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Background: The centrality of community engagement in disease prevention and health promotion interventions highlights the need to understand the contextual factors that shape participation. Sense of Community (SoC), characterized by feelings of belonging, connection, and interdependence among members of a community, has emerged as a key component of community capacity and is therefore expected to influence engagement outcomes. However, empirical evidence is needed to assess its actual impact on community engagement. Additionally, the literature lacks a broader synthesis of the role and implications of SoC in this context. This study aims to review the empirical literature on SoC in disease prevention and health promotion, with a special focus on its association with community engagement. Methods: A scoping review was conducted following the PRISMA guidelines, searching for empirical studies published between 1974 and 2023 via Scopus, Web of Science, and PubMed. Results: Nineteen studies were included in the review, revealing three key themes: (1) the community to which SoC refers – among intervention participants, within community coalitions, and defined by the place of residence; (2) the interpretation of SoC, either as a generic, intuitive concept or as a theoretically defined construct; (3) the ways in which SoC is studied – as a predictor of engagement but also as an outcome of the interventions. Generic SoC among intervention participants emerged as a positive outcome and a factor contributing to engagement. However, as the scope expanded to encompass broader communities and SoC became more theoretically grounded, these dynamics shifted. SoC related to the place of residence did not exhibit significant improvement after interventions. Broader community-level SoC showed positive associations with engagement among members of community coalitions, but evidence was less consistent among the individuals targeted by interventions. Conclusions: The review highlighted a scarcity of empirical research on SoC despite its recognition as a key component of community capacity. Contextualizing SoC is crucial, as its interpretation significantly influences its role in disease prevention and health promotion interventions. Further research is needed to clarify whether SoC can foster engagement at all community levels, especially among the general population. This is particularly relevant amid the current context of escalating health needs and strained traditional resources, where community engagement is increasingly essential to ensuring the sustainable delivery of disease prevention and health promotion efforts. If SoC can drive widespread engagement, it could play a pivotal role in building more proactive and autonomous health-promoting communities. [ABSTRACT FROM AUTHOR]

Introduction: Preventive care practices are a challenge in community care. This study examined hantavirus preventive practices and their relationship with personal and social factors, lifestyle, and cultural beliefs. Method: An explanatory sequential mixed methods design, guided by Leininger's Theory of Culture Care Diversity and Universality, was used in two phases: (a) a cross-sectional relational design (n = 109) and (b) ethnonursing research (n = 30), in an endemic community in Panama. Univariate and bivariate analyses were used to analyze the quantitative data, whereas the Leininger's analysis model was used to analyze the qualitative data. Results: In the quantitative phase, the most frequent preventive practice was household hygiene, and the least frequent was vector control. Two of the eight preventive practices were associated with personal factors and two were associated with social factors. In the qualitative phase, lifestyle, beliefs, and context were found to influence the adoption of hantavirus preventive practices and help explain the quantitative findings. Discussion: Knowledge and understanding of the social and cultural contexts are essential for hantavirus prevention. [ABSTRACT FROM AUTHOR]

Background: Black race, inadequate health literacy, and poor perceived control are predictors of increased cardiovascular disease (CVD) risk. The purpose of this study was to explore the relationships among race, health literacy, perceived control, and CVD risk while controlling for known risk factors in incarcerated men. Methods: We included data from 349 incarceratedmen to examine race and CVD risk (Framingham Risk Score) using a serial mediation model with health literacy and perceived control using 95%confidence intervals (CIs) from 5000 bootstrap samples. Results: Of the participants (age, 36 ± 10; education, 12 ± 2; bodymass index, 28.3 ± 5.0), 64.2%wereWhite and 35.8%were Black. Black incarcerated men were younger (P = .047) with lower levels of health literacy (P < .001). All 3 indirect effects of race on CVD were significant, whereas the direct effect of race was not. Black incarcerated men had higher levels of CVD risk through health literacy (a1b1 = 0.3571; 95%CI, 0.0948-0.7162) and lower levels of CVD risk through perceived control (a2b2 = -0.1855; 95%CI, -0.4388 to -0.0077). Black incarceratedmen had higher levels of CVD risk through health literacy influenced by perceived control (a1b2d21 = 0.0627; 95% CI, 0.0028-0.1409), indicating that despite the protective effect of higher levels of perceived control in Black incarcerated men, CVD risk remained higher compared with their White counterparts. Conclusion: Future CVD risk reduction interventions in incarcerated men, specifically Black incarcerated men, should include goals of improving health literacy and perceived control as modifiable risk factors. [ABSTRACT FROM AUTHOR]

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The Hajj pilgrimage, one of the largest annual gatherings in the world, presents unique medical challenges due to the convergence of millions of individuals from diverse geographical and cultural backgrounds. This study aims to identify the most prevalent diseases and health disorders encountered during the Hajj season, highlighting the risks posed by overcrowding, environmental conditions, and the physical demands of the pilgrimage. Key findings indicate that respiratory infections, including upper and lower tract infections, are among the most common health issues, exacerbated by close contact among pilgrims. Heat-related disorders, such as heat exhaustion and heatstroke, are prevalent due to extreme temperatures, particularly affecting vulnerable populations. Gastrointestinal disorders, primarily from foodborne illnesses and traveler's diarrhea, also pose significant health risks. Additionally, chronic disease exacerbation, infectious disease outbreaks, injuries from falls and stampedes, dermatological issues, and psychological stress further complicate the health landscape during Hajj. The results underscore the importance of implementing effective public health measures, including vaccination programs, hygiene education, and mental health support, to enhance the safety and well-being of pilgrims. This survey provides valuable insights for health authorities and organizers to improve preparedness and response strategies for future Hajj seasons. [ABSTRACT FROM AUTHOR]

Microbial fermentation is a well-known strategy for enhancing the nutraceutical attributes of foods. Among the fermentation outcomes, bioactive peptides (BAPs), short chains of amino acids resulting from proteolytic activity, are emerging as promising components thanks to their bioactivities. Indeed, BAPs offer numerous health benefits, including antimicrobial, antioxidant, antihypertensive, and anti-inflammatory properties. This review focuses on the production of bioactive peptides during the fermentation process, emphasizing how different microbial strains and fermentation conditions influence the quantity and quality of these peptides. Furthermore, it examines the health benefits of BAPs from fermented foods, highlighting their potential in disease prevention and overall health promotion. Additionally, this review addresses the challenges and future directions in this field. This comprehensive overview underscores the promise of fermented foods as sustainable and potent sources of bioactive peptides, with significant implications for developing functional foods and nutraceuticals. [ABSTRACT FROM AUTHOR]

Background: Although national food guides are designed, ostensibly, to translate scientific evidence with respect to food, dietary patterns, and health, their development has increasingly become a corporate/political process as well as scientific one; often with corporate/political influences overriding science. Our aim was to construct an unbiased, sustainable, evidence-informed Universal Food Guide to serve as a template for countries to develop their unique guides, thereby, provide a valid resource for health professionals, health authorities, and the public. Methods: To address our aim, we conducted an integrative review of multiple evidence-informed sources (e.g., established databases, evidence syntheses, scholarly treatises, and policy documents) related to four areas: 1. Food guides' utility and conflicts of interest; 2. The evidence-based healthiest diet; 3. Constituents of the Universal Food Guide template; and 4. Implications for population health; regulation/governance; environment/climate/planetary health; and ethics. Results: The eating pattern that is healthiest for humans (i.e., most natural, and associated with maximal health across the life cycle; reduced non-communicable disease (NCD) risk; and minimal end-of-life illness) is whole food, low fat, plant-based, especially vegan, with the absence of ultra-processed food. Disparities in national food guide recommendations can be explained by factors other than science, specifically, corporate/political interests reflected in heavily government-subsidized, animal-sourced products; and trends toward dominance of daily consumption of processed/ultra-processed foods. Both trends have well-documented adverse consequences, i.e., NCDs and endangered environmental/planetary health. Commitment to an evidence-informed plant-based eating pattern, particularly vegan, will reduce risks/manifestations of NCDs; inform healthy food and nutrition policy regulation/governance; support sustainable environment/climate and planetary health; and is ethical with respect to 'best' evidence-based practice, and human and animal welfare. Conclusion: The Universal Food Guide that serves as a template for national food guides is both urgent and timely given the well-documented health-harming influences that corporate stakeholders/politicians and advisory committees with conflicts of interest, exert on national food guides. Such influence contributes to the largely-preventable NCDs and environmental issues. Policy makers, health professionals, and the public need unbiased, scientific evidence as informed by the Universal Food Guide, to inform their recommendations and choices. [ABSTRACT FROM AUTHOR]

