1. CD4+ T cells that help B cells – a proposal for uniform nomenclature
- Author
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Stuart G. Tangye, Nicolas Fazilleau, Joe Craft, Stephanie C. Eisenbarth, Carola G. Vinuesa, Dirk Baumjohann, Cindy S. Ma, Michelle A. Linterman, Yale School of Medicine [New Haven, Connecticut] (YSM), Medizinische Klinik und Poliklinik III [Bonn, Germany], Universitätsklinikum Bonn (UKB), University of Bonn, Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Garvan Institute of medical research, University of New South Wales [Sydney] (UNSW), Australian National University (ANU), The Babraham Institute [Cambridge, UK], ANR-16-CE15-0019,Ig-MemImpact,Rôle de la classe des Ig / BCR dans les interactions cellulaires supportant la mémoire immune et impact immunopathologique(2016), ANR-16-CE15-0002,MEMO-SIGN,IMPACT DE LA FORMULATION VACCINALE SUR LA COMPOSITION DES COMPARTMENTS LYMPHOCYTAIRES A MEMOIRE TFH ET B(2016), Benson-Rumiz, Alicia, Rôle de la classe des Ig / BCR dans les interactions cellulaires supportant la mémoire immune et impact immunopathologique - - Ig-MemImpact2016 - ANR-16-CE15-0019 - AAPG2016 - VALID, and IMPACT DE LA FORMULATION VACCINALE SUR LA COMPOSITION DES COMPARTMENTS LYMPHOCYTAIRES A MEMOIRE TFH ET B - - MEMO-SIGN2016 - ANR-16-CE15-0002 - AAPG2016 - VALID
- Subjects
MESH: Cell Differentiation ,Immunology ,Cell ,Biology ,Lymphocyte Activation ,Article ,Chemokine receptor ,Immune system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,medicine ,Immunology and Allergy ,MESH: Immunity, Humoral ,MESH: T-Lymphocytes, Helper-Inducer ,MESH: Lymphocyte Activation ,B cell ,B-Lymphocytes ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Cell Differentiation ,T-Lymphocytes, Helper-Inducer ,Germinal Center ,BCL6 ,Isotype ,Immunity, Humoral ,medicine.anatomical_structure ,Humoral immunity ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,biology.protein ,MESH: Germinal Center ,Antibody ,MESH: B-Lymphocytes ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in secondary lymphoid tissues. 'Tfh-like' populations not expressing the canonical Tfh cell transcription factor BCL6 have also been described, which can aid particular aspects of B cell differentiation. Tfh and Tfh-like cells are essential for protective and pathological humoral immunity. These CD4+ T cells that help B cells are polarized to produce diverse combinations of cytokines and chemokine receptors and can be grouped into distinct subsets that promote antibodies of different isotype, affinity, and duration, according to the nature of immune challenge. However, unified nomenclature to describe the distinct functional Tfh and Tfh-like cells does not exist. While explicitly acknowledging cellular plasticity, we propose categorizing these cell states into three groups based on phenotype and function, paired with their anatomical site of action.
- Published
- 2021