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1. Synthesis of carbohydrate conjugated 6A,6D-bifunctionalized β cyclodextrin derivatives as potential liver cancer drug carriers

Author

Yili Ding, Chamakura V.N.S. Vara Prasad, Bingyun Wang, and Charles Ding

Subjects
Drug, Polymers and Plastics, media_common.quotation_subject, Carbohydrates, Antineoplastic Agents, Conjugated system, 010402 general chemistry, 01 natural sciences, Materials Chemistry, medicine, Organic chemistry, Solubility, media_common, Drug Carriers, 010405 organic chemistry, Chemistry, Liver Neoplasms, beta-Cyclodextrins, Organic Chemistry, Carbohydrate, medicine.disease, Cyclodextrin Derivatives, 0104 chemical sciences, carbohydrates (lipids), SN2 reaction, Indicators and Reagents, Drug carrier, Liver cancer
Abstract

Galactosyl and lactosyl conjugated 6A,6D-bifunctionlized β cyclodextrin derivatives were designed and synthesized as the potential liver cancer drug carriers through SN2 replacement and click reactions in order to increase liver cancer drug's targeting ability, solubility and stability. The synthetic methods and strategies to obtain the designed compounds were discussed.

Published
2018
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