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Objective To explore the correlation between age of Kasai portoenterostomy and early prognosis to provide references for timing of Kasai surgery in biliary atresia (BA) children. Methods Retrospective review was conducted for clinical data of hospitalized BA children from January 2019 to December 2021.General profiles (gender & operative age) and parameters of liver function, coagulation function and blood ammonia were collected. According to the jaundice clearance at 3 months post-operation, they were assigned into two groups of non-jaundice clearance (n=47) and jaundice clearance (n=66).The cut-off value of operative age was calculated. Then two groups were divided according to operative age. The prognostic parameters of Kasai portoenterostomy at 3 months post-operation were compared, including alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), direct bilirubin (DBIL), postoperative DBIL/ preoperative DBIL, gamma-glutamyltransferase (GGT), total bile acid (TBA), total bilirubin (TBIL), platelet count (PLT), aspartate aminotransferase-to-platelet ratio index (APRI) and international normalized ratio (INR). Results A total of 113 cases were collected, including 49 males and 64 females. The operative age was 59.00 (40.50, 69.00) days. Univariate analysis of the preoperative indexes of the non-jaundice clearance group and the jaundice clearance group showed that the age of operation(64 (52, 79) d vs. 55 (33, 67) d), AST (202.00 (138.00, 332.00) U/L vs. 147.50 (100.00, 242.00) U/L), indirect bilirubin (IBIL) ((70.60±20.31)μmol/L vs. (79.96±27.13)μmol/L), total protein(TP) ((55.88±6.59)g/L vs. (53.13±4.71)g/L) between the two groups were statistically significant (P < 0.05). The indexes with P < 0.1 in univariate analysis [age of operation, albumin (ALB), ALT, AST, IBIL, TP, activated partial thromboplastin time(APTT)] were included in the multivariate Logistic regression analysis, and the results showed that the age of operation (OR=0.974, 95%CI: 0.951-0.997, P=0.030) was an independent factor influencing the jnundice clearance at 3 months after Kasai protoentrostomy. According to the cut-off value (46.5d) of the operative age group, the results showed that the levels of ALP(365.00 (316.00, 514.75) U/L vs. 492.00 (343.00, 684.00) U/L), ALT ((76.35±81.33) U/L vs. (134.09±97.45)U/L), AST (67.50 (41.50, 99.50) U/L vs. 112.00 (79.00, 168.00) U/L), DBIL (2.55 (1.78, 6.95) μmol/L vs. 9.80 (3.60, 36.80) μmol/L), postoperative DBIL/ preoperative DBIL(0.05 (0.03, 0.09) vs. 0.12 (0.05, 0.54)), TBA (45.50 (25.93, 92.93) μmol/L vs.106.20 (41.20, 187.50) μmol/L), TBIL (9.65 (6.98, 15.43) μmol/L vs. 21.50 (10.40, 66.90) μmol/L) and APRI (0.32 (0.22, 0.48) vs.0.62 (0.41, 0.93)) in the operation age ≤46.5 d group were significantly lower than those in the operation age > 46.5 d group, the difference was statistically significant (P < 0.05). Conclusion Early prognostic parameters are superior in group with operative age≤46.5 days to group with operative age >46.5 days. And early Kasai portoenterostomy may improve the prognosis of BA. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To analyze the control effect and prognosis of Levetiracetam injection on convulsive epileptic status ( CSE), in order to promote its clinical application. Methods　A total of 80 CSE patients were enrolled in the Department of Neurology intensive Care Unit (NICU) of Qujing No.1 Hospital from September 2018 to April 2021. 40 patients in the Levetiracetam group (experimental group) and 40 patients in the Valproate group (control group) were randomly assigned to compare the efficacy, adverse reactions, EEG changes, Synek grading and prognosis. Results　 The effective control rate was 77.5% in the Levetiracetam group and 67.5% in the Valproate group, with no statistical difference between the two groups (P = 0.317). The onset time of Levetiracetam group was shorter than that of Valproate group, and the difference between the two groups was statistically significant (P < 0.05). Prognostic analysis: Univariate analysis showed that symptoms were not effectively controlled, successful control time ≥60 min, abnormal discharge in EEG, Synek grading and poor prognosis were significantly correlated (P < 0.05). Multivariate Logitstic regression analysis showed that, Synek grade was negatively correlated with prognosis (β= -3.867, OR < 1), and higher Synek grade was an independent risk factor and predictor of poor prognosis (P < 0.05). Conclusion　 Levetiracetam injection can control CSE more quickly and effectively, which can be used in clinic. EEG analysis (EEG abnormal discharge and Synek grading) can provide a reliable basis for judging the prognosis of CSE. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Cancer Biotherapy is the property of Editorial Office of Chinese Journal of Cancer Biotherapy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)