1. Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications
- Author
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Mukesh Sharma, Véronique Coma, and Armando J. D. Silvestre, Eduardo M. Costa, Guillaume Chantereau, Mariana Veiga, Carmen S. R. Freire, F. Antunes, Mara G. Freire, Atiye Abednejad, Carla Vilela, M. M. Pintado, Gilles Sèbe, Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Team 2 LCPO : Biopolymers & Bio-sourced Polymers, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Centro de Investigacao em Materiais Ceramicaos e Compositos (CICECO), Universidade de Aveiro, Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), TEAM 2 LCPO, Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), and Veritati - Repositório Institucional da Universidade Católica Portuguesa
- Subjects
Skin care applications ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Nanocellulose ,chemistry.chemical_compound ,Antioxidant activity ,Materials Chemistry ,Salt metathesis reaction ,Organic chemistry ,Physical and Theoretical Chemistry ,Solubility ,Thermal analysis ,Vitamin B ,Spectroscopy ,ComputingMilieux_MISCELLANEOUS ,Chemistry ,Plasticizer ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Cholinium-based ILs ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Bioavailability ,Ionic liquids ,Membrane ,[CHIM.POLY]Chemical Sciences/Polymers ,Bacterial nanocellulose ,Ionic liquid ,0210 nano-technology - Abstract
The development of innovative bio-based skin care products has received an increased attention in the latter years. In the present work, the synthesis of original active principle ingredients based on ionic liquids (ILs) with cholinium cation and vitamins B anions, followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications, is reported. Three ILs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of ILs in BC led to translucent and homogeneous membranes stable up to 190 °C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-ILs were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications.
- Published
- 2020
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