1. Diterpenoids from Leaves of Cultivated Plectranthus ornatus
- Author
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Taynara Simão Matos, Nilberto R.F. Nascimento, Talles Luann Abrantes Ferreira, Manoel Odorico de Moraes, Matheus Carlos Matos da Silva, Norberto K.V. Monteiro, Otília Deusdênia L. Pessoa, Andrea F. Moura, Alison da Silva Batista, Fábio do Nascimento Ávila, and Lidivânia Silva Freitas Mesquita
- Subjects
Stereochemistry ,Plectranthus ,Guinea Pigs ,Pharmaceutical Science ,Ileum ,01 natural sciences ,Analytical Chemistry ,Drug Discovery ,medicine ,Animals ,Humans ,Cytotoxicity ,Pharmacology ,Molecular Structure ,biology ,Plant Extracts ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Carbon-13 NMR ,biology.organism_classification ,Terpenoid ,0104 chemical sciences ,Intestinal motility ,Plant Leaves ,010404 medicinal & biomolecular chemistry ,medicine.anatomical_structure ,Complementary and alternative medicine ,Molecular Medicine ,Lamiaceae ,Diterpenes ,Human cancer - Abstract
Two new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (3–13) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6 and 9 were moderately cytotoxic against HL-60, whereas 6 and 13 were more active on SF-295 and HCT-116.
- Published
- 2020
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