Search

Your search keyword '"van den Heuvel, J."' showing total 114 results
Start Over Author "van den Heuvel, J." Search Limiters Peer Reviewed
114 results on '"van den Heuvel, J."'

42. Use of oral immunosuppressive drugs in the treatment of atopic dermatitis in the Netherlands.

Author

Garritsen, F. M., van den Heuvel, J. M., Bruijnzeel-Koomen, C. A. F. M., Maitland-van der Zee, A. H., van den Broek, M. P. H., and de Bruin-Weller, M. S.

Subjects
*IMMUNOSUPPRESSIVE agents, *ATOPIC dermatitis, *SKIN diseases, *PHARMACY databases, *CYCLOSPORINE
Abstract

Background Although atopic dermatitis (AD) is a very common skin disease, data on the percentage of patients with really difficult-to-treat AD are scarce. From socio-economic perspective, it is important to have more insight into these numbers, as new very effective, but expensive, treatment options will be available in the near future for difficult-to-treat AD. Estimating the number of patients with AD using oral immunosuppressive drugs can give an impression of the percentage of difficult-to-treat patients in the total AD population. Objective To give an overview of the use of oral immunosuppressive drugs in patients with AD in the Netherlands. Methods Prescription data of oral immunosuppressive drugs in the Netherlands were extracted from a pharmaceutical database (NControl) containing data of 557 million prescriptions and 7.2 million patients. An algorithm, based on the WHO Anatomical Therapeutic Chemical (ATC) codes, was used to identify patients with AD. The prescription of oral immunosuppressive drugs in patients with AD between 1 January 2012 and 1 January 2017 was evaluated. Results Based on the algorithm, 65 943 patients with AD were selected. 943 patients with AD (1.4%) used cyclosporine A, methotrexate, azathioprine or mycophenolic acid. Methotrexate was most commonly used, followed by azathioprine and cyclosporine A. A switch in medication was rarely seen. In the evaluation period, a decrease in the prescription of cyclosporine A was seen, together with an increase in the prescription of methotrexate. In 31% of the patients who stopped treatment, the discontinuation took place within the first months of treatment. Conclusion In this study population, 1.4% of the patients with AD used oral immunosuppressive drugs for their eczema in a 5-year period. Methotrexate was the most commonly used systemic drug in the Netherlands for the treatment of AD. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

46. The ambipolar diffusion length measured by the surface photovoltage technique.

Author

van den Heuvel, J. C., Geerts, M. J., and Metselaar, J. W.

Subjects
*DIFFUSION, *SILICON, *EQUATIONS, *AMORPHOUS substances, *SEMICONDUCTORS
Abstract

Presents a study which determined the diffusion length in hydrogenated amorphous silicon (a-Si:H) using the surface photovoltage (SVP) technique. Characteristics of the SPV; Diffusion equation used in obtaining the diffusion length in crystalline semiconductors; Details on the equation for a-Si:H; Description of the difference between the hole drift mobility and electron drift mobility.

Published
1990
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results