Social and community service organizations (SCSOs) may be a promising new environment to more successfully reach people with a lower socioeconomic position (SEP) for smoking cessation support. However, studies that investigate clients' perspectives of the suitability of SCSOs as a setting to discuss smoking are scarce. This study aimed to (i) investigate the suitability of smoking cessation support provided by SCSOs, according to people with a low SEP, and (ii) explore their reasons for considering it suitable or unsuitable. Semi-structured interviews were conducted with 19 individuals with a low SEP who smoked regularly (N = 14) or had smoked regularly (N = 5). They have been in contact with SCSOs in a specific neighborhood in Amsterdam. Data were analyzed using a thematic approach. Participants generally considered SCSOs as suitable for providing smoking cessation support, as professionals are involved, build a relationship of trust, and offer personalized and holistic support. SCSOs are located nearby and familiar, they provide support in both group and individual settings and might offer additional supportive (group)activities. A number of participants expressed doubts about the waiting time for support, the fact that the needed support might exceed professionals' expertise, and the lack of aftercare. SCSOs can be an additional opportunity for providing smoking cessation support that aligns with the circumstances of lower SEP people. To harness the potential, smoking cessation could be integrated into education programs and training among professionals could be promoted. Policy changes within and outside SCSOs would be needed. [ABSTRACT FROM AUTHOR]

Long-term fasting (LTF) and caloric restriction (CR) have garnered increasing interest as interventions that may confer numerous health benefits, including improved metabolic health, enhanced cardiovascular function, neuroprotection, and extended longevity. The potential to influence physiological processes such as insulin sensitivity, lipid metabolism, inflammation, oxidative stress, and cellular repair mechanisms makes these interventions promising avenues for both disease prevention and health optimization. This systematic review examines the body of research surrounding LTF and CR, their physiological impacts, the molecular mechanisms driving these changes, and the challenges and risks associated with their long-term application. We also explore future research directions and possible therapeutic applications in the context of aging and age-related diseases. [ABSTRACT FROM AUTHOR]

Human papillomavirus (HPV) and COVID-19 are contagious diseases for which effective vaccines exist. Dental care professionals' involvement in vaccination campaigns for these conditions has been proposed, but there is a lack of understanding of dentists' roles in vaccination, specifically assessing patients' attitudes around dentists as vaccinators for HPV and COVID-19. Using a cross-sectional design and convenience sampling, a 12-item validated survey was distributed to community members to determine perceptions about dentists' roles in vaccination for HPV and COVID-19. Demographic characteristics, vaccination status, knowledge of the diseases, vaccination intentions, and willingness to receive education about, recommendations for, and administration of vaccine from a dentist were assessed. Responses were analyzed using bivariate and multivariate analysis. Of 618 participants, most were vaccinated previously against HPV and COVID-19 (n = 462 [75.6%] and n = 371 [61.0%], respectively). Participants responded more favorably to dentist involvement in educating, discussing, and administering COVID-19 vaccines than HPV vaccines (P <.05). Participants' knowledge of HPV was found to be low compared with that of COVID-19. There were significant differences across demographic groups, with race most frequently associated with differences in responses to COVID-19 and HPV-related questions. Formative data to develop interventions to support dentists' participation in vaccination campaigns are provided. Participants' acceptance of COVID-19 vaccination over HPV vaccination may reflect the public awareness of COVID-19 vs HPV due to daily relevance of this disease, or the lack of knowledge about HPV, particularly its oropharyngeal impacts. The authors provide evidence to support dentists' involvement in vaccine education and distribution, expanding previous literature into evaluation of a new disease context (COVID-19). Lack of knowledge of HPV may affect willingness to receive the HPV vaccine, presenting an opportunity for education. [ABSTRACT FROM AUTHOR]

Aquaculture and the production of aquatic goods are rapidly growing industries in the world. These industries involve the cultivation of various saltwater and freshwater fish as well as shellfish species, and they undergo regular updates in their manufacturing processes. The increasing popularity of aquaculture is driven by the desire to achieve long-term sustainability in food production. However, the intensification of farming techniques can lead to economic losses due to fish mortality, which is often caused by infectious and stressful conditions. To address this challenge, it is crucial to enhance the immune response of fish as part of sustainable intensification and aquaculture management. Recently, there has been growing interest in eco-friendly and natural bioactive solutions as potential alternatives to synthetic compounds used for disease prevention in aquaculture. Medicinal plants, available as whole plants, plant extracts, or synthetic analogues of natural substances known as phytomedicines or phytopharmaceuticals, have shown high efficacy in disease prevention for humans and animals. One such medicinal plant is Saussurea lappa, which is extensively utilized in various forms of medicine for treating multiple diseases. The bioactive chemicals derived from S. lappa exhibit a wide range of biological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer properties, along with immunostimulatory effects. Given the diverse biological activities of S. lappa and its potential to enhance the immune responses of aquatic species, this review focuses on exploring its contributions in this area. By examining the numerous benefits and applications of S. lappa, we aim to shed light on its potential role in improving the immune response of aquatic species. [ABSTRACT FROM AUTHOR]

Over the years, human activity and performance show a normal decline in cognitive and sensorimotor tasks. Objective: To identify physical activity strategies for mild cognitive impairment (MCI) and describe their main predictors during aging. This systematic review identified the outcomes of physical activity strategies used in MCI and described their main predictors during aging. It was conducted using PubMed/MEDLINE, Scopus, LILACS, SPORTDiscus and Embase databases. The risk of bias analysis was adapted from the Cochrane handbook manual scale for experimental studies. Twenty-one studies were qualitatively analyzed, the sample total included 2023 older adults, which revealed the main predictors of MCI to be changes in glycated hemoglobin, brain-derived neurotrophic factor, and vascular endothelial growth factor-induced neovascularization. As a strategy for learning and presynaptic plasticity in the ageing population, the intervention should be conducted in a regular and moderate way, prioritizing memory and executive function with light exercises. Health professionals be aware of the predictors highlighted in this study, as well as the strategies that can be used in clinical practice to enhance the functionality of these individuals, seeking greater social bonding, autonomy and a sense of competence. Future research should be conducted with strong methodological rigor to investigate more predictors and effective strategies to improve the quality of life of this population, since more precise mechanisms on how to introduce changes in the cortical areas of memory, based on strategies with specific characteristics of MCI, are still something to be explored. [ABSTRACT FROM AUTHOR]

