 mg/kg·BW) was injected intraperitoneally to establish a T2DM rat model, and records were recorded during the experiment. Rat body weight, food intake, water consumption, fasting blood glucose (FBG) was measured every two weeks, and glucose tolerance (OGTT) test was performed in the last week of the test; the insulin (INS) level was measured by Elisa method, and insulin resistance was calculated Index (HOMA-IR). Determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) levels, as well as the levels of superoxide dismutase (SOD), cystathione (GSH), catalase (CAT), and malondialdehyde (MDA) were detected by Western Blot to detect the expression levels of Nrf2, Keap1, and HO-1. Results: Treatment with chrysanthemum polysaccharides could alleviate the weight loss of T2DM rats, reduce their food intake and water consumption, improve the glucose tolerance of T2DM rats, and reduce INS and HOMA-IR in rats. It could significantly reduce the levels of TC, TG, LDL-C in T2DM rats (P＜0.05), and significantly increase the level of HDL-C (P＜0.05). The levels of SOD, GSH and CAT in T2DM rats increased significantly (P＜0.05), and the level of MDA decreased significantly (P＜0.05). The Nrf2, Keap1, and HO-1 protein levels of T2DM rats treated with chrysanthemum polysaccharides tended to normal protein levels. Conclusion: Chrysanthemum polysaccharide can effectively improve the symptoms of "three more and one less" in T2DM rats, reduce FBG levels, increase OGTT, improve INS levels and HOMA-IR, improve abnormal lipid metabolism and oxidative stress levels in T2DM rats, and through regulation Nrf2/Keap1/HO-1 pathway related proteins play a role in the treatment of T2DM.

The non-repeated support advanced support equipment in environments with small space, large vibration, and severe electromagnetic interference has problems of low sensing technology level, imprecise motion control, and complex operation process. In order to solve the above problems, a non-repeated support advanced support intelligent control system is proposed. According to the controlled requirements of the non-repeated support advanced support technology, it has the capability to detect surrounding environmental information such as posture, obstacles, and positions. It has control methods of adaptive, self- adjusting, and self -decision-making. It has fast, stable, and precise execution components. It is pointed out that this intelligent control system proposes three key technologies: intelligent perception, logical control and execution. Based on the control functions and task flow of the intelligent control system for non-repeated support advanced support, the overall architecture of the system is proposed. The multi-sensor fusion technology based on attitude, obstacle recognition, pressure, position, and velocity information is proposed to control and execute multi working condition motion control strategies. The integrated prototype of 'turn-transport-support' for advanced support in transportation roadways is developed. And ground tests are conducted. The test results show that the intelligent control system for non-repeated support advanced support can achieve visual recognition of the center point and obstacles of the support, automatic walking and stroke judgment of the support handling trolley, automatic offset and rotation of the support, and automatic grasping and lifting functions of the support. The visual recognition sensor can achieve support frame number coding recognition, support posture, and support area decision-making functions. The automated operation process of 'walk-grasp-lower-turn-walk-turn-lift-loose-lower' is implemented. It can meet the application requirements.

Anaesthesia is associated with the routine use of volatile anaesthetic agents, all of which are potent greenhouse gases in varying degrees. Desflurane, in particular, has a high global warming potential and in recent years, there has been a global movement to reduce or remove its usage entirely from operating theatres. We work in a large tertiary teaching hospital in Singapore with deeply entrenched practices of using desflurane to facilitate high turnover of operating theatre cases. We launched a quality improvement project to (1) reduce the median usage of desflurane by 50% (by volume), and (2) reduce the number of theatre cases administering desflurane by 50% over a period of 6 months.We collected baseline data to determine departmental monthly median usage of desflurane. We then deployed sequential quality improvement methods to educate staff and to eliminate misconceptions, as well as to promote a gradual cultural change.We successfully reduced monthly median desflurane usage from 31.5 L to 12.2 L per month (61.3% reduction) within our targeted time frame. We also achieved a reduction in the number of theatre cases using desflurane by approximately 80%. This translated to significant cost savings of US$195 000 per year and over 840 tonnes of carbon dioxide equivalents saved.Healthcare is a resource intensive industry. Anaesthetists are well placed to play an important role in reducing healthcare-related carbon emissions by choosing anaesthetic techniques and resources responsibly. Through multiple Plan-Do-Study-Act cycles and a persistent, multifaceted campaign, we achieved a sustained change in our institution.

