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Introduction: Psoriasis is a chronic inflammation of the skin-immune system characterized by arterial erythematous plaques. Carotid artery intima measurement can be a tool for early detection of atherosclerosis in the preocclusion stage and has clinical signs. Material and Methods: This case-control study was performed on 30 patients with psoriasis and 30 control people aged 20 to 60 years who referred to the dermatology clinic at 22 Bahman Hospital in Mashhad during 2018-2019, sampling was performed by available method. After explaining the research process and obtaining patients informed concept, data was recorded in the checklist. Radiologist colleague of this study using ultrasound for a Carotid-Intima Media Thickness (CIMT) measurement. In this study of SPSS16 and statistical tests of Anova, Man Whitney, and Pearson were used to analyze the data. Results: CIMT was found in patients and the control group at 0.059 ± 0.51 and 0.047 ± 0.47 mm, respectively ( p value= 0.010). Pearson correlation coefficient did not report a significant relationship between mean CIMT in patients with age, sex and BMI. Conclusion: Since CIMT has been reported to be significantly higher in patients with psoriasis, stricter control of other risk factors for atherosclerosis than others and stricter control of inflammation in these individuals are necessary. [ABSTRACT FROM AUTHOR]

The article presents the case study of the 47-year-old white woman suffering from persistent swelling of the labia majora, diffuse lichenification of the perineal and pubic area, alopecia of the pubic hair and multiple erosions involving the perianal area. The is identified as the case of Granulomatous vulvitis (GV) and anogenital granulomatosis (AGG) that are rare inflammatory, chronic, relapsing erythema, oedema and ulcerations in the genitoperineal area.

Background Recent findings have shown that psoriasis is frequently associated with atherosclerosis. Intima-media thickness (IMT) is a surrogate marker of atherosclerosis damage. Psoriasis patients had impaired endothelial function and thicker IMT of the carotid artery, compared with the healthy control subjects. Objectives The aim of our study is to evaluate the prevalence of subclinical atherosclerosis in patients affected by cutaneous psoriasis without arthritis, considering the IMT as a subclinical feature of atherosclerosis. Methods Intima-media thickness of the common carotid artery was measured using High-resolution B-mode ultrasound in 40 psoriasis patients and 40 control patients matched for age and gender. We also measured triglycerides, PASI, total cholesterol, LDL cholesterol and BMI. Pearson's partial correlation test was used to determine the correlation between each variable. Results Intima-media thickness in subjects with psoriasis was statistically higher than those in the control subjects (1.465 mm, P value < 0.001). A positive strong correlation between IMT and age (r = 0.464 P < 0.01), total cholesterol (r = 0.466 P < 0.01), LDL cholesterol (r = 0.518 P < 0.01), triglycerides (r = 0.285 P = 0.01) and PASI (r = 0.515 P < 0.01) was observed. There was no statistically significant correlation between IMT and BMI (r = 0.132 P = 0.244). Conclusions Our study showed a significant increase in IMT in cutaneous psoriatic patients with moderate to severe psoriasis compared with a control group. IMT seems to be uncorrelated with BMI value. It can be assumed that the assessment of IMT, through a reliable and non-invasive technique such as ultrasound, appears particularly useful in the clinical evaluation of patients with psoriasis who may benefit from early intervention. [ABSTRACT FROM AUTHOR]

Background: Interdigital psoriasis (IP) of the feet is often missed and is commonly mistaken for interdigital fungal infection. Objective: To assess the characteristics and the clinical presentation of IP, in order to better understand if IP should be considered a distinct form of psoriasis or not. Methods: We performed a 1-year observational study on 164 psoriatic patients, affected by moderate to severe cutaneous psoriasis and undergoing systemic therapy, examining each patient between the digits of both feet. In every suspected case of IP, differential diagnosis with interdigital fungal infection was excluded by direct microscopic examination of skin scrapings, by culture and by skin biopsy. Results: We suspected IP in 7 of the 164 patients. IP was confirmed in 6 patients and in the other one a diagnosis of tinea pedis was made. Conclusion: IP proved to be not rare or atypical since IP localized between the toes usually presents as characteristic whitish and sodden plaques or patches. Such a diagnosis should be considered in all patients presenting characteristic lesions especially if these have a negative fungal culture, are resistant to antimycotic treatment and involve patients with a history of psoriasis. Copyright © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

A letter to the editor is presented which discusses the study related on the experience of three Italian Psoriasis Centres with a total of 42 patients on the use of Infliximab as premedication for psoriasis.

The article presents a study which examined patients with psoriasis and psoriatic arthritis based on the result of QuantiFERON-TB Gold In-Tube procedure to assess the frequency of latent tuberculosis infection (LTBI) and the host immune reactivity. Patients who received biological treatment were selected based on age and gender, presence of comorbidities and other therapeutic protocols given to them. An analysis of interferon-γ release after biological therapy is also performed.