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Widespread submarine hydrocarbon seepage can form complex fluid seepage characteristics, with submarine sediment geochemistry effectively recording seepage activities and fluid component changes due to hydrocarbon seepage. This is crucial for offshore oil and gas exploration and understanding global climate change. Therefore, using the geochemical information of submarine sediments to trace hydrocarbon seepage activities is of great significance. In order to identify the geochemical anomaly characteristics and genetic types of acid-hydrolyzed hydrocarbons in submarine sediments in the Yantai Depression of the South Yellow Sea Basin, Eastern China, and to explore the relationship between these anomalies and deep oil and gas, geochemical columnar samples were taken at 100 stations in the study area. A total of 100 sets of acid-hydrolyzed hydrocarbon data and 26 sets of carbon isotope data were analyzed. The results show that the content of acid-hydrolyzed hydrocarbons at each station is in the following order: methane (AC1) > ethane (AC2) > propane (AC3) > butane (AC4) > pentane (AC5). The determination coefficient between the saturated hydrocarbon indicators exceeds 0.9, indicating that these components have the same source. Data analysis reveals that the genetic type of hydrocarbon gases in the study area is generally thermogenic, with limited microbial contribution to saturated hydrocarbons, indicating deep oil and gas characteristics. The coincidence between the anomalous areas and geological structures indicates that the distribution of these anomalies is closely related to fault distribution. [ABSTRACT FROM AUTHOR]

The East China Sea Basin (ECSB) is an integral part of the Western Pacific tectonic system. Its development is linked to the Kula–Pacific Plate and the formation and expansion of the Philippine Sea Basin. Recent advancements in exploration technologies and theory have been applied to Mesozoic basins in the East China Sea. Researchers have posited that the southern basin has great oil and gas exploration potential. However, the characteristics and evolution of fault structures and their influence on hydrocarbon accumulation remain unclear. Here, in-depth geometric and kinematic analyses of Mesozoic fault structures in the southern ECSB were conducted using the latest interpretations of 2D seismic data and structural analysis theory. The findings revealed that the fault system was well developed and predominantly exhibited multiphase extensional and extensional-torsional features. Based on their lateral distribution and morphology, faults were categorized into three structural styles and seven combinations. According to their developmental timing, periods of active faulting were attributed to the Yanshan and Himalayan epochs. Multiphase fault activities strongly controlled the formation of traps and thus hydrocarbon accumulation, while earlier NE-trending faults controlled the formation of structural belts and hydrocarbon source areas. [ABSTRACT FROM AUTHOR]

To analyze the impact of volcanic rocks in the Offshore Indus Basin on hydrocarbon reservoir formation, seismic data interpretation, seismic data inversion, and sea–land correlation analysis were carried out. The results show that, longitudinally, volcanic rocks are mainly distributed at the top of the Cretaceous system or at the bottom of the Paleocene, and carbonate rock platforms or reefs of the Paleocene–Eocene are usually developed on them. On the plane, volcanic rocks are mainly distributed on the Saurashtra High in the southeastern part of the basin. In terms of thickness, the volcanic rocks revealed by drilling in Karachi nearshore are about 70 m thick. We conducted sparse spike inversion for acoustic impedance in the volcanic rock area. The results show that the thickness of the Deccan volcanic rocks in the study area is between 250 and 750 m which is thinning from southeast to northwest. Based on sea–land comparison and comprehensive research, the distribution of volcanic rocks in the Indian Fan Offshore Basin played a constructive role in the Mesozoic oil and gas accumulation in the Indus offshore. Therefore, in the Indian Fan Offshore Basin, attention should be paid to finding Mesozoic self-generated and self-stored hydrocarbon reservoirs and Cenozoic lower-generated and upper-stored hydrocarbon reservoirs. [ABSTRACT FROM AUTHOR]