Early detection of pre-eclampsia is challenging due to the low sensitivity and specificity of current clinical methods and biomarkers. This study investigates the potential of high-wavenumber FTIR spectroscopy (region between 2800 and 3600 cm−1) as an innovative diagnostic approach capable of providing comprehensive biochemical insights with minimal sample preparation. Blood samples were collected from 33 pregnant women and their corresponding 33 newborns during induction or spontaneous labor. By analyzing the dried blood plasma samples, we identified biomarkers associated with FTIR vibrational modes, including 2853.6 cm−1 (CH2 stretching in lipids), 2873.0 cm−1 (CH3 stretching in lipids and proteins), and 3279.7 cm−1 (O–H stretching related to water and proteins). Machine learning classification revealed 76.3% ± 3.5% sensitivity and 56.1% ± 4.4% specificity in distinguishing between pre-eclamptic and non-pre-eclamptic pregnant women, along with 79.0% ± 3.5% sensitivity and 76.9% ± 6.2% specificity for newborns. The overall accuracy for classifying all pregnant women and newborns was 71.8% ± 2.5%. The results indicate that high-wavenumber FTIR spectroscopy can enhance classification performance when combined with other analytical methods. Our findings suggest that investigating hydrophilic sites may complement plasma analysis in clinical settings. [ABSTRACT FROM AUTHOR]

A telomere is a repetitive DNA sequence located at the end of human chromosomes, and its length shortens with age. Research has demonstrated that estrogen is associated with the aging of various types of cells, including brain, muscle, and bone cells. This study explored the cross-sectional association between estrogen usage and telomere length, utilizing data from the US National Health and Nutrition Examination Survey (NHANES) 1999-2002. The final number of participants included in this study was 491. This study's bivariate Rao-Scott χ2 test revealed a significant association between telomere length and gender (p < 0.01). Females have longer telomeres than males, indicated by a rate ratio of 1.72. A positive relationship between estrogen usage and telomere length was observed among female participants, yielding a rate ratio of 1.44. The mosaic diagram and Pearson residuals confirmed the statistical significance of this difference (p < 0.001). This suggests that estrogen administration may preserve telomeres and contribute to healthy aging. In conjunction with the findings from the literature, this study supports the need for further investigations into the effects of estrogen administration on telomere length. [ABSTRACT FROM AUTHOR]

Several meta-analyses have consistently demonstrated that the consumption of an adequate level of fruit and vegetables (F&V), along with other food groups, is associated with a low risk of all-cause mortality, and, as such, represents one of the major modifiable risk factors related to the growing burden of Non-Communicable Diseases (NCDs). The aim of the present narrative review was to provide an up-to-date analysis of systematic reviews and meta-analyses published in the past five years, dealing with the effects of F&V consumption on human health, focusing on specific pathologies, such as total mortality, cancer, cardiovascular diseases (CVDs), type 2 diabetes, intestinal inflammation, and bone and respiratory illnesses. The results of our evaluation confirmed and consolidated the protective role of F&V consumption against the development of NCDs, especially CVDs. However, the need to corroborate existing evidence and clarify the role of confounding factors by performing additional randomized control trials and adopting more standardized approaches and study designs also emerged. Moreover, evaluating the protective role of fruit and vegetables as separate food categories appeared to be one of the most interesting areas to investigate in the near future. Overall, these outcomes could help in addressing future research to better establish a causal relationship between F&V consumption and human health. [ABSTRACT FROM AUTHOR]

Given the plethora of studies today that focus on the same topic, clinicians and other healthcare professionals increasingly rely on meta-analysis to aid in their evidence-based decision-making. This research method, which combines data from multiple studies to produce a single, more precise estimate of effect size, is invaluable for synthesizing evidence, resolving inconsistencies and guiding clinical practice and public health policies. Especially in disease prevention and control, meta-analysis has emerged as a critical tool. Meta-analysis is particularly valuable in assessing the effectiveness of preventive interventions such as vaccines, lifestyle modifications and screening programs. It provides robust evidence that supports the implementation of effective preventive measures and the discontinuation of ineffective or harmful ones. Furthermore, meta-analysis provides evidence to develop clinical practice guidelines, ensuring patients receive evidence-based treatments. In addition, public health policies aimed at disease prevention and control often rely on evidence from meta-analyses, which provide the data needed to justify and design large-scale public health initiatives. This comprehensive review delves into the role of meta-analysis in disease prevention and control, exploring its advantages, applications, challenges and overall impact on guiding clinical practice and public health policies. Through case studies and an examination of future directions, this paper underscores the pivotal role of meta-analysis in disease prevention and control. [ABSTRACT FROM AUTHOR]

Inflammatory and infectious diseases encompass a wide array of pathologic processes underscored by inflammatory immune dysfunction and infections. They are commonly caused by immuno-toxic lifestyle habits (poor diet, inadequate sleep, lack of exercise) and infectious agents. Management of the disease spectrum is challenging. Immune dysfunction enhances their pathogenesis and clinical symptoms. Hence, immune optimization interventions are useful for their prevention and management. T-cell dysfunction disease mediating models describing inflammatory and infective disease processes underlying inflammatory and infectious diseases exist. However, they do not highlight inflammatory and infective dysfunctional processes underlying the diseases concerning toxin-mediated epigenetic T-cell dysfunction. Online searches were conducted on databases such as Google Scholar, PubMed, Biomed Central, and SciELO. Articles were reviewed using keywords such as Immune optimization/dysfunction, T lymphocyte activation/dysfunction, cytokines, inflammatory/infectious pathogenesis, therapeutic adjunct, and disease prevention. There is a putative T cell toxin-mediated dysfunction disease model for Immune-Mediated Inflammatory Diseases (IMIDs), which may apply to inflammatory and infectious diseases. The putative disease model may highlight the actual inflammatory/infective immune dysfunctional processes underlying T cell disease mediation in inflammatory and infectious diseases. We proposed putative inflammatory and infectious disease models that highlight inflammatory and infectious dysfunctional processes underlying T cell dysfunction disease mediation which may be validated by multi-omic studies. Validation of the putative disease models using inflammatory and infective heart diseases as classic examples should pave the way for a better understanding of the pathogenesis of inflammatory and infectious diseases. Insights from these putative disease models can guide effective interventions. [ABSTRACT FROM AUTHOR]

Sexually transmitted infections (STIs) continue to be a health concern in the United States, particularly in rural settings. Point‐of‐care (POC) STI testing is useful in overcoming access barriers in these settings. The purpose of this project was to implement POC STI testing to increase access to care in rural settings and test the feasibility of this model. Six mobile health clinics were implemented by a nurse‐led team in three rural communities in the Blackbelt region of Alabama utilizing the Binx IO® to test for chlamydia and gonorrhea. Mobile clinic volunteers participated in focus groups to determine provider satisfaction with clinic workflow. The mobile health clinics were a feasible way to increase access to STI testing in rural settings with reported provider and client satisfaction in work flow. [ABSTRACT FROM AUTHOR]

Diabetes mellitus (DM) is a global health challenge that requires advanced strategies for its early detection and prevention. This study evaluates the South Korean population using the Korea National Health and Nutrition Examination Survey (KNHANES) dataset from 2015 to 2021, provided by the Korea Disease Control and Prevention Agency (KDCA), focusing on improving diabetes prediction models. Outlier removal was implemented using Mahalanobis distance (MAH), and feature selection was based on multicollinearity (MC) and reliability analysis (RA). The proposed Extreme Gradient Boosting (XGBoost) model demonstrated exceptional performance, achieving an accuracy of 98.04% (95% CI: 97.89~98.59), an F1-score of 98.24%, and an Area Under the Curve (AUC) of 98.71%, outperforming other state-of-the-art models. The study highlights the significance of rigorous outlier detection and feature selection in enhancing the predictive power of diabetes risk models. Notably, a significant increase in diabetes cases was observed during the COVID-19 pandemic, particularly linked to male sex, older age, rural location, hypertension, and obesity, underscoring the need for enhanced public health strategies for early intervention and targeted prevention. [ABSTRACT FROM AUTHOR]

