1. Plasma-synthesized mussel-inspired gold nanoparticles promote autophagy-dependent damage-associated molecular pattern release to potentiate immunogenic cancer cell death
- Author
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Linh Nhat Nguyen, Liem Quang Nguyen, Nagendra Kumar Kaushik, Pradeep Bhartiya, Sintayehu Kebede Gurmessa, Hwa-Jung Kim, Neha Kaushik, and Eun Ha Choi
- Subjects
Chemistry ,health care facilities, manpower, and services ,General Chemical Engineering ,medicine.medical_treatment ,media_common.quotation_subject ,education ,Autophagy ,technology, industry, and agriculture ,Damage-associated molecular pattern ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Immune system ,Cancer immunotherapy ,Immunity ,Cancer cell ,medicine ,Cancer research ,Immunogenic cell death ,0210 nano-technology ,Internalization ,media_common - Abstract
The development of an efficient tumor-specific therapeutic approach, which functions against the primary tumor and also repairs the host immune system to eradicate distant tumors, remains a clinical issue. Herein, this study focuses on the use of polydopamine-coated gold nanoparticles (Au@PDA NPs) that showed excellent selectivity towards cancer cells. The Au@PDA NPs were prepared by a plasma synthesis method with a short reaction time and minimize the use of chemicals. Prominently, Au@PDA NPs not only exhibited high cellular internalization but also stimulated immunogenic cell death (ICD) in aggressive breast carcinoma cells. Moreover, it was observed that damage-associated molecular patterns (DAMPs) were released by damaged cells together with the autophagy process after Au@PDA NPs exposure, which acted as endogenous danger signals to regulate the consequent immune response. This study highlights the novel mechanism of Au@PDA NPs-triggered anti-tumor immunity against immunosuppressive cancers, demonstrated the potential of the Au@PDA NPs for cancer immunotherapy.
- Published
- 2021