1. Motobamide, an Antitrypanosomal Cyclic Peptide from a Leptolyngbya sp. Marine Cyanobacterium
- Author
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Kiyotake Suenaga, Ryota Suzuki, Toshinori Sato, Ghulam Jeelani, Naoaki Kurisawa, Arihiro Iwasaki, Tomoyoshi Nozaki, Teruhiko Matsubara, and Hiroki Takahashi
- Subjects
Pharmacology ,chemistry.chemical_classification ,010405 organic chemistry ,Stereochemistry ,Organic Chemistry ,Absolute configuration ,Pharmaceutical Science ,Trypanosoma brucei rhodesiense ,01 natural sciences ,High-performance liquid chromatography ,Cyclic peptide ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Residue (chemistry) ,Complementary and alternative medicine ,chemistry ,Drug Discovery ,Molecular Medicine ,Cytotoxicity ,IC50 ,Leptolyngbya sp - Abstract
Motobamide (1), a new cyclic peptide containing a C-prenylated cyclotryptophan residue, was isolated from a marine Leptolyngbya sp. cyanobacterium. Its planar structure was established by spectroscopic and MS/MS analyses. The absolute configuration was elucidated based on a combination of chemical degradations, chiral-phase HPLC analyses, spectroscopic analyses, and computational chemistry. Motobamide (1) moderately inhibited the growth of bloodstream forms of Trypanosoma brucei rhodesiense (IC50 2.3 µM). However, it exhibited a weaker cytotoxicity against normal human cells (IC50 55 µM). more...
- Published
- 2021
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