Abstract Background The centrality of community engagement in disease prevention and health promotion interventions highlights the need to understand the contextual factors that shape participation. Sense of Community (SoC), characterized by feelings of belonging, connection, and interdependence among members of a community, has emerged as a key component of community capacity and is therefore expected to influence engagement outcomes. However, empirical evidence is needed to assess its actual impact on community engagement. Additionally, the literature lacks a broader synthesis of the role and implications of SoC in this context. This study aims to review the empirical literature on SoC in disease prevention and health promotion, with a special focus on its association with community engagement. Methods A scoping review was conducted following the PRISMA guidelines, searching for empirical studies published between 1974 and 2023 via Scopus, Web of Science, and PubMed. Results Nineteen studies were included in the review, revealing three key themes: (1) the community to which SoC refers – among intervention participants, within community coalitions, and defined by the place of residence; (2) the interpretation of SoC, either as a generic, intuitive concept or as a theoretically defined construct; (3) the ways in which SoC is studied – as a predictor of engagement but also as an outcome of the interventions. Generic SoC among intervention participants emerged as a positive outcome and a factor contributing to engagement. However, as the scope expanded to encompass broader communities and SoC became more theoretically grounded, these dynamics shifted. SoC related to the place of residence did not exhibit significant improvement after interventions. Broader community-level SoC showed positive associations with engagement among members of community coalitions, but evidence was less consistent among the individuals targeted by interventions. Conclusions The review highlighted a scarcity of empirical research on SoC despite its recognition as a key component of community capacity. Contextualizing SoC is crucial, as its interpretation significantly influences its role in disease prevention and health promotion interventions. Further research is needed to clarify whether SoC can foster engagement at all community levels, especially among the general population. This is particularly relevant amid the current context of escalating health needs and strained traditional resources, where community engagement is increasingly essential to ensuring the sustainable delivery of disease prevention and health promotion efforts. If SoC can drive widespread engagement, it could play a pivotal role in building more proactive and autonomous health-promoting communities.

Abstract Background Mosquitoes (Diptera: Culicidae) are important arthropod vectors that are responsible for transmitting numerous pathogens of major diseases. Adult mosquito traps help in effective surveillance. In this study, we compared the efficacy of the Biogents® Sentinel (BGS) traps and CO2-baited CDC traps for adult mosquito collection within four sites in India. Results We found that BGS traps collected significantly more Culex quinquefasciatus and Aedes aegypti mosquitoes (85.8% of the total catch) than CDC traps (14.9% of the total catch). We also conducted a follow-up experiment to study the effect of adding CO2 as bait along with the BG lure to determine if it increases the number of mosquitoes collected. The results showed that BGS traps with BG lure + CO2 collected significantly more mosquitoes (69.5% of the total catch) than BGS traps with BG lure only (30.5% of the total catch). Although BGS traps were developed for surveillance of Ae. albopictus (Skuse) and Ae. aegypti (L.), the traps collected more Cx. quinquefasciatus (Say.) than any other mosquito species. Conclusion BGS trap is an efficient surveillance tool, and it can be used as part of an integrated mosquito management program by public health officials in order to combat mosquito-borne diseases.

Abstract Background Although national food guides are designed, ostensibly, to translate scientific evidence with respect to food, dietary patterns, and health, their development has increasingly become a corporate/political process as well as scientific one; often with corporate/political influences overriding science. Our aim was to construct an unbiased, sustainable, evidence-informed Universal Food Guide to serve as a template for countries to develop their unique guides, thereby, provide a valid resource for health professionals, health authorities, and the public. Methods To address our aim, we conducted an integrative review of multiple evidence-informed sources (e.g., established databases, evidence syntheses, scholarly treatises, and policy documents) related to four areas: 1. Food guides’ utility and conflicts of interest; 2. The evidence-based healthiest diet; 3. Constituents of the Universal Food Guide template; and 4. Implications for population health; regulation/governance; environment/climate/planetary health; and ethics. Results The eating pattern that is healthiest for humans (i.e., most natural, and associated with maximal health across the life cycle; reduced non-communicable disease (NCD) risk; and minimal end-of-life illness) is whole food, low fat, plant-based, especially vegan, with the absence of ultra-processed food. Disparities in national food guide recommendations can be explained by factors other than science, specifically, corporate/political interests reflected in heavily government-subsidized, animal-sourced products; and trends toward dominance of daily consumption of processed/ultra-processed foods. Both trends have well-documented adverse consequences, i.e., NCDs and endangered environmental/planetary health. Commitment to an evidence-informed plant-based eating pattern, particularly vegan, will reduce risks/manifestations of NCDs; inform healthy food and nutrition policy regulation/governance; support sustainable environment/climate and planetary health; and is ethical with respect to ‘best’ evidence-based practice, and human and animal welfare. Conclusion The Universal Food Guide that serves as a template for national food guides is both urgent and timely given the well-documented health-harming influences that corporate stakeholders/politicians and advisory committees with conflicts of interest, exert on national food guides. Such influence contributes to the largely-preventable NCDs and environmental issues. Policy makers, health professionals, and the public need unbiased, scientific evidence as informed by the Universal Food Guide, to inform their recommendations and choices.

The aquaculture industry is suffering from significant financial setbacks due to an increasing frequency of disease outbreaks, posing a threat to the sector's sustainability. Various bacterial, viral, parasitic, and fungal pathogens have led to massive mortalities in farmed fish worldwide. Throughout the years, the management of fish diseases has predominantly centered around the utilization of conventional antibiotics and chemicals. Nevertheless, their indiscriminate use has given rise to serious implications, including an increase in resistant pathogens, disruptions in the metabolic processes of fish, degradation of the aquatic environment, the presence of drug residues in aquatic products, and a potential threat to human health. Various effective bio-based and immunoprophylaxis alternative therapies have been developed to overcome these impediments. Recent alternative therapeutic approaches to fish diseases encompass a range of strategies, including phytotherapeutics, nanotherapeutics, probiotics, prebiotics, synbiotics, phage therapy, vaccination, quorum quenching, antimicrobial peptides, biosurfactants, bacteriocins, stem cells, and diagnostic-based therapy. Advancements in biotechnology have significantly enhanced the efficacy of these therapies. However, additional research is essential to refine the utilization of these therapeutic approaches. Critical concerns, such as efficacy, cost, risks, availability, and adverse effects on fish and the ecosystem, need to be addressed to establish guidelines for their sustainable application in aquaculture. This review will increase aquaculturists' awareness of recent therapies used in fish farming, their mechanisms, challenges, and impacts while promoting the sustainability of commercial aquaculture. [ABSTRACT FROM AUTHOR]

Biosecurity plans are crucial for preventing economic and environmental impacts caused by disease outbreaks in aquaculture. These plans focus on prevention, early detection, and effective control measures. With the global threat of emerging infectious diseases and the need for sustainable production practices, the importance of biosecurity continues to grow. Scientometric analysis is a valuable tool for assessing the impact and influence of scientific research within a particular field or discipline. Scientometric analysis of aquaculture biosecurity publications reveals significant activity in the field, with the highest number of publications recorded in 2021. Cottier-Cook EJ emerged as the most prolific author, while USA and the Centre for Environment Fisheries Aquaculture Science were identified as leading contributors. Physical biosecurity measures prevent the entry of pathogens and wild fish into aquaculture systems. Biological biosecurity measures enhance immunity and reduce disease risks. Operational biosecurity measures, such as feed management and hygiene protocols, maintain animal health. Innovative technologies such as sensors and artificial intelligence improve biosecurity efficiency. Effective management of disease outbreaks requires coordination, risk assessment, and established response plans. Aquaculture biosecurity offers benefits such as disease prevention, environmental protection, and food safety, but may have disadvantages including costs and negative environmental impacts. The industry should focus on implementing effective and sustainable biosecurity measures, improving disease prevention, reducing environmental impact, and ensuring product safety and quality. [ABSTRACT FROM AUTHOR]

