1. Associations with intraocular pressure across Europe
- Author
-
Khawaja, Anthony P., Springelkamp, Henriët, Creuzot Garcher, Catherine, Delcourt, Cécile, Hofman, Albert, Höhn, René, Iglesias, Adriana I., Wolfs, Roger C. W., Korobelnik, Jean François, Silva, Rufino, Topouzis, Fotis, Williams, Katie M., Bron, Alain M., Buitendijk, Gabriëlle H. S., Cachulo, Maria Da Luz, Cougnard Grégoire, Audrey, Dartigues, Jean François, Hammond, Christopher J., Pfeiffer, Norbert, Salonikiou, Angeliki, van Duijn, Cornelia M., Vingerling, Johannes R., Luben, Robert N., Mirshahi, Alireza, Lamparter, Julia, Klaver, Caroline C. W., Jansonius, Nomdo M., Foster, Paul J., Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara Blanco, Augusto, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Brétillon, Lionel, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Annemarie, Cumberland, Philippa, Cunha Vaz, José, Daien, Vincent, Deak, Gabor, Delyfer, Marie Noëlle, Hollander, Anneke Den, Dietzel, Martha, Erke, Maja Gran, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Göbel, Arno, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Helmer, Catherine, Hense, Hans Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Khawaja, Anthony, Klaver, Caroline, Le Goff, Mélanie, Leal, Sergio, Lechanteur, Yara, Lehtimäki, Terho, Lotery, Andrew, Leung, Irene, Mauschitz, Matthias, Merle, Bénédicte, Meyer Zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mohan Saïd, Sadek, Muldrew, Alyson, Mueller, Michael, Nunes, Sandrina, Oexle, Konrad, Peto, Tunde, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Ribeiro, Luisa, Rougier, Marie Bénédicte, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz Valckenberg, Steffen, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Springelkamp, Henriet, Tapp, Robyn, Verhoeven, Virginie, von Hanno, Therese, Vujosevic, Stela, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Zwiener, Isabella, Perceptual and Cognitive Neuroscience (PCN), School of Clinical Medicine, University of Cambridge [UK] (CAM), Moorfields Eye Hospital NHS Foundation Trust, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Ophthalmology, Radboud University Medical Center [Nijmegen], Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB), Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), Mainz University Medical Center, University Hospital of Bern, ISPED, CHU Bordeaux [Bordeaux], Coimbra University Hospital (CHUC), University of Coimbra, Association for Innovation and Biomedical Research on Light and Image (AIBILI), Aristotle University of Thessaloniki, King‘s College London, Dardenne Eye Hospital, University Medical Center Groningen [Groningen] (UMCG), Other departments, ANS - Complex Trait Genetics, ARD - Amsterdam Reproduction and Development, Human Genetics, and Epidemiology
- Subjects
Male ,Ocular Hypertension/epidemiology ,Intraocular pressure ,genetic structures ,JAPANESE ,Epidemiology ,Glaucoma ,BLOOD-PRESSURE ,Cohort Studies ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Dioptre ,Body mass index ,Aged, 80 and over ,2. Zero hunger ,[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology ,Age Factors ,Middle Aged ,3. Good health ,PREVALENCE ,MEDITERRANEAN DIET ,Refractive errors ,TAJIMI ,Blood pressure ,Female ,OPEN-ANGLE GLAUCOMA ,Cohort study ,medicine.medical_specialty ,610 Medicine & health ,Europe/epidemiology ,03 medical and health sciences ,Ophthalmology ,GENERAL ELDERLY POPULATION ,THESSALONIKI EYE ,Humans ,Intraocular Pressure/physiology ,[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,Risk factor ,Aged ,business.industry ,medicine.disease ,ROTTERDAM ,BEIJING EYE ,eye diseases ,Cross-Sectional Studies ,030221 ophthalmology & optometry ,sense organs ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Group Authors: European Eye Epidemiology, E3; Raised intraocular pressure (IOP) is the most important risk factor for developing glaucoma, the second commonest cause of blindness globally. Understanding associations with IOP and variations in IOP between countries may teach us about mechanisms underlying glaucoma. We examined cross-sectional associations with IOP in 43,500 European adults from 12 cohort studies belonging to the European Eye Epidemiology (E-3) consortium. Each study conducted multivariable linear regression with IOP as the outcome variable and results were pooled using random effects meta-analysis. The association of standardized study IOP with latitude was tested using meta-regression. Higher IOP was observed in men (0.18 mmHg; 95 % CI 0.06, 0.31; P = 0.004) and with higher body mass index (0.21 mmHg per 5 kg/m(2); 95 % CI 0.14, 0.28; P < 0.001), shorter height (-0.17 mmHg per 10 cm; 95 % CI -0.25, -0.08; P < 0.001), higher systolic blood pressure (0.17 mmHg per 10 mmHg; 95 % CI 0.12, 0.22; P < 0.001) and more myopic refraction (0.06 mmHg per Dioptre; 95 % CI 0.03, 0.09; P < 0.001). An inverted U-shaped trend was observed between age and IOP, with IOP increasing up to the age of 60 and decreasing in participants older than 70 years. We found no significant association between standardized IOP and study location latitude (P = 0.76). Novel findings of our study include the association of lower IOP in taller people and an inverted-U shaped association of IOP with age. We found no evidence of significant variation in IOP across Europe. Despite the limited range of latitude amongst included studies, this finding is in favour of collaborative pooling of data from studies examining environmental and genetic determinants of IOP in Europeans.
- Published
- 2016
- Full Text
- View/download PDF