Due to the research paradigm of the conventional Visible Light Communications (VLC), researchers usually assume that the optical sources follow the Lambertian spatial radiation characteristics. Objectively, this assumption ignores that the potential heterogeneous optical beams based on distinct beams, and the essential exploration for the coverage of the VLC based on the above heterogeneous optical beams. To address the issue, we comprehensively consider the distinct non-Lambertian optical beams characteristics of commercial light emitting diodes, and provide several potential heterogeneous optical beams configuration. Simultaneously, in typical indoor scenario, the coverage characteristics are compared between the conventional Lambertian beam based transmitter configuration and the proposed heterogeneous optical beams configuration. Numerical results show that, compared with the well-known Lambertian transmitter design, the proposed heterogeneous optical beams configuration could provide up to 1.97 dB minimum Signal-to-Noise Ratio (SNR) gain, and modify the SNR fluctuation extent from about 22.75 dB of original design to about 15.33 dB in the heterogeneous configuration. Moreover, via the heterogeneous configuration, the weak coverage proportion with lower than 30 dB SNR, is reduced to about 7.23% from original proportion of about 13.2%. Therefore, to indoor spatial coverage, the effects induced by the heterogeneous optical beams are verified preliminarily.

Non-enhanced CT scanning is the first choice for the diagnosis of suspected cerebral hemorrhage in the emergency room.Medical staffs usually use CT images to manually segment the lesions of patients with suspected acute cerebral hemorrhage, and then classify them based on clinical experience.This method of manual diagnosis requires the physician's experience and is highly subjective.Moreover, the segmentation and classification tasks are performed separately, and the characteristic information associated between the two tasks cannot be fully utilized, and the time cost is high, which increases the difficulty of quickly segmenting and classifying cerebral hemorrhage lesions based on CT images.In response to the above problems, the paper proposes a model for segmentation and classification of cerebral hemorrhage images based on multi-task learning.On the one hand, the weight of the loss function is optimized according to the difficulty of learning different tasks.On the other hand, public information sharing is realized in the shallow layer of the multi-task learning network, and private information of different tasks is extracted deeply to obtain more representative features, so as to quickly and accurately segment and classify the CT images of patients with cerebral hemorrhage.The experimental results show that the segmentation annotations generated by the multi-task learning network have good visual consistency with the real annotations.Under the optimal weight, the average Dice coefficient (DSC) of all subjects is 0.828, the sensitivity is 0.842, the specificity is 0.985, and the positive predictive value (PPV) is 0.838.The accuracy, sensitivity, specificity and AUC value of multi-task learning network classification are 95.00%, 90.48%, 100.00% and 0.982, respectively.Compared with single-task deep learning, Y-Net and multi task learning assisted by classification, this method makes more effective use of relevant task information, and at the same time improves the segmentation and classification accuracy of hemorrhage lesions by adjusting the weight of the loss function.

C10H14N2O2, monoclinic, P21/c (no. 14), a = 4.1183(15) Å, b = 9.787(4) Å, c = 12.649(5) Å, β = 100.411(12)°, V = 501.4(3) Å3, Z = 2, Rgt(F) = 0.0484, wRref(F2) = 0.0925, T = 293 K.