This retrospective study examines risk factors and electromyographic (EMG) characteristics associated with acquired weakness in critically ill patients and assesses their impact on patient prognosis. Methods: Ninety-seven critically ill patients, ventilated for over 48 hours, were included. Patient data, encompassing general condition, medical history, Medical Research Council (MRC) scores, serum markers (c-reactive protein, calcitonin gene, albumin, brain natriuretic peptide, urea nitrogen, creatinine), EMG characteristics, respiratory treatment modalities, and parameters, were recorded. Mechanical ventilation duration, ICU stay duration, hospitalization duration, and patient prognosis were documented. Based on MRC scores, patients were categorized into the ICU-acquired weakness (ICU-AW) group (MRC < 48 points) and the non-ICU-AW group (MRC ≥ 48 points). Results: The study comprised 47 ICU-AW and 50 non-ICU-AW patients. Significant differences (p < 0.05) were observed in age, MRC scores, albumin levels, c-reactive protein, calcitonin gene, brain natriuretic peptide, urea nitrogen, creatinine, mechanical ventilation duration, ICU stay duration, and hospitalization duration between groups. In the ICU-AW group, nerve conduction examinations revealed slow conduction velocity, reduced wave amplitude, and in severe cases, a complete loss of motor and sensory potentials. Multivariate logistic analysis identified low serum albumin levels and MRC scores as potential ICU-AW risk factors. Conclusion: This study suggests that low serum albumin levels and MRC scores may contribute to ICU-AW risk. The ICU-AW group exhibited varied peripheral nerve damage and slow conduction velocities on EMG. Additionally, severe systemic inflammatory responses, renal function, brain natriuretic peptide levels, prolonged mechanical ventilation, and peripheral nerve damage may be associated with ICU-AW. Follow-up studies are essential for further understanding these complex interactions. [ABSTRACT FROM AUTHOR]

Deepwater regions have emerged as pivotal domains for global oil and gas exploration and development, serving as strategic alternatives to conventional resources. The Silk Road region is distinguished by its abundant oil and gas reserves and stands as a leading arena for worldwide exploration and development in the oil and gas sector. Since 2012, a series of atmospheric fields have been discovered in the deep sea of the Luwuma Basin and the Tanzania Basin, with cumulative recoverable reserves reaching 4.4 × 1012 and 8.3 × 1011 m3, including multiple oil and gas fields ranking among the top ten global discoveries at that time. Profound advancements have been achieved in the exploration of deepwater oil and gas reserves along the Silk Road. However, deepwater oil and gas exploration presents challenges, such as high development costs and risks, leading to certain areas remaining underexplored and exhibiting a relatively low level of exploration activity, thereby hinting at considerable untapped potential. Deepwater sedimentary basins along the Silk Road predominantly adhere to a distribution pattern characterized as "one horizontal and one vertical". The "horizontal" dimension refers to the deepwater basin grouping within the Neo-Tethys tectonic domain, primarily extending from east to west. Conversely, the "vertical" dimension denotes the deepwater basin grouping along the East African continental margin, predominantly extending from north to south. Recent discoveries of deepwater oil and gas reserves validate the presence of foundational elements within Silk Road basins conducive to the formation of substantial oil and gas reservoirs and the establishment of efficient migration pathways. Despite these achievements, exploration activities in deepwater oil and gas resources along the Silk Road remain relatively limited. Future exploration endeavors in deepwater regions will predominantly focus on identifying structural and lithological traps. In the deepwater areas of the Bay of Bengal, the emphasis is on lithological traps formed by Neogene turbidite sandstone deposits. In the deepwater regions of Pakistan, the focus shifts to lithological traps emerging from Neogene bio-reefs and river-channel sandstone accumulations. Along the deepwater coastline of East Africa, the focus is on lithological traps formed by nearshore Mesozoic–Cenozoic bio-reefs and seafloor turbidite sandstone formations. Within the deepwater regions of Southeast Asia, the primary objective is to locate large structural-type oil and gas fields. Analyzing the characteristics of oil and gas discoveries in deepwater areas aims to enhance the theory of the control of the formation of deepwater oil and gas, providing valuable insights for predicting future exploration directions. [ABSTRACT FROM AUTHOR]