Background: Alcohol use and abuse remain prevalent in China, though mounting evidence shows that even drinking in moderation is detrimental to health. While many countries' intake is on the decline, China's alcohol consumption is rising fast and is on the path to overtaking countries like the United States, even on a per capita level. Objectives: This paper aims to analyze the danger of lax enforcement of laws and regulations against alcohol use and abuse and underscores the imperative for effective health interventions to curb problematic alcohol consumption in China. Results: Different from their Western counterparts, Chinese drinkers often consume more spirit with a high percentage of alcohol in social settings that encourage the "ganbei culture"—making toasts with alcohol filled to the brim and downed in one go to show respect—which perpetuates excessive drinking at a fast pace. Though the country has various laws and regulations in place to curb problematic alcohol consumption, like workplace drinking, their impacts are dismal. Considering that China has 1.4 billion people, the country's uncurbed alcohol consumption trend could have a detrimental effect on national strategic objectives like "Healthy China 2030" and international ones like the Sustainable Development Goals. To further compound the situation, prevalent campaigns promoted by liquor companies—like alcohol-infused coffee, chocolate, and ice cream—may groom young people to develop alcohol consumption habits, if not addictions, for generations to come. Conclusions: We developed the Framework of 5Vs of China's "Ganbei Culture to shed light on the issue, with the hope that it, along with the overarching insights of this paper, can assist health professionals and policymakers in better guarding and improving public health against the harms of alcohol use and abuse in China and beyond. [ABSTRACT FROM AUTHOR]

Yan Wu,1 Zhenzhen Xu,2 Jing Dong,3 Wenzhong Zhang,2 Jing Li,2 Hong Ji1 1Department of Nursing, The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan, Shandong, 250014, People’s Republic of China; 2School of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250014, People’s Republic of China; 3School of Nursing, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong Province, 271016, People’s Republic of ChinaCorrespondence: Hong Ji, Department of Nursing, The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan, Shandong, 250014, People’s Republic of China, Tel +86-13791120369, Email honghongji-2005@163.comBackground: Older age and female sex are risk factors for osteoarthritis and osteoporosis (OP). This study evaluated the knowledge, attitudes, and practices of patients with knee osteoarthritis (KOA) in China regarding OP and its prevention. This cross-sectional, questionnaire-based study enrolled patients with KOA at four grade-A tertiary hospitals in Shandong Province between 1st September and 20th November 2022.Methods: The administered questionnaire contained 55 items across four dimensions (demographic information, knowledge, attitude, and practice). Logistic regression analyses were performed to identify factors associated with an overall questionnaire score ≥ 70% of the maximum possible score. SPSS 26.0 was used for the analyses; P< 0.05 was considered significant.Results: The analysis included 434 participants (261 females). The median knowledge, attitude, and practice scores were 7 (interquartile range: 5– 10) (possible range, 0– 17 points), 44 (interquartile range: 42– 49) (possible range, 11– 55 points), and 43 (interquartile range: 38– 47) (possible range, 13– 65 points), respectively. Multivariable logistic regression indicated that female sex (odds ratio [OR], 2.421; 95% confidence interval [95% CI] 1.558– 3.762; P< 0.001), age 56– 65 years-old (OR, 4.222; 95% CI, 1.763– 10.109; P=0.001 vs ≤ 55 years-old), age > 65 years-old (OR, 4.358; 95% CI, 1.863– 10.195; P=0.001 vs ≤ 55 years-old), middle/high/technical secondary school education (OR, 1.853; 95% CI, 1.002– 3.428; P=0.049 vs primary school or below), and having KOA for 4– 5 years (OR, 2.682; 95% CI, 1.412– 5.094; P=0.003 vs ≤ 3 years) were independently associated with a high KAP score.Conclusion: There is room for improvement in the knowledge and practices of patients with osteoarthritis in China regarding OP. The findings of this study may facilitate the design and implementation of education programs to increase awareness about OP prevention among patients with KOA.Keywords: osteoarthritis of the knee, osteoporosis, disease prevention, surveys and questionnaires, health knowledge, attitudes, practice

Abstract Background Previne Brasil is a new way of financing Primary Health Care (PHC) in Brazil that places users of public health services at the center of the system’s analysis and attention through the use of seven performance indicators. This study aims to analyze the performance of Primary Health Care in Brazil under the new financing model (Previne Brasil) in the period from the first four months of 2022 to the first four months of 2023. Methods This is a territorial ecological study using secondary data from the Primary Care Health Information System (SISAB). Seven performance indicators were included and analyzed according to Brazil, its regions, states and capitals. A comparative descriptive analysis was carried out between the spatial units. Results Of the seven indicators analyzed, only one (Proportion of pregnant women tested for syphilis and HIV) reached the proposed target considering the average of the four-month periods evaluated (target: 60%; Observed: 62.5%). The Northeast was the region with the best performance, surpassing the target in three of the seven indicators (prenatal consultations, tests for syphilis and HIV in pregnant women and dental care for pregnant women). The states and capitals showed progressive improvement in the performance indicators over the four quarters analyzed, although unevenly between the indicators. The indicators related to hypertension and diabetes were the worst. The Final Synthetic Indicator (FSI) showed an increase in the median over the four quarters (4.78; 5.65; 6.02 6.29), which represents an increase of 1.51 in the indicator between the first four months of 2022 and the first four months of 2023. Conclusion Although there have been improvements in the performance of Primary Health Care in Brazil, the achievement of the agreed targets for the indicators seems a long way off. The socio-spatial inequalities in the indicators reflect the country’s health complexity and reinforce the need for policies that take into account the local-regional context.

Abstract Background Breast and cervical cancer are major public health issues globally. The reduction in incidence and mortality rates of these cancers is linked to effective prevention, early detection, and appropriate treatment measures. This study aims to analyze the temporal trends in the prevalence of mammography and Papanicolaou test coverage among women living in Brazilian state capitals between 2007 and 2023, and to compare the coverage of these tests before and during the Covid-19 pandemic. Methods A time series study was conducted using data from the Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey from 2007 to 2023. The variables analyzed included mammography and Papanicolaou test coverage according to education level, age group, race/skin color, regions, and Brazilian capitals. The Prais-Winsten regression model was used to analyze the time series, and Student’s t-test was employed to compare the prevalence rates between 2019 and 2023. Results Between 2007 and 2023, mammography coverage showed a stationary trend (71.1% in 2007 and 73.1% in 2023; p-value = 0.75) with a declining trend observed among women with 12 years or more of education (APC= -0.52% 95%CI -1.01%; -0.02%). Papanicolaou test coverage for all women aged between 25 and 64 exhibited a downward trend from 82% in 2007 to 76.8% in 2023 (APC= -0.45% 95%CI -0.76%; -0.13%). This decline was also noticed among those with 9 years or more of education; in the 25 to 44 age group; among women with white and mixed race; and in the Northeast, Central-West, Southeast, and South regions. When comparing coverage before and during Covid-19 pandemic, a reduction was noted for both tests. Conclusions Over the years, there has been stability in mammography coverage and a decline in Papanicolaou test. The COVID-19 pandemic negatively impacted the number of these tests carried out among women, highlighting the importance of actions aimed at increasing coverage, especially among the most vulnerable groups.

