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Objective: To explore the treatment of anal condyloma acuminata. Method: Human papillomavirus (HPV) subtypes were detected in 108 patients with anal condyloma acuminata using flow through hybridization and gent chip. All patients with anal condyloma acuminata were treated by CO2 laser and 5-aminolevulinic acid—photodynamic therapy (ALA-PDT), and the patients with recurrent anal condyloma acuminata were treated by CO2 laser and ALA-PDT and imiquimod. Result: There were 81 positive cases in 108 patients with anal condyloma acuminate, the ratio of total HPV infection was 75.0 %. The ratio of single types was 47.2 % and the rate of multiple types was 27.8 %. The predominant type of single infection was HPV 6 and the ratio was 27.8 %, followed by HPV 11 (19.4 %). The complete remission was 89 of 108 (79.6 %) after first treatment and 10 of 19 (52.7 %) after second treatment. The recurrence rate was 22.1%and 20.0%respectively. After two treatments, the recurrence rate was 2 of 77 (2.6 %). Conclusion: HPV6, HPV11 and HPV6 + HPV11 are the predominant genotypes in the patients with anal condyloma acuminate. ALA-PDT combined with CO2 laser and imiquimod is effective in treatment of anal condyloma acuminate and can reduce the recurrence rate. [ABSTRACT FROM AUTHOR]