1. Synthesis, Crystal Structure and Inhibitory Activities of 2-(N-Tert-Butoxycarbonylamino)Pyridine Derivatives
- Author
-
Bao-Tong Li, Ming-Yu Zhao, Xu-Liang Nie, Xugen Shi, Yun-Lian Shi, Da-Yong Peng, Ming-Zhu Shi, Tao Huang, and Xue-Xiang Ren
- Subjects
Pyricularia ,biology ,Chemistry ,Stereochemistry ,Biological activity ,General Chemistry ,Crystal structure ,Carbon-13 NMR ,010402 general chemistry ,010403 inorganic & nuclear chemistry ,Condensed Matter Physics ,Alternaria ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Crystallography ,Pyridine ,Proton NMR ,Organometallic chemistry - Abstract
2-(N-tert-butoxycarbonylamino) pyridine and 2-(N-tert-butoxycarbonylamino)-3-methylpyridine were synthesized in a one-step method using either 2-aminopyridine or 2-amino-3-methyphyridine with tert-butylcarbonyl anhydride as the starting materials. The products were characterized by single-crystal X-ray diffraction, 1H NMR, 13C NMR, and HRMS. The biological activity of the two compounds against five fungi was determined. 2-(N-tert-butoxycarbonylamino) pyridine has more than 50% inhibitory activity against Pyricularia oryzae, Colletotrichum gloeosporioides, and Alternaria alternate. In addition, the inhibitory activity of 2-(N-tert-butoxycarbonylamino)-3-methylpyridine against Alternaria alternate reached 67.69%. Two 2-BOC aminopyridine derivatives were synthesized and structurally characterized by 1H NMR, 13C NMR, HRMS analysis and X-ray crystal diffraction. The inhibitory activity both compounds was studied.
- Published
- 2020