Objective: This study aimed to investigate the antioxidant activity of polysaccharides from Platycodon grandiflorum and its hypoglycemic effect on type 2 diabetic rats. Methods: Extraction and determination of P. grandiflorum polysaccharide content and its ability to scavenge different free radicals The rats were fed with high-fat and high-sugar feed for 6 weeks. After 6 weeks, the rats were intraperitoneally injected with STZ (30 mg/kg·BW) to establish type 2 diabetes models (T2DM), which were divided into normal group, model group, and P. grandiflorum-polysaccharide high-dose group (400 mg/kg) and low-dose group (200 mg/kg), and positive group (metformin 200 mg/kg). The body weight and fasting blood glucose (FBG) were measured regularly for 8 weeks. In the last week, an oral glucose tolerance (OGTT) test was performed, and rat serum and liver were taken to determine the changes in lipid metabolism indexes and related oxidases in rats. Results: The content of platycodon grandiflorum polysaccharide was 89.65%, and the scavenging ability of DPPH·, ABTS+·, ·OH and PTIO at a concentration of 1 000 μg/mL were 91.3%, 89.7%, 83.8%, and 90.4%, respectively. Compared with the model group, P. grandiflorum polysaccharide could effectively alleviate the weight loss of T2DM rats, significantly reduced their FBG (P＜0.05), and significantly increased the level of OGTT (P＜0.05). After high-dose treatment of P. grandiflorum polysaccharide, the levels of TC, TG, LDL-C and MDA decreased significantly, and the levels of HDL-C, SOD, GSH, and CAT increased significantly (P＜0.05) with dose-dependence. Conclusion: P. grandiflorum polysaccharide has good antioxidant properties and can reduce blood sugar by improving lipid metabolism and oxidative stress levels in T2DM rats.

C14H13Cl1N2O4, monoclinic, I2/a (no. 15), a = 13.257(5) Å, b = 16.161(4) Å, c = 13.262(3) Å, β = 97.47(3)°, V = 2817.2(14) Å3, Z = 8, R gt(F) = 0.0578, wR ref(F 2) = 0.1714, T = 293 K.

The safety of imported shortening is still a key content in port supervision and inspection.For port scientific regulation,accurate inspection,safe and fast clearance,food safety assurance and trade development promotion,94 laboratory analysis certificates,health certificates and plant quarantine certificates that must attached in 47 batch of shortenings imported from Indonesia from May 2019 to June 2020 were studied comparatively with ISO/IEC17025,shortening and their relevant Chinese national food safety standards.The results showed that 4 laboratories’ certificate of shortening analysis had 12～20 testing items,the components of the sample test date were incomplete or different,and 3 of them did not indicate the test date.2 laboratories’ test certificates did not indicate the testing and conformity assessment which were obtained based on Chinese national food safety standards; 1 laboratory issued two kinds of analysis certificates (5 copies of which cited or 10 copies of which did not cited Chinese national food safety testing and conformity assessment standards); Invalidation standard citation or cited standards were too many and inaccurate.The solvent residue conformity assessment was carried out according to GB2716:2005,and there was a risk of exceeding the standard.The antioxidant application conformity assessment method did not specify the requirements of GB2760A,A.2,and there was a risk of exceeding GB2760 limits.The core content of the health certificate was expressed in a variety of ways,which was not standardized and unified.The plant quarantine certificate did not indicate the scientific name,Latin scientific name of plant varieties and the shortening production (press) time.

This study purposed to develop conductivity 3D printed (3DP) fingertips and confirm their potential for use in a pressure sensor. Index fingertips were 3D printed using thermoplastic polyurethane filament with three types of infill patterns (Zigzag (ZG), Triangles (TR), Honeycomb (HN)) and densities (20%, 50%, 80%). Hence, the 3DP index fingertip was dip-coated with 8 wt% graphene/waterborne polyurethane composite solution. The coated 3DP index fingertips were analyzed by appearance property, weight changes, compressive property, and electrical property. As results, the weight increased from 1.8 g to 2.9 g as infill density increased. By infill pattern, ZG was the largest, and the pick-up rate decreased from 18.9% for 20% infill density to 4.5% for 80% infill density. Compressive properties were confirmed. Compressive strength increased as infill density increased. In addition, the compressive strength after coating was improved more than 1000 times. Especially, TR had excellent compressive toughness as 13.9 J for 20%, 17.2 J for 50%, and 27.9 J for 80%. In the case of electrical properties, the current become excellent at 20% infill density. By infill patterns at 20% infill density, TR has 0.22 mA as the best conductivity. Therefore, we confirmed the conductivity of 3DP fingertips, and the infill pattern of TR at 20% was most suitable.

