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1,372 results on '"Zhong, Jing"'

1. Exploration of morphological coherence in open clusters with a 'core-shell' structure

Author

Hu, Qingshun, Zhang, Yu, Qin, Songmei, Zhong, Jing, Chen, Li, and Luo, Yangping

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

The study of their morphological coherence allows us to obtain a better understanding of the morphological evolution of open clusters. We employed the ellipsoid fitting method to delineate the 3D spatial structure of the sample clusters while using the morphological dislocation (MD) defined in our previous work and the ellipticity ratio (ER) of the clusters' inner and outer structures to characterize the morphological coherence of the sample clusters. The results show an inverse correlation between the ER of the sample clusters and the number of their members, indicating that sample clusters with a much more elliptical external morphology than internal shape generally tend to host a large number of members. Meanwhile, a slight shrinking of the MD of the sample clusters with their members' number may shed light on the significant role of the gravitational binding of the sample clusters in maintaining their morphological stability. Moreover, there are no correlations between the MD and ER of the sample clusters and their age. They are also not significantly correlated with the X-axis, the Y-axis, their orbital eccentricities, and the radial and vertical forces on them. However, the ER of the sample clusters displays some fluctuations in the distributions between it and the above covariates, implying that the morphologies of the sample clusters are sensitive to the external environment if sample effects are not taken into account. Finally, the analysis of the 3D spatial shapes of sample clusters with a small ER or a large ER demonstrates that the number of members lays an important foundation for forming a dense internal system for sample clusters. At the same time, the MD of the sample clusters can serve well as an indicator of their morphological stability, which is built upon a certain amount of member stars., Comment: 17 pages, 13 figures, 1 table. Accepted by Astronomy & Astrophysics

Published
2024
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8. Reparameterization of the mW model to accurately predict the experimental phase diagram of methane hydrate.

Author

Jin, Dongliang and Zhong, Jing

Subjects
*MEAN square algorithms, *CHEMICAL potential, *PHASE diagrams, *THERMODYNAMICS, *GAS hydrates, *MELTING, *METHANE hydrates
Abstract

Due to their high computational efficiency, the coarse-grained water models are of particular importance for practical molecular simulations of gas hydrates. In these models, the mW model is successfully used to study many thermodynamics and dynamics of methane hydrate. Yet, despite several decades of intense research, the mW model is still found to overestimate the melting temperature of methane hydrate. We here employ the minimum mean squared error estimation to revisit the key parameter of the mW model, which determines the strength of the tetrahedral angle of the water system. Relying on the free energy calculations, we first estimate the chemical potentials of water in the liquid phase for temperatures at which methane hydrate forms. We then turn to the mean squared error to describe the chemical potential deviation between the mW model and the TIP4P/ice model (the latter could reproduce the experimental phase diagram of methane hydrate). By minimizing the mean squared error, we finally have an optimized parameter for the mW model. In this part, we also discuss the pressure effect on such reparameterization procedure. Moreover, relying on the direct coexistence method, the melting temperature determined using the reparameterized mW model is found to be consistent with the experimental data. This strategy provides a means to improve the coarse-grained model to match the experimental observations for temperatures in the range of interest. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Angiotensin II mediates hypertensive cardiac fibrosis via an Erbb4-IR-dependent mechanism

Author

Jian-Chun Li, Jian Jia, Li Dong, Zhong-Jing Hu, Xiao-Ru Huang, Hong-Lian Wang, Li Wang, Si-Jin Yang, and Hui-Yao Lan

Subjects
MT: Non-coding RNAs, angiotensin II, cardiac fibrosis, Erbb4-IR, Smad7, miR-29, Therapeutics. Pharmacology, RM1-950
Abstract

Transforming growth factor β (TGF-β)/Smad3 plays a vital role in hypertensive cardiac fibrosis. The long non-coding RNA (lncRNA) Erbb4-IR is a novel Smad3-dependent lncRNA that mediates kidney fibrosis. However, the role of Erbb4-IR in hypertensive heart disease remains unexplored and was investigated in the present study by ultrasound-microbubble-mediated silencing of cardiac Erbb4-IR in hypertensive mice induced by angiotensin II. We found that chronic angiotensin II infusion induced hypertension and upregulated cardiac Erbb4-IR, which was associated with cardiac dysfunction, including a decrease in left ventricle ejection fraction (LVEF) and LV fractional shortening (LVFS) and an increase in LV mass. Knockdown of cardiac Erbb4-IR by Erbb4-IR short hairpin RNA (shRNA) gene transfer effectively improved the angiotensin II-induced deterioration of cardiac function, although blood pressure was not altered. Furthermore, silencing cardiac Erbb4-IR also inhibited angiotensin II-induced progressive cardiac fibrosis, as evidenced by reduced collagen I and III, alpha-smooth muscle actin (α-SMA), and fibronectin accumulation. Mechanistically, improved hypertensive cardiac injury by specifically silencing cardiac Erbb4-IR was associated with increased myocardial Smad7 and miR-29b, revealing that Erbb4-IR may target Smad7 and miR-29b to mediate angiotensin II-induced hypertensive cardiac fibrosis. In conclusion, Erbb4-IR is pathogenic in angiotensin II (Ang II)-induced cardiac remodeling, and targeting Erbb4-IR may be a novel therapy for hypertensive cardiovascular diseases.

Published
2023
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