The potential for being able to identify individuals at high disease risk solely based on genotype data has garnered significant interest. Although widely applied, traditional polygenic risk scoring methods fall short, as they are built on additive models that fail to capture the intricate associations among single nucleotide polymorphisms (SNPs). This presents a limitation, as genetic diseases often arise from complex interactions between multiple SNPs. To address this challenge, we developed DeepRisk, a biological knowledge-driven deep learning method for modeling these complex, nonlinear associations among SNPs, to provide a more effective method for scoring the risk of common diseases with genome-wide genotype data. Evaluations demonstrated that DeepRisk outperforms existing PRS-based methods in identifying individuals at high risk for four common diseases: Alzheimer's disease, inflammatory bowel disease, type 2 diabetes, and breast cancer.

ABSTRACT: The objective of this review was to outline current implementation of biosecurity, the impact of biosecurity on the industry, and producers' and veterinarians' perceptions of biosecurity, with a focus on the Canadian dairy industry. Biosecurity has an important role in farm safety by reducing the spread of pathogens and contaminants, improving animal health and production, and maintaining human safety. Implementation of biosecurity practices varies among farms and countries. Because Canada's supply management system is different than other countries, different barriers and perceptions of biosecurity may exist. Producers may have negative perspectives on biosecurity, such as it being expensive or time consuming. Producers are motivated or deterred from biosecurity implementation for many reasons, including perceived value, disease risk, and financial incentives or deterrents. In addition, because veterinarians are a trusted source of information, their approaches to discussions on biosecurity implementation are important to understand. Veterinarians and producers appear to have differing opinions on the importance of biosecurity and approaches to discussing biosecurity. Improving biosecurity implementation requires a multifactorial approach, such as individualized education and awareness for producers, further research into efficacy of and barriers to biosecurity, and development of strategies for effective communication between veterinarians and producers.

Abstract African swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by African swine fever virus (ASFV). The mortality rate associated with ASF is remarkably high, almost approaching 100%. Since the introduction of ASF into China in 2018, its rapid spread has caused marked economic losses in the country’s swine industry. To date, there are no safe and effective commercial vaccines or antiviral drugs against ASF; thus, there is an urgent need to develop novel prevention and control strategies. Traditional Chinese medicine (TCM), which comprises various herbs that are abundant in various potential functional components, holds great promise for the prevention and control of ASF. Here, we provide a comprehensive review of the advancements in TCM and the effects of its compound formulas against ASF, including the antiviral abilities, immunoregulatory activities, and practical application of these formulas for the prevention and control of ASF. We specifically examined the potential and constraints of natural product-derived extracts and TCM formulas in combating ASFV. This review aims to offer insights and ideas for the holistic management and containment of ASF.

AbstractNanotechnology has emerged as a pivotal force in biomedical research, offering groundbreaking solutions for disease treatment and prevention through the integration of nanoscience with biology. This review explores the multifaceted applications of nano-bio interfaces in revolutionizing therapeutic interventions and public health strategies. At the forefront of innovation, nanomaterial-based drug delivery systems demonstrate unparalleled precision and efficacy in targeted drug delivery, minimizing systemic toxicity and maximizing therapeutic outcomes. Furthermore, the development of multifunctional nanoparticles capable of simultaneous drug delivery and diagnostic imaging enables real-time monitoring of treatment responses, heralding a new era of personalized medicine. Nano-bio interfaces also play a crucial role in advancing vaccine development and immunotherapies, with nanoparticle-based vaccine platforms offering enhanced antigen delivery and immune stimulation for robust and durable immune responses against infectious diseases and cancer. In the realm of disease prevention, antimicrobial nanomaterials provide effective strategies for infection control, while nanovaccines and prophylactic drug delivery systems offer tailored solutions for mitigating the spread of infectious agents. Through a comprehensive exploration of these pioneering approaches, this review, we believe, highlights the transformative potential of nano-bio interfaces in reshaping the landscape of disease treatment and prevention. [ABSTRACT FROM AUTHOR]

Background: Previne Brasil is a new way of financing Primary Health Care (PHC) in Brazil that places users of public health services at the center of the system's analysis and attention through the use of seven performance indicators. This study aims to analyze the performance of Primary Health Care in Brazil under the new financing model (Previne Brasil) in the period from the first four months of 2022 to the first four months of 2023. Methods: This is a territorial ecological study using secondary data from the Primary Care Health Information System (SISAB). Seven performance indicators were included and analyzed according to Brazil, its regions, states and capitals. A comparative descriptive analysis was carried out between the spatial units. Results: Of the seven indicators analyzed, only one (Proportion of pregnant women tested for syphilis and HIV) reached the proposed target considering the average of the four-month periods evaluated (target: 60%; Observed: 62.5%). The Northeast was the region with the best performance, surpassing the target in three of the seven indicators (prenatal consultations, tests for syphilis and HIV in pregnant women and dental care for pregnant women). The states and capitals showed progressive improvement in the performance indicators over the four quarters analyzed, although unevenly between the indicators. The indicators related to hypertension and diabetes were the worst. The Final Synthetic Indicator (FSI) showed an increase in the median over the four quarters (4.78; 5.65; 6.02 6.29), which represents an increase of 1.51 in the indicator between the first four months of 2022 and the first four months of 2023. Conclusion: Although there have been improvements in the performance of Primary Health Care in Brazil, the achievement of the agreed targets for the indicators seems a long way off. The socio-spatial inequalities in the indicators reflect the country's health complexity and reinforce the need for policies that take into account the local-regional context. [ABSTRACT FROM AUTHOR]

The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. Implementing biosecurity protocols is necessary to reduce the spread of disease on dairy farms. In Ontario biosecurity implementation is variable among farms, and the barriers to implementing biosecurity are unknown. Thirty-five semistructured interviews were conducted between July 2022 and January 2023 with dairy producers (n = 17) and veterinarians (n = 18). Participants also completed a demographic survey. Thematic analysis was performed with constructivist and grounded theory paradigms. Thematic coding was done inductively using NVivo software. Dairy producers' understanding of the definition of biosecurity varied, with all understanding that it was to prevent the spread of disease. Furthermore, the most common perception was that biosecurity prevented the spread of disease onto the farm. Both veterinarians and producers stated that closed herds were one of the most important biosecurity protocols. Barriers to biosecurity implementation included a lack of resources, internal and external business influencers, individual perceptions of biosecurity, and a lack of industry initiative. Understanding the barriers producers face provides veterinarians with the chance to tailor their communication to ensure barriers are reduced or for other industry members to reduce the barriers. [ABSTRACT FROM AUTHOR]

Advancements in vaccination technologies mitigate disease transmission risks but may inadvertently suppress the behavioral immune system, an evolved disease avoidance mechanism. Applying behavioral immune system theory and utilizing robust big data analytics, we examined associations between rising vaccination coverage and government policies, public mobility, and online information seeking regarding disease precautions. We tested whether cultural tightness–looseness moderates the relationship between mass immunization and disease prevention vigilance. Comprehensive time series analyses were conducted using American data (Study 1) and international data (Study 2), employing transfer function modeling, cross‐correlation function analysis, and meta‐regression analysis. Across both the US and global analyses, as vaccination rates rose over time, government COVID‐19 restrictions significantly relaxed, community mobility increased, and online searches for prevention information declined. The relationship between higher vaccination rates and lower disease prevention vigilance was stronger in culturally looser contexts. Results provide initial evidence that mass immunization may be associated with attenuated sensitivity and enhanced flexibility of disease avoidance psychology and actions. However, cultural tightness–looseness significantly moderates this relationship, with tighter cultures displaying sustained vigilance amidst immunization upticks. These findings offer valuable perspectives to inform nuanced policymaking and public health strategies that balance prudent precautions against undue alarm when expanding vaccine coverage worldwide. [ABSTRACT FROM AUTHOR]

