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Your search keyword '"MESH: Sinusitis"' showing total 2 results
Start Over Descriptor "MESH: Sinusitis" Topic [sdv.mhep.psr]life sciences [q-bio]/human health and pathology/pulmonology and respiratory tract
2 results on '"MESH: Sinusitis"'

1. Clinical characteristics, functional respiratory decline and follow-up in adult patients with primary ciliary dyskinesia

Author

L. Bassinet, André Coste, N. Dufeu, Bernard Maitre, Justine Frija-Masson, Pierre-Régis Burgel, Jean Francois Papon, Bruno Housset, Estelle Escudier, Isabelle Honoré, Service de pneumologie [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHI Créteil, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'ORL [Créteil], Centre Hospitalier Intercommunal de Créteil (CHIC), Service d’ORL et de chirurgie cervico-faciale [CHU Le Kremlin-Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Physiopathologie des maladies génétiques d'expression pédiatrique, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Couvet, Sandrine, Service de génétique et embryologie médicales [CHU Trousseau], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Male, MESH: Bronchiectasis, Biopsy, [SDV]Life Sciences [q-bio], MESH: Respiratory Function Tests, Disease, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Gastroenterology, MESH: Biopsy, 0302 clinical medicine, Medicine, Respiratory function, Longitudinal Studies, 030212 general & internal medicine, Respiratory system, MESH: Longitudinal Studies, Lung, Rhinitis, Primary ciliary dyskinesia, MESH: Aged, MESH: Middle Aged, MESH: Rhinitis, MESH: Follow-Up Studies, Middle Aged, Respiratory Function Tests, Bronchiectasis, [SDV] Life Sciences [q-bio], Phenotype, Disease Progression, Female, MESH: Disease Progression, Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, MESH: Sinusitis, Rare lung diseases, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, MESH: Phenotype, 03 medical and health sciences, Internal medicine, Humans, MESH: Lung, Sinusitis, Aged, Retrospective Studies, MESH: Adolescent, MESH: Humans, Kartagener Syndrome, business.industry, MESH: Adult, MESH: Retrospective Studies, Retrospective cohort study, medicine.disease, MESH: Male, Surgery, Situs inversus, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, 030228 respiratory system, Respiratory failure, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, MESH: Kartagener Syndrome, business, MESH: Female, Follow-Up Studies
Abstract

International audience; Introduction: Primary ciliary dyskinesia (PCD) is a genetic disease characterised by abnormalities in ciliary function, responsible for chronic pulmonary and sinonasal diseases. Adult clinical features and outcome are poorly described.Objectives: To assess the clinical characteristics and disease progression in adults with PCD.Methods: Bicentric retrospective study, focusing on adults (≥18 years) with an asserted diagnosis of PCD based on the presence of bronchiectasis with typical ultrastructural defect of cilia and/or situs inversus (SI). Clinical symptoms, respiratory function, extent of bronchiectasis, microbiology and molecular analysis were assessed. Results are expressed as median (25th; 75th centile).Results: 78 patients were included with a median follow-up of 8.1 years. 91% of patients had respiratory symptoms and 95% had chronic rhinosinusitis. Half of ultrastructural defects concerned dynein arms. Respiratory function was significantly lower in women (FEV1=60% predicted (50; 76), vs 77% (62; 95), p=0.009) and in patients with chronic airway Pseudomonas aeruginosa (PA, n=21) infection (FEV1=60% (48; 71) vs 75% (55; 89), p=0.04). FEV1 was associated with gender (regression coefficient for men =13.8, p=0.009), chest CT score (r=-0.42, p

Published
2016
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2. Le syndrome des ongles jaunes : présentation de cinq cas. [The yellow nail syndrome: a series of five cases]

Author

Letheulle, Julien, Deslee, Gaëtan, Guy, T., Lebargy, F., Jego, Patrick, Delaval, Philippe, Desrues, Benoit, Jouneau, Stéphane, Service de pneumologie [Rennes] = Pneumology [Rennes], CHU Pontchaillou [Rennes], Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 (PERPMP), Université de Reims Champagne-Ardenne (URCA)-Centre Hospitalier Universitaire de Reims (CHU Reims)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes], and Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)

Subjects
Transsudat, MESH: Aged, MESH: Bronchiectasis, MESH: Humans, MESH: Middle Aged, integumentary system, MESH: Sinusitis, MESH: Chronic Disease, MESH: Retrospective Studies, Chylothorax, Lymphœdème, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, MESH: Male, Syndrome des ongles jaunes, MESH: Chylothorax, MESH: Yellow Nail Syndrome, Bronchectasies, Épanchement pleural, MESH: Pleural Effusion
Abstract

International audience; INTRODUCTION: The yellow nail syndrome is a rare disorder described for the first time in 1964. The pathophysiology remains unclear. Its definition is based on a clinical triad of yellow nails, lymphoedema and chronic respiratory disorders including pleural effusions and bronchiectasis. CASES REPORTS: We describe a retrospective series of five patients diagnosed with the yellow nail syndrome. All the patients were male, aged from 52 to 71 years (median=56). Three patients were diagnosed with the classic triad, whereas the other two had only yellow nails and bronchiectasis. Yellow nails and chronic sinusitis were present in all five patients. We also report atypical manifestations such as a transudative pleural effusion and facial oedema. The yellow nail syndrome was associated with cancer in two cases. CONCLUSION: More common alternative diagnoses must be excluded. The association with cancer should be explored. The treatment is only symptomatic.

Published
2012
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