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Start Over Author "Centre d'Investigations Cliniques en Biothérapies [Marseille]" Topic [sdv.mhep.hem]life sciences [q-bio]/human health and pathology/hematology
2 results on '"Centre d'Investigations Cliniques en Biothérapies [Marseille]"'

1. Analysis of a large single institution cohort of related donors fails to detect a relation between SDF1/CXCR4 or VCAM/VLA4 genetic polymorphisms and the level of hematopoietic progenitor cell mobilization in response to G-CSF

Author

Sylvain Garciaz, Patrick Sfumato, Angela Granata, Anne-Marie Imbert, Claire Fournel, Boris Calmels, Claude Lemarie, Jacques Chiaroni, Didier Blaise, Jean-Marie Boher, Christophe Picard, Christian Chabannon, Julie di Cristofaro, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre d'Investigations Cliniques en Biothérapies [Marseille], Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie des Groupes Sanguins [Marseille], Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), This work was supported by Institut Paoli-Calmettes, Inserm and by Etablissement Français du Sang and CNRS., Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Bodescot, Myriam

Subjects
[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Male, Heredity, Cell Transplantation, Physiology, Artificial Gene Amplification and Extension, Integrin alpha4beta1, Polymerase Chain Reaction, Database and Informatics Methods, Animal Cells, Granulocyte Colony-Stimulating Factor, Living Donors, Medicine and Health Sciences, Blood and Lymphatic System Procedures, Bone Marrow Stem Cells, Stem Cells, Hematopoietic Stem Cell Transplantation, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Middle Aged, Hematopoietic Stem Cell Mobilization, Body Fluids, Genetic Mapping, Blood, Medicine, Female, Anatomy, Cellular Types, Sequence Analysis, Research Article, Adult, Receptors, CXCR4, Bioinformatics, Science, Vascular Cell Adhesion Molecule-1, Surgical and Invasive Medical Procedures, Bone Marrow Cells, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, Research and Analysis Methods, Polymorphism, Single Nucleotide, Young Adult, Genetics, Humans, Transplantation, Homologous, Molecular Biology Techniques, Molecular Biology, Aged, Evolutionary Biology, Transplantation, Population Biology, Biology and Life Sciences, Cell Biology, Hematopoietic Stem Cells, Chemokine CXCL12, Blood Counts, Haplotypes, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Genetic Polymorphism, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Population Genetics, Stem Cell Transplantation
Abstract

International audience; We studied a cohort of 367 healthy related donors who volunteered to donate their hematopoietic stem cells for allogeneic transplantation. All donors were homogeneously cared for at a single institution, and received rhG-CSF as a mobilization treatment prior to undergoing apheresis. Peripheral blood CD34+ cell counts were used as the main surrogate marker for rhG-CSF induced mobilization. We searched whether inter-individual variations in known genetic polymorphisms located in genes whose products are functionally important for mobilization, could affect the extent of CD34+ mobilization, either individually or in combination. We found little or no influence of individual SNPs or haplotypes for the SDF1, CXCR4, VCAM and VLA4 genes, whether using CD34+ cell counts as a continuous or a categorical variable. Simple clinical characteristics describing donors such as body mass index, age and possibly sex are more potent predictors of stem cell mobilization. The size of our cohort remains relatively small for genetic analyses, however compares favorably with cohorts analyzed in previously published reports suggesting associations of genetic traits to response to rhG-CSF; notwithstanding this limitation, our data do not support the use of genetic analyses when the choice exists of several potential donors for a given patient.

Published
2020
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2. The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy

Author

John A. Snowden, Malgorzata Mikulska, Rafael F. Duarte, Christian Chabannon, Rafael de la Cámara, Nicolaus Kröger, Bregje Verhoeven, Mohamad Mohty, Ibrahim Yakoub-Agha, Harry Dolstra, Selim Corbacioglu, Per Ljungman, Régis Peffault de Latour, John Murray, Silvia Montoto, Arjan C. Lankester, Grzegorz W. Basak, Jan Styczyński, Marrow Transplantation, UAM. Departamento de Medicina, Bodescot, Myriam, Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Università degli studi di Genova = University of Genoa (UniGe), Hospital Universitario de La Princesa, Medical University of Warsaw - Poland, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre d'Investigations Cliniques en Biothérapies [Marseille], Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Regensburg (UR), Hospital Universitario Puerta de Hierro [Madrid, Espagne], Radboud University Medical Center [Nijmegen], Leiden University Medical Center (LUMC), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Barts Health NHS Trust [London, UK], The Christie NHS Foundation Trust [Manchester, Royaume-Uni], BMT Unit [Paris], Department of Hematology [Paris], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sheffield Teaching Hospitals NHS Foundation Trust [Sheffield, Royaume-Uni], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Nicolaus Copernicus University [Toruń], The authors acknowledge the support of other members of the EBMT. These include Eoin McGrath, JACIE, Nina Worel, EBMT donor committee, and Helene Schoemans, Complications Working Party., European Society for Blood and Marrow Transplantation, University of Genoa (UNIGE), Hospital de la Princesa [Madrid, Espagne], and Universiteit Leiden

Subjects
[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Office Visits, medicine.medical_treatment, Infectious Disease Transmission, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], Adoptive, Diseases, Hematopoietic stem cell transplantation, Disease, Immunotherapy, Adoptive, Accreditation, Infectious Disease Transmission, Professional-to-Patient, Cell therapy, Patient-to-Professional, 0302 clinical medicine, COVID-19 Testing, Hematopoietic cell transplantation (HCT, Pandemic, Viral, Allografts, COVID-19, Clinical Laboratory Techniques, Continuity of Patient Care, Cross Infection, Delivery of Health Care, Europe, Health Personnel, Humans, Immunocompromised Host, Infection Control, Infectious Disease Transmission, Patient-to-Professional, Procedures and Techniques Utilization, SARS-CoV-2, Telemedicine, Tissue Donors, Transplant Recipients, Transplantation, Autologous, Visitors to Patients, Betacoronavirus, Coronavirus Infections, Hematopoietic Stem Cell Transplantation, Pandemics, Pneumonia, Viral, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, CAR T cells, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology, 3. Good health, surgical procedures, operative, 030220 oncology & carcinogenesis, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Perspective, Immunotherapy, Stem cell, Autologous, medicine.medical_specialty, Professional-to-Patient, Medicina, 03 medical and health sciences, medicine, Intensive care medicine, Transplantation, European Society for Blood and Marrow Transplantation (EBMT), business.industry, Health care, Cancer, Correction, Pneumonia, medicine.disease, business, 030215 immunology
Abstract

The new coronavirus SARS-CoV-2 has rapidly spread over the world causing the disease by WHO called COVID-19. This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell transplantation (HCT) and cellular therapy such as with CAR T cells. Risk factors for severe disease include age and predisposing conditions such as cancer. The true impact on stem cell transplant and CAR T-cell recipients in unknown. The European Society for Blood and Marrow Transplantation (EBMT) has therefore developed recommendations for transplant programs and physicians caring for these patients. These guidelines were developed by experts from the Infectious Diseases Working Party and have been endorsed by EBMT’s scientific council and board. This work intends to provide guidelines for transplant centers, management of transplant candidates and recipients, and donor issues until the COVID-19 pandemic has passed.

Published
2020
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