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Your search keyword '"Wan-Ru Zhuang"' showing total 2 results
Start Over Author "Wan-Ru Zhuang" Topic 01 natural sciences
2 results on '"Wan-Ru Zhuang"'

1. Histone-inspired biomimetic polymeric gene vehicles with excellent biocompatibility and enhanced transfection efficacy

Author

Yu-Jing He, Peng-Fei Cui, Jian-Bin Qiao, Jia-Liang Zhang, Lei Xing, Qing-Ri Jin, Cheng-Qiong Luo, Wan-Ru Zhuang, and Hu-Lin Jiang

Subjects
Polymers and Plastics, biology, Biocompatibility, Chemistry, Genetic enhancement, Organic Chemistry, Bioengineering, 02 engineering and technology, Transfection, Gene delivery, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Biochemistry, Smart polymer, 0104 chemical sciences, chemistry.chemical_compound, Histone, Nucleic acid, biology.protein, 0210 nano-technology, DNA
Abstract

Limited delivery options have hindered the development of nucleic acid drugs in clinical practice. Inspired by the natural DNA compressing ability of histones, herein we have synthesized novel polymeric carriers called PCAmHn designed to mimic the histone mechanism for gene delivery. These smart polymers, composed of cell penetrating guanidine groups and pH sensitive imidazole groups, exhibited superior transfection efficiency. Simultaneously, GSH-responsive degradation endowed PCAmHn with capabilities of real-time DNA release as well as timely biodegradation. In summary, these histone-inspired PCAmHn have shown a great potential in gene therapy.

Published
2016

2. A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

Author

Fangyuan Li, Xi Hu, Jian-Bin Qiao, Peng-Fei Cui, Wan-Ru Zhuang, Yu-Jing He, Daishun Ling, Ru-Yi Yu, Hu-Lin Jiang, and Lei Xing

Subjects
Polymers, Stacking, Antineoplastic Agents, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Guanidines, Catalysis, Fluorescence, Hydrophilic polymers, Materials Chemistry, medicine, Animals, Humans, Doxorubicin, Drug Carriers, Mice, Inbred BALB C, Chemistry, Hydrophobic drug, Metals and Alloys, General Chemistry, 021001 nanoscience & nanotechnology, Combinatorial chemistry, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Drug Liberation, Drug delivery, Ceramics and Composites, MCF-7 Cells, Female, Delivery system, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions, medicine.drug
Abstract

A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π–π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.

Published
2018

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