1. N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils
- Author
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Yi Liang, Tianxin Xie, Yimin Chen, Yuying Li, Bin Dai, Jiapei Dai, Mengchao Cui, Hongwei Tan, Chang Yuan, and Kaixiang Zhou
- Subjects
Boron Compounds ,Male ,Protein Conformation ,Stereochemistry ,tau Proteins ,Biosensing Techniques ,010402 general chemistry ,Fibril ,Hippocampus ,01 natural sciences ,Catalysis ,Mice ,chemistry.chemical_compound ,Alzheimer Disease ,β amyloid ,Biological property ,Presenilin-1 ,Materials Chemistry ,Animals ,Humans ,Moiety ,Benzamide ,Fluorescent Dyes ,Aged, 80 and over ,Amyloid beta-Peptides ,Spectroscopy, Near-Infrared ,010405 organic chemistry ,Chemistry ,Optical Imaging ,Near-infrared spectroscopy ,Metals and Alloys ,Biological Transport ,General Chemistry ,Fluorescence ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Disease Models, Animal ,Spectrometry, Fluorescence ,Benzamides ,Ceramics and Composites ,Female ,Hydrophobic and Hydrophilic Interactions ,Protein Binding - Abstract
In this study, a series of organo difluoroboron probes with a BF2 benzamide moiety was designed, prepared and evaluated. Among them, 2c displayed the best optical and biological properties, and may be used as a useful near-infrared fluorescent probe for the detection of Aβ plaques and neurofibrillary tangles in AD.
- Published
- 2020