Objective: To observe the effects of general anesthesia combined with femoral nerve and sciatic nerve block on postoperative awakening quality, stress response and cognitive function in patients with lower limb fractures. Methods: 103 patients with lower limb fractures who were treated in our hospital from July 2020 to July 2021 were aelected, and they were divided into control group(51cases, general anesthesia) and observation group(52 cases, general anesthesia combined with femoral nerve and sciatic nerve block)according to the double color ball method. The changes of hemodynamics, postoperative awakening quality, stress response and cognitive function in two groups were observed, and the perioperative adverse reactions in two groups were recorded. Results: The heart rate(HR)and mean arterial pressure(MAP) in the two groups after induction anesthesia(T2) time points were lower than those before anesthesia(T1). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). HR and MAP in the observation group were lower than those in the control group from immediately(T3) to 60min(T5) after laryngeal mask(P<0.05). The awakening time in the observation group was shorter than that in the control group, and the incidence of agitation was lower than that in the control group(P<0.05). The adrenaline(E) and cortisol(Cor) in the two groups in the anesthesia awakening period were higher than those in the anesthesia maintenance period, but the observation group was lower than the control group(P<0.05). The scores and total scores of visual space and execution, memory, naming, attention, language, abstraction, directional force and delayed recall in the observation group were higher than those in the control group(P<0.05). Conclusion: General anesthesia combined with femoral nerve and sciatic nerve block for patients with lower limb fracture can stabilize hemodynamics, improve postoperative awakening quality, reduce stress response and influence on cognitive function. [ABSTRACT FROM AUTHOR]