Fire blight disease, caused by Erwinia amylovora is present worldwide and affects over 40 countries in Europe where it is listed as a quarantine or regulated pest often due to ineffective control strategies maladapted to the respective production systems. In Portugal, the disease was confirmed in 2010 and the occurrence of disease outbreaks in new production areas has risen over the years. The disease affects the national production of apple and pear fruits, with greater impact on the national pear variety 'Rocha', widely exported to European countries and Brazil. The mild temperatures and high relative humidity promote the progression of the disease during winter, revealing the potential activity of the bacterium in the latency period (LP) of the host. Infection alert risk using the established predictive models Maryblight TM, Cougarblight and BIS98 was put in place in 2013 by Centro Operativo e Tecnológico Hortofrutícola Nacional (COTHN). These attempts to control the spread of this disease, showed low accuracy for the Portuguese epidemiological reality. Within the framework of project Fire4CAST we developed a new epidemiological model to predict fire blight disease using a systems biology approach integrating microbiological, cytological and genomic pathogen data with phenological host development and climatic variables. The presence of E. amylovora was monitored in orchards with fire blight history using standard laboratory tests. Simultaneously, the implementation of immune-flow cytometry (IFCM) highlighted the viability of E. amylovora populations prevailing during winter and early spring, long before bloom risk period. The integration of the whole data set allowed the development of the Fire4CAST predictive model, able to monitor the expected infection date (EID) and to define accurate outbreak alarms. Fire4CAST model enabled the detection of outbreak risk during winter based on rules that consider climatic data variables, which were validated by effective presence of live and active E. amylovora populations and real-time quantitative PCR (qPCR) data, accomplishing a precision rate of 83%. Field application of Fire4CAST can hopefully guide the implementation of successful control strategies, leading to more sustainable pome chain production areas. [ABSTRACT FROM AUTHOR]

Pharmaceutical drugs, including vaccines, pre- and post-exposure prophylactics, and chronic drug therapies, are crucial tools in the prevention and treatment of infectious diseases. These drugs have the ability to increase survival and improve patient quality of life; however, infectious diseases still accounted for more than 10.2 million deaths in 2019 before the COVID-19 pandemic. High mortality can be, in part, attributed to challenges in the availability of adequate drugs and vaccines, limited accessibility, poor drug bioavailability, the high cost of some treatments, and low patient adherence. A majority of these factors are logistical rather than technical challenges, providing an opportunity for existing drugs and vaccines to be improved through formulation. Injectable controlled-release drug delivery systems are one class of formulations that have the potential to overcome many of these limitations by releasing their contents in a sustained manner to reduce the need for frequent readministration and improve clinical outcomes. This review provides an overview of injectable controlled drug delivery platforms, including microparticles, nanoparticles, and injectable gels, detailing recent developments using these systems for singleinjection vaccination, long-acting prophylaxis, and sustained-release treatments for infectious disease. [ABSTRACT FROM AUTHOR]

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Breast and cervical cancer are major public health issues globally. The reduction in incidence and mortality rates of these cancers is linked to effective prevention, early detection, and appropriate treatment measures. This study aims to analyze the temporal trends in the prevalence of mammography and Papanicolaou test coverage among women living in Brazilian state capitals between 2007 and 2023, and to compare the coverage of these tests before and during the Covid-19 pandemic. Methods: A time series study was conducted using data from the Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey from 2007 to 2023. The variables analyzed included mammography and Papanicolaou test coverage according to education level, age group, race/skin color, regions, and Brazilian capitals. The Prais-Winsten regression model was used to analyze the time series, and Student's t-test was employed to compare the prevalence rates between 2019 and 2023. Results: Between 2007 and 2023, mammography coverage showed a stationary trend (71.1% in 2007 and 73.1% in 2023; p-value = 0.75) with a declining trend observed among women with 12 years or more of education (APC= -0.52% 95%CI -1.01%; -0.02%). Papanicolaou test coverage for all women aged between 25 and 64 exhibited a downward trend from 82% in 2007 to 76.8% in 2023 (APC= -0.45% 95%CI -0.76%; -0.13%). This decline was also noticed among those with 9 years or more of education; in the 25 to 44 age group; among women with white and mixed race; and in the Northeast, Central-West, Southeast, and South regions. When comparing coverage before and during Covid-19 pandemic, a reduction was noted for both tests. Conclusions: Over the years, there has been stability in mammography coverage and a decline in Papanicolaou test. The COVID-19 pandemic negatively impacted the number of these tests carried out among women, highlighting the importance of actions aimed at increasing coverage, especially among the most vulnerable groups. [ABSTRACT FROM AUTHOR]

Simple Summary: Biosecurity measures are necessary to the development of a family alpine farming system. In this study, good practices and areas of improvement have been investigated. In particular, practices related to quarantine, cleaning, waste milk feeding to calves, immunization, and diagnostics could be improved to implement optimal biosecurity measures. Farmers confirm that they are willing to adopt effective preventive measures under the recommendation of the veterinarian, and this attitude may be crucial to designing multisectoral participatory activities and strategies. Further investigations and the development of customized applications and digital toolkits are now required to better understand farmers' drivers toward biosecurity and to provide support. Background: Biosecurity measures are essential to improve animal health and welfare, tackle antimicrobial resistance (AMR), minimize the burden of infectious diseases, and enhance the safety, security, and quality of sustainable agricultural products. However, the implementation of these measures in small mountain farms can be influenced by several factors, which probably differ from the main variables that affect intensive farming systems. Methods: This study investigated the awareness among farmers regarding the implementation of biosecurity measures at the local level in small dairy farms located in the Autonomous Province of Bolzano/Bozen (Italy). In order to determine to what extent these measures are in line with the recommendations, a questionnaire was conceptualized and sent by post to a representative group of local farmers. The initiative was voluntary and anonymous. Results: A total of 50 farmers responded to the questionnaire, resulting in a response rate of 27.5%. This study confirms that most of the farmers are familiar with biosecurity, and 38% of them know its comprehensive definition. The results indicate that 77% of respondents are willing to implement preventive measures to reduce the use of antimicrobials, and 76% of them acknowledge that they would follow the recommendations provided by veterinarians. In agreement with other studies, the role of the veterinarian as a person of trust among farmers is confirmed. Conclusions: Main strengths and areas of improvement have been identified. Additional data and effective tools are needed to better investigate drivers toward biosecurity and to implement impactful and practical measures for mountain farming. [ABSTRACT FROM AUTHOR]

Monkeypox is a rare disease caused by the monkeypox virus (MPXV). This virus can enter the host through different routes, such as the oropharynx, nasopharynx and intradermal routes, among others. In 2022, an outbreak was reported in which the virus seemed to have mutations that would make it spread more efficiently. We present three cases of monkeypox in a family of eight members. Patient 1, a 32-year-old man, presented with a papule under the left eye, which was hatched manually by his wife. He then developed endophthalmitis associated with fever and headache, in addition to nonpainful vesicular pruritic lesions on the extremities and genitalia. He was eventually clinically diagnosed with monkeypox infection. Patient 2, a 27-year-old woman (wife of patient 1), presented with vesicular and pustular lesions on the chest, extremities and anal area six days after exposure through close contact with patient 1. She subsequently developed myalgia, fever and odynophagia, with a positive molecular test result for MPXV. Patient 3, an 8-year-old boy, presented with odynophagia, tinnitus, fever, cervical lymphadenopathy, and umbilicated papules on the abdomen, left arm, and right buttock seven days after the onset of symptoms in his mother (patient 2). He also tested positive for MPXV on a molecular test. The other family members did not present clinical manifestations despite being in intrafamilial contact with the patients for approximately two weeks, during which they shared common areas and utensils without restrictions. [ABSTRACT FROM AUTHOR]

