1. Analysis of Bisulfite Via a Nitro Derivative of Cyanine-3 (NCy3) in the Microfluidic Channel
- Author
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Cody Masters, Haishi Cao, Haley A. Houtwed, Aatiya Ahmad, Kristy L. Kounovsky-Shafer, Melissa M. Davison, and Meng Xie
- Subjects
Sociology and Political Science ,Absorption spectroscopy ,010405 organic chemistry ,Clinical Biochemistry ,Substituent ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Biochemistry ,Article ,0104 chemical sciences ,Bisulfite ,Clinical Psychology ,chemistry.chemical_compound ,chemistry ,Nitration ,Nitro ,Reactivity (chemistry) ,Cyanine ,Law ,Spectroscopy ,Social Sciences (miscellaneous) ,Derivative (chemistry) - Abstract
NCy3, a derivative of Cyanine 3 with a nitro substituent, showed a high reactivity to bisulfite in aqueous media, instantly leading to ratiometric change of absorption spectra and significant fluorescence quenching. Applied in the microfluidic channel, NCy3 functionalize as a sensitive approach for quantitative detection of bisulfite, particularly for samples with a small volume.
- Published
- 2019
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