1. Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group
- Author
-
Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stéphanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew, Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette, Kordes, Uwe, Kramm, Chris, van Vuurden, Dannis, Hulleman, Esther, Janssens, Geert, Solanki, Guirish, van Veelen, Marie-Luise, Thomale, Ulrich, Schuhmann, Martin, Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve, Pfister, Stefan, Van Gool, Stefaan, Kramm, Christof, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Department of Pediatric Oncology, Alder Hey Children's Hospital, Alder Hey Children's Hospital, Department of Paediatric Neurosurgery, Necker Enfants Malades Hospital, Paris, France., Institut Curie [Paris], Laboratoire d'Imagerie Biomédicale (LIB), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Medizinische Universität Wien = Medical University of Vienna, Cavendish Laboratory, University of Cambridge [UK] (CAM), Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University of Bonn, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), University Hospital Gasthuisberg, Expt Immunol Lab, Université Catholique de Louvain = Catholic University of Louvain (UCL), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neurosurgery, Murray, Matthew [0000-0002-4480-1147], and Apollo - University of Cambridge Repository
- Subjects
standards [Biological Specimen Banks] ,0301 basic medicine ,Male ,standards [Medical Oncology] ,medicine.medical_specialty ,methods [Translational Research, Biomedical] ,organization & administration [Translational Research, Biomedical] ,[SDV]Life Sciences [q-bio] ,MEDLINE ,ethics [Biological Specimen Banks] ,Translational research ,standards [Translational Medical Research] ,Disease ,standards [Translational Research, Biomedical] ,Medical Oncology ,organization & administration [Biological Specimen Banks] ,Central Nervous System Neoplasms ,Translational Research, Biomedical ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Biomarkers, Tumor ,Humans ,ddc:610 ,methods [Translational Medical Research] ,organization & administration [Medical Oncology] ,CNS tumours ,childhood cancer ,SIOPE Brain Tumour Group ,biological material ,Medical diagnosis ,Intensive care medicine ,Child ,Biological Specimen Banks ,business.industry ,Precision medicine ,Biobank ,3. Good health ,Data sharing ,030104 developmental biology ,trends [Medical Oncology] ,Oncology ,organization & administration [Translational Medical Research] ,030220 oncology & carcinogenesis ,Position paper ,Female ,business - Abstract
International audience; Paediatric CNS tumours are the most common cause of childhood cancer-related morbidity and mortality, and improvements in their diagnosis and treatment are needed. New genetic and epigenetic information about paediatric CNS tumours is transforming the field dramatically. For most paediatric CNS tumour entities, subgroups with distinct biological characteristics have been identified, and these characteristics are increasingly used to facilitate accurate diagnoses and therapeutic recommendations. Future treatments will be further tailored to specific molecular subtypes of disease, specific tumour predisposition syndromes, and other biological criteria. Successful biomaterial collection is a key requirement for the application of contemporary methodologies for the validation of candidate prognostic factors, the discovery of new biomarkers, the establishment of appropriate preclinical research models for targeted agents, a quicker clinical implementation of precision medicine, and for other therapeutic uses (eg, for immunotherapies). However, deficits in organisational structures and interdisciplinary cooperation are impeding the collection of high-quality biomaterial from CNS tumours in most centres. Practical, legal, and ethical guidelines for consent, storage, material transfer, biobanking, data sharing, and funding should be established by research consortia and local institutions to allow optimal collection of primary and subsequent tumour tissue, body fluids, and normal tissue. Procedures for the collection and storage of biomaterials and related data should be implemented according to the individual and organisational structures of the local institutions.
- Published
- 2018
- Full Text
- View/download PDF