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Gastrointestinal helminthiasis, particularly toxocarosis, is the most common invasive disease of dogs in our country and abroad. It is important to note that toxocarosis is a zoonosis that poses a threat not only to animals but also to humans. It is known that one of the manifestations of the toxic effect of toxocar byproducts is the activation of the processes of peroxide oxidation of cell membrane lipids. Lipid peroxidation is one of the most essential oxidation processes in the body of dogs. Currently, this process is considered one of the leading causes of cell damage and death due to the negative effect of reactive oxygen species. Any sufficiently powerful impact on the animal body, including the development of toxocarosis, can initiate lipid peroxidation processes. That is why the work aimed to determine the effect of toxocarosis infestation on the level of intermediate and final products of lipid peroxide oxidation in the body of dogs. 12 dogs aged two to four months were used for experimental research, and two groups of six animals each were formed: control and experimental. Puppies of the control group were clinically healthy. Puppies of the research group were experimentally infected with the causative agent of toxocarosis at a dose of 5,000 invasive T. canis eggs per kg of body weight. The development of toxocarosis in dogs leads to a significant and probable (P < 0.001) accumulation in the blood of dogs in all periods of the study of the content of intermediate (diene conjugates) and final (TBK-active products) products of lipid peroxidation. In dogs with experimental toxocarosis, an increase in these LPO products was established, especially on the 28th and 35th days of the experiment, where, accordingly, the level of diene conjugates ranged from 0.750 ± 0.004 to 0.675 ± 0.003 odA/ml (Р < 0.001), and the level of TBC-active products - in the range of 38.38 ± 0.174 – 38.18 ± 0.137 μmol/l (Р < 0.001). These changes may be because, in the pathogenesis of toxocariasis in dogs, an important role is played by the increased formation of reactive oxygen species, which subsequently cause a disturbance in the balance between the content of oxidants and antioxidants in the body of dogs. It is also worth paying attention to more significant changes in the level of intermediate POL products in dogs' blood during experimental toxocarosis compared to the final products. [ABSTRACT FROM AUTHOR]

Most types of helminths are widespread in many countries and severely threaten human health. One of the most dangerous zooanthropohelminthiases is toxocarosis. The causative agent of toxocarosis – the nematode Toxocara canis in the imaginal stage parasitizes in the small intestine of carnivores and the larval stage (Visceralis larva migrans) – in various organs and tissues of animals and humans. Toxocarosis has both veterinary and social significance. Toxocara canis larvae can migrate in the human body and cause various pathologies: hepatitis, encephalitis, chorioretinitis. The purpose of the research was to analyze data from the reporting documentation of the Poltava Veterinary Center regarding the prevalence of toxocarosis among the domestic dog population. According to the results of the analysis of the statistical data of the reporting documentation of the veterinary center of the Shevchenkivskyi district of the city of Poltava for 2019–2022, it was established that the average infestation of dogs by the causative agent of toxocarosis in the territory of the city of Poltava is 22.89 %, with a range from 17.51 to 28.02 %. The share of toxocarosis in the total parasitic pathology diagnosed in dogs was 27 %. The mestizos were the most affected by the causative agent of toxocarosis, where the extent of invasion was 29.26 %. A lower rate of toxocares was found in dogs of decorative (24.05 %), service (21.24 %), and hunting (18.56 %) breeds. In particular, the highest values of the extent of infestation were found in Yorkshire terriers (39.71 %). Less often, toxocarosis was diagnosed in toy terriers (extent of infestation – 19.12 %), English cocker spaniels (19.83 %), dachshunds (18.03 %), pugs (16.37 %), Jack Russell terriers (15.82 %) and pickiness (12.6 %). Seasonal dynamics of toxocarosis in dogs are characterized by the peak of invasion in the spring and autumn periods, where the infection rates of animals were at 35.0 and 30.0 %, respectively. The extent of toxocarosis infestation declined in winter – by 12.0 %. The obtained data indicate the relevance of the problem of toxocarosis as a zooanthroponous invasion in connection with the significant damage to domestic dogs by toxocares in the city of Poltava. [ABSTRACT FROM AUTHOR]

The purpose of the research: the study of the efficacy of the preparations for veterinary use "Inspector Quadro C" and "Inspector Quadro K" against ecto- and endoparasitoses of dogs and cats. Materials and methods. Studies were conducted on spontaneously infected dogs and cats of different sexes, age, weight and breed. The diagnosis of infection with ectoparasites was made based on the clinical picture and laboratory methods of investigation (microscopy of scrapings taken from ectoparasitized skin areas, examination of the coat for fleas, lice, worms, ixodids). Infection with helminths was established by detecting eggs of helminths in faeces of animals by the method of Füleleborn and mature segments of cestodes. Preparations were applied to the animals by drip application on dry undamaged skin in places inaccessible to licking in a dose of 0.1-0.4 ml per 1 kg of body weight. The results were statistically processed. Results and discussion. "Inspector Quadro S" and "Inspector Quadro K" showed 100% efficacy at sarcoptosis in dogs, notoedrosis in cats, otodectosis in dogs and cats, ixodidoses and entomoses. "Inspector Quadro C" showed a high efficiency (92.3%) at demodecosis in dogs. However, single mites were found in one dog. 100% efficacy of "Inspector Quadro C" and "Inspector Quadro K" has been established against intestinal nematodes and cestodes in dogs and cats. Negative effects of drugs on the body of animals have not been revealed.