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Your search keyword '"European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)"' showing total 2 results
Start Over Author "European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)" Topic [chim.anal] chemical sciences/analytical chemistry
2 results on '"European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)"'

1. How do haloacetamides and haloacetic acids affect human intestinal epithelial cells?

Author

Dejaeger, K, Criquet, Justine, Vanoppen, M, Cornelissen, E, Billon, G, Vignal, C, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculty of Bioscience Engineering [Ghent], Universiteit Gent = Ghent University (UGENT), European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019), CRIQUET, JUSTINE, Dejaeger, Karlien, and IWA

Subjects
Inflammation, [CHIM.ANAL] Chemical Sciences/Analytical chemistry, [SDE.IE]Environmental Sciences/Environmental Engineering, [SDE.MCG]Environmental Sciences/Global Changes, drinking water, disinfection-by-products, Caco-2, [SDU.ENVI] Sciences of the Universe [physics]/Continental interfaces, environment, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDE.MCG] Environmental Sciences/Global Changes, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Medicine and Health Sciences, gene expression, cytotoxicity, [SDE.IE] Environmental Sciences/Environmental Engineering, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

International audience; In this research, human intestinal epithelial cells (Caco-2) were exposed to haloacetamides and haloacetic acids. A 24, 48 and 72h exposure was conducted to determine the cytotoxicity of these compounds. The unregulated haloacetamides were clearly more cytotoxic than the regulated haloacetic acids. Moreover, changing the halogen from Cl to I increased the toxicity extensively. A 6h stimulation with 1 µM of each compound and subsequent RNA extraction showed high upregulation of genes involved in both oxidative stress and inflammatory pathways with haloacetamide exposure, while no significant changes were seen for haloacetic acid exposure.

Published
2022

2. Disinfection by-products in drinking water: Where do they come from and are they safe to drink?

Author

Dejaeger, Karlien, Vignal, Cécile, Criquet, Justine, Vanoppen, Marjolein, Cornelissen, Emile, Billon, Gabriel, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculty of Bioscience Engineering [Ghent], Universiteit Gent = Ghent University (UGENT), Centre for Advanced Process Technology for Urban Resource Recovery (CAPTURE), KWR Watercycle Research Institute, IWA, European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019), Dejaeger, Karlien, and CRIQUET, JUSTINE

Subjects
[PHYS]Physics [physics], [CHIM.ANAL] Chemical Sciences/Analytical chemistry, chlorination, [SDE.IE]Environmental Sciences/Environmental Engineering, [SDE.MCG]Environmental Sciences/Global Changes, drinking water, Membrane fractionation, [SDU.ENVI] Sciences of the Universe [physics]/Continental interfaces, environment, Modelling, [PHYS] Physics [physics], [SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDE.MCG] Environmental Sciences/Global Changes, Disinfection by-products, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE.IE] Environmental Sciences/Environmental Engineering, DBPs, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; During drinking water disinfection, potentially harmful disinfection by-products are formed due to the reaction of organic matter with chlorine. Therefore, in this research, human intestinal epithelial cells (Caco-2) were exposed to haloacetamides (HAcAm) and haloacetic acids (HAAs). A 24, 48 and 72h exposure was conducted to determine the cytotoxicity of these compounds. The unregulated HAcAms were clearly more cytotoxic than the regulated HAAs. Moreover, changing the halogen from Cl to I increased the toxicity extensively. Hence, a membrane fractionation process is developed to split organic matter into three fractions which should facilitate the identification of both HAA and HAcAm precursors after chlorination.

Published
2022

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