1. Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters
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Rabah Boukherroub, J. Sebag, Dawei Hua, Amar Abderrahmani, Juan C. Fraire, Michael G. Harrington, Alexandre Barras, Inès de Hoon, Christophe Lethien, Kevin Braeckmans, Félix Sauvage, Stefaan C. De Smedt, Sabine Szunerits, Gaëtan Buvat, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Laboratory of General Biochemistry and Physical Pharmacy [Ghent, Belgium] (Department of Pharmaceutics), Universiteit Gent = Ghent University [Belgium] (UGENT), Circuits Systèmes Applications des Micro-ondes - IEMN (CSAM - IEMN ), Renatech networkfunding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 810685 (DelNam project)., Renatech Network, European Project: 810685,DelNAM, Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Universiteit Gent = Ghent University (UGENT), Réseau sur le stockage électrochimique de l'énergie (RS2E), Université de Nantes (UN)-Aix Marseille Université (AMU)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Collège de France (CdF (institution))-Université de Picardie Jules Verne (UPJV)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA), PCMP PCP, and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)
- Subjects
Collagen i ,genetic structures ,medicine.medical_treatment ,Vision Disorders ,Vitrectomy ,02 engineering and technology ,[CHIM.THER]Chemical Sciences/Medicinal Chemistry ,pulsed-laser ,010402 general chemistry ,01 natural sciences ,collagen fibers ,carbon quantum dots (CQDs) ,Vitreous floaters ,Quantum Dots ,medicine ,Medicine and Health Sciences ,Humans ,General Materials Science ,Eye floaters ,fibrillation ,Retina ,Chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,021001 nanoscience & nanotechnology ,Carbon ,eye diseases ,0104 chemical sciences ,Vitreous Body ,ophthalmology ,medicine.anatomical_structure ,Carbon quantum dots ,Biophysics ,sense organs ,medicine.symptom ,0210 nano-technology ,Type I collagen ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Common in myopia and aging, vitreous opacities arise from clumped collagen fibers within the vitreous body that cast shadows on the retina, appearing as 'floaters' to the patient. Vitreous opacities degrade contrast sensitivity function and can cause significant impairment in visionrelated quality-of-life, representing an unmet and underestimated medical need. One therapeutic approach could be the use of versatile light-responsive nanostructures which (i) interfere with the formation of collagen fibers and /or (ii) destroy aggregates of vitreous collagen upon pulsed-laser irradiation at low fluences. In this work, the potential of positively and negatively charged carbon quantum dots (CQDs) to interfere with the aggregation of type I collagen is investigated. We demonstrate that fibrillation of collagen I is prevented most strongly by positively charged CQDs (CQDs-2) and that pulsed-laser illumination allowed to destroy type I collagen aggregates and vitreous opacities (as obtained from patients after vitrectomy) treated with CQDs-2.
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