Introduction: The distressing rate of critical illnesses in Malaysia was contributed by the nation's low level of health literacy where many Malaysians failed to well-manage their illness as they are incompetent in communicating the health conditions to obtain the necessary medical services. This study was conducted cross-sectionally to determine the relationship and effects of health literacy, encompassed of health care, disease prevention and health promotion domains towards health communication competence among low-wage workers in Kelantan, Malaysia. Materials and methods:: Quota sampling was applied in selecting the targeted respondents from three districts of Machang, Kota Bharu and Bachok. 150 samples, encompassing gardeners and janitors were conveniently selected as the study's respondents. A set of questionnaires was used as the instrument and was physically distributed to the respondents. Results: The results from the descriptive analysis showed that more low-wage workers in urban areas possessed adequate level of health literacy and good level of health communication competence in comparison to those in sub-urban area. Meanwhile, the correlational analysis findings showed the overall and domains of health literacy were positively and strongly correlated to health communication competence. The results of multiple regression analysis have also revealed that every domain of health literacy had significant effects towards low-wage workers' health communication competence, with health promotion as the strongest predictor. Conclusion: Health literacy was found to be significantly, positively and strongly associated to health communication competence among lowwage workers in Kelantan, Malaysia. This study has highlighted the significance of health literacy in developing health communication competence in which those who work in sub-urban areas need to particularly be prioritized. Accordingly, this study suggests the health departments to organize various health promotion and education programs for the society to enhance their awareness on health literacy. [ABSTRACT FROM AUTHOR]

The objective of this review was to outline current implementation of biosecurity, the impact of biosecurity on the industry, and producers' and veterinarians' perceptions of biosecurity, with a focus on the Canadian dairy industry. Biosecurity has an important role in farm safety by reducing the spread of pathogens and contaminants, improving animal health and production, and maintaining human safety. Implementation of biosecurity practices varies among farms and countries. Because Canada's supply management system is different than other countries, different barriers and perceptions of biosecurity may exist. Producers may have negative perspectives on biosecurity, such as it being expensive or time consuming. Producers are motivated or deterred from biosecurity implementation for many reasons, including perceived value, disease risk, and financial incentives or deterrents. In addition, because veterinarians are a trusted source of information, their approaches to discussions on biosecurity implementation are important to understand. Veterinarians and producers appear to have differing opinions on the importance of biosecurity and approaches to discussing biosecurity. Improving biosecurity implementation requires a multifactorial approach, such as individualized education and awareness for producers, further research into efficacy of and barriers to biosecurity, and development of strategies for effective communication between veterinarians and producers. [ABSTRACT FROM AUTHOR]

Aims This study aimed to assess the effects of chlorine dioxide (ClO2) in water on whiteleg shrimp Penaeus vannamei , evaluating its impact on the stomach microbiota, gill transcriptome, and pathogens. Methods and results ClO2 was added to the aquarium tanks containing the shrimp. The application of ClO2 to rearing water was lethal to shrimp at concentrations above 1.2 ppm. On the other hand, most of the shrimp survived at 1.0 ppm of ClO2. Microbiome analysis showed that ClO2 administration at 1.0 ppm significantly reduced the α-diversity of bacterial community composition in the shrimp stomach, and this condition persisted for at least 7 days. Transcriptome analysis of shrimp gill revealed that ClO2 treatment caused massive change of the gene expression profile, including stress response genes. However, after 7 days of the treatment, the gene expression profile was similar to that of shrimp in the untreated control group, suggesting a recovery to the normal state. This 1.0-ppm ClO2 significantly reduced shrimp mortality in artificial challenges with an acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus and white spot syndrome virus, which were added to rearing water. Conclusions The use of ClO2 at appropriate concentrations effectively eliminates a significant portion of the bacteria in the shrimp stomach and pathogens in the water. The results of this study provide fundamental knowledge on the disinfection of pathogens in water using ClO2 and the creation of semi germ-free shrimp, which has significantly decreased microbiome in the stomach. [ABSTRACT FROM AUTHOR]

Background: High BMI (Body Mass Index) is a significant factor impacting health, with a clear link to an increased risk of leukemia. Research on this topic is limited. Understanding the epidemiological trends of leukemia attributable to high BMI risk is crucial for disease prevention and patient support. Methods: We obtained the data from the Global Burden of Disease Study, analyzing the ASR (age-standardized rates), including ASDR (age-standardized death rate) and age-standardized disability-adjusted life years (DALYs) rate, and estimated annual percentage change (EAPC) by gender, age, country, and region from 1990 to 2019. Results: In 2019, deaths and DALYs have significantly increased to 21.73 thousand and 584.09 thousand. The global age-standardized death and DALYs rates have slightly increased over the past 30 years (EAPCs: 0.34 and 0.29). Among four common leukemia subtypes, only CML (Chronic Myeloid Leukemia) exhibited a significant decrease in ASDR and age-standardized DALYs rate, with EAPC of -1.74 and -1.52. AML (Acute Myeloid Leukemia) showed the most pronounced upward trend in ASDR, with an EAPC of 1.34. These trends vary by gender, age, region, and national economic status. Older people have been at a significantly greater risk. Females globally have borne a higher burden. While males have shown an increasing trend. The regions experiencing the greatest growth in ASR were South Asia. The countries with the largest increases were Equatorial Guinea. However, It is worth noting that there may be variations among specific subtypes of leukemia. Regions with high Socio-demographic Index (SDI) have had the highest ASR, while low-middle SDI regions have shown the greatest increase in these rates. All ASRs values have been positively correlated with SDI, but there has been a turning point in medium to high SDI regions. Conclusions: Leukemia attributable to high BMI risk is gradually becoming a heavier burden globally. Different subtypes of leukemia have distinct temporal and regional patterns. This study's findings will provide information for analyzing the worldwide disease burden patterns and serve as a basis for disease prevention, developing suitable strategies for the modifiable risk factor. [ABSTRACT FROM AUTHOR]

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aging represents a key risk factor for a plethora of diseases. Targeting detrimental processes which occur during aging, especially before onset of age-related disease, could provide drastic improvements in healthspan. There is increasing evidence that dietary restriction (DR), including caloric restriction, fasting, or fasting-mimicking diets, extend both lifespan and healthspan. This has sparked interest in the use of dietary regimens as a non-pharmacological means to slow aging and prevent disease. Here, we review the current evidence on the molecular mechanisms underlying DR-induced health improvements, including removal of senescent cells, metabolic reprogramming, and epigenetic rejuvenation. [ABSTRACT FROM AUTHOR]

African swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by African swine fever virus (ASFV). The mortality rate associated with ASF is remarkably high, almost approaching 100%. Since the introduction of ASF into China in 2018, its rapid spread has caused marked economic losses in the country's swine industry. To date, there are no safe and effective commercial vaccines or antiviral drugs against ASF; thus, there is an urgent need to develop novel prevention and control strategies. Traditional Chinese medicine (TCM), which comprises various herbs that are abundant in various potential functional components, holds great promise for the prevention and control of ASF. Here, we provide a comprehensive review of the advancements in TCM and the effects of its compound formulas against ASF, including the antiviral abilities, immunoregulatory activities, and practical application of these formulas for the prevention and control of ASF. We specifically examined the potential and constraints of natural product-derived extracts and TCM formulas in combating ASFV. This review aims to offer insights and ideas for the holistic management and containment of ASF. [ABSTRACT FROM AUTHOR]