To investigate the effect and medical imaging of modified hemispherectomy on patients with infantile hemiparesis and medically refractory epilepsy.

The Glucose 6-phosphatase (G6Pase) catalytic subunit (G6PC) catalyzes glucose 6-phosphate (G6P) to inorganic phosphate and glucose, playing a critical role in endogenous energy supply. Here, the G6PC gene family was investigated and characterized in common carp (Cyprinus carpio).

This paper is focused on the nonlinear state estimation problem with finite-step correlated noises and packet loss. Firstly, by using the projection theorem repeatedly, the mean and covariance of process noise and measurement noise in the condition of measurements before the current epoch are calculated. Then, based on the Gaussian approximation recursive filter (GASF) and the prediction compensation mechanism, one-step predictor and filter with packet dropouts are derived, respectively. Based on these, a nonlinear Gaussian recursive filter is proposed. Subsequently, the numerical implementation is derived based on the cubature Kalman filter (CKF), which is suitable for general nonlinear system and with higher accuracy compared to the algorithm expanded from linear system to nonlinear system through Taylor series expansion. Finally, the strong nonlinearity model is used to show the superiority of the proposed algorithm.

Polymer-based nanoparticles have good solubility, stability, safety, and sustained release,which increases the absorption of loaded drugs, protects the drugs from degradation, and prolongs their circulation time and targeted delivery. Generally, we believe that prevention and control of infectious diseases through inoculation is the most efficient measure. However, these vaccines including live attenuated vaccines, inactivated vaccines, protein subunit vaccines, recombinant subunit vaccines, synthetic peptide vaccines and DNA vaccines have several defects, such as immune tolerance, poor immunogenicity, low expression level and induction of respiration pathological changes. All kinds of biodegradable natural and synthetic polymers play major roles in the vaccine delivery system to control the release of antigens for an extended period of time. In addition, these polymers also serve as adjuvants to enhance the immunogenicity of vaccine. This review mainly introduces natural and synthetic polymer-based nanoparticles and their formulation and properties. Moreover, polymer-based nanoparticles as adjuvants and delivery carriers in the applications of vaccine are also discussed. This review provides the basis for further operation of nano vaccines by utilizing the polymer-based nanoparticles as vaccine adjuvants and delivery systems. Polymer-based nanoparticles have exhibited great potential in improving the immunogenicity of antigens and the development of nano vaccines in future.

Long-QT Syndrome (LQTS) is a cardiac electrical disorder, distinguished by irregular heart rates and sudden death. Accounting for ∼40% of cases, LQTS Type 2 (LQTS2), is caused by defects in the Kv11.1 (hERG) potassium channel that is critical for cardiac repolarization. Drug block of hERG channels or dysfunctional channel variants can result in acquired or inherited LQTS2, respectively, which are typified by delayed repolarization and predisposition to lethal arrhythmia. As such, there is significant interest in clear identification of drugs and channel variants that produce clinically meaningful perturbation of hERG channel function. While toxicological screening of hERG channels, and phenotypic assessment of inherited channel variants in heterologous systems is now commonplace, affordable, efficient, and insightful whole organ models for acquired and inherited LQTS2 are lacking. Recent work has shown that zebrafish provide a viable in vivo or whole organ model of cardiac electrophysiology. Characterization of cardiac ion currents and toxicological screening work in intact embryos, as well as adult whole hearts, has demonstrated the utility of the zebrafish model to contribute to the development of therapeutics that lack hERG-blocking off-target effects. Moreover, forward and reverse genetic approaches show zebrafish as a tractable model in which LQTS2 can be studied. With the development of new tools and technologies, zebrafish lines carrying precise channel variants associated with LQTS2 have recently begun to be generated and explored. In this review, we discuss the present knowledge and questions raised related to the use of zebrafish as models of acquired and inherited LQTS2. We focus discussion, in particular, on developments in precise gene-editing approaches in zebrafish to create whole heart inherited LQTS2 models and evidence that zebrafish hearts can be used to study arrhythmogenicity and to identify potential anti-arrhythmic compounds.

