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Objective: The aim of this study was to evaluate the clinical effects in patients who had undergone primary total knee arthroplasty(TKA) with 2 different closed negative pressure drainage(not clip pipe; clip to remain open after 6 hours). Methods: A total of 52 patients(52 knees) underwent primary TKA in our hospital from 2015.06 to 2017.06 was conducted. They were randomly divided into two groups(don’t clip pipe group, clip pipe 6 h). Comparing three groups of patients with postoperative total flow rate and amount of allogeneic blood transfusion, total blood loss and hidden blood loss, postoperative week diameter growth of leg, incision infection rate,incidence of thrombosis and the function of knee joint after December(HSS score) evaluate the situation. Results: There were no significant difference in the baseline characteristics including age, gender, height, weight and time of operation between the two groups(P>0.05). However, total blood loss, hidden blood loss, blood transfusion in study group were higher than that in control group(P<0.05).Multiple comparison between groups of patients, postoperative 1 d, 3 d weeks diameter growth of leg, postoperative incidence of thrombosis, incision infection rate and postoperative HSS score 12 months were no significant statistical difference(P>0.05). Conclusion: Early continuous negative pressure drainage after clip pipe(6 h) can significantly reduce the amount of blood loss and the blood transfusion rate, and do not increase the obvious adverse consequences. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical efficacy of cocktail neuroprotective agents(N6) in treatment of spasm in patient with traumatic spinal cord injury (TSCI). METHODS: 189 patients with TSCI diagnosed by Jinan Military General Hospital from Jan.2013 to Jun.2016 were retrospectively selected and divided into observation group (102 cases) and control group(87 cases) according to the application of cocktail neuroprotective agents(N6). The incidence of spasm of two groups were observed and compared at 2 months and 12 months after injured;for patients stricken by spasm at 2 months after injured, the total effective rate at 12 months after injured were observed and compared. RESULTS: At 2 months and 12 months after injured, the incidence of spasm of the observation group was significantly lower than that of the control group, with statistically significant difference (P ＜ 0.05). 12 months after injured,the total effective rate of the observation group (62.79％, 27/43) was significantly higher than that of the control group(35.85％, 19/53), with statistically significant difference(P ＜0.05). CONCLUSIONS: The cocktail neuroprotective agents(N6) can effectively reduce the incidence of spasm in patient with TSCI, with high cure rate. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the clinical efficacy of percutaneous transforaminal endoscopic discectomy(PTED) in the treatment of lumbar disc herniation. Methods: The clinical and follow-up data of 194 patients who were admitted in our hospital from 2009 to 2013 and diagnosed as lumbar disc herniation were treated by PTED were retrospectively analyzed. The clinical efficacy was evaluated by visual analogue scale(VAS), Lehmann Lumbar function score, modified Macnab criteria and SF-36 before and after operation. Results: All the patients were followed up at least 12 months after the operation. The postoperative VAS score, lumbar function, quality of life were obviously improved on the day after surgery, at the 3rd, 12 th month after surgery compared with those preoperation(P<0.05)..At the 3rd, 12 th month after surgery, the excellent rate of modified Macnab criteria were 90.7%, 92.3%,respectively. Conclusion: PTED was a safe and effective treatment for lumbar disc herniation, which could obviously relieve the lumbar spinal function and improve the quality of life with high safety. [ABSTRACT FROM AUTHOR]

Objective： To compare the clinical, radiological outcomes and complication of unilateral pedicle screw (UPS) versus bilateral pedicle screw (BPS) in degenerative lumbar diseases after MIS-TLIF. Methods： In this study, we retrospectively analyzed 96 consecutive patients who had two-level MIS-TLIF at IA/L5 and L5/S1 from January 2012 to January 2016 and the clinical and radiological outcome and the complication were compared. Of the 96 patients for analysis, 44 patients underwent unilateral fixation, and 52 patients underwent bilateral fixation. All patients received at least 12 months fellow up. Clinical outcomes were evaluated by VAS, ODI, fusion rate, operation idex and complication. Results： There was no statistically significant difference in baseline demographic characteristics between the two groups (P>0.05). There was a significantly longer operating time, more blood loss and X-ray exposure times in BPS comparing with UPS (P<0.05). Clinical outcomes in two groups such as the pain (VAS) and Oswestry Disability Index (ODI) improved significantly after surgery (P<0.05) and no difference was found between them (P>0.05). No significant difference was found in fusion rate and total complication rate between the two groups (P>0.05). Conclusions： There was no significant difference between the two fixation methods of MIS-TLIF in clinical outcomes and complications. However, unilateral pedicle screw has some superiorities such as shorter operating time, lower cost, less blood loss and X-ray exposure. Unilateral pedicle screw might be more suitable in performing two-level pedicle screw fixation after MIS-TLIF. [ABSTRACT FROM AUTHOR]

Objective: To comparison the clinical efficacy and safety of transforamina 1 lumbar interbody fusion and posterior lumbar interbody fusion in treating patients with degenerative lumbar spondylolisthesis combined with lumbar spinal stenosis. Methods: A total of 90 patients with degenerative lumbar spondylolisthesis combined with lumbar spinal stenosis in our hospital from June 2013 to June 2015 were enrolled in this study. The subjects were divided into TLIF group (n=45) and PLIF group (n=45) randomly. The TLIF group were treated with TLIF. the PLIF group were treated with PLIF. The operation time, intraoperative blood loss, postoperative flow and postoperative time in bed of the two groups were compared. The VAS score and ODI score of the two groups before and after treatment were compared. The complications such as nerve root injury, infection and epidural cyst rupture of the two groups after treatment were compared. Results: The operation time, intraoperative blood loss, postoperative flow and postoperative time in bed of the TLIF group were ignificantly lower than that of the PLIF group (P<0.05). There were no significantly differences of the VAS score and ODI score of the two groups before treatment (P>0.05). After treatment, the VAS score and ODI score of the two groups were significantly lower than before treatment, and that of the TLIF group were significantly lower than the PLIF group (P<0.05). The incidence of adverse reactions after treatment of the TLIF group was significantly lower than that of the PLIF group (X2=3.873. P=0.049). Conclusion: Compared with PLIF. TLIF for patients with degenerative lumbar spondylolisthesis combined with lumbar spinal stenosis have good clinical efficacy and security, can help the recovery of the lumbar fuction. it was worthy clinical application. [ABSTRACT FROM AUTHOR]