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Your search keyword '"Vangala Venugopal"' showing total 2 results
Start Over Author "Vangala Venugopal" Topic 01 natural sciences
2 results on '"Vangala Venugopal"'

1. ‘AIE + ESIPT’ assisted photorelease: fluorescent organic nanoparticles for dual anticancer drug delivery with real-time monitoring ability

Author

Sandipan Biswas, N. D. Pradeep Singh, Rakesh Mengji, Vangala Venugopal, Avijit Jana, and Shrabani Barman

Subjects
Time Factors, Cell Survival, Nanoparticle, Excited state intramolecular proton transfer, Antineoplastic Agents, 02 engineering and technology, 010402 general chemistry, Photochemistry, 01 natural sciences, Catalysis, Drug Delivery Systems, Materials Chemistry, Humans, Aggregation-induced emission, Fluorescent Dyes, Phenylacetates, Molecular Structure, Chemistry, Metals and Alloys, General Chemistry, Photochemical Processes, 021001 nanoscience & nanotechnology, Anticancer drug, Fluorescence, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Ceramics and Composites, Nanoparticles, Protons, 0210 nano-technology, HeLa Cells
Abstract

‘Aggregation Induced Emission + Excited State Intramolecular Proton Transfer (AIE + ESIPT)’-assisted photorelease of an anticancer drug by a p-hydroxyphenacyl (pHP) phototrigger with real-time monitoring has been demonstrated.

Published
2018

2. Intramolecular macrolactonization, photophysical and biological studies of new class of polycyclic pyrrole derivatives

Author

Arabinda Mandal, Avijit Jana, Suresh Kumar Mondal, Vangala Venugopal, Susanta Kumar Manna, Maidul Hossain, Sk Asraf Ali, and Shubhankar Samanta

Subjects
Reaction conditions, Biological studies, 010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, Intramolecular cyclization, 010402 general chemistry, 01 natural sciences, Biochemistry, Fluorescence, Combinatorial chemistry, Pyrrole derivatives, Coupling reaction, 0104 chemical sciences, Intramolecular force, Physical and Theoretical Chemistry
Abstract

Herein, we report an efficient synthesis of N-substituted pyrrole derivatives and their application to construct macrocyclic oxazocinone via a two-component coupling reaction followed by base mediated intramolecular cyclization. This methodology provides an easy two-step approach to constitute a library of fused pyrrolo-oxazocinone derivatives in good yields under mild reaction conditions. The present methodology offers an easy access to the synthesis of a library of fluorescent pyrole derivatives. Among them, tert-butyl 2-(2-(3-hydroxypropyl)-7-methoxy-4,5-dihydro-2H-benzo[e]isoindol-1-yl)acetate has been employed in bio-analytical imaging which shows efficient cellular internalization along with no obvious cellular toxicity.

Published
2017

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