1. One new spirocyclic lactone and one new benzopyran derivative from Aspergillus terreus
- Author
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Pan Han, Chunmei Chen, Zhaodi Wu, Yongji Lai, Dongyan Li, Hucheng Zhu, Jieru Guo, Qingyi Tong, and Yonghui Zhang
- Subjects
Pharmacology ,chemistry.chemical_classification ,Natural product ,biology ,010405 organic chemistry ,Stereochemistry ,Organic Chemistry ,Pharmaceutical Science ,General Medicine ,Ring (chemistry) ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,Benzopyran ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,Drug Discovery ,Molecular Medicine ,Aspergillus terreus ,Derivative (chemistry) ,Human cancer ,Lactone - Abstract
One new spirocyclic lactone, terreinlactone C (1), and one new benzopyran derivative, 2,2-dimethyl-3-hydroxychroman-6-aldehyde (2), were discovered from the fungus Aspergillus terreus. The chemical structures of compounds 1 and 2 were elucidated by detailedly analyzing NMR and HRESIMS data. Compound 1 is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway is proposed. Two compounds were tested for their cytotoxic activities against five human cancer cell lines.[Formula: see text].
- Published
- 2020