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Start Over Author "Ding-Qiang Fu" Topic 01 natural sciences
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1. Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine

Author

Zhuo Tang, Guangxun Li, Gao-feng Yang, Xin Cui, Jinzhong Zhao, Jin Huang, Xiao-kang Nie, and Ding-qiang Fu

Subjects
In situ, Tandem, 010405 organic chemistry, Chemistry, Organic Chemistry, Enantioselective synthesis, Regioselectivity, Stereoisomerism, 010402 general chemistry, Transfer hydrogenation, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Benzodiazepines, Cascade reaction, Cyclization, Reducing Agents
Abstract

The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chemistry. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with symmetric and unsymmetric

Published
2021

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