In the era of digital economy, using effective personalized advertising recommendation strategies to guide online consumers to make green purchasing decisions is one of the important ways to accelerate the construction of green consumption system. Based on the theory of online consumers' purchasing decision-making process and the inconsistent preference theory, this investigation adopted 2x2 between-subjects factor experiment method (online experiments) and sent out 370 and 700 questionnaires respectively. 340 and 660 valid ones were retrieved. On this basis, we used data analysis methods such as factor analysis, one-way ANOVA, Logistics regression analysis, etc. to verify the impact of different advertising recommendation types on consumers' two-stage decision-making process ( including screening and payment) of online green purchases. The results showed that: (1) The types of personalized advertising recommendation had no significant effects on the screening stage of online green purchase decision-making process. (2) The types of personalized advertising recommendation had a positive impact on the payment stage of online green purchase decision-making process. (3) Green involvement had distinct adjusting effects on the purchase path of online green purchase decision-making influenced by personalized advertising recommendations. (4) Product attributes had significant adjusting effects on the payment stage of online green purchase path influenced by different personalized advertising recommendations. The countermeasures and suggestions based on the research are as follows: (T) According to the different stages of purchase decision-making process, online shopping platforms (enterprises, online merchants, etc. ) should appropriately push to the target consumers products recommended by others in the payment stage. (2) Online shopping platforms should adopt big data to subdivide target users reasonably, and provide emphatically those users of high green involvement with personalized recommendations of green products. (3) Personalized advertising recommendation schemes with product attributes matching the recommendation types should be adopted. [ABSTRACT FROM AUTHOR]

Gastric cancer remains the second most common cause of cancer-related death worldwide. Because of the poor prognosis of late-stage gastric cancer patients, it is imperative to develop new strategies to improve the survival rate of this disease. Currently, immunotherapy is considered as an innovative approach for cancers such as lung cancer, gastric cancer and breast cancer. In fact, previous works have revealed promising results in this field. With further understanding of immunogenomics of gastric cancer, new immune checkpoint regulators could become more important. In addition, whole-genome sequencing and genome editing provide us with more information on the heterogeneity of gastric cancer, showing helpful tools to identify new predictive biomarkers and to achieve personalized treatment. Further research and better understanding of the functions of immune system will enhance immunotherapy treatment in the future. [ABSTRACT FROM AUTHOR]

Abstract: Long non‐coding RNAs (lncRNAs) have been illustrated to function as important regulators in carcinogenesis and cancer progression. However, the roles of lncRNA NNT‐AS1 in gastric cancer remain unclear. In the present study, we investigate the biological role of NNT‐AS1 in gastric cancer tumorigenesis. Results revealed that NNT‐AS1 expression level was significantly up‐regulated in GC tissue and cell lines compared with adjacent normal tissue and normal cell lines. The ectopic overexpression of NNT‐AS1 indicated the poor prognosis of GC patients. In vitro experiments validated that NNT‐AS1 knockdown suppressed the proliferation and invasion ability and induced the GC cell cycle progression arrest at G0/G1 phase. In vivo xenograft assay, NNT‐AS1 silencing decreased the tumour growth of GC cells. Bioinformatics online program predicted that miR‐424 targeted the 3′‐UTR of NNT‐AS1. Luciferase reporter assay, RNA‐immunoprecipitation (RIP) and RNA pull‐down assay validated the molecular binding within NNT‐AS1 and miR‐424, therefore jointly forming the RNA‐induced silencing complex (RISC). Moreover, E2F1 was verified to act as the target gene of NNT‐AS1/miR‐424, indicating the NNT‐AS1/miR‐424/E2F1 axis. In conclusion, our study indicates that NNT‐AS1 sponges miR‐424/E2F1 to facilitate GC tumorigenesis and cycle progress, revealing the oncogenic role of NNT‐AS1 for GC. [ABSTRACT FROM AUTHOR]

By analyzing the composition of n -alkane and macroelements in the surface sediments of the central South Yellow Sea of China, we evaluated the influencing factors on the distribution of organic matter. The analysis indicates that the distribution of total organic carbon (TOC) was low in the west and high in the east, and TOC was more related to Al 2 O 3 content than medium diameter (MD). The composition of n -alkanes indicated the organic matter was mainly derived from terrestrial higher plants. Contributions from herbaceous plants and woody plants were comparable. The comprehensive analysis of the parameters of macroelements and n -alkanes showed the terrestrial organic matter in the central South Yellow Sea was mainly from the input of the modern Yellow River and old Yellow River. However, some samples exhibited evident input characteristics from petroleum sources, which changed the original n -alkanes of organic matter in sediments. [ABSTRACT FROM AUTHOR]