The stability of loess subgrade is affected by many factors. Freeze-thaw cycles are a common factor that causes the strength of loess subgrades to be damaged. In order to study the influence of freezethaw cycles on the stability of loess subgrades, reveal the mechanism of freeze-thaw cycles on the strength of loess subgrades. It is necessary to sample the loess soil samples in this area, and perform compaction test, freeze-thaw cycle test, unconfined compression test and electron microscope scanning test on the soil sample to analyze the influence of freeze-thaw cycle on the strength and microstructure of loess soil. . In this way, the potential relationship between the microstructure and the strength of the soil can be obtained. The results found that the freeze-thaw cycle of loess led to a trend of first increase and then decrease in soil strength. The microstructure showed a trend of smaller soil particles and increased soil voids. The potential relationship between the microstructure and the strength of the soil was analyzed. It explains the conclusion that the strength of the soil first increases and then decreases.

The failure of friction plate and steel disc in the brake of an automatic transmission is analyzed profoundly. The wave shape deformation of steel disc is caused by the thermal load distributing in its inner radius area. With checking the design,assemble,manufacture,heat-treatment and part quality,the main causes of failure is concerned with little thickness of steel disc,unreasonable design of supporting structure and large difference in characteristics of wave spring. The lifetime of the brake is markedly improved by optimizing the thickness of steel disc with the software ANSYS,filtering and using wave spring in groups. For finishing the durability test of an automatic transmission on the bench,the fault for the brake is effectively solved.

For distortion problem of fisheye images collected by video monitoring system of coal mine, an automatic obtaining method of adjustment parameters was put forward based on image content according to line constrain of ideal spherical perspective projection model. The method detects image edge characteristic lines by preprocessing the fisheye distortion image using math morphologic and random Hough transform, then gets the optimal adjustment parameters through the statistic of horizontal and vertical lines proportion. In order to decrease effect of large image information on adjustment parameter obtaining, the ideal spherical perspective projection model was improved and an improved adjustment method of fisheye distortion images was proposed, which realized center transfer of the fisheye distortion image and magnifying of part regions. The experimental results show the method can get a better adjustment effect of fisheye distortion image.

Friction stir processing was applied to cool-rolled DC04 IF steel plates with a thickness of 3 mm,and the microstructure and mechanical properties of the processed zone were investigated. A defect-free specimen with a shiny and smooth surface is fabricated at a tool rotation rate of 950 r·min-1 and a travel speed of 60 mm·min-1 using additional forced cooling technology after processing.A fine equiaxed grain structure can be obtained in the processed zone,which causes a higher hardness of HV 135.6,1.4 times as large as the base metal at the center of the processed zone,and the highest hardness of HV 312.8 in the surface. The ultimate tensile strength of processed samples with and without the surface fine-grained layer increases by 50.9% and 47.6% compared to that of the base material,respectively. The both fracture surfaces of samples before and after friction stir processing exhibit dimple ductile fracture characterization. Grain refinement is considered to be the main reason for improving the ultimate tensile strength.

For 3D geological modelling of oil and gas reservoirs, well pattern density is directly related to the number of samples involved in the calculation, which determines the variation function of stochastic modelling and has great impacts on the results of reservoir modelling. This paper focuses on the relationship between well pattern density and the variogram of stochastic modelling, selects the large Sulige gas field with many well pattern types as the research object, and establishes a variogram database of stochastic models for different well pattern densities. First, the well pattern in the study area is divided into three different types (well patterns A, B, and C) according to well and row space. Several different small blocks (model samples) are selected from each type of well pattern to establish the model, and their reasonable variogram values (major range, minor range and vertical range) are obtained. Then, the variogram values of all model samples with similar well pattern densities are analysed and counted, and the variogram database corresponding to each type of well pattern is established. Finally, the statistical results are applied to the modelling process of other blocks with similar well pattern density to test their accuracy. The results show that the reservoir model established by using the variation function provided in this paper agrees well with the actual geological conditions and that the random model has a high degree of convergence. This database has high adaptability